{"id":"https://openalex.org/W1992336928","doi":"https://doi.org/10.1016/s0014-4827(03)00013-2","title":"Extension of replicative lifespan in WI-38 human fibroblasts by dexamethasone treatment is accompanied by suppression of p21Waf1/Cip1/Sdi1 levels","display_name":"Extension of replicative lifespan in WI-38 human fibroblasts by dexamethasone treatment is accompanied by suppression of p21Waf1/Cip1/Sdi1 levels","publication_year":2003,"publication_date":"2003-04-01","ids":{"openalex":"https://openalex.org/W1992336928","doi":"https://doi.org/10.1016/s0014-4827(03)00013-2","mag":"1992336928","pmid":"https://pubmed.ncbi.nlm.nih.gov/12681289"},"language":"en","primary_location":{"id":"doi:10.1016/s0014-4827(03)00013-2","doi":"https://doi.org/10.1016/s0014-4827(03)00013-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0014-4827(03)00013-2","pdf_url":null,"source":{"id":"https://openalex.org/S132505712","display_name":"Experimental Cell Research","issn_l":"0014-4827","issn":["0014-4827","1090-2422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Cell Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089401971","display_name":"Madhu Mawal-Dewan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I182321934","display_name":"Lankenau Institute for Medical Research","ror":"https://ror.org/030g3hg75","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I182321934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madhu Mawal-Dewan","raw_affiliation_strings":["Lankenau Institute for Medical Research, 100 Lancaster Ave., Wynnewood, PA 19096, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lankenau Institute for Medical Research, 100 Lancaster Ave., Wynnewood, PA 19096, USA","institution_ids":["https://openalex.org/I182321934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073455682","display_name":"Lorenza Frisoni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I182321934","display_name":"Lankenau Institute for Medical Research","ror":"https://ror.org/030g3hg75","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I182321934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lorenza Frisoni","raw_affiliation_strings":["Lankenau Institute for Medical Research, 100 Lancaster Ave, Wynnewood, PA 19096, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lankenau Institute for Medical Research, 100 Lancaster Ave, Wynnewood, PA 19096, USA","institution_ids":["https://openalex.org/I182321934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055763114","display_name":"Vincent J. Cristofalo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I182321934","display_name":"Lankenau Institute for Medical Research","ror":"https://ror.org/030g3hg75","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I182321934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincent J Cristofalo","raw_affiliation_strings":["Lankenau Institute for Medical Research, 100 Lancaster Ave, Wynnewood, PA 19096, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lankenau Institute for Medical Research, 100 Lancaster Ave, Wynnewood, PA 19096, USA","institution_ids":["https://openalex.org/I182321934"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038670151","display_name":"Christian Sell","orcid":"https://orcid.org/0000-0002-4332-1141","observed_orcids":["https://orcid.org/0000-0002-4332-1141"]},"institutions":[{"id":"https://openalex.org/I182321934","display_name":"Lankenau Institute for Medical Research","ror":"https://ror.org/030g3hg75","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I182321934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian Sell","raw_affiliation_strings":["Lankenau Institute for Medical Research, 100 Lancaster Ave, Wynnewood, PA 19096, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lankenau Institute for Medical Research, 100 Lancaster Ave, Wynnewood, PA 19096, USA","institution_ids":["https://openalex.org/I182321934"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I182321934"],"apc_list":{"value":3270,"currency":"USD","value_usd":3270},"apc_paid":null,"fwci":0.3357,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.49343453,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"285","issue":"1","first_page":"91","last_page":"98"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/replicative-lifespan","display_name":"replicative lifespan","score":0.8920000195503235},{"id":"https://openalex.org/keywords/replicative-senescence","display_name":"replicative senescence","score":0.9660000205039978},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9890000224113464},{"id":"https://openalex.org/keywords/p21waf1-cip1-sdi1","display_name":"p21Waf1/Cip1/Sdi1","score":0.9829999804496765},{"id":"https://openalex.org/keywords/p16ink4a","display_name":"p16INK4a","score":0.9959999918937683},{"id":"https://openalex.org/keywords/wi-38-fibroblasts","display_name":"WI-38 fibroblasts","score":0.9089999794960022},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8460000157356262},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.8190000057220459},{"id":"https://openalex.org/keywords/cellular-aging","display_name":"cellular aging","score":0.44999998807907104}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8746075630187988},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.8525840640068054},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.8240058422088623},{"id":"https://openalex.org/C190474072","wikidata":"https://www.wikidata.org/wiki/Q7950532","display_name":"WI-38","level":4,"score":0.6168080568313599},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6060030460357666},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4894925355911255},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.4857807457447052},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47805550694465637},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4323463439941406},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.343050479888916},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19611814618110657},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08742597699165344},{"id":"https://openalex.org/C143191323","wikidata":"https://www.wikidata.org/wiki/Q118406","display_name":"Ploidy","level":3,"score":0.07119953632354736},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016213","descriptor_name":"Cyclins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050759","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p21","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0014-4827(03)00013-2","doi":"https://doi.org/10.1016/s0014-4827(03)00013-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0014-4827(03)00013-2","pdf_url":null,"source":{"id":"https://openalex.org/S132505712","display_name":"Experimental Cell Research","issn_l":"0014-4827","issn":["0014-4827","1090-2422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Cell Research","raw_type":"journal-article"},{"id":"pmid:12681289","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12681289","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental cell research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W123634254","https://openalex.org/W1500532974","https://openalex.org/W1537309584","https://openalex.org/W1793373281","https://openalex.org/W1966550850","https://openalex.org/W1966826646","https://openalex.org/W1992934869","https://openalex.org/W1994140739","https://openalex.org/W1996413533","https://openalex.org/W2004314923","https://openalex.org/W2007772649","https://openalex.org/W2013932828","https://openalex.org/W2018333710","https://openalex.org/W2022912215","https://openalex.org/W2024619097","https://openalex.org/W2044057392","https://openalex.org/W2050551830","https://openalex.org/W2063786789","https://openalex.org/W2073565503","https://openalex.org/W2082921795","https://openalex.org/W2085797277","https://openalex.org/W2111686512","https://openalex.org/W2121739926","https://openalex.org/W2134812217","https://openalex.org/W2142831855","https://openalex.org/W2144790226","https://openalex.org/W2162797616","https://openalex.org/W2163386603","https://openalex.org/W6630007649","https://openalex.org/W6648316654"],"related_works":["https://openalex.org/W2018333710","https://openalex.org/W2121825688","https://openalex.org/W7096167703","https://openalex.org/W2070207313","https://openalex.org/W1500532974","https://openalex.org/W2158713934","https://openalex.org/W2137755738","https://openalex.org/W2082116042","https://openalex.org/W3205551073","https://openalex.org/W2971276440"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
