{"id":"https://openalex.org/W1992299238","doi":"https://doi.org/10.1021/bi060723g","title":"Characterization of the Bifunctional Aminoglycoside-Modifying Enzyme ANT(3\u2018 \u2018)-Ii/AAC(6\u2018)-IId from Serratia marcescens","display_name":"Characterization of the Bifunctional Aminoglycoside-Modifying Enzyme ANT(3\u2018 \u2018)-Ii/AAC(6\u2018)-IId from Serratia marcescens","publication_year":2006,"publication_date":"2006-06-20","ids":{"openalex":"https://openalex.org/W1992299238","doi":"https://doi.org/10.1021/bi060723g","mag":"1992299238","pmid":"https://pubmed.ncbi.nlm.nih.gov/16819836"},"language":"en","primary_location":{"id":"doi:10.1021/bi060723g","doi":"https://doi.org/10.1021/bi060723g","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi060723g","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049306478","display_name":"Choon Keun Kim","orcid":"https://orcid.org/0000-0003-0306-8935","observed_orcids":["https://orcid.org/0000-0003-0306-8935"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Choonkeun Kim","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556","Department of Chemistry and Biochemistry, University of Notre Dame Notre Dame, Indiana 46556 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556","institution_ids":["https://openalex.org/I107639228"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Notre Dame Notre Dame, Indiana 46556 USA","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069198023","display_name":"Du\u0161an Hesek","orcid":"https://orcid.org/0000-0001-6288-8824","observed_orcids":["https://orcid.org/0000-0001-6288-8824"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dusan Hesek","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074318077","display_name":"Jaroslav Zaj\u00ed\u010dek","orcid":"https://orcid.org/0000-0002-9398-1922","observed_orcids":["https://orcid.org/0000-0002-9398-1922"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaroslav Zaj\u00ed\u010dek","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043351423","display_name":"Sergei B. Vakulenko","orcid":"https://orcid.org/0000-0002-5327-8124","observed_orcids":["https://orcid.org/0000-0002-5327-8124"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sergei B. Vakulenko","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013812375","display_name":"Shahriar Mobashery","orcid":"https://orcid.org/0000-0002-7695-7883","observed_orcids":["https://orcid.org/0000-0002-7695-7883"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shahriar Mobashery","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556","institution_ids":["https://openalex.org/I107639228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5013812375"],"corresponding_institution_ids":["https://openalex.org/I107639228"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.5826,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.79162747,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"45","issue":"27","first_page":"8368","last_page":"8377"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serratia-marcescens","display_name":"Serratia marcescens","score":0.925000011920929},{"id":"https://openalex.org/keywords/aminoglycoside-resistance","display_name":"aminoglycoside resistance","score":0.925000011920929},{"id":"https://openalex.org/keywords/acetyltransferase","display_name":"acetyltransferase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/kanamycin-a","display_name":"kanamycin A","score":0.7419999837875366},{"id":"https://openalex.org/keywords/streptomycin","display_name":"streptomycin","score":0.9229999780654907},{"id":"https://openalex.org/keywords/spectinomycin","display_name":"spectinomycin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.6190000176429749},{"id":"https://openalex.org/keywords/theorell-chance-mechanism","display_name":"Theorell-Chance mechanism","score":0.9340000152587891},{"id":"https://openalex.org/keywords/ordered-bi-bi-mechanism","display_name":"ordered bi-bi mechanism","score":0.8949999809265137},{"id":"https://openalex.org/keywords/solvent-isotope-effect","display_name":"solvent isotope effect","score":0.8960000276565552},{"id":"https://openalex.org/keywords/solvent-viscosity-effects","display_name":"solvent viscosity effects","score":0.7739999890327454},{"id":"https://openalex.org/keywords/feedback-inhibition","display_name":"product inhibition","score":0.6779999732971191},{"id":"https://openalex.org/keywords/dead-end-inhibition","display_name":"dead-end inhibition","score":0.7870000004768372},{"id":"https://openalex.org/keywords/gene-fusion","display_name":"gene fusion","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C2777787772","wikidata":"https://www.wikidata.org/wiki/Q45355603","display_name":"Aminoglycoside","level":3,"score":0.7251321077346802},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.625468909740448},{"id":"https://openalex.org/C2779649592","wikidata":"https://www.wikidata.org/wiki/Q2655970","display_name":"Acetyltransferase","level":4,"score":0.5141382813453674},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5005578994750977},{"id":"https://openalex.org/C58431802","wikidata":"https://www.wikidata.org/wiki/Q420663","display_name":"Phosphofructokinase 2","level":3,"score":0.484942227602005},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.48005685210227966},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4701887369155884},{"id":"https://openalex.org/C2908843251","wikidata":"https://www.wikidata.org/wiki/Q3381520","display_name":"Phosphotransferases","level":3,"score":0.4539952874183655},{"id":"https://openalex.org/C2780920689","wikidata":"https://www.wikidata.org/wiki/Q27094615","display_name":"Kanamycin","level":3,"score":0.4362812340259552},{"id":"https://openalex.org/C2776309202","wikidata":"https://www.wikidata.org/wiki/Q140004","display_name":"Serratia marcescens","level":4,"score":0.4357141852378845},{"id":"https://openalex.org/C160403918","wikidata":"https://www.wikidata.org/wiki/Q4682322","display_name":"Adenylylation","level":4,"score":0.433610200881958},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.3515697419643402},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.34806472063064575},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.318103164434433},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23387479782104492},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.18010357022285461},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.10119134187698364},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000123","descriptor_name":"Acetyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000123","descriptor_name":"Acetyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000123","descriptor_name":"Acetyltransferases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000249","descriptor_name":"Adenosine Monophosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000617","descriptor_name":"Aminoglycosides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004352","descriptor_name":"Drug Resistance, Microbial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009713","descriptor_name":"Nucleotidyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009713","descriptor_name":"Nucleotidyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009713","descriptor_name":"Nucleotidyltransferases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012706","descriptor_name":"Serratia marcescens","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D012706","descriptor_name":"Serratia marcescens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019677","descriptor_name":"Artificial Gene Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi060723g","doi":"https://doi.org/10.1021/bi060723g","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi060723g","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:16819836","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16819836","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W14782221","https://openalex.org/W43163001","https://openalex.org/W1533496027","https://openalex.org/W1566419712","https://openalex.org/W1653306470","https://openalex.org/W1912520552","https://openalex.org/W1970835076","https://openalex.org/W1970931523","https://openalex.org/W1972091494","https://openalex.org/W1973442246","https://openalex.org/W1974439854","https://openalex.org/W1975361143","https://openalex.org/W1983457131","https://openalex.org/W1984252886","https://openalex.org/W1987635163","https://openalex.org/W1988499080","https://openalex.org/W1991954878","https://openalex.org/W1994629432","https://openalex.org/W1995601766","https://openalex.org/W1997624484","https://openalex.org/W1999890029","https://openalex.org/W2000271307","https://openalex.org/W2015828459","https://openalex.org/W2020747321","https://openalex.org/W2029204005","https://openalex.org/W2031902562","https://openalex.org/W2035788433","https://openalex.org/W2036033565","https://openalex.org/W2039204060","https://openalex.org/W2040285752","https://openalex.org/W2053707219","https://openalex.org/W2056194121","https://openalex.org/W2063822490","https://openalex.org/W2066431887","https://openalex.org/W2067981587","https://openalex.org/W2069602336","https://openalex.org/W2070678009","https://openalex.org/W2071265011","https://openalex.org/W2073703928","https://openalex.org/W2085232354","https://openalex.org/W2090651792","https://openalex.org/W2093591309","https://openalex.org/W2105240505","https://openalex.org/W2110424949","https://openalex.org/W2112901195","https://openalex.org/W2116214229","https://openalex.org/W2127439444","https://openalex.org/W2129260125","https://openalex.org/W2131946678","https://openalex.org/W2132905138","https://openalex.org/W2132911648","https://openalex.org/W2156569781","https://openalex.org/W2158119633","https://openalex.org/W2164448039","https://openalex.org/W2166801599","https://openalex.org/W2324815695","https://openalex.org/W2336036809","https://openalex.org/W2411711202","https://openalex.org/W2739616593","https://openalex.org/W2921073505"],"related_works":["https://openalex.org/W2017140509","https://openalex.org/W2014003966","https://openalex.org/W2080830188","https://openalex.org/W1974439854","https://openalex.org/W14782221","https://openalex.org/W2805300175","https://openalex.org/W7099822034","https://openalex.org/W2140697648","https://openalex.org/W2084494110","https://openalex.org/W2079929958"],"abstract_inverted_index":{"A":[0,34],"newly":[1],"discovered":[2],"bifunctional":[3,170],"antibiotic":[4,123,143],"resistance":[5,171,200],"enzyme":[6,115],"from":[7],"Serratia":[8],"marcescens":[9],"catalyzes":[10,102],"adenylation":[11,37],"and":[12,35,40,45,58,85,92,120,154],"acetylation":[13,26],"of":[14,20,32,43,83,165,186,199],"aminoglycoside":[15,119,202],"antibiotics.":[16],"The":[17,48,81,131,163],"structure":[18],"assignment":[19],"the":[21,30,36,61,88,93,99,103,114,118,121,125,142,145,151,160,184,197],"enzymic":[22],"products":[23],"indicated":[24],"that":[25,73,98,148],"takes":[27],"place":[28],"on":[29,38],"6'-amine":[31],"kanamycin":[33],"3''-":[39],"9-hydroxyl":[41],"groups":[42],"streptomycin":[44],"spectinomycin,":[46],"respectively.":[47],"adenyltransferase":[49,100],"domain":[50,63,101,133],"appears":[51],"to":[52,56,113,117,128,150,159,168,201],"be":[53,129],"highly":[54],"specific":[55],"spectinomycin":[57],"streptomycin,":[59],"while":[60],"acetyltransferase":[62,132],"shows":[64],"a":[65,77,106,193],"broad":[66],"substrate":[67,147],"profile.":[68],"Initial":[69],"velocity":[70],"patterns":[71],"indicate":[72],"both":[74],"domains":[75],"follow":[76],"sequential":[78],"kinetic":[79,108,138],"mechanism.":[80],"use":[82],"dead-end":[84],"product":[86,127],"inhibition,":[87],"solvent":[89,94],"isotope":[90],"effect,":[91],"viscosity":[95],"effect":[96],"reveals":[97],"reaction":[104],"by":[105],"Theorell-Chance":[107],"mechanism,":[109,139],"where":[110],"ATP":[111],"binds":[112,149],"prior":[116,158],"modified":[122,161],"is":[124,144,156],"last":[126],"released.":[130],"follows":[134],"an":[135],"ordered":[136],"bi-bi":[137],"in":[140,180,188,196],"which":[141,191],"first":[146],"active":[152],"site":[153],"CoASH":[155],"released":[157],"aminoglycoside.":[162],"merging":[164],"two":[166],"genes":[167],"create":[169],"enzymes":[172],"with":[173],"expanded":[174],"profiles":[175],"has":[176],"now":[177],"been":[178],"documented":[179],"four":[181],"instances,":[182],"including":[183],"subject":[185],"study":[187],"this":[189],"report,":[190],"suggests":[192],"new":[194],"trend":[195],"emergence":[198],"antibiotics":[203],"among":[204],"pathogens.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
