{"id":"https://openalex.org/W1992299009","doi":"https://doi.org/10.1007/s10165-012-0645-6","title":"Efficacy of weekly mizoribine pulse therapy in refractory lupus nephritis","display_name":"Efficacy of weekly mizoribine pulse therapy in refractory lupus nephritis","publication_year":2012,"publication_date":"2012-04-21","ids":{"openalex":"https://openalex.org/W1992299009","doi":"https://doi.org/10.1007/s10165-012-0645-6","mag":"1992299009","pmid":"https://pubmed.ncbi.nlm.nih.gov/22526831"},"language":"en","primary_location":{"id":"doi:10.1007/s10165-012-0645-6","doi":"https://doi.org/10.1007/s10165-012-0645-6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10165-012-0645-6","pdf_url":null,"source":{"id":"https://openalex.org/S30446230","display_name":"Modern Rheumatology","issn_l":"1439-7595","issn":["1439-7595","1439-7609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Rheumatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110517964","display_name":"Eiko Nishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405282892","display_name":"Saitama Medical Center, Saitama Medical University","ror":"https://ror.org/00ma6wk53","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405282892"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eiko Nishi","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama, 350-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama, 350-8550, Japan","institution_ids":["https://openalex.org/I4405282892"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058629132","display_name":"Hideto Kameda","orcid":"https://orcid.org/0000-0002-4330-5782","observed_orcids":["https://orcid.org/0000-0002-4330-5782"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideto Kameda","raw_affiliation_strings":["Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105939126","display_name":"Hiroe Ogawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405282892","display_name":"Saitama Medical Center, Saitama Medical University","ror":"https://ror.org/00ma6wk53","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405282892"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroe Ogawa","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama 350-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama 350-8550, Japan","institution_ids":["https://openalex.org/I4405282892"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074411927","display_name":"Hayato Nagasawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405282892","display_name":"Saitama Medical Center, Saitama Medical University","ror":"https://ror.org/00ma6wk53","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405282892"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hayato Nagasawa","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama 350-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama 350-8550, Japan","institution_ids":["https://openalex.org/I4405282892"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100899818","display_name":"Hirofumi Takei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405282892","display_name":"Saitama Medical Center, Saitama Medical University","ror":"https://ror.org/00ma6wk53","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405282892"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirofumi Takei","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama 350-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama 350-8550, Japan","institution_ids":["https://openalex.org/I4405282892"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108271205","display_name":"Ayumi Okuyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405282892","display_name":"Saitama Medical Center, Saitama Medical University","ror":"https://ror.org/00ma6wk53","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405282892"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ayumi Okuyama","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama 350-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama 350-8550, Japan","institution_ids":["https://openalex.org/I4405282892"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110333794","display_name":"Takahiko Kurasawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiko Kurasawa","raw_affiliation_strings":["Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110522221","display_name":"Tsuneo Kondo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405282892","display_name":"Saitama Medical Center, Saitama Medical University","ror":"https://ror.org/00ma6wk53","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405282892"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsuneo Kondo","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama 350-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama 350-8550, Japan","institution_ids":["https://openalex.org/I4405282892"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102719996","display_name":"Koji Nishimura","orcid":"https://orcid.org/0000-0003-0507-8184","observed_orcids":["https://orcid.org/0000-0003-0507-8184"]},"institutions":[{"id":"https://openalex.org/I4405282892","display_name":"Saitama Medical Center, Saitama Medical University","ror":"https://ror.org/00ma6wk53","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405282892"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koji Nishimura","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama 350-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama 350-8550, Japan","institution_ids":["https://openalex.org/I4405282892"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113900114","display_name":"Yuichiro Shirai","orcid":"https://orcid.org/0000-0002-6864-8941","observed_orcids":["https://orcid.org/0000-0002-6864-8941"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuichiro Shirai","raw_affiliation_strings":["Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044730707","display_name":"Ryota Sakai","orcid":"https://orcid.org/0000-0003-0785-495X","observed_orcids":["https://orcid.org/0000-0003-0785-495X"]},"institutions":[{"id":"https://openalex.org/I4405282892","display_name":"Saitama Medical Center, Saitama Medical University","ror":"https://ror.org/00ma6wk53","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405282892"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryota Sakai","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama 350-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama 350-8550, Japan","institution_ids":["https://openalex.org/I4405282892"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085733466","display_name":"Tatsuya Ito","orcid":"https://orcid.org/0009-0009-8658-8012","observed_orcids":["https://orcid.org/0009-0009-8658-8012","https://orcid.org/0009-0009-8887-5779"]},"institutions":[{"id":"https://openalex.org/I4405282892","display_name":"Saitama Medical Center, Saitama Medical University","ror":"https://ror.org/00ma6wk53","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405282892"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuya Ito","raw_affiliation_strings":["Department of Internal Medicine, Saitama Yorii Hospital, 395 Yodo, Yorii, Ohsato County, Saitama 369-1211, Japan","Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama 350-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Saitama Yorii Hospital, 395 Yodo, Yorii, Ohsato County, Saitama 369-1211, Japan","institution_ids":[]},{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama 350-8550, Japan","institution_ids":["https://openalex.org/I4405282892"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083314956","display_name":"Tsutomu Takeuchi","orcid":"https://orcid.org/0000-0003-1111-8218","observed_orcids":["https://orcid.org/0000-0003-1111-8218"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsutomu Takeuchi","raw_affiliation_strings":["Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087307078","display_name":"Koichi Amano","orcid":"https://orcid.org/0000-0002-4228-2056","observed_orcids":["https://orcid.org/0000-0002-4228-2056"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Koichi Amano","raw_affiliation_strings":["Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan","institution_ids":["https://openalex.org/I203951103"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5087307078"],"corresponding_institution_ids":["https://openalex.org/I203951103"],"apc_list":{"value":3208,"currency":"USD","value_usd":3208},"apc_paid":null,"fwci":0.9791,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.7563433,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"23","issue":"1","first_page":"97","last_page":"103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mizoribine","display_name":"mizoribine","score":0.9259999990463257},{"id":"https://openalex.org/keywords/lupus-nephritis","display_name":"lupus nephritis","score":0.8939999938011169},{"id":"https://openalex.org/keywords/refractory-lupus-nephritis","display_name":"refractory lupus nephritis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/pulse-therapy","display_name":"pulse therapy","score":0.8769999742507935},{"id":"https://openalex.org/keywords/intermittent-dosing","display_name":"intermittent dosing","score":0.9649999737739563},{"id":"https://openalex.org/keywords/steroid-sparing-therapy","display_name":"steroid-sparing therapy","score":0.640999972820282},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.5090000033378601},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.8159999847412109},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.5080000162124634}],"concepts":[{"id":"https://openalex.org/C2777882293","wikidata":"https://www.wikidata.org/wiki/Q6884708","display_name":"Mizoribine","level":2,"score":0.7557359337806702},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.578400731086731},{"id":"https://openalex.org/C198451711","wikidata":"https://www.wikidata.org/wiki/Q327657","display_name":"Rheumatology","level":2,"score":0.5551641583442688},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5381190776824951},{"id":"https://openalex.org/C2779912601","wikidata":"https://www.wikidata.org/wiki/Q1621830","display_name":"Lupus nephritis","level":3,"score":0.49285101890563965},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.45508721470832825},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.38182333111763},{"id":"https://openalex.org/C509550671","wikidata":"https://www.wikidata.org/wiki/Q126945","display_name":"Medical education","level":1,"score":0.33548903465270996},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0922684371471405},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008181","descriptor_name":"Lupus Nephritis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008181","descriptor_name":"Lupus Nephritis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008181","descriptor_name":"Lupus Nephritis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012263","descriptor_name":"Ribonucleosides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012263","descriptor_name":"Ribonucleosides","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D012263","descriptor_name":"Ribonucleosides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020551","descriptor_name":"Pulse Therapy, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057915","descriptor_name":"Drug Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10165-012-0645-6","doi":"https://doi.org/10.1007/s10165-012-0645-6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10165-012-0645-6","pdf_url":null,"source":{"id":"https://openalex.org/S30446230","display_name":"Modern Rheumatology","issn_l":"1439-7595","issn":["1439-7595","1439-7609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Rheumatology","raw_type":"journal-article"},{"id":"pmid:22526831","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22526831","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern rheumatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1497642289","https://openalex.org/W1599627537","https://openalex.org/W1964393419","https://openalex.org/W1971821439","https://openalex.org/W1977296848","https://openalex.org/W1993258772","https://openalex.org/W2004781282","https://openalex.org/W2023862046","https://openalex.org/W2064154721","https://openalex.org/W2066528218","https://openalex.org/W2074642663","https://openalex.org/W2079781097","https://openalex.org/W2080725161","https://openalex.org/W2084533229","https://openalex.org/W2094074845","https://openalex.org/W2096194879","https://openalex.org/W2105845428","https://openalex.org/W2110793425","https://openalex.org/W2132174947","https://openalex.org/W2148306888","https://openalex.org/W2149459259","https://openalex.org/W2171121999","https://openalex.org/W2322831651","https://openalex.org/W2333020195","https://openalex.org/W2951505772"],"related_works":["https://openalex.org/W2004781282","https://openalex.org/W2325125327","https://openalex.org/W2105845428","https://openalex.org/W2088884438","https://openalex.org/W2133132746","https://openalex.org/W1979003887","https://openalex.org/W2323781607","https://openalex.org/W1989139370","https://openalex.org/W2082983805","https://openalex.org/W2322831651"],"abstract_inverted_index":{"OBJECTIVE:":[0],"We":[1],"investigated":[2],"the":[3,18,26,100,117,143,156,174],"efficacy":[4,23],"of":[5,20,30,104,116,145,151,155,163,173,183,200,209],"a":[6,86],"high-dose":[7],"intermittent":[8],"dosing":[9],"treatment":[10],"method":[11],"(weekly":[12],"mizoribine":[13,31,55,105,171,210],"pulse":[14,56],"therapy)":[15],"conceived":[16],"in":[17,32,114,189,195],"hope":[19],"achieving":[21],"better":[22],"by":[24,85],"increasing":[25],"peak":[27,101,169],"blood":[28,102,213],"levels":[29,103,135,214],"patients":[33,40,158],"with":[34,41],"refractory":[35,220],"lupus":[36,42,221],"nephritis.":[37,222],"METHODS:":[38],"Seventeen":[39],"nephritis":[43],"who":[44],"had":[45],"been":[46],"resistant":[47],"to":[48,92,106,109,141],"corticosteroid":[49],"and":[50,78,125,137,161,192,215],"immunosuppressant":[51],"therapy":[52],"received":[53],"weekly":[54],"therapy.":[57],"Mizoribine":[58],"(350":[59],"mg)":[60],"was":[61,139,176,187],"administered":[62],"three":[63],"times":[64],"at":[65],"12":[66],"h":[67],"intervals":[68],"over":[69],"2":[70],"consecutive":[71],"days":[72],"(700":[73],"mg":[74,80],"for":[75,81,219],"day":[76,82,90,93],"1":[77,190],"350":[79],"2),":[83],"followed":[84],"washout":[87],"period":[88],"from":[89],"3":[91,112],"7.":[94],"RESULTS:":[95],"This":[96],"therapeutic":[97],"strategy":[98],"enabled":[99],"be":[107,217],"increased":[108],"more":[110],"than":[111],"\u03bcg/mL":[113],"most":[115],"patients.":[118],"Although":[119],"SLEDAI,":[120],"anti-ds-DNA":[121],"antibody":[122],"titer,":[123],"CH-50,":[124],"serum":[126,170,184],"albumin":[127],"level":[128],"did":[129],"not":[130],"significantly":[131],"improve,":[132],"urinary":[133],"protein":[134],"decreased,":[136],"it":[138],"possible":[140],"taper":[142],"dose":[144],"concomitant":[146],"steroids.":[147],"Using":[148],"our":[149],"definition":[150],"clinical":[152],"response,":[153],"10":[154],"17":[157],"were":[159,165,204],"responders":[160,175],"4":[162,196],"them":[164],"nonresponders.":[166],"The":[167],"average":[168],"concentration":[172],"as":[177,179],"high":[178],"3.5":[180],"\u03bcg/mL.":[181],"Elevation":[182],"liver":[185],"enzymes":[186],"seen":[188],"patient,":[191],"hyperuricemia":[193],"occurred":[194],"cases,":[197],"but":[198],"none":[199],"these":[201],"adverse":[202],"events":[203],"serious.":[205],"CONCLUSION:":[206],"Intermittent":[207],"administration":[208],"can":[211],"increase":[212],"may":[216],"effective":[218]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
