{"id":"https://openalex.org/W1992298398","doi":"https://doi.org/10.1002/jcb.1170","title":"Caveolae and the organization of carbohydrate metabolism in vascular smooth muscle","display_name":"Caveolae and the organization of carbohydrate metabolism in vascular smooth muscle","publication_year":2001,"publication_date":"2001-07-30","ids":{"openalex":"https://openalex.org/W1992298398","doi":"https://doi.org/10.1002/jcb.1170","mag":"1992298398","pmid":"https://pubmed.ncbi.nlm.nih.gov/11500916"},"language":"en","primary_location":{"id":"doi:10.1002/jcb.1170","doi":"https://doi.org/10.1002/jcb.1170","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcb.1170","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112390978","display_name":"Pamela G. Lloyd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pamela G. Lloyd","raw_affiliation_strings":["Department of Physiology, University of Missouri, Columbia, Missouri 65212, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Missouri, Columbia, Missouri 65212, USA","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034288284","display_name":"Christopher D. Hardin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher D. Hardin","raw_affiliation_strings":["Department of Physiology, University of Missouri, Columbia, Missouri 65212"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Missouri, Columbia, Missouri 65212","institution_ids":["https://openalex.org/I76835614"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5034288284"],"corresponding_institution_ids":["https://openalex.org/I76835614"],"apc_list":{"value":5110,"currency":"USD","value_usd":5110},"apc_paid":null,"fwci":0.7933,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.68179925,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"82","issue":"3","first_page":"399","last_page":"408"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caveolae","display_name":"caveolae","score":1.0},{"id":"https://openalex.org/keywords/vascular-smooth-muscle","display_name":"vascular smooth muscle","score":0.9350000023841858},{"id":"https://openalex.org/keywords/carbohydrate-metabolism","display_name":"carbohydrate metabolism","score":0.8050000071525574},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.9559999704360962},{"id":"https://openalex.org/keywords/gluconeogenesis","display_name":"gluconeogenesis","score":1.0},{"id":"https://openalex.org/keywords/metabolic-compartmentalization","display_name":"metabolic compartmentation","score":0.7350000143051147},{"id":"https://openalex.org/keywords/plasma-membrane-microdomains","display_name":"plasma membrane microdomains","score":0.9350000023841858},{"id":"https://openalex.org/keywords/cerebral-microvasculature","display_name":"cerebral microvasculature","score":0.8050000071525574},{"id":"https://openalex.org/keywords/fructose-1-6-bisphosphate","display_name":"fructose-1,6-bisphosphate","score":0.875},{"id":"https://openalex.org/keywords/lactic-acid-production","display_name":"lactic acid production","score":0.8230000138282776}],"concepts":[{"id":"https://openalex.org/C49866891","wikidata":"https://www.wikidata.org/wiki/Q1051872","display_name":"Caveolae","level":3,"score":0.9403233528137207},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.7702265977859497},{"id":"https://openalex.org/C20904676","wikidata":"https://www.wikidata.org/wiki/Q191835","display_name":"Gluconeogenesis","level":3,"score":0.577688455581665},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49886274337768555},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49479740858078003},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.46577852964401245},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4273070991039276},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.39026498794555664},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3531090021133423},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3105694055557251}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D003505","descriptor_name":"Cyclodextrins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005635","descriptor_name":"Fructosediphosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005943","descriptor_name":"Gluconeogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021941","descriptor_name":"Caveolae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D021941","descriptor_name":"Caveolae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021941","descriptor_name":"Caveolae","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D047392","descriptor_name":"beta-Cyclodextrins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050260","descriptor_name":"Carbohydrate Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/jcb.1170","doi":"https://doi.org/10.1002/jcb.1170","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcb.1170","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},{"id":"pmid:11500916","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11500916","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.40059998631477356}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3322533174","display_name":"Cardiovascular/Renal Physiology, Pharmacology &Biochem.","funder_award_id":"T32HL007094","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W259631714","https://openalex.org/W1498915175","https://openalex.org/W1549194476","https://openalex.org/W1583163003","https://openalex.org/W1589243674","https://openalex.org/W1910359624","https://openalex.org/W1934687632","https://openalex.org/W1966949741","https://openalex.org/W1972238666","https://openalex.org/W1978279440","https://openalex.org/W1980905934","https://openalex.org/W1981716920","https://openalex.org/W1985721977","https://openalex.org/W1988431963","https://openalex.org/W1988601919","https://openalex.org/W1989544026","https://openalex.org/W1997726565","https://openalex.org/W2017518453","https://openalex.org/W2017921679","https://openalex.org/W2018810553","https://openalex.org/W2020024927","https://openalex.org/W2030801878","https://openalex.org/W2030931411","https://openalex.org/W2031129524","https://openalex.org/W2035508242","https://openalex.org/W2042695353","https://openalex.org/W2049215266","https://openalex.org/W2053100392","https://openalex.org/W2054537480","https://openalex.org/W2055394225","https://openalex.org/W2055679682","https://openalex.org/W2059683783","https://openalex.org/W2059895279","https://openalex.org/W2061845411","https://openalex.org/W2068908631","https://openalex.org/W2069155725","https://openalex.org/W2069444054","https://openalex.org/W2073250749","https://openalex.org/W2073323954","https://openalex.org/W2073863107","https://openalex.org/W2084379296","https://openalex.org/W2091881341","https://openalex.org/W2095480781","https://openalex.org/W2110581720","https://openalex.org/W2117468682","https://openalex.org/W2133093662","https://openalex.org/W2138217548","https://openalex.org/W2168582463","https://openalex.org/W2208500899","https://openalex.org/W2314402474","https://openalex.org/W2400236325","https://openalex.org/W2410118235","https://openalex.org/W2418051569","https://openalex.org/W2432135227","https://openalex.org/W2466219369","https://openalex.org/W4249820771"],"related_works":["https://openalex.org/W2090646870","https://openalex.org/W2314402474","https://openalex.org/W17022417","https://openalex.org/W4231391858","https://openalex.org/W2024895814","https://openalex.org/W2059737190","https://openalex.org/W1982288232","https://openalex.org/W2466219369","https://openalex.org/W3175088701","https://openalex.org/W1526499817"],"abstract_inverted_index":{"We":[0,38],"have":[1,39,172],"previously":[2],"found":[3,41],"that":[4,42,64,91,160],"glycolysis":[5,65,93],"and":[6,25,29,54,66,127,136,219],"gluconeogenesis":[7,67,100],"occur":[8],"in":[9,81,95,113,143,174,198,210],"separate":[10],"\"compartments\"":[11],"of":[12,23,84,118,131,155,177,181,203],"the":[13,129,165,191],"VSM":[14],"cell.":[15],"These":[16],"compartments":[17],"may":[18,68,170,195,222],"result":[19],"from":[20],"spatial":[21],"separation":[22],"glycolytic":[24,134,166],"gluconeogenic":[26,141],"enzymes":[27],"(Lloyd":[28,53],"Hardin":[30,55],"[1999]":[31],"Am":[32,57],"J":[33,58],"Physiol":[34,59],"Cell":[35,60],"Physiol.":[36,61],"277:C1250-C1262).":[37],"also":[40,171,208],"an":[43],"intact":[44],"plasma":[45,73],"membrane":[46,74],"is":[47,101],"essential":[48],"for":[49],"compartmentation":[50],"to":[51,103,157,183,205],"exist":[52],"[2000]":[56],"278:C803-C811),":[62],"suggesting":[63,159],"be":[69],"associated":[70],"with":[71,97,123],"distinct":[72],"microdomains.":[75],"Caveolae":[76,168],"are":[77],"one":[78],"such":[79],"microdomain,":[80],"which":[82],"proteins":[83],"related":[85],"function":[86],"colocalize.":[87],"Thus,":[88,213],"we":[89,110],"hypothesized":[90],"membrane-associated":[92],"occurs":[94],"association":[96],"caveolae,":[98],"while":[99],"localized":[102],"non-caveolae":[104],"domains.":[105],"To":[106],"test":[107],"this":[108],"hypothesis,":[109],"disrupted":[111,164],"caveolae":[112],"vascular":[114],"smooth":[115],"muscle":[116],"(VSM)":[117],"pig":[119],"cerebral":[120],"microvessels":[121],"(PCMV)":[122],"beta":[124],"methyl-cyclodextrin":[125],"(CD)":[126],"examined":[128],"metabolism":[130],"[2-(13)C]glucose":[132,156],"(a":[133],"substrate)":[135],"[1-(13)C]fructose":[137],"1,6-bisphosphate":[138],"(FBP,":[139],"a":[140,175,214],"substrate":[142],"PCMV)":[144],"using":[145],"(13)C":[146],"nuclear":[147],"magnetic":[148],"resonance":[149],"spectroscopy.":[150],"Caveolar":[151],"disruption":[152,162,169],"reduced":[153],"flux":[154],"[2-(13)C]lactate,":[158],"caveolar":[161,217],"partially":[163],"pathway.":[167],"resulted":[173],"breakdown":[176],"compartmentation,":[178],"since":[179,201],"conversion":[180,202],"[1-(13)C]FBP":[182,204],"[3-(13)C]lactate":[184,193],"was":[185,207],"increased":[186,192],"by":[187],"CD":[188],"treatment.":[189],"Alternatively,":[190],"production":[194],"reflect":[196],"changes":[197],"FBP":[199],"uptake,":[200],"[3-(13)C]glucose":[206],"elevated":[209],"CD-treated":[211],"cells.":[212],"link":[215],"between":[216],"organization":[218,221],"metabolic":[220],"exist.":[223]},"counts_by_year":[{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
