{"id":"https://openalex.org/W1992285196","doi":"https://doi.org/10.1007/bf00296939","title":"Activation mechanisms to chemical toxicity","display_name":"Activation mechanisms to chemical toxicity","publication_year":1987,"publication_date":"1987-05-01","ids":{"openalex":"https://openalex.org/W1992285196","doi":"https://doi.org/10.1007/bf00296939","mag":"1992285196","pmid":"https://pubmed.ncbi.nlm.nih.gov/3304217"},"language":"en","primary_location":{"id":"doi:10.1007/bf00296939","doi":"https://doi.org/10.1007/bf00296939","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00296939","pdf_url":null,"source":{"id":"https://openalex.org/S87018847","display_name":"Archives of Toxicology","issn_l":"0340-5761","issn":["0340-5761","1432-0738"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Toxicology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111711531","display_name":"Dennis V. Parke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28290843","display_name":"University of Surrey","ror":"https://ror.org/00ks66431","country_code":"GB","type":"education","lineage":["https://openalex.org/I28290843"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Dennis V. Parke","raw_affiliation_strings":["Department of Biochemistry, University of Surrey, Guildford, UK","Dept. of Biochemistry, University of Surrey, Guildford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Surrey, Guildford, UK","institution_ids":["https://openalex.org/I28290843"]},{"raw_affiliation_string":"Dept. of Biochemistry, University of Surrey, Guildford, UK","institution_ids":["https://openalex.org/I28290843"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111711531"],"corresponding_institution_ids":["https://openalex.org/I28290843"],"apc_list":{"value":5690,"currency":"USD","value_usd":5690},"apc_paid":null,"fwci":2.8998,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.89655172,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"60","issue":"1-3","first_page":"5","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8070999979972839,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8070999979972839,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.12349999696016312,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.026000000536441803,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemical-toxicity","display_name":"chemical toxicity","score":0.9369999766349792},{"id":"https://openalex.org/keywords/oxidative-activation","display_name":"oxidative activation","score":0.5979999899864197},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.9700000286102295},{"id":"https://openalex.org/keywords/cytochrome-p-448","display_name":"cytochrome P-448","score":0.9929999709129333},{"id":"https://openalex.org/keywords/flavoprotein-monooxygenase","display_name":"flavoprotein monooxygenase","score":0.9559999704360962},{"id":"https://openalex.org/keywords/hydroxyl-radicals","display_name":"hydroxyl radicals","score":0.7210000157356262},{"id":"https://openalex.org/keywords/redox-cycling","display_name":"redox cycling","score":0.8029999732971191},{"id":"https://openalex.org/keywords/necrosis","display_name":"necrosis","score":0.7269999980926514},{"id":"https://openalex.org/keywords/oxygen-toxicity","display_name":"oxygen toxicity","score":0.8299999833106995},{"id":"https://openalex.org/keywords/conjugation","display_name":"conjugation","score":0.5740000009536743},{"id":"https://openalex.org/keywords/detoxication","display_name":"detoxication","score":0.9070000052452087},{"id":"https://openalex.org/keywords/benzo-a-pyrene-hydroxylation","display_name":"benzo[a]pyrene hydroxylation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/phenobarbital","display_name":"phenobarbital","score":0.6179999709129333},{"id":"https://openalex.org/keywords/3-methylcholanthrene","display_name":"3-methylcholanthrene","score":0.9919999837875366},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.5619999766349792},{"id":"https://openalex.org/keywords/species-differences-in-toxicity","display_name":"species differences in toxicity","score":0.5920000076293945},{"id":"https://openalex.org/keywords/enzyme-active-site","display_name":"enzyme active site","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7937624454498291},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.7005023956298828},{"id":"https://openalex.org/C2781109383","wikidata":"https://www.wikidata.org/wiki/Q898497","display_name":"Hydroxylation","level":3,"score":0.6047083139419556},{"id":"https://openalex.org/C13002179","wikidata":"https://www.wikidata.org/wiki/Q6901821","display_name":"Monooxygenase","level":4,"score":0.5789741277694702},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5543985962867737},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5410636067390442},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5067580342292786},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4996771812438965},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.4791247546672821},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.46578091382980347},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.45571234822273254},{"id":"https://openalex.org/C62300524","wikidata":"https://www.wikidata.org/wiki/Q7115638","display_name":"Oxidative enzyme","level":3,"score":0.43055835366249084},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4185813367366791},{"id":"https://openalex.org/C89311334","wikidata":"https://www.wikidata.org/wiki/Q1124842","display_name":"Drug metabolism","level":3,"score":0.4146365821361542},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.33578741550445557},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06799003481864929}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003580","descriptor_name":"Cytochromes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf00296939","doi":"https://doi.org/10.1007/bf00296939","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00296939","pdf_url":null,"source":{"id":"https://openalex.org/S87018847","display_name":"Archives of Toxicology","issn_l":"0340-5761","issn":["0340-5761","1432-0738"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Toxicology","raw_type":"journal-article"},{"id":"pmid:3304217","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3304217","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W19173194","https://openalex.org/W62903774","https://openalex.org/W110687579","https://openalex.org/W656103724","https://openalex.org/W1483556659","https://openalex.org/W1484423608","https://openalex.org/W1508536142","https://openalex.org/W1542868541","https://openalex.org/W1589382058","https://openalex.org/W1607549921","https://openalex.org/W1848642262","https://openalex.org/W1951021898","https://openalex.org/W1967195855","https://openalex.org/W1978392142","https://openalex.org/W1982687431","https://openalex.org/W1983122290","https://openalex.org/W1988403667","https://openalex.org/W1989640442","https://openalex.org/W1994668199","https://openalex.org/W1996203696","https://openalex.org/W1997408976","https://openalex.org/W2011245669","https://openalex.org/W2016402578","https://openalex.org/W2016941766","https://openalex.org/W2017729229","https://openalex.org/W2017801426","https://openalex.org/W2030230131","https://openalex.org/W2031171480","https://openalex.org/W2032200772","https://openalex.org/W2038678657","https://openalex.org/W2039780690","https://openalex.org/W2040825351","https://openalex.org/W2051915753","https://openalex.org/W2059307001","https://openalex.org/W2059998429","https://openalex.org/W2068993050","https://openalex.org/W2080066625","https://openalex.org/W2081159465","https://openalex.org/W2083548377","https://openalex.org/W2086180279","https://openalex.org/W2088442836","https://openalex.org/W2091101852","https://openalex.org/W2103915468","https://openalex.org/W2111133550","https://openalex.org/W2139508000","https://openalex.org/W2169491218","https://openalex.org/W2171590562","https://openalex.org/W2183361744","https://openalex.org/W2339571923","https://openalex.org/W2399270064","https://openalex.org/W2404979841","https://openalex.org/W2437887389","https://openalex.org/W2475817801","https://openalex.org/W2890642703","https://openalex.org/W4211054414","https://openalex.org/W4289258093"],"related_works":["https://openalex.org/W1998579341","https://openalex.org/W2016402578","https://openalex.org/W237855393","https://openalex.org/W2314134777","https://openalex.org/W2098802759","https://openalex.org/W2088524561","https://openalex.org/W2475209206","https://openalex.org/W585551753","https://openalex.org/W2498742521","https://openalex.org/W2923803081"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
