{"id":"https://openalex.org/W1992272087","doi":"https://doi.org/10.1246/bcsj.71.1863","title":"Convenient Synthesis of the Central 3,6-Di(2-thiazolyl)-2-(4-thiazolyl)pyridine Skeleton of a Macrocyclic Antibiotic, GE 2270 A","display_name":"Convenient Synthesis of the Central 3,6-Di(2-thiazolyl)-2-(4-thiazolyl)pyridine Skeleton of a Macrocyclic Antibiotic, GE 2270 A","publication_year":1998,"publication_date":"1998-08-01","ids":{"openalex":"https://openalex.org/W1992272087","doi":"https://doi.org/10.1246/bcsj.71.1863","mag":"1992272087"},"language":"en","primary_location":{"id":"doi:10.1246/bcsj.71.1863","doi":"https://doi.org/10.1246/bcsj.71.1863","is_oa":false,"landing_page_url":"https://doi.org/10.1246/bcsj.71.1863","pdf_url":null,"source":{"id":"https://openalex.org/S95305481","display_name":"Bulletin of the Chemical Society of Japan","issn_l":"0009-2673","issn":["0009-2673","1348-0634"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin of the Chemical Society of Japan","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113954524","display_name":"Kazuo Okumura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I41802502","display_name":"Kanagawa University","ror":"https://ror.org/02j6c0d67","country_code":"JP","type":"education","lineage":["https://openalex.org/I41802502"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuo Okumura","raw_affiliation_strings":["Laboratory of Organic Chemistry, Faculty of Technology, Kanagawa UniversityRokkakubashi, Kanagawa-ku, Yokohama 221"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Organic Chemistry, Faculty of Technology, Kanagawa UniversityRokkakubashi, Kanagawa-ku, Yokohama 221","institution_ids":["https://openalex.org/I41802502"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000539432","display_name":"Hiroyuki Saito","orcid":"https://orcid.org/0000-0003-1497-1425","observed_orcids":["https://orcid.org/0000-0003-1497-1425"]},"institutions":[{"id":"https://openalex.org/I41802502","display_name":"Kanagawa University","ror":"https://ror.org/02j6c0d67","country_code":"JP","type":"education","lineage":["https://openalex.org/I41802502"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Saito","raw_affiliation_strings":["Laboratory of Organic Chemistry, Faculty of Technology, Kanagawa UniversityRokkakubashi, Kanagawa-ku, Yokohama 221"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Organic Chemistry, Faculty of Technology, Kanagawa UniversityRokkakubashi, Kanagawa-ku, Yokohama 221","institution_ids":["https://openalex.org/I41802502"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111563177","display_name":"Chung\u2010gi Shin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I41802502","display_name":"Kanagawa University","ror":"https://ror.org/02j6c0d67","country_code":"JP","type":"education","lineage":["https://openalex.org/I41802502"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chung-gi Shin","raw_affiliation_strings":["Laboratory of Organic Chemistry, Faculty of Technology, Kanagawa UniversityRokkakubashi, Kanagawa-ku, Yokohama 221"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Organic Chemistry, Faculty of Technology, Kanagawa UniversityRokkakubashi, Kanagawa-ku, Yokohama 221","institution_ids":["https://openalex.org/I41802502"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071374765","display_name":"Kazuyuki Umemura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79746392","display_name":"IRYO Sosei University","ror":"https://ror.org/04v5axh10","country_code":"JP","type":"education","lineage":["https://openalex.org/I79746392"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuyuki Umemura","raw_affiliation_strings":["College of Science and Engineering, Iwaki Meisei UniversityIwaki 970"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Science and Engineering, Iwaki Meisei UniversityIwaki 970","institution_ids":["https://openalex.org/I79746392"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112643558","display_name":"Juji Yoshimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79746392","display_name":"IRYO Sosei University","ror":"https://ror.org/04v5axh10","country_code":"JP","type":"education","lineage":["https://openalex.org/I79746392"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Juji Yoshimura","raw_affiliation_strings":["College of Science and Engineering, Iwaki Meisei UniversityIwaki 970"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Science and Engineering, Iwaki Meisei UniversityIwaki 970","institution_ids":["https://openalex.org/I79746392"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":305000,"currency":"JPY","value_usd":2040},"apc_paid":null,"fwci":1.4434,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.7649506,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"71","issue":"8","first_page":"1863","last_page":"1870"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13208","display_name":"Synthesis of heterocyclic compounds","score":0.5473999977111816,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13208","display_name":"Synthesis of heterocyclic compounds","score":0.5473999977111816,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13649","display_name":"Advanced Synthetic Organic Chemistry","score":0.11140000075101852,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13859","display_name":"Organic Chemistry Synthesis Methods","score":0.0835999995470047,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macrocyclic-antibiotics","display_name":"macrocyclic antibiotics","score":0.8199999928474426},{"id":"https://openalex.org/keywords/total-synthesis","display_name":"total synthesis","score":0.8339999914169312},{"id":"https://openalex.org/keywords/hantzsch-synthesis","display_name":"Hantzsch synthesis","score":0.722000002861023},{"id":"https://openalex.org/keywords/thioamides","display_name":"thioamides","score":0.46299999952316284},{"id":"https://openalex.org/keywords/carbaldehyde","display_name":"carbaldehyde","score":0.8389999866485596}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9680466055870056},{"id":"https://openalex.org/C18969341","wikidata":"https://www.wikidata.org/wiki/Q1169129","display_name":"Skeleton (computer programming)","level":2,"score":0.7415779232978821},{"id":"https://openalex.org/C2779485729","wikidata":"https://www.wikidata.org/wiki/Q210385","display_name":"Pyridine","level":2,"score":0.7334839105606079},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5677585005760193},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.49447178840637207},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.35234934091567993},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.346954345703125},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05995073914527893},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.043941766023635864},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1246/bcsj.71.1863","doi":"https://doi.org/10.1246/bcsj.71.1863","is_oa":false,"landing_page_url":"https://doi.org/10.1246/bcsj.71.1863","pdf_url":null,"source":{"id":"https://openalex.org/S95305481","display_name":"Bulletin of the Chemical Society of Japan","issn_l":"0009-2673","issn":["0009-2673","1348-0634"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin of the Chemical Society of Japan","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1966750283","https://openalex.org/W1969853354","https://openalex.org/W1975682012","https://openalex.org/W1979890284","https://openalex.org/W2009705792","https://openalex.org/W2014855991","https://openalex.org/W2044105679","https://openalex.org/W2071163694","https://openalex.org/W2076115609","https://openalex.org/W2085668372","https://openalex.org/W2510258194","https://openalex.org/W2949266387","https://openalex.org/W2952289212"],"related_works":["https://openalex.org/W2951368023","https://openalex.org/W2055146516","https://openalex.org/W2952697637","https://openalex.org/W2953390607","https://openalex.org/W2086899605","https://openalex.org/W2949119998","https://openalex.org/W2951035556","https://openalex.org/W2072911765","https://openalex.org/W2951318435","https://openalex.org/W2148115738"],"abstract_inverted_index":{"Abstract":[0],"It":[1],"was":[2,47,85,91],"shown":[3],"that":[4],"6-dimethoxymethyl-1,2-dihydro-2-oxo-3-pyridinecarbonitrile":[5],"(5)":[6],"is":[7],"easily":[8],"convertible":[9],"into":[10,29,68],"the":[11,20,33,54,58,69,73,78,89,95],"titled":[12],"ring":[13],"system":[14],"by":[15,38],"a":[16,50,105],"stepwise":[17],"method.":[18],"Both":[19],"3-cyano":[21],"and":[22,35,40,61,65],"6-dimethoxymethyl":[23],"groups":[24,31,37],"of":[25,81,98],"5":[26],"were":[27],"converted":[28,67],"2-thiazolyl":[30],"via":[32,53],"thioamide":[34],"carbaldehyde":[36],"Hantzsch":[39],"Shioiri":[41],"methods,":[42],"respectively.":[43],"The":[44],"2-pyridone":[45],"function":[46],"changed":[48],"to":[49,94],"bromoacetyl":[51],"group":[52],"coupling":[55],"reaction":[56],"between":[57],"corresponding":[59],"triflate":[60],"ethyl":[62],"vinyl":[63],"ether,":[64],"then":[66],"4-thiazolyl":[70],"group.":[71],"Thus,":[72],"useful":[74],"3,6-di(2-thiazolyl)-2-(4-thiazolyl)pyridine":[75],"derivative":[76],"for":[77],"total":[79,96],"synthesis":[80,97],"GE":[82],"2270":[83],"A":[84],"obtained.":[86],"In":[87],"fact,":[88],"method":[90],"recently":[92],"applied":[93],"an":[99],"antibiotic,":[100],"micrococcin":[101],"P,":[102],"which":[103],"has":[104],"similar":[106],"central":[107],"skeleton.":[108]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
