{"id":"https://openalex.org/W1992270752","doi":"https://doi.org/10.1080/03086648808074346","title":"SYNTHESIS OF \u03b1-HALOGENATED METHANEDIPHOSPHONATES1a, b","display_name":"SYNTHESIS OF \u03b1-HALOGENATED METHANEDIPHOSPHONATES1a, b","publication_year":1988,"publication_date":"1988-05-01","ids":{"openalex":"https://openalex.org/W1992270752","doi":"https://doi.org/10.1080/03086648808074346","mag":"1992270752"},"language":"en","primary_location":{"id":"doi:10.1080/03086648808074346","doi":"https://doi.org/10.1080/03086648808074346","is_oa":false,"landing_page_url":"https://doi.org/10.1080/03086648808074346","pdf_url":null,"source":{"id":"https://openalex.org/S4210229243","display_name":"Phosphorous and Sulfur and the Related Elements","issn_l":"0308-664X","issn":["0308-664X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phosphorous and Sulfur and the Related Elements","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011933351","display_name":"Charles E. McKenna","orcid":"https://orcid.org/0000-0002-3540-6663","observed_orcids":["https://orcid.org/0000-0002-3540-6663"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles E. McKenna","raw_affiliation_strings":["Department of Chemistry, University of Southern California, Los Angeles, California, 90089-0744, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Southern California, Los Angeles, California, 90089-0744, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021299258","display_name":"Leslie A. Khawli","orcid":"https://orcid.org/0000-0002-7346-2818","observed_orcids":["https://orcid.org/0000-0002-7346-2818"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leslie A. Khawli","raw_affiliation_strings":["Department of Chemistry, University of Southern California, Los Angeles, California, 90089-0744, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Southern California, Los Angeles, California, 90089-0744, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027478913","display_name":"Wan-Yaacob Ahmad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wan-Yaacob Ahmad","raw_affiliation_strings":["Department of Chemistry, University of Southern California, Los Angeles, California, 90089-0744, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Southern California, Los Angeles, California, 90089-0744, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019278243","display_name":"Phuong Pham","orcid":"https://orcid.org/0000-0002-8802-2188","observed_orcids":["https://orcid.org/0000-0002-8802-2188"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phuong Pham","raw_affiliation_strings":["Department of Chemistry, University of Southern California, Los Angeles, California, 90089-0744, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Southern California, Los Angeles, California, 90089-0744, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029469694","display_name":"Jean\u2010Pierre Bongartz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean-Pierre Bongartz","raw_affiliation_strings":["Department of Chemistry, University of Southern California, Los Angeles, California, 90089-0744, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Southern California, Los Angeles, California, 90089-0744, USA","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":null,"apc_paid":null,"fwci":3.4696,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.9175093,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"37","issue":"1-2","first_page":"1","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11748","display_name":"Organophosphorus compounds synthesis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11748","display_name":"Organophosphorus compounds synthesis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12191","display_name":"Chemical Reaction Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10807","display_name":"Synthesis and characterization of novel inorganic/organometallic compounds","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/organophosphorus-synthesis","display_name":"organophosphorus synthesis","score":0.8579999804496765},{"id":"https://openalex.org/keywords/hydrochloric-acid-hydrolysis","display_name":"hydrochloric acid hydrolysis","score":0.765999972820282},{"id":"https://openalex.org/keywords/antiresorptive-agents","display_name":"antiresorptive agents","score":0.7620000243186951},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8239427804946899},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.765148401260376},{"id":"https://openalex.org/C201194858","wikidata":"https://www.wikidata.org/wiki/Q898238","display_name":"Steric effects","level":2,"score":0.7128137350082397},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.6424804329872131},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.5925825834274292},{"id":"https://openalex.org/C42058472","wikidata":"https://www.wikidata.org/wiki/Q810214","display_name":"Base (topology)","level":2,"score":0.42227500677108765},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.4157964885234833},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3825418949127197},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.16745945811271667},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1080/03086648808074346","doi":"https://doi.org/10.1080/03086648808074346","is_oa":false,"landing_page_url":"https://doi.org/10.1080/03086648808074346","pdf_url":null,"source":{"id":"https://openalex.org/S4210229243","display_name":"Phosphorous and Sulfur and the Related Elements","issn_l":"0308-664X","issn":["0308-664X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phosphorous and Sulfur and the Related Elements","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.6200000047683716,"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1494411444","https://openalex.org/W1963702664","https://openalex.org/W1980545483","https://openalex.org/W1983071926","https://openalex.org/W1988573432","https://openalex.org/W1993890911","https://openalex.org/W1995181451","https://openalex.org/W1995745336","https://openalex.org/W1997478306","https://openalex.org/W2008567437","https://openalex.org/W2022693787","https://openalex.org/W2034806368","https://openalex.org/W2050600228","https://openalex.org/W2066971622","https://openalex.org/W2069607377","https://openalex.org/W2080580656","https://openalex.org/W2093507161","https://openalex.org/W2313900076","https://openalex.org/W2344729993","https://openalex.org/W2408306201"],"related_works":["https://openalex.org/W2406379567","https://openalex.org/W2366000936","https://openalex.org/W2430569666","https://openalex.org/W140676415","https://openalex.org/W2022693787","https://openalex.org/W1993890911","https://openalex.org/W2048295651","https://openalex.org/W2044345752","https://openalex.org/W2008567437","https://openalex.org/W2528182739"],"abstract_inverted_index":{"Methanediphospnonate":[0],"(MDP)":[1],"anions":[2],"can":[3],"exhibit":[4],"anti-viral":[5],"activity,":[6],"inhibit":[7],"bone":[8],"resorption,":[9],"and":[10,39,67,83,93,105,111,116,122,158,170,178],"act":[11],"as":[12,172],"ligands":[13],"in":[14,86,108,125],"radiopharmaceuticals.":[15],"\u03b1-Halo-substitution":[16],"provides":[17],"MDP":[18],"derivatives":[19],"(XYMDP,":[20],"where":[21],"\u00d7":[22],"=":[23,30,65,70,91,96,114,119,145],"H,":[24,75,97,101,146,150],"F,":[25,31,79,81,154,156],"CI":[26],"or":[27,33],"Br;":[28,76,78,102,151,153],"Y":[29,69,95,118,144],"Cl":[32,121],"Br)":[34,160],"with":[35],"modified":[36],"acid-base,":[37],"steric":[38],"other":[40],"properties.":[41],"These":[42],"compounds":[43],"are":[44,56,134],"conveniently":[45],"made":[46],"from":[47],"the":[48,137],"corresponding":[49,168],"\u03b1-halogenated":[50],"XYMDP":[51,62,141],"esters":[52],"(RO)2P(O)CXYP(O)(OR)2.":[53],"Detailed":[54],"procedures":[55],"given":[57],"for":[58,63,89,112,136],"synthesis":[59],"of":[60,166],"R4":[61],"R":[64,90,113],"Pri":[66],"X,":[68,94,117],"H.":[71],"Cl;":[72,74,80,98,100,147,149,155],"Cl,":[73,84,106,120,148,159],"Br,":[77,103,123,152],"Br":[82,85,104,124,157],"88\u201396%":[87],"yield;":[88,110],"Et":[92],"Cl.":[99],"F":[107],"81\u201394%":[109],"Me":[115],"72\u201380%":[126],"yield.":[127],"NMR":[128],"data":[129],"(1H,":[130],"31P,":[131],"13C.":[132],"(19F))":[133],"presented":[135],"products":[138],"obtained.":[139],"The":[140],"acids":[142],"(X,":[143],"were":[161],"prepared":[162],"by":[163,175],"HCl":[164],"hydrolysis":[165],"a":[167],"ester":[169],"characterized":[171],"tris(dicyclohexylammonium)":[173],"salts":[174],"elemental":[176],"analyses":[177],"31P":[179],"NMR.":[180]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
