{"id":"https://openalex.org/W1992262467","doi":"https://doi.org/10.1291/hypres.24.699","title":"Nitric Oxide Buffers Renal Medullary Vasoconstriction Induced by Prostaglandins Synthesis Blockade.","display_name":"Nitric Oxide Buffers Renal Medullary Vasoconstriction Induced by Prostaglandins Synthesis Blockade.","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W1992262467","doi":"https://doi.org/10.1291/hypres.24.699","mag":"1992262467","pmid":"https://pubmed.ncbi.nlm.nih.gov/11768730"},"language":"en","primary_location":{"id":"doi:10.1291/hypres.24.699","doi":"https://doi.org/10.1291/hypres.24.699","is_oa":true,"landing_page_url":"https://doi.org/10.1291/hypres.24.699","pdf_url":"https://www.jstage.jst.go.jp/article/hypres/24/6/24_6_699/_pdf","source":{"id":"https://openalex.org/S67902008","display_name":"Hypertension Research","issn_l":"0916-9636","issn":["0916-9636","1348-4214"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/hypres/24/6/24_6_699/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025252422","display_name":"Kazushige Nakanishi","orcid":"https://orcid.org/0000-0002-9219-306X","observed_orcids":["https://orcid.org/0000-0002-9219-306X"]},"institutions":[{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazushige NAKANISHI","raw_affiliation_strings":["Second Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan. kazunaka@med.toho-u.ac.jp","Second Department of Internal Medicine, Toho University, School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan. kazunaka@med.toho-u.ac.jp","institution_ids":["https://openalex.org/I129634264"]},{"raw_affiliation_string":"Second Department of Internal Medicine, Toho University, School of Medicine","institution_ids":["https://openalex.org/I129634264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062718571","display_name":"Akira CHINEN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira CHINEN","raw_affiliation_strings":["Second Department of Internal Medicine, Toho University, School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Toho University, School of Medicine","institution_ids":["https://openalex.org/I129634264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111775523","display_name":"Yoshihito David Saito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihito SAITO","raw_affiliation_strings":["Second Department of Internal Medicine, Toho University, School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Toho University, School of Medicine","institution_ids":["https://openalex.org/I129634264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112159982","display_name":"Kaoru Hamada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kaoru HAMADA","raw_affiliation_strings":["Second Department of Internal Medicine, Toho University, School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Toho University, School of Medicine","institution_ids":["https://openalex.org/I129634264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113946145","display_name":"Noriko Hara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noriko HARA","raw_affiliation_strings":["Second Department of Internal Medicine, Toho University, School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Toho University, School of Medicine","institution_ids":["https://openalex.org/I129634264"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103455486","display_name":"Yohko Nagai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yohko NAGAI","raw_affiliation_strings":["Second Department of Internal Medicine, Toho University, School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Toho University, School of Medicine","institution_ids":["https://openalex.org/I129634264"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I129634264"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":null,"fwci":0.1201,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.31891755,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"24","issue":"6","first_page":"699","last_page":"704"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.649399995803833,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.649399995803833,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.188400000333786,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.04320000112056732,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prostaglandin-synthesis-inhibition","display_name":"prostaglandin synthesis inhibition","score":0.890999972820282},{"id":"https://openalex.org/keywords/meclofenamate","display_name":"meclofenamate","score":0.9480000138282776},{"id":"https://openalex.org/keywords/cyclooxygenase-inhibitors","display_name":"cyclooxygenase inhibitors","score":0.871999979019165},{"id":"https://openalex.org/keywords/l-name","display_name":"L-NAME","score":0.9210000038146973},{"id":"https://openalex.org/keywords/renal-medullary-blood-flow","display_name":"renal medullary blood flow","score":0.7829999923706055},{"id":"https://openalex.org/keywords/cortical-blood-flow","display_name":"cortical blood flow","score":0.9070000052452087},{"id":"https://openalex.org/keywords/sodium-excretion","display_name":"sodium excretion","score":0.7990000247955322},{"id":"https://openalex.org/keywords/sodium-retention","display_name":"sodium retention","score":0.9129999876022339},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.7760000228881836},{"id":"https://openalex.org/keywords/renal-hemodynamics","display_name":"renal hemodynamics","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.7551649212837219},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6595544219017029},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6553961038589478},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5581823587417603},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5131148099899292},{"id":"https://openalex.org/C142225936","wikidata":"https://www.wikidata.org/wiki/Q1129139","display_name":"Renal blood flow","level":3,"score":0.5063780546188354},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.506372332572937},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.49286937713623047},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.48232007026672363},{"id":"https://openalex.org/C195121873","wikidata":"https://www.wikidata.org/wiki/Q1131385","display_name":"Medullary cavity","level":2,"score":0.4760396480560303},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.4699554443359375},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4562155306339264},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.41750526428222656},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24010437726974487},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08867830038070679},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07695889472961426},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07506877183914185},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002021","descriptor_name":"Buffers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007679","descriptor_name":"Kidney Medulla","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008469","descriptor_name":"Meclofenamic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009318","descriptor_name":"Natriuresis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011448","descriptor_name":"Prostaglandin Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014661","descriptor_name":"Vasoconstriction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019331","descriptor_name":"NG-Nitroarginine Methyl Ester","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019331","descriptor_name":"NG-Nitroarginine Methyl Ester","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1291/hypres.24.699","doi":"https://doi.org/10.1291/hypres.24.699","is_oa":true,"landing_page_url":"https://doi.org/10.1291/hypres.24.699","pdf_url":"https://www.jstage.jst.go.jp/article/hypres/24/6/24_6_699/_pdf","source":{"id":"https://openalex.org/S67902008","display_name":"Hypertension Research","issn_l":"0916-9636","issn":["0916-9636","1348-4214"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension Research","raw_type":"journal-article"},{"id":"pmid:11768730","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11768730","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension research : official journal of the Japanese Society of Hypertension","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1291/hypres.24.699","doi":"https://doi.org/10.1291/hypres.24.699","is_oa":true,"landing_page_url":"https://doi.org/10.1291/hypres.24.699","pdf_url":"https://www.jstage.jst.go.jp/article/hypres/24/6/24_6_699/_pdf","source":{"id":"https://openalex.org/S67902008","display_name":"Hypertension Research","issn_l":"0916-9636","issn":["0916-9636","1348-4214"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1992262467.pdf"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W104012062","https://openalex.org/W1810611328","https://openalex.org/W1924078875","https://openalex.org/W1925127818","https://openalex.org/W1930499844","https://openalex.org/W1985311729","https://openalex.org/W1991507615","https://openalex.org/W2028236174","https://openalex.org/W2039190712","https://openalex.org/W2060104036","https://openalex.org/W2075808026","https://openalex.org/W2119223853","https://openalex.org/W2138855237","https://openalex.org/W2140704005","https://openalex.org/W2167809710","https://openalex.org/W2168856182","https://openalex.org/W2275546552","https://openalex.org/W2280736138","https://openalex.org/W2281229447","https://openalex.org/W2308411785","https://openalex.org/W2330381984","https://openalex.org/W2410778888","https://openalex.org/W2422038029","https://openalex.org/W2432649147"],"related_works":["https://openalex.org/W2138855237","https://openalex.org/W7043025174","https://openalex.org/W2101005537","https://openalex.org/W2168856182","https://openalex.org/W1924078875","https://openalex.org/W2119223853","https://openalex.org/W7098745954","https://openalex.org/W2195858434","https://openalex.org/W2166315881","https://openalex.org/W2266621694"],"abstract_inverted_index":{"The":[0,149],"aim":[1],"of":[2,67,111,151,173,188],"this":[3,152],"study":[4,153],"was":[5],"to":[6],"examine":[7],"whether":[8],"nitric":[9],"oxide":[10],"(NO)":[11],"buffers":[12],"the":[13,108,156,180,186],"renal":[14,157,181],"medullary":[15,41,158,182],"vasoconstriction":[16,183],"induced":[17,164,184],"by":[18,47,165,169,185],"a":[19,69,84,94,120,130,137,170],"prostaglandins":[20],"(PG)":[21],"synthesis":[22,122,190],"inhibitor.":[23],"Daily":[24],"blood":[25,37,42],"pressure":[26,91],"measurements":[27],"were":[28,45,63],"made":[29],"with":[30],"implanted":[31,48],"catheters":[32],"and":[33,40,51,60,93,100,113,136,143,161,175],"changes":[34],"in":[35,56,88,98,134,141,191],"cortical":[36],"flow":[38,43,53],"(CBF)":[39],"(MBF)":[44],"determined":[46],"optical":[49],"fibers":[50],"laser-Doppler":[52],"measurement":[54],"techniques":[55],"conscious":[57,192],"rats.":[58,193],"Sodium":[59],"water":[61],"balance":[62],"also":[64],"determined.":[65],"Infusion":[66],"meclofenamate,":[68],"nonisozyme-specific":[70],"cyclooxygenase":[71],"(COX)":[72],"inhibitor,":[73,123],"at":[74],"5":[75],"microg/kg/min":[76],"over":[77,124],"4":[78,125],"consecutive":[79,126],"days":[80,127],"(n=12":[81],"rats)":[82],"elicited":[83],"transitory":[85,95],"increase":[86,132],"(p<0.05)":[87,97,140],"mean":[89],"arterial":[90],"(MAP)":[92],"decrease":[96,139],"MBF":[99,142],"sodium":[101,144,162],"excretion":[102,145],"without":[103,146],"altering":[104,147],"CBF.":[105,148],"In":[106],"contrast,":[107],"simultaneous":[109],"infusion":[110],"meclofenamate":[112,166],"N(G)-nitro-L-arginine":[114],"methyl":[115],"ester":[116],"(L-NAME,":[117],"0.8":[118],"microg/kg/min),":[119],"NO":[121,177],"(n=12)":[128],"produced":[129],"continuous":[131,138],"(p<0.01)":[133],"MAP":[135],"results":[150],"suggest":[154],"that":[155,176],"vasoconstrictor":[159],"effects":[160],"retention":[163],"are":[167],"enhanced":[168],"subpressor":[171],"dose":[172],"L-NAME,":[174],"may":[178],"buffer":[179],"blockade":[187],"PG":[189]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
