{"id":"https://openalex.org/W1992258564","doi":"https://doi.org/10.1002/(sici)1098-2272(1997)14:6<1053::aid-gepi82>3.0.co;2-g","title":"Effects of genotype-by-sex interaction on quantitative trait linkage analysis","display_name":"Effects of genotype-by-sex interaction on quantitative trait linkage analysis","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W1992258564","doi":"https://doi.org/10.1002/(sici)1098-2272(1997)14:6<1053::aid-gepi82>3.0.co;2-g","mag":"1992258564","pmid":"https://pubmed.ncbi.nlm.nih.gov/9433623"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1098-2272(1997)14:6<1053::aid-gepi82>3.0.co;2-g","doi":"https://doi.org/10.1002/(sici)1098-2272(1997)14:6<1053::aid-gepi82>3.0.co;2-g","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1098-2272(1997)14:6<1053::aid-gepi82>3.0.co;2-g","pdf_url":null,"source":{"id":"https://openalex.org/S136352176","display_name":"Genetic Epidemiology","issn_l":"0741-0395","issn":["0741-0395","1098-2272"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetic Epidemiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026845322","display_name":"Bradford Towne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19648265","display_name":"Wright State University","ror":"https://ror.org/04qk6pt94","country_code":"US","type":"education","lineage":["https://openalex.org/I19648265"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bradford Towne","raw_affiliation_strings":["Department of Community Health, Wright State University School of Medicine, Dayton, Ohio 45435, USA","Wright State University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Community Health, Wright State University School of Medicine, Dayton, Ohio 45435, USA","institution_ids":["https://openalex.org/I19648265"]},{"raw_affiliation_string":"Wright State University;","institution_ids":["https://openalex.org/I19648265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113539510","display_name":"Roger M. Siervogel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19648265","display_name":"Wright State University","ror":"https://ror.org/04qk6pt94","country_code":"US","type":"education","lineage":["https://openalex.org/I19648265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roger M. Siervogel","raw_affiliation_strings":["Division of Human Biology, Department of Community Health, Wright State University School of Medicine, Dayton, Ohio","Wright State University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Human Biology, Department of Community Health, Wright State University School of Medicine, Dayton, Ohio","institution_ids":["https://openalex.org/I19648265"]},{"raw_affiliation_string":"Wright State University;","institution_ids":["https://openalex.org/I19648265"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004538115","display_name":"John Blangero","orcid":"https://orcid.org/0000-0001-6250-5723","observed_orcids":["https://orcid.org/0000-0001-6250-5723"]},"institutions":[{"id":"https://openalex.org/I1289525096","display_name":"Texas Biomedical Research Institute","ror":"https://ror.org/00wbskb04","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289525096"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Blangero","raw_affiliation_strings":["Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas","SW Found. for Biomedical Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas","institution_ids":["https://openalex.org/I1289525096"]},{"raw_affiliation_string":"SW Found. for Biomedical Research","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5026845322"],"corresponding_institution_ids":["https://openalex.org/I19648265"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":1.9529,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.85415857,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"14","issue":"6","first_page":"1053","last_page":"1058"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.826200008392334,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.826200008392334,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.1662999987602234,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genotype-by-sex-interaction","display_name":"genotype by sex interaction","score":0.9909999966621399},{"id":"https://openalex.org/keywords/extended-pedigrees","display_name":"extended pedigrees","score":0.5600000023841858},{"id":"https://openalex.org/keywords/nuclear-family","display_name":"nuclear family","score":0.9020000100135803},{"id":"https://openalex.org/keywords/lod-score","display_name":"lod score","score":0.6990000009536743},{"id":"https://openalex.org/keywords/sex-specific-genetic-effects","display_name":"sex-specific genetic effects","score":0.34599998593330383}],"concepts":[{"id":"https://openalex.org/C22593422","wikidata":"https://www.wikidata.org/wiki/Q3242583","display_name":"Pedigree chart","level":3,"score":0.8565298318862915},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.8216739296913147},{"id":"https://openalex.org/C68220480","wikidata":"https://www.wikidata.org/wiki/Q720069","display_name":"Nuclear family","level":2,"score":0.7051693201065063},{"id":"https://openalex.org/C142870003","wikidata":"https://www.wikidata.org/wiki/Q843863","display_name":"Genetic linkage","level":3,"score":0.6775890588760376},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6659659743309021},{"id":"https://openalex.org/C855514","wikidata":"https://www.wikidata.org/wiki/Q1665869","display_name":"Interaction","level":2,"score":0.6523123383522034},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6521912217140198},{"id":"https://openalex.org/C106934330","wikidata":"https://www.wikidata.org/wiki/Q1971873","display_name":"Trait","level":2,"score":0.6205010414123535},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.588557779788971},{"id":"https://openalex.org/C31266012","wikidata":"https://www.wikidata.org/wiki/Q6554340","display_name":"Linkage (software)","level":3,"score":0.5725936889648438},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.5590227246284485},{"id":"https://openalex.org/C2991772755","wikidata":"https://www.wikidata.org/wiki/Q751748","display_name":"Gene interaction","level":3,"score":0.5260869264602661},{"id":"https://openalex.org/C2910653347","wikidata":"https://www.wikidata.org/wiki/Q843863","display_name":"Recombination Fraction","level":5,"score":0.5107421875},{"id":"https://openalex.org/C2776547343","wikidata":"https://www.wikidata.org/wiki/Q24284978","display_name":"Major gene","level":3,"score":0.4123806357383728},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3352431058883667},{"id":"https://openalex.org/C122735190","wikidata":"https://www.wikidata.org/wiki/Q715789","display_name":"Gene mapping","level":4,"score":0.3016287684440613},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.2708032727241516},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D004777","descriptor_name":"Environment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008126","descriptor_name":"Lod Score","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009679","descriptor_name":"Nuclear Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010375","descriptor_name":"Pedigree","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012727","descriptor_name":"Sex Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016013","descriptor_name":"Likelihood Functions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019655","descriptor_name":"Quantitative Trait, Heritable","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/(sici)1098-2272(1997)14:6<1053::aid-gepi82>3.0.co;2-g","doi":"https://doi.org/10.1002/(sici)1098-2272(1997)14:6<1053::aid-gepi82>3.0.co;2-g","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1098-2272(1997)14:6<1053::aid-gepi82>3.0.co;2-g","pdf_url":null,"source":{"id":"https://openalex.org/S136352176","display_name":"Genetic Epidemiology","issn_l":"0741-0395","issn":["0741-0395","1098-2272"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetic Epidemiology","raw_type":"journal-article"},{"id":"pmid:9433623","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9433623","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetic epidemiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2118811039","display_name":null,"funder_award_id":"HD12252","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G4145764554","display_name":"Adiposity, Disease Risk Factors, and Lifetime Health","funder_award_id":"R01HD012252","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G4397490065","display_name":"GENETICS OF ADIPOSE TISSUE DEPOSITION DURING CHILDHOOD","funder_award_id":"R29HD031621","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G4433098062","display_name":"THE GENETIC EPIDEMIOLOGY OF PATTERNS OF GROWTH","funder_award_id":"R01HD026971","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G6407603","display_name":null,"funder_award_id":"HD 26971","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G9000005599","display_name":null,"funder_award_id":"HD31621","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1586905899","https://openalex.org/W1601433968","https://openalex.org/W1765369324","https://openalex.org/W1842826833","https://openalex.org/W1992770340","https://openalex.org/W2019889150","https://openalex.org/W2078977693","https://openalex.org/W2100811600","https://openalex.org/W2106941401","https://openalex.org/W2115550628","https://openalex.org/W2142315064","https://openalex.org/W2142635246","https://openalex.org/W2160729986","https://openalex.org/W2169083041","https://openalex.org/W2226655261","https://openalex.org/W4237377395"],"related_works":["https://openalex.org/W1561194605","https://openalex.org/W2416391165","https://openalex.org/W3012927154","https://openalex.org/W2012107361","https://openalex.org/W2105415937","https://openalex.org/W1901428944","https://openalex.org/W2131570202","https://openalex.org/W4281774725","https://openalex.org/W1495147141","https://openalex.org/W2027738088"],"abstract_inverted_index":{"Genotype-by-sex":[0],"(G":[1],"x":[2,19,68,92,118,143,191,198,218,253,261,276],"S)":[3],"interaction":[4,8,21,70,94,120,193,200,220,255,263,278],"refers":[5],"to":[6,62,74,89,213,226,246,269],"the":[7,41,64,72,96,114,133,177,184,202,207,210,224,230,235,243,267,274],"of":[9,29,32,43,58,66,116,131,174,209,216,259],"autosomal":[10],"genes":[11],"with":[12],"male":[13],"or":[14,250],"female":[15],"physiological":[16],"\"environments.\"":[17],"G":[18,67,91,117,142,190,197,217,252,260,275],"S":[20,69,93,119,144,192,199,219,254,262,277],"has":[22,53],"been":[23,54],"demonstrated":[24],"in":[25,49,79,121,160,229],"quantitative":[26,125],"genetic":[27,126],"analysis":[28,149],"a":[30,124],"variety":[31],"traits":[33],"including":[34],"serum":[35],"lipid":[36],"concentrations":[37],"and":[38,40,105,136,165,188],"anthropometrics,":[39],"importance":[42],"considering":[44],"sex-specific":[45],"major":[46,97],"gene":[47,98],"effects":[48,65,221,264,279],"segregation":[50],"analyses":[51,208],"also":[52,222],"demonstrated.":[55],"The":[56],"goal":[57],"this":[59],"study":[60],"was":[61,83,87,150,181,256],"examine":[63],"on":[71,156],"power":[73,225,241,268],"detect":[75,227,247,270],"linkage.":[76],"Trait":[77],"Q3":[78,122],"GAW10":[80,157],"Problem":[81],"2":[82],"analyzed":[84],"because":[85],"it":[86],"modeled":[88],"have":[90],"at":[95,176],"locus":[99],"MG3.":[100],"All":[101],"200":[102,106,162,166],"nuclear":[103,134,163,231,236],"family":[104,135,164,232],"extended":[107,137,167,185,211,244],"pedigree":[108,138,168,186],"replicates":[109,139],"were":[110],"first":[111],"screened":[112],"for":[113],"presence":[115],"using":[123,153,183],"method.":[127],"More":[128],"than":[129,242],"half":[130],"both":[132],"evidenced":[140],"significant":[141],"interaction.":[145],"Variance":[146],"components":[147],"linkage":[148,228],"then":[151],"performed":[152],"all":[154,161],"markers":[155],"chromosome":[158],"4":[159],"replicates.":[169],"A":[170],"peak":[171,203],"lod":[172,204],"score":[173,205],"1.92":[175],"correct":[178],"chromosomal":[179],"location":[180],"obtained":[182],"data":[187],"incorporating":[189,196],"effects.":[194],"Not":[195],"lowered":[201],"from":[206],"pedigrees":[212,245],"1.53.":[214],"Incorporation":[215,258],"increased":[223],"replicates,":[233],"although":[234],"families":[237],"had":[238],"considerably":[239],"less":[240],"linkage,":[248,271],"whether":[249],"not":[251],"modeled.":[257],"can":[265],"increase":[266],"even":[272],"when":[273],"are":[280],"modest.":[281]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}