{"id":"https://openalex.org/W1992257521","doi":"https://doi.org/10.1021/ja00745a035","title":"Proton magnetic resonance study of the indole NH resonances of lysozyme. Assignment, deuterium exchange kinetics, and inhibitor binding","display_name":"Proton magnetic resonance study of the indole NH resonances of lysozyme. Assignment, deuterium exchange kinetics, and inhibitor binding","publication_year":1971,"publication_date":"1971-08-01","ids":{"openalex":"https://openalex.org/W1992257521","doi":"https://doi.org/10.1021/ja00745a035","mag":"1992257521","pmid":"https://pubmed.ncbi.nlm.nih.gov/5138305"},"language":"en","primary_location":{"id":"doi:10.1021/ja00745a035","doi":"https://doi.org/10.1021/ja00745a035","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja00745a035","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076316291","display_name":"W. D. Phillips","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W. D. Phillips","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108442630","display_name":"Jerry D. Glickson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. D. Glickson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111559403","display_name":"J.A. Rupley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. A. Rupley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":4.8891,"has_fulltext":false,"cited_by_count":84,"citation_normalized_percentile":{"value":0.96582122,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"93","issue":"16","first_page":"4031","last_page":"4038"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.023600000888109207,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lysozyme","display_name":"lysozyme","score":0.9980000257492065},{"id":"https://openalex.org/keywords/inhibitor-binding","display_name":"inhibitor binding","score":0.8050000071525574},{"id":"https://openalex.org/keywords/enzyme-active-site","display_name":"enzyme active site","score":0.45500001311302185},{"id":"https://openalex.org/keywords/proton-nmr-resonance-assignment","display_name":"proton NMR resonance assignment","score":0.6520000100135803},{"id":"https://openalex.org/keywords/enzyme-inhibitor-complex","display_name":"enzyme-inhibitor complex","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9787784814834595},{"id":"https://openalex.org/C58364064","wikidata":"https://www.wikidata.org/wiki/Q102296","display_name":"Deuterium","level":2,"score":0.8392062783241272},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.7500571012496948},{"id":"https://openalex.org/C192527728","wikidata":"https://www.wikidata.org/wiki/Q1465700","display_name":"Indole test","level":2,"score":0.7161245346069336},{"id":"https://openalex.org/C167569220","wikidata":"https://www.wikidata.org/wiki/Q5954985","display_name":"Hydrogen\u2013deuterium exchange","level":3,"score":0.6342015266418457},{"id":"https://openalex.org/C54516573","wikidata":"https://www.wikidata.org/wiki/Q2294","display_name":"Proton","level":2,"score":0.6113742589950562},{"id":"https://openalex.org/C2776966407","wikidata":"https://www.wikidata.org/wiki/Q24779410","display_name":"Lysozyme","level":2,"score":0.5604777336120605},{"id":"https://openalex.org/C139210041","wikidata":"https://www.wikidata.org/wiki/Q2145840","display_name":"Resonance (particle physics)","level":2,"score":0.48942676186561584},{"id":"https://openalex.org/C2988005100","wikidata":"https://www.wikidata.org/wiki/Q1979695","display_name":"Proton magnetic resonance","level":2,"score":0.4523027539253235},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.3942030072212219},{"id":"https://openalex.org/C512968161","wikidata":"https://www.wikidata.org/wiki/Q556","display_name":"Hydrogen","level":2,"score":0.21989208459854126},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.21396249532699585},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.12787243723869324},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.12460240721702576},{"id":"https://openalex.org/C184779094","wikidata":"https://www.wikidata.org/wiki/Q26383","display_name":"Atomic physics","level":1,"score":0.10483959317207336},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09745797514915466},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003903","descriptor_name":"Deuterium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011489","descriptor_name":"Protein Denaturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011522","descriptor_name":"Protons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013053","descriptor_name":"Spectrophotometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014961","descriptor_name":"X-Ray Diffraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ja00745a035","doi":"https://doi.org/10.1021/ja00745a035","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja00745a035","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmid:5138305","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5138305","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2070942533","https://openalex.org/W1998616365","https://openalex.org/W1999482679","https://openalex.org/W2086827051","https://openalex.org/W1991078043","https://openalex.org/W2046566050","https://openalex.org/W1999723996","https://openalex.org/W2013395097","https://openalex.org/W2079310698","https://openalex.org/W2411481747"],"abstract_inverted_index":{"ADVERTISEMENT":[0],"RETURN":[1],"TO":[2],"ISSUEPREVArticleNEXTProton":[3],"magnetic":[4],"resonance":[5],"study":[6],"of":[7,12,64,99,125],"the":[8,61,92,97,126,137,150,153,158,165,171],"indole":[9],"NH":[10],"resonances":[11],"lysozyme.":[13],"Assignment,":[14],"deuterium":[15],"exchange":[16],"kinetics,":[17],"and":[18,26,74,79,108,152,169,185,187],"inhibitor":[19],"bindingW.":[20],"D.":[21,24],"Phillips,":[22],"J.":[23,27,31],"Glickson,":[25],"A.":[28],"RupleyCite":[29],"this:":[30],"Am.":[32],"Chem.":[33],"Soc.":[34],"1971,":[35],"93,":[36],"16,":[37],"4031\u20134038Publication":[38],"Date":[39],"(Print):August":[40],"1,":[41],"1971Publication":[42],"History":[43],"Published":[44],"online1":[45],"May":[46],"2002Published":[47],"inissue":[48],"1":[49],"August":[50],"1971https://pubs.acs.org/doi/10.1021/ja00745a035https://doi.org/10.1021/ja00745a035research-articleACS":[51],"PublicationsRequest":[52],"reuse":[53],"permissionsArticle":[54],"Views294Altmetric-Citations64LEARN":[55],"ABOUT":[56],"THESE":[57],"METRICSArticle":[58],"Views":[59],"are":[60,83,96],"COUNTER-compliant":[62],"sum":[63],"full":[65],"text":[66],"article":[67,131],"downloads":[68],"since":[69],"November":[70],"2008":[71],"(both":[72],"PDF":[73],"HTML)":[75],"across":[76],"all":[77],"institutions":[78],"individuals.":[80],"These":[81],"metrics":[82],"regularly":[84],"updated":[85,109],"to":[86,91],"reflect":[87],"usage":[88],"leading":[89],"up":[90],"last":[93],"few":[94],"days.Citations":[95],"number":[98],"other":[100],"articles":[101],"citing":[102],"this":[103],"article,":[104],"calculated":[105],"by":[106],"Crossref":[107,115],"daily.":[110],"Find":[111,161],"more":[112,162],"information":[113,163],"about":[114,149],"citation":[116],"counts.The":[117],"Altmetric":[118,166],"Attention":[119,167],"Score":[120,168],"is":[121,173],"a":[122,129,142],"quantitative":[123],"measure":[124],"attention":[127],"that":[128],"research":[130],"has":[132],"received":[133],"online.":[134],"Clicking":[135],"on":[136,164],"donut":[138],"icon":[139],"will":[140],"load":[141],"page":[143],"at":[144],"altmetric.com":[145],"with":[146,181],"additional":[147],"details":[148],"score":[151,172],"social":[154],"media":[155],"presence":[156],"for":[157],"given":[159],"article.":[160],"how":[170],"calculated.":[174],"Share":[175,190],"Add":[176],"toView":[177],"InAdd":[178],"Full":[179],"Text":[180],"ReferenceAdd":[182],"Description":[183],"ExportRISCitationCitation":[184],"abstractCitation":[186],"referencesMore":[188],"Options":[189],"onFacebookTwitterWechatLinked":[191],"InRedditEmail":[192],"Other":[193],"access":[194],"optionsGet":[195],"e-Alertsclose":[196],"Get":[197],"e-Alerts":[198]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}