{"id":"https://openalex.org/W199225514","doi":"https://doi.org/10.4049/jimmunol.182.supp.35.20","title":"Inhibition of activation-induced T cell death by AIP2-mediated ubiquitination of EGR2 (35.20)","display_name":"Inhibition of activation-induced T cell death by AIP2-mediated ubiquitination of EGR2 (35.20)","publication_year":2009,"publication_date":"2009-04-01","ids":{"openalex":"https://openalex.org/W199225514","doi":"https://doi.org/10.4049/jimmunol.182.supp.35.20","mag":"199225514"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.182.supp.35.20","doi":"https://doi.org/10.4049/jimmunol.182.supp.35.20","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.182.supp.35.20","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043224088","display_name":"Deyu Fang","orcid":"https://orcid.org/0000-0002-4211-2751","observed_orcids":["https://orcid.org/0000-0002-4211-2751"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deyu Fang","raw_affiliation_strings":["Microbiology and Immunology, University of Missouri , Columbia, MO","1Microbiology and Immunology, University of Missouri, Columbia, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology and Immunology, University of Missouri , Columbia, MO","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"1Microbiology and Immunology, University of Missouri, Columbia, MO","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100687046","display_name":"An Chen","orcid":"https://orcid.org/0000-0001-7607-977X","observed_orcids":["https://orcid.org/0000-0001-7607-977X"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"An Chen","raw_affiliation_strings":["Microbiology and Immunology, University of Missouri , Columbia, MO","1Microbiology and Immunology, University of Missouri, Columbia, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology and Immunology, University of Missouri , Columbia, MO","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"1Microbiology and Immunology, University of Missouri, Columbia, MO","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082336809","display_name":"Sang\u2010Myeong Lee","orcid":"https://orcid.org/0000-0002-3624-3392","observed_orcids":["https://orcid.org/0000-0002-3624-3392"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sang-Myeong Lee","raw_affiliation_strings":["Microbiology and Immunology, University of Missouri , Columbia, MO","1Microbiology and Immunology, University of Missouri, Columbia, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology and Immunology, University of Missouri , Columbia, MO","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"1Microbiology and Immunology, University of Missouri, Columbia, MO","institution_ids":["https://openalex.org/I76835614"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I76835614"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"182","issue":"Supplement_1","first_page":"35.20","last_page":"35.20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.7720000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.7720000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.2085999995470047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.9480000138282776},{"id":"https://openalex.org/keywords/egr2","display_name":"EGR2","score":0.9760000109672546},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.7860000133514404},{"id":"https://openalex.org/keywords/t-cell-apoptosis","display_name":"T cell apoptosis","score":0.8069999814033508},{"id":"https://openalex.org/keywords/fas-ligand","display_name":"Fas ligand","score":0.9169999957084656},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.8199999928474426},{"id":"https://openalex.org/keywords/il-2-production","display_name":"IL-2 production","score":0.8629999756813049},{"id":"https://openalex.org/keywords/hect-e3-ligases","display_name":"HECT E3 ligases","score":0.7829999923706055},{"id":"https://openalex.org/keywords/zinc-finger-transcription-factor","display_name":"zinc finger transcription factor","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.8295284509658813},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.8121405839920044},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.727070689201355},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6941165924072266},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5667946934700012},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5415433049201965},{"id":"https://openalex.org/C2777265272","wikidata":"https://www.wikidata.org/wiki/Q18030005","display_name":"NEDD4","level":5,"score":0.5358539819717407},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.5086437463760376},{"id":"https://openalex.org/C66008609","wikidata":"https://www.wikidata.org/wiki/Q14866113","display_name":"Fas ligand","level":4,"score":0.5073999762535095},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49647170305252075},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4755651354789734},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.43266165256500244},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3387809097766876},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3292836546897888},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.276692271232605},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.22191449999809265},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.1293824017047882},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12904343008995056},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0856344997882843},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06580108404159546},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.182.supp.35.20","doi":"https://doi.org/10.4049/jimmunol.182.supp.35.20","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.182.supp.35.20","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.5,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2072672377","https://openalex.org/W3208790418","https://openalex.org/W2029439166","https://openalex.org/W2789689653","https://openalex.org/W2978665024","https://openalex.org/W2033084145","https://openalex.org/W2118263920","https://openalex.org/W2092582603","https://openalex.org/W2049686095","https://openalex.org/W199225514"],"abstract_inverted_index":{"Abstract":[0],"E3":[1,20,44],"ubiquitin":[2,21,135],"ligases,":[3,22],"which":[4],"target":[5],"specific":[6],"molecules":[7],"for":[8],"proteolytic":[9],"destruction,":[10],"have":[11,30],"emerged":[12],"as":[13],"key":[14],"regulators":[15],"of":[16,53,69,79,102,118],"immune":[17],"functions.":[18],"Several":[19],"including":[23],"c-Cbl,":[24],"Cbl-b,":[25],"GRAIL,":[26],"Itch,":[27],"and":[28,63,75,111,114],"Nedd4,":[29],"been":[31,88],"shown":[32],"to":[33,90],"negatively":[34],"regulate":[35,91],"T-cell":[36,49],"activation.":[37,50],"Here":[38],"we":[39],"report":[40],"that":[41,86],"the":[42,116,134],"HECT-type":[43],"ligase,":[45],"AIP2,":[46],"positively":[47],"regulates":[48,123],"Ectopic":[51],"expression":[52,95,104,113,132],"AIP2":[54,72,103,122],"in":[55],"mouse":[56],"primary":[57],"T":[58,70,98,119,125],"cells":[59],"enhances":[60,115],"their":[61],"proliferation":[62],"IL-2":[64],"production":[65],"by":[66,105,128],"suppressing":[67,129],"apoptosis":[68,117],"cells.":[71,120],"interacts":[73],"with":[74],"promotes":[76],"ubiquitin-mediated":[77],"degradation":[78],"EGR2,":[80],"a":[81],"zinc":[82],"finger":[83],"transcription":[84],"factor":[85],"has":[87],"found":[89],"Fas":[92],"ligand":[93],"(FasL)":[94],"during":[96],"activation-induced":[97,124],"cell":[99,126],"death.":[100],"Suppression":[101],"small":[106],"RNA":[107],"interference":[108],"upregulates":[109],"EGR2":[110],"FasL":[112,131],"Therefore,":[121],"death":[127],"EGR2-mediated":[130],"via":[133],"pathway.":[136]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}