{"id":"https://openalex.org/W1992247495","doi":"https://doi.org/10.1371/journal.pone.0085409","title":"A Novel Role for p115RhoGEF in Regulation of Epithelial Plasticity","display_name":"A Novel Role for p115RhoGEF in Regulation of Epithelial Plasticity","publication_year":2014,"publication_date":"2014-01-23","ids":{"openalex":"https://openalex.org/W1992247495","doi":"https://doi.org/10.1371/journal.pone.0085409","mag":"1992247495","pmid":"https://pubmed.ncbi.nlm.nih.gov/24465552","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3900421"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0085409","doi":"https://doi.org/10.1371/journal.pone.0085409","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0085409","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0085409&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0085409&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053394357","display_name":"Swapnil S. Kher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Swapnil S. Kher","raw_affiliation_strings":["Department of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, New Orleans, Louisiana, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, New Orleans, Louisiana, United States of America","institution_ids":["https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088624455","display_name":"Amanda Parker Struckhoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda P. Struckhoff","raw_affiliation_strings":["Stanley S. Scott Cancer Center, LSU Health Sciences Center, New Orleans, Louisiana, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanley S. Scott Cancer Center, LSU Health Sciences Center, New Orleans, Louisiana, United States of America","institution_ids":["https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023869395","display_name":"Arthur S. Alberts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1317189400","display_name":"Van Andel Institute","ror":"https://ror.org/00wm07d60","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1317189400"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur S. Alberts","raw_affiliation_strings":["Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, Michigan, United States of America","institution_ids":["https://openalex.org/I1317189400"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016349093","display_name":"Rebecca A. Worthylake","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rebecca A Worthylake","raw_affiliation_strings":["Department of Oral Biology, LSU Health Sciences Center, New Orleans, Louisiana, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Biology, LSU Health Sciences Center, New Orleans, Louisiana, United States of America","institution_ids":["https://openalex.org/I75420490"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5016349093"],"corresponding_institution_ids":["https://openalex.org/I75420490"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.833,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.67038892,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"9","issue":"1","first_page":"e85409","last_page":"e85409"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8446999788284302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8446999788284302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.05860000103712082,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.01730000041425228,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p115rhogef","display_name":"p115RhoGEF","score":0.9480000138282776},{"id":"https://openalex.org/keywords/epithelial-plasticity","display_name":"epithelial plasticity","score":0.9800000190734863},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.8820000290870667},{"id":"https://openalex.org/keywords/cell-cell-contact","display_name":"cell-cell contact","score":0.9419999718666077},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.9710000157356262},{"id":"https://openalex.org/keywords/rho-gtpase-signaling","display_name":"Rho GTPase signaling","score":0.8069999814033508},{"id":"https://openalex.org/keywords/diaphanous-related-formins","display_name":"diaphanous-related formins","score":0.8169999718666077},{"id":"https://openalex.org/keywords/cell-protrusions","display_name":"cell protrusions","score":0.8360000252723694},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9919999837875366},{"id":"https://openalex.org/keywords/breast-epithelial-cells","display_name":"breast epithelial cells","score":0.9139999747276306},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.6759999990463257},{"id":"https://openalex.org/keywords/tissue-regeneration","display_name":"tissue regeneration","score":0.8709999918937683}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7251649498939514},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5535826086997986},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.5309590697288513},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.45703187584877014},{"id":"https://openalex.org/C29350253","wikidata":"https://www.wikidata.org/wiki/Q189073","display_name":"Cell junction","level":3,"score":0.43719029426574707},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.43679821491241455},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4120280146598816},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.39664340019226074},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.23589342832565308},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07451832294464111},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05829688906669617}],"mesh":[{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022005","descriptor_name":"Adherens Junctions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064067","descriptor_name":"Rho Guanine Nucleotide Exchange Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0085409","doi":"https://doi.org/10.1371/journal.pone.0085409","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0085409","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0085409&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2885798","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3900421","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:24465552","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24465552","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3900421","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3900421/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:c8f5e8577197413fbd656d93850750d2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c8f5e8577197413fbd656d93850750d2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 1, p e85409 (2014)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/909903","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_A_Novel_Role_for_p115RhoGEF_in_Regulation_of_Epithelial_Plasticity_/909903","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0085409","doi":"https://doi.org/10.1371/journal.pone.0085409","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0085409","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0085409&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2368677986","display_name":"Mentoring Translational Researchers in Louisiana","funder_award_id":"P20GM103501","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3815968133","display_name":"Mentoring Translational Researchers in Louisiana","funder_award_id":"P20RR021970","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G4197882860","display_name":"Mentoring Oral Health Research in Louisiana","funder_award_id":"P20RR020160","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5216610361","display_name":"Mechanisms Governing Monocyte Recruitment during Periodontal Inflammation","funder_award_id":"R03DE019166","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1992247495.pdf","grobid_xml":"https://content.openalex.org/works/W1992247495.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1532124327","https://openalex.org/W1553815101","https://openalex.org/W1965791697","https://openalex.org/W1973688965","https://openalex.org/W1976075428","https://openalex.org/W1977186103","https://openalex.org/W1978094459","https://openalex.org/W1990408088","https://openalex.org/W1994263572","https://openalex.org/W1994930629","https://openalex.org/W2007554905","https://openalex.org/W2011343310","https://openalex.org/W2016979375","https://openalex.org/W2017423449","https://openalex.org/W2018823276","https://openalex.org/W2019102772","https://openalex.org/W2022002610","https://openalex.org/W2038351958","https://openalex.org/W2048136762","https://openalex.org/W2055236272","https://openalex.org/W2061228001","https://openalex.org/W2061954658","https://openalex.org/W2072400772","https://openalex.org/W2073772257","https://openalex.org/W2098159442","https://openalex.org/W2098410928","https://openalex.org/W2109006491","https://openalex.org/W2112680319","https://openalex.org/W2113419485","https://openalex.org/W2117403796","https://openalex.org/W2126300909","https://openalex.org/W2129138105","https://openalex.org/W2136556113","https://openalex.org/W2137604636","https://openalex.org/W2146473598","https://openalex.org/W2148450224","https://openalex.org/W2151712953","https://openalex.org/W2155258698","https://openalex.org/W2159303181","https://openalex.org/W2163858320","https://openalex.org/W2166598280"],"related_works":["https://openalex.org/W2016979375","https://openalex.org/W2779752536","https://openalex.org/W22391692","https://openalex.org/W2037612255","https://openalex.org/W3036258629","https://openalex.org/W4302304614","https://openalex.org/W2412360528","https://openalex.org/W3191252994","https://openalex.org/W2101295963","https://openalex.org/W2601759044"],"abstract_inverted_index":{"Epithelial":[0],"plasticity":[1,20,77],"plays":[2],"a":[3,32,92,107,170],"critical":[4,33,93],"role":[5,68,94,109,172],"during":[6],"physiological":[7],"processes,":[8],"such":[9,26,49],"as":[10,27,50],"wound":[11],"healing":[12],"and":[13,16,38,53,125,128,137,141],"tissue":[14],"regeneration,":[15],"dysregulation":[17],"of":[18,35,40,46,62,69,75,86,97,114,118,132,145,152,177],"epithelial":[19,36,65,76,98,103,115,164,178],"can":[21],"lead":[22],"to":[23,121],"pathological":[24],"conditions,":[25],"cancer.":[28],"Cell-cell":[29],"junctions":[30,41,63,100],"are":[31,158],"feature":[34],"cells":[37],"loss":[39],"is":[42,181],"associated":[43],"with":[44],"acquisition":[45],"mesenchymal":[47],"features,":[48],"enhanced":[51,126,134],"protrusion":[52,140],"migration.":[54,129,142],"Although":[55],"Rho":[56,70,147],"has":[57,78],"been":[58,80],"implicated":[59],"in":[60,64,72,95,101,112,163,175],"regulation":[61,74,96,113,176],"cells,":[66],"the":[67,73,87,153],"signaling":[71,185],"not":[79],"understood.":[81],"We":[82,105],"show":[83],"that":[84,150],"members":[85,151],"RGS":[88],"RhoGEFs":[89],"family":[90,157],"play":[91],"cell-cell":[99],"breast":[102],"cells.":[104],"identify":[106],"novel":[108,171],"for":[110,160,173],"p115RhoGEF":[111,119,133,174],"plasticity.":[116,165],"Loss":[117],"leads":[120],"decreased":[122],"junctional":[123,135],"E-cadherin":[124,136],"protrusiveness":[127],"Conversely,":[130],"overexpression":[131],"inhibited":[138],"cell":[139],"siRNA":[143],"screen":[144],"23":[146],"effectors":[148],"showed":[149],"Diaphanous-Related":[154],"Formin":[155],"(DRF)":[156],"required":[159],"p115RhoGEF-mediated":[161],"changes":[162],"Thus,":[166],"our":[167],"data":[168],"indicates":[169],"plasticity,":[179],"which":[180],"dependent":[182],"on":[183],"Rho-DRF":[184],"module.":[186]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
