{"id":"https://openalex.org/W1992233787","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a003307","title":"Functions of the D-Ribosyl Moiety and the Lower Axial Ligand of the Nucleotide Loop of Coenzyme B12 in Diol Dehydratase and Ethanolamine Ammonia-lyase Reactions","display_name":"Functions of the D-Ribosyl Moiety and the Lower Axial Ligand of the Nucleotide Loop of Coenzyme B12 in Diol Dehydratase and Ethanolamine Ammonia-lyase Reactions","publication_year":2002,"publication_date":"2002-12-01","ids":{"openalex":"https://openalex.org/W1992233787","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a003307","mag":"1992233787","pmid":"https://pubmed.ncbi.nlm.nih.gov/12473196"},"language":"en","primary_location":{"id":"doi:10.1093/oxfordjournals.jbchem.a003307","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a003307","is_oa":false,"landing_page_url":"https://doi.org/10.1093/oxfordjournals.jbchem.a003307","pdf_url":null,"source":{"id":"https://openalex.org/S184547178","display_name":"The Journal of Biochemistry","issn_l":"0021-924X","issn":["0021-924X","1756-2651"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"M. Fukuoka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Fukuoka","raw_affiliation_strings":["Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University, Tsushima-naka, Okayama 700-8530, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University, Tsushima-naka, Okayama 700-8530, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111777800","display_name":"Shuich Yamada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S. Yamada","raw_affiliation_strings":["Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University Tsushima-naka, Okayama 700-8530"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University Tsushima-naka, Okayama 700-8530","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S. Miyoshi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S. Miyoshi","raw_affiliation_strings":["Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University Tsushima-naka, Okayama 700-8530"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University Tsushima-naka, Okayama 700-8530","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045738608","display_name":"Kaori Yamashita","orcid":"https://orcid.org/0000-0002-0159-7588","observed_orcids":["https://orcid.org/0000-0002-0159-7588"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Yamashita","raw_affiliation_strings":["Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University Tsushima-naka, Okayama 700-8530"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University Tsushima-naka, Okayama 700-8530","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111834522","display_name":"Mamoru Yamanishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Yamanishi","raw_affiliation_strings":["Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University Tsushima-naka, Okayama 700-8530"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University Tsushima-naka, Okayama 700-8530","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103111217","display_name":"Xiang Zou","orcid":"https://orcid.org/0000-0002-1064-2029","observed_orcids":["https://orcid.org/0000-0002-1064-2029"]},"institutions":[{"id":"https://openalex.org/I4210106879","display_name":"Ohio University","ror":"https://ror.org/01jr3y717","country_code":"US","type":"education","lineage":["https://openalex.org/I4210106879"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"X. Zou","raw_affiliation_strings":["\u2020 Department of Chemistry and Biochemistry, Ohio University Athens, OH 45701, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020 Department of Chemistry and Biochemistry, Ohio University Athens, OH 45701, USA","institution_ids":["https://openalex.org/I4210106879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101408625","display_name":"Kenneth L. Brown","orcid":"https://orcid.org/0000-0002-0864-3110","observed_orcids":["https://orcid.org/0000-0002-0864-3110"]},"institutions":[{"id":"https://openalex.org/I4210106879","display_name":"Ohio University","ror":"https://ror.org/01jr3y717","country_code":"US","type":"education","lineage":["https://openalex.org/I4210106879"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. L. Brown","raw_affiliation_strings":["\u2020 Department of Chemistry and Biochemistry, Ohio University Athens, OH 45701, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020 Department of Chemistry and Biochemistry, Ohio University Athens, OH 45701, USA","institution_ids":["https://openalex.org/I4210106879"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077518647","display_name":"Tetsuo Toraya","orcid":"https://orcid.org/0000-0003-1074-9907","observed_orcids":["https://orcid.org/0000-0003-1074-9907"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"T. Toraya","raw_affiliation_strings":["Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University Tsushima-naka, Okayama 700-8530"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University Tsushima-naka, Okayama 700-8530","institution_ids":["https://openalex.org/I163770644"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5077518647"],"corresponding_institution_ids":["https://openalex.org/I163770644"],"apc_list":{"value":3276,"currency":"USD","value_usd":3276},"apc_paid":null,"fwci":0.3254,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.51159517,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"132","issue":"6","first_page":"935","last_page":"943"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12441","display_name":"Porphyrin Metabolism and Disorders","score":0.625,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12441","display_name":"Porphyrin Metabolism and Disorders","score":0.625,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.10080000013113022,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.03830000013113022,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coenzyme-b12","display_name":"coenzyme B12","score":0.9399999976158142},{"id":"https://openalex.org/keywords/adenosylcobalamin","display_name":"adenosylcobalamin","score":0.9890000224113464},{"id":"https://openalex.org/keywords/diol-dehydratase","display_name":"diol dehydratase","score":0.8830000162124634},{"id":"https://openalex.org/keywords/ethanolamine-ammonia-lyase","display_name":"ethanolamine ammonia-lyase","score":0.996999979019165},{"id":"https://openalex.org/keywords/axial-ligands","display_name":"axial ligands","score":0.8399999737739563},{"id":"https://openalex.org/keywords/coenzyme-analogs","display_name":"coenzyme analogs","score":0.7770000100135803},{"id":"https://openalex.org/keywords/suicide-inactivation","display_name":"suicide inactivation","score":0.8700000047683716},{"id":"https://openalex.org/keywords/cobalt-carbon-bond-cleavage","display_name":"cobalt-carbon bond cleavage","score":0.7699999809265137},{"id":"https://openalex.org/keywords/competitive-inhibition","display_name":"competitive inhibition","score":0.5529999732971191},{"id":"https://openalex.org/keywords/enzyme-catalysis","display_name":"enzyme catalysis","score":0.4189999997615814}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7965353727340698},{"id":"https://openalex.org/C2781374117","wikidata":"https://www.wikidata.org/wiki/Q5252382","display_name":"Dehydratase","level":3,"score":0.6760261058807373},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6642913222312927},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.5861374735832214},{"id":"https://openalex.org/C2778979354","wikidata":"https://www.wikidata.org/wiki/Q239593","display_name":"Adenosylcobalamin","level":4,"score":0.545062243938446},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.5283454060554504},{"id":"https://openalex.org/C2779216040","wikidata":"https://www.wikidata.org/wiki/Q410387","display_name":"Ethanolamine","level":2,"score":0.4591156840324402},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.4320662021636963},{"id":"https://openalex.org/C2777269803","wikidata":"https://www.wikidata.org/wiki/Q407727","display_name":"Lyase","level":3,"score":0.4226686954498291},{"id":"https://openalex.org/C2779123261","wikidata":"https://www.wikidata.org/wiki/Q407635","display_name":"Coenzyme A","level":4,"score":0.4188006818294525},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.4161002039909363},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2759477496147156},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.26569753885269165},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.11796712875366211},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001051","descriptor_name":"Apoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001051","descriptor_name":"Apoenzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003038","descriptor_name":"Cobamides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003038","descriptor_name":"Cobamides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004981","descriptor_name":"Ethanolamine Ammonia-Lyase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004981","descriptor_name":"Ethanolamine Ammonia-Lyase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011408","descriptor_name":"Propanediol Dehydratase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011408","descriptor_name":"Propanediol Dehydratase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013057","descriptor_name":"Spectrum Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/oxfordjournals.jbchem.a003307","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a003307","is_oa":false,"landing_page_url":"https://doi.org/10.1093/oxfordjournals.jbchem.a003307","pdf_url":null,"source":{"id":"https://openalex.org/S184547178","display_name":"The Journal of Biochemistry","issn_l":"0021-924X","issn":["0021-924X","1756-2651"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biochemistry","raw_type":"journal-article"},{"id":"pmid:12473196","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12473196","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.860.2161","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.860.2161","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jb.oxfordjournals.org/content/132/6/935.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7095147812","https://openalex.org/W1482932073","https://openalex.org/W2076105148","https://openalex.org/W2075829782","https://openalex.org/W2066863293","https://openalex.org/W1549504807","https://openalex.org/W1480773097","https://openalex.org/W2283192542","https://openalex.org/W2077351634","https://openalex.org/W2089865740"],"abstract_inverted_index":{"The":[0,33,58,75,95],"roles":[1],"of":[2,11,15,26,112,132,139,154,158,213,223],"the":[3,7,12,41,63,85,108,130,140,145,152,159,166,174,178,189,197,201,211,221,224,235],"D-ribosyl":[4],"moiety":[5,199],"and":[6,52,62,72,80,91,169],"bulky":[8],"axial":[9],"ligand":[10],"nucleotide":[13,160],"loop":[14,161],"adenosylcobalamin":[16],"in":[17,40,180,247],"coenzymic":[18],"function":[19],"have":[20],"been":[21],"investigated":[22],"using":[23],"two":[24],"series":[25],"coenzyme":[27,48,65,77,87,103,141],"analogs":[28],"bearing":[29],"various":[30],"artificial":[31],"bases.":[32],"2-methylbenzimidazolyl":[34],"trimethylene":[35,60,191],"analog":[36,61,97],"that":[37,121,151,187,196,210,234],"exists":[38],"exclusively":[39],"base-off":[42],"form":[43],"was":[44,78,127,148,183],"a":[45,55,133,155,241],"totally":[46],"inactive":[47],"for":[49,69,88,104,114,122,164,177,188,227],"diol":[50,70,89,123,181,228,248],"dehydratase":[51,71,90,182],"served":[53,98],"as":[54,82,84,99],"competitive":[56],"inhibitor.":[57],"benzimidazolyl":[59],"benzimidazolylcobamide":[64],"were":[66],"highly":[67],"active":[68,83],"ethanolamine":[73,92,115],"ammonia-lyase.":[74],"imidazolylcobamide":[76,179],"59":[79],"9%":[81],"normal":[86],"ammonia-lyase,":[93],"respectively.":[94],"latter":[96],"an":[100],"effective":[101],"suicide":[102,205],"both":[105,165],"enzymes,":[106],"although":[107],"partition":[109],"ratio":[110],"(k(cat)/k(inact))":[111],"630":[113],"ammonia-lyase":[116],"is":[117,162,194,217,238],"much":[118],"lower":[119],"than":[120,186],"dehydratase.":[124,229,249],"Suicide":[125],"inactivation":[126],"accompanied":[128],"by":[129,220],"accumulation":[131],"cob(II)amide":[134],"species,":[135],"indicating":[136],"irreversible":[137],"cleavage":[138],"Co-C":[142,214,236],"bond":[143,215,237],"during":[144],"inactivation.":[146,206],"It":[147],"thus":[149],"concluded":[150],"bulkiness":[153,222],"Co-coordinating":[156,225],"base":[157,226],"essential":[163],"initial":[167],"activity":[168],"continuous":[170],"catalytic":[171],"turnovers.":[172],"Since":[173],"k(cat)/k(inact)":[175],"value":[176],"27-times":[184],"higher":[185],"imidazolyl":[190],"analog,":[192],"it":[193,231],"clear":[195],"ribosyl":[198],"protects":[200],"reaction":[202],"intermediates":[203],"from":[204],"Stopped-flow":[207],"measurements":[208],"indicated":[209],"rate":[212],"homolysis":[216],"essentially":[218],"unaffected":[219],"Thus,":[230],"seems":[232],"unlikely":[233],"labilized":[239],"through":[240],"ground":[242],"state":[243],"mechanochemical":[244],"triggering":[245],"mechanism":[246]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
