{"id":"https://openalex.org/W1992223744","doi":"https://doi.org/10.1016/j.sleep.2008.12.009","title":"Sleep deprivation worsens inflammation and delays recovery in a mouse model of colitis","display_name":"Sleep deprivation worsens inflammation and delays recovery in a mouse model of colitis","publication_year":2009,"publication_date":"2009-04-29","ids":{"openalex":"https://openalex.org/W1992223744","doi":"https://doi.org/10.1016/j.sleep.2008.12.009","mag":"1992223744","pmid":"https://pubmed.ncbi.nlm.nih.gov/19403332","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3509796"},"language":"en","primary_location":{"id":"doi:10.1016/j.sleep.2008.12.009","doi":"https://doi.org/10.1016/j.sleep.2008.12.009","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.sleep.2008.12.009","pdf_url":null,"source":{"id":"https://openalex.org/S183718435","display_name":"Sleep Medicine","issn_l":"1389-9457","issn":["1389-9457","1878-5506"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sleep Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3509796","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103199442","display_name":"Yueming Tang","orcid":"https://orcid.org/0009-0009-3079-0756","observed_orcids":["https://orcid.org/0009-0009-3079-0756"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yueming Tang","raw_affiliation_strings":["Department of Internal Medicine, Division of Digestive Disease and Nutrition, Rush University Medical Center, 1725 W. Harrison, Suite 206, Chicago, IL 60612, USA. yueming_tang@rush.edu","Department of Internal Medicine, Division of Digestive Disease and Nutrition, Rush University Medical Center, 1725 W. Harrison, Suite 206, Chicago, IL 60612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Digestive Disease and Nutrition, Rush University Medical Center, 1725 W. Harrison, Suite 206, Chicago, IL 60612, USA. yueming_tang@rush.edu","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Department of Internal Medicine, Division of Digestive Disease and Nutrition, Rush University Medical Center, 1725 W. Harrison, Suite 206, Chicago, IL 60612, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018162452","display_name":"Fabian Preuss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fabian Preuss","raw_affiliation_strings":["Center for Sleep & Circadian Biology, Department of Neurobiology & Physiology, Northwestern University, Evanston, IL 60208, USA","Department of Internal Medicine, Division of Digestive Disease and Nutrition, Rush University Medical Center, 1725 W. Harrison, Suite 206, Chicago, IL 60612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Sleep & Circadian Biology, Department of Neurobiology & Physiology, Northwestern University, Evanston, IL 60208, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Internal Medicine, Division of Digestive Disease and Nutrition, Rush University Medical Center, 1725 W. Harrison, Suite 206, Chicago, IL 60612, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084820716","display_name":"Fred William Turek","orcid":"https://orcid.org/0000-0002-4031-4229","observed_orcids":["https://orcid.org/0000-0002-4031-4229"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fred W. Turek","raw_affiliation_strings":["Center for Sleep & Circadian Biology, Department of Neurobiology & Physiology, Northwestern University, Evanston, IL 60208, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Sleep & Circadian Biology, Department of Neurobiology & Physiology, Northwestern University, Evanston, IL 60208, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077088911","display_name":"Shriram M. Jakate","orcid":"https://orcid.org/0000-0002-8355-3481","observed_orcids":["https://orcid.org/0000-0002-8355-3481"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shriram Jakate","raw_affiliation_strings":["Department of Pathology, Rush University Medical Center, Chicago, IL 60612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Rush University Medical Center, Chicago, IL 60612, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002619544","display_name":"Ali Keshavarzian","orcid":"https://orcid.org/0000-0002-7969-3369","observed_orcids":["https://orcid.org/0000-0002-7969-3369"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ali Keshavarzian","raw_affiliation_strings":["Department of Internal Medicine, Division of Digestive Disease and Nutrition, Rush University Medical Center, 1725 W. Harrison, Suite 206, Chicago, IL 60612, USA","Department of Pharmacology and Molecular Biophysics & Physiology, Rush University Medical Center, Chicago, IL 60612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Digestive Disease and Nutrition, Rush University Medical Center, 1725 W. Harrison, Suite 206, Chicago, IL 60612, USA","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Department of Pharmacology and Molecular Biophysics & Physiology, Rush University Medical Center, Chicago, IL 60612, USA","institution_ids":["https://openalex.org/I1285301757"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5103199442"],"corresponding_institution_ids":["https://openalex.org/I1285301757"],"apc_list":{"value":4350,"currency":"USD","value_usd":4350},"apc_paid":null,"fwci":4.8435,"has_fulltext":false,"cited_by_count":148,"citation_normalized_percentile":{"value":0.95368852,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"10","issue":"6","first_page":"597","last_page":"603"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.016100000590085983,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sleep-deprivation","display_name":"sleep deprivation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/colitis","display_name":"colitis","score":0.8009999990463257},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.9879999756813049},{"id":"https://openalex.org/keywords/colonic-inflammation","display_name":"colonic inflammation","score":0.8349999785423279},{"id":"https://openalex.org/keywords/dextran-sodium-sulfate","display_name":"dextran sodium sulfate","score":0.777999997138977},{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.8410000205039978},{"id":"https://openalex.org/keywords/sleep-disturbance","display_name":"sleep disorders","score":0.5709999799728394},{"id":"https://openalex.org/keywords/colon-histopathology","display_name":"colon histopathology","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.878252387046814},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7608896493911743},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7061427235603333},{"id":"https://openalex.org/C2778329153","wikidata":"https://www.wikidata.org/wiki/Q1364801","display_name":"Sleep deprivation","level":3,"score":0.6269473433494568},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.5787051320075989},{"id":"https://openalex.org/C203565725","wikidata":"https://www.wikidata.org/wiki/Q420012","display_name":"Myeloperoxidase","level":3,"score":0.5411481261253357},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5294387340545654},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.5098925828933716},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4828636944293976},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.41343390941619873},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3464508056640625},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33761143684387207},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.20707327127456665},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2042907476425171},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006471","descriptor_name":"Gastrointestinal Hemorrhage","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009195","descriptor_name":"Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012002","descriptor_name":"Rectal Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D012892","descriptor_name":"Sleep Deprivation","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D012892","descriptor_name":"Sleep Deprivation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016264","descriptor_name":"Dextran Sulfate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.sleep.2008.12.009","doi":"https://doi.org/10.1016/j.sleep.2008.12.009","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.sleep.2008.12.009","pdf_url":null,"source":{"id":"https://openalex.org/S183718435","display_name":"Sleep Medicine","issn_l":"1389-9457","issn":["1389-9457","1878-5506"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sleep Medicine","raw_type":"journal-article"},{"id":"pmid:19403332","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19403332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sleep medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3509796","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3509796","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Sleep Med","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3509796","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3509796","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Sleep Med","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.550000011920929,"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1401819796","display_name":null,"funder_award_id":"R01-AA 013745","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G8968096851","display_name":"Alcohol, iNOS upregulation, leaky gut & liver disease","funder_award_id":"5r01aa013745-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1509457286","https://openalex.org/W1855226200","https://openalex.org/W1967217097","https://openalex.org/W1967404039","https://openalex.org/W1968123260","https://openalex.org/W1970138464","https://openalex.org/W1974161819","https://openalex.org/W1975065988","https://openalex.org/W1979768971","https://openalex.org/W1985015494","https://openalex.org/W1991723267","https://openalex.org/W1991801110","https://openalex.org/W1993155622","https://openalex.org/W1993678078","https://openalex.org/W2020358486","https://openalex.org/W2022056474","https://openalex.org/W2035813653","https://openalex.org/W2040936681","https://openalex.org/W2047445016","https://openalex.org/W2049445917","https://openalex.org/W2056738560","https://openalex.org/W2065994153","https://openalex.org/W2071697888","https://openalex.org/W2078621117","https://openalex.org/W2089531750","https://openalex.org/W2092894230","https://openalex.org/W2099376515","https://openalex.org/W2106065202","https://openalex.org/W2113855055","https://openalex.org/W2139685560","https://openalex.org/W2160240762","https://openalex.org/W2167987062","https://openalex.org/W2322010248","https://openalex.org/W3092133778","https://openalex.org/W4292198229"],"related_works":["https://openalex.org/W1985294033","https://openalex.org/W2021886664","https://openalex.org/W2053651068","https://openalex.org/W2168644074","https://openalex.org/W7220144568","https://openalex.org/W2033284440","https://openalex.org/W4413312940","https://openalex.org/W7213342433","https://openalex.org/W2507751163","https://openalex.org/W2945222323"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}