{"id":"https://openalex.org/W1992211704","doi":"https://doi.org/10.3987/com-08-s(d)memoire-3","title":"John W. Daly: The Early Years. The NIH Shift and Cyclic-AMP Assays: Early Pharmacological Breakthroughs","display_name":"John W. Daly: The Early Years. The NIH Shift and Cyclic-AMP Assays: Early Pharmacological Breakthroughs","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W1992211704","doi":"https://doi.org/10.3987/com-08-s(d)memoire-3","mag":"1992211704"},"language":"en","primary_location":{"id":"doi:10.3987/com-08-s(d)memoire-3","doi":"https://doi.org/10.3987/com-08-s(d)memoire-3","is_oa":true,"landing_page_url":"https://doi.org/10.3987/com-08-s(d)memoire-3","pdf_url":"https://doi.org/10.3987/com-08-s(d)memoire-3","source":{"id":"https://openalex.org/S27298842","display_name":"Heterocycles","issn_l":"0385-5414","issn":["0385-5414","1881-0942"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"HETEROCYCLES","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.3987/com-08-s(d)memoire-3","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106132762","display_name":"Kenneth L. Kirk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth L. Kirk","raw_affiliation_strings":["Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, MD 20892, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, MD 20892, USA;","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108753892","display_name":"Fabian Gusovsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151718","display_name":"Eisai (United States)","ror":"https://ror.org/0469x1750","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151718","https://openalex.org/I55881946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fabian Gusovsky","raw_affiliation_strings":["Eisai Research Institute, Andover, MA 01810, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eisai Research Institute, Andover, MA 01810, USA;","institution_ids":["https://openalex.org/I4210151718"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"79","issue":"1","first_page":"85","last_page":"85"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14475","display_name":"History of Science and Medicine","score":0.8403000235557556,"subfield":{"id":"https://openalex.org/subfields/1207","display_name":"History and Philosophy of Science"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T14475","display_name":"History of Science and Medicine","score":0.8403000235557556,"subfield":{"id":"https://openalex.org/subfields/1207","display_name":"History and Philosophy of Science"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T14275","display_name":"Historical Medical Research and Treatments","score":0.07119999825954437,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.03889999911189079,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nih-shift","display_name":"NIH shift","score":0.9580000042915344},{"id":"https://openalex.org/keywords/julius-axelrod","display_name":"Julius Axelrod","score":0.8360000252723694},{"id":"https://openalex.org/keywords/history-of-pharmacology","display_name":"history of pharmacology","score":0.7940000295639038},{"id":"https://openalex.org/keywords/history-of-biochemistry","display_name":"history of biochemistry","score":0.8450000286102295},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"organic chemistry","score":0.4300000071525574},{"id":"https://openalex.org/keywords/national-institutes-of-health","display_name":"National Institutes of Health","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6499940156936646},{"id":"https://openalex.org/C2779714115","wikidata":"https://www.wikidata.org/wiki/Q593644","display_name":"Chemist","level":2,"score":0.5611647963523865},{"id":"https://openalex.org/C95124753","wikidata":"https://www.wikidata.org/wiki/Q875686","display_name":"Environmental ethics","level":1,"score":0.3239949643611908},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.1150774359703064},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09850642085075378}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3987/com-08-s(d)memoire-3","doi":"https://doi.org/10.3987/com-08-s(d)memoire-3","is_oa":true,"landing_page_url":"https://doi.org/10.3987/com-08-s(d)memoire-3","pdf_url":"https://doi.org/10.3987/com-08-s(d)memoire-3","source":{"id":"https://openalex.org/S27298842","display_name":"Heterocycles","issn_l":"0385-5414","issn":["0385-5414","1881-0942"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"HETEROCYCLES","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3987/com-08-s(d)memoire-3","doi":"https://doi.org/10.3987/com-08-s(d)memoire-3","is_oa":true,"landing_page_url":"https://doi.org/10.3987/com-08-s(d)memoire-3","pdf_url":"https://doi.org/10.3987/com-08-s(d)memoire-3","source":{"id":"https://openalex.org/S27298842","display_name":"Heterocycles","issn_l":"0385-5414","issn":["0385-5414","1881-0942"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"HETEROCYCLES","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1992211704.pdf","grobid_xml":"https://content.openalex.org/works/W1992211704.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W165638364","https://openalex.org/W1529705405","https://openalex.org/W1548437481","https://openalex.org/W1594189146","https://openalex.org/W1839376091","https://openalex.org/W1981215615","https://openalex.org/W1987346819","https://openalex.org/W1990294420","https://openalex.org/W1995861538","https://openalex.org/W2004266853","https://openalex.org/W2010903979","https://openalex.org/W2017491498","https://openalex.org/W2034507000","https://openalex.org/W2042403921","https://openalex.org/W2046849301","https://openalex.org/W2048078487","https://openalex.org/W2058515772","https://openalex.org/W2062701554","https://openalex.org/W2066648805","https://openalex.org/W2066869625","https://openalex.org/W2070332580","https://openalex.org/W2073741743","https://openalex.org/W2091003207","https://openalex.org/W2092083452","https://openalex.org/W2141804782","https://openalex.org/W2329605444","https://openalex.org/W2418805812","https://openalex.org/W2429559569","https://openalex.org/W2444058501"],"related_works":["https://openalex.org/W2138652756","https://openalex.org/W2075878089","https://openalex.org/W2115645276","https://openalex.org/W3101385300","https://openalex.org/W1976431691","https://openalex.org/W1993601025","https://openalex.org/W2114023542","https://openalex.org/W2440974397","https://openalex.org/W2260823697","https://openalex.org/W3101545256"],"abstract_inverted_index":{"Although":[0],"trained":[1],"as":[2],"an":[3],"organic":[4],"chemist,":[5],"John":[6],"Daly":[7],"embarked":[8],"in":[9,37,57],"his":[10,80],"early":[11,88],"years":[12],"at":[13],"NIH":[14,62],"on":[15],"several":[16],"research":[17,81],"projects":[18],"that":[19],"involved":[20],"a":[21,68],"significant":[22],"and":[23,28,64,86],"sophisticated":[24],"application":[25],"of":[26,53,60,67,79],"biochemistry":[27],"pharmacology.He":[29],"was":[30],"able":[31],"to":[32,70],"work":[33],"with":[34],"impressive":[35],"leaders":[36],"these":[38,85],"fields,":[39],"including":[40],"the":[41,58,61,65],"late":[42],"Nobel":[43],"Laureate,":[44],"Julius":[45],"Axelrod.In":[46],"this":[47,54],"report,":[48],"we":[49],"highlight":[50],"two":[51],"aspects":[52],"work-his":[55],"involvement":[56],"discovery":[59],"shift":[63],"development":[66],"method":[69],"quickly":[71],"assay":[72],"cyclic":[73],"AMP":[74],"biosynthesis.The":[75],"strong":[76],"pharmacological":[77],"component":[78],"career":[82],"evolved":[83],"from":[84],"other":[87],"seminal":[89],"discoveries.":[90]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}