{"id":"https://openalex.org/W199220374","doi":null,"title":"THE ROLE OF TRAF6 PHOSPHORYLATION IN Src/TRAF6-MEDIATED IKK, JNK, Akt ACTIVATION AND TUMORIGENESIS","display_name":"THE ROLE OF TRAF6 PHOSPHORYLATION IN Src/TRAF6-MEDIATED IKK, JNK, Akt ACTIVATION AND TUMORIGENESIS","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W199220374","mag":"199220374"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1533","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/494","pdf_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/494","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/494","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112841406","display_name":"Yun Seong Jeong","orcid":"https://orcid.org/0000-0001-8632-226X","observed_orcids":["https://orcid.org/0000-0001-8632-226X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yun Seong Jeong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5112841406"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/traf6","display_name":"TRAF6","score":0.9900000095367432},{"id":"https://openalex.org/keywords/src-kinase","display_name":"Src kinase","score":0.9660000205039978},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.8190000057220459},{"id":"https://openalex.org/keywords/ikk-activation","display_name":"IKK activation","score":0.8980000019073486},{"id":"https://openalex.org/keywords/jnk-activation","display_name":"JNK activation","score":0.8690000176429749},{"id":"https://openalex.org/keywords/akt-activation","display_name":"Akt activation","score":0.8529999852180481},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9539999961853027},{"id":"https://openalex.org/keywords/igf1r-signaling","display_name":"IGF1R signaling","score":0.8190000057220459},{"id":"https://openalex.org/keywords/il-1-signaling","display_name":"IL-1 signaling","score":0.7730000019073486},{"id":"https://openalex.org/keywords/rankl-signaling","display_name":"RANKL signaling","score":0.8090000152587891},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.7940000295639038},{"id":"https://openalex.org/keywords/ubc13","display_name":"Ubc13","score":0.8730000257492065},{"id":"https://openalex.org/keywords/ubiquitin-conjugating-enzyme","display_name":"E2 ubiquitin-conjugating enzyme","score":0.8230000138282776},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7089999914169312},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7730000019073486}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6428326368331909},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.5931978225708008},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5832244157791138},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5531206130981445},{"id":"https://openalex.org/C100175707","wikidata":"https://www.wikidata.org/wiki/Q6103519","display_name":"I\u03baB kinase","level":4,"score":0.5453190207481384},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5260881185531616},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40733134746551514},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.26977401971817017},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2537239193916321},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23876351118087769},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16059616208076477},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13713419437408447},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.084170401096344},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05949118733406067}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1533","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/494","pdf_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/494","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},{"id":"mag:199220374","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=1533&context=utgsbs_dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1533","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/494","pdf_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/494","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W199220374.pdf","grobid_xml":"https://content.openalex.org/works/W199220374.grobid-xml"},"referenced_works_count":150,"referenced_works":["https://openalex.org/W45936251","https://openalex.org/W114843030","https://openalex.org/W171251970","https://openalex.org/W1504914687","https://openalex.org/W1513954632","https://openalex.org/W1549736588","https://openalex.org/W1551653695","https://openalex.org/W1617532721","https://openalex.org/W1618017788","https://openalex.org/W1665454629","https://openalex.org/W1799136447","https://openalex.org/W1832030339","https://openalex.org/W1943552404","https://openalex.org/W1963767618","https://openalex.org/W1964396270","https://openalex.org/W1964718737","https://openalex.org/W1965404141","https://openalex.org/W1966892912","https://openalex.org/W1966998035","https://openalex.org/W1968160256","https://openalex.org/W1968422877","https://openalex.org/W1969090908","https://openalex.org/W1971128251","https://openalex.org/W1972459670","https://openalex.org/W1973237224","https://openalex.org/W1973425911","https://openalex.org/W1973680986","https://openalex.org/W1974755980","https://openalex.org/W1976197008","https://openalex.org/W1977223602","https://openalex.org/W1977830503","https://openalex.org/W1979652500","https://openalex.org/W1979945691","https://openalex.org/W1981891742","https://openalex.org/W1983007339","https://openalex.org/W1985044548","https://openalex.org/W1986461964","https://openalex.org/W1986635401","https://openalex.org/W1988336108","https://openalex.org/W1990599804","https://openalex.org/W1990720057","https://openalex.org/W1990915902","https://openalex.org/W1991371485","https://openalex.org/W1991683855","https://openalex.org/W1995117011","https://openalex.org/W1997617537","https://openalex.org/W1997681070","https://openalex.org/W1997685431","https://openalex.org/W1998079639","https://openalex.org/W1998499862","https://openalex.org/W2004064281","https://openalex.org/W2004385163","https://openalex.org/W2004465286","https://openalex.org/W2005572311","https://openalex.org/W2006842094","https://openalex.org/W2007251599","https://openalex.org/W2007456673","https://openalex.org/W2008869198","https://openalex.org/W2010164613","https://openalex.org/W2011399788","https://openalex.org/W2013245082","https://openalex.org/W2014866717","https://openalex.org/W2015348280","https://openalex.org/W2019645337","https://openalex.org/W2020031294","https://openalex.org/W2021909299","https://openalex.org/W2023245305","https://openalex.org/W2024161072","https://openalex.org/W2024587309","https://openalex.org/W2024694132","https://openalex.org/W2026495245","https://openalex.org/W2026647332","https://openalex.org/W2029245460","https://openalex.org/W2032972084","https://openalex.org/W2036064716","https://openalex.org/W2036224418","https://openalex.org/W2036285327","https://openalex.org/W2039132486","https://openalex.org/W2044182846","https://openalex.org/W2044368898","https://openalex.org/W2045736180","https://openalex.org/W2046163031","https://openalex.org/W2056402897","https://openalex.org/W2060441844","https://openalex.org/W2061212004","https://openalex.org/W2064122617","https://openalex.org/W2064918308","https://openalex.org/W2073357083","https://openalex.org/W2073643950","https://openalex.org/W2073702893","https://openalex.org/W2074688366","https://openalex.org/W2074987160","https://openalex.org/W2076039998","https://openalex.org/W2076649145","https://openalex.org/W2076842028","https://openalex.org/W2077494922","https://openalex.org/W2078997251","https://openalex.org/W2079022347","https://openalex.org/W2081883332","https://openalex.org/W2082270045","https://openalex.org/W2084082316","https://openalex.org/W2084434864","https://openalex.org/W2085637098","https://openalex.org/W2090023298","https://openalex.org/W2090023502","https://openalex.org/W2093153238","https://openalex.org/W2096407508","https://openalex.org/W2099113454","https://openalex.org/W2100694483","https://openalex.org/W2101257013","https://openalex.org/W2106009840","https://openalex.org/W2106877484","https://openalex.org/W2110307590","https://openalex.org/W2114348576","https://openalex.org/W2116063836","https://openalex.org/W2118995428","https://openalex.org/W2120855201","https://openalex.org/W2121766083","https://openalex.org/W2121881330","https://openalex.org/W2123253262","https://openalex.org/W2124205852","https://openalex.org/W2132892038","https://openalex.org/W2139030718","https://openalex.org/W2144770839","https://openalex.org/W2145345398","https://openalex.org/W2145468317","https://openalex.org/W2147005308","https://openalex.org/W2148019980","https://openalex.org/W2148392040","https://openalex.org/W2148842373","https://openalex.org/W2149849865","https://openalex.org/W2151713088","https://openalex.org/W2153071302","https://openalex.org/W2155237371","https://openalex.org/W2156539075","https://openalex.org/W2158567858","https://openalex.org/W2160476725","https://openalex.org/W2164919571","https://openalex.org/W2166655452","https://openalex.org/W2167259834","https://openalex.org/W2170218211","https://openalex.org/W2171114341","https://openalex.org/W2171342661","https://openalex.org/W2238980248","https://openalex.org/W2313054549","https://openalex.org/W2388163742","https://openalex.org/W2612688512","https://openalex.org/W2953170317","https://openalex.org/W4298419914","https://openalex.org/W7074248790"],"related_works":["https://openalex.org/W2074517544","https://openalex.org/W2148392040","https://openalex.org/W7095104438","https://openalex.org/W1517010032","https://openalex.org/W2387833818","https://openalex.org/W2024136349","https://openalex.org/W2080458188","https://openalex.org/W2934846924","https://openalex.org/W4254809785","https://openalex.org/W2766078895"],"abstract_inverted_index":{"TRAF6":[0,59,87,105,116,130,143,165,170,198,204,209,222,248,252],"E3":[1],"ligase":[2],"regulates":[3],"numerous":[4],"essential":[5,140],"biological":[6],"processes":[7],"such":[8],"as":[9,138,160,254],"innate":[10],"immune":[11],"response,":[12],"cell":[13,82],"survival":[14,83,236],"and":[15,25,40,54,84,98,136,153,166,184,211,230,250,263],"osteoclast":[16],"differentiation.":[17],"Upon":[18],"activation,":[19,186],"it":[20],"mediates":[21],"activation":[22,70,72,94,144,249,262],"of":[23,32,43,73,95,169,245,247],"IKK/NF-\u03baB":[24],"JNK":[26,97,185],"signaling":[27,69,147],"in":[28,67,79],"response":[29],"to":[30,46,64,214],"engagement":[31],"toll-like":[33],"receptor":[34,38,41,77,102],"4":[35],"(TLR4),":[36],"interleukin-1":[37],"(IL-1R),":[39],"activator":[42],"NF-\u03baB":[44],"(RANK)":[45],"their":[47],"cognate":[48],"ligands,":[49],"including":[50,149],"lipopolysaccharide":[51],"(LPS),":[52],"IL-1,":[53,151],"RANK":[55],"ligand":[56],"(RANKL).":[57],"Recently,":[58],"has":[60],"also":[61],"been":[62],"shown":[63],"be":[65,189],"involved":[66],"Akt":[68,99],"upon":[71],"insulin-like":[74],"growth":[75],"factor-1":[76],"(IGF-1R),":[78],"turn":[80],"orchestrating":[81],"tumorigenesis.":[85],"Therefore,":[86],"is":[88,107,117,133,206,224],"a":[89,161,167,232,255],"key":[90],"player":[91],"for":[92,142,164,208,226,234,258],"the":[93,112,242],"IKK,":[96,182],"by":[100,109,114,145,191,196],"diverse":[101],"signaling.":[103],"Although":[104],"activity":[106],"induced":[108,135],"these":[110,120],"receptors,":[111],"mechanism":[113],"which":[115,187],"activated":[118],"under":[119],"stimulating":[121],"conditions":[122],"remains":[123],"largely":[124],"unclear.":[125],"Here,":[126],"we":[127,174,201,219],"show":[128,202],"that":[129,176,203,221],"Y473":[131,171],"phosphorylation":[132,205,223,253],"commonly":[134],"serves":[137],"an":[139],"mode":[141,257],"multiple":[146],"stimuli":[148],"IGF-1,":[150],"LPS,":[152],"RANKL.":[154],"We":[155],"identify":[156],"Src":[157,177],"tyrosine":[158],"kinase":[159,163,261],"direct":[162],"mediator":[168],"phosphorylation.":[172],"Notably,":[173],"find":[175,220],"or":[178],"Traf6":[179],"deficiency":[180],"impairs":[181],"Akt,":[183],"can":[188],"rescued":[190],"phosphomimetic":[192],"TRAF6,":[193],"but":[194],"not":[195],"phosphorylation-dead":[197],"mutant.":[199],"Mechanistically,":[200],"imperative":[207],"dimerization/oligomerization":[210],"its":[212],"binding":[213],"E2":[215],"enzyme,":[216],"UBC13.":[217],"Significantly,":[218],"critical":[225],"TRAF6-mediated":[227],"cancer":[228],"progression":[229],"represents":[231],"biomarker":[233],"poor":[235],"outcome.":[237],"Our":[238],"study":[239],"therefore":[240],"resolves":[241],"long-standing":[243],"puzzle":[244],"achievement":[246],"elucidates":[251],"central":[256],"Src/TRAF6-mediated":[259],"downstream":[260],"tumorigenesis":[264]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
