{"id":"https://openalex.org/W1992199374","doi":"https://doi.org/10.1038/nature05059","title":"Scaling and the design of miniaturized chemical-analysis systems","display_name":"Scaling and the design of miniaturized chemical-analysis systems","publication_year":2006,"publication_date":"2006-07-01","ids":{"openalex":"https://openalex.org/W1992199374","doi":"https://doi.org/10.1038/nature05059","mag":"1992199374","pmid":"https://pubmed.ncbi.nlm.nih.gov/16871204"},"language":"en","primary_location":{"id":"doi:10.1038/nature05059","doi":"https://doi.org/10.1038/nature05059","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nature05059","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1992199374"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090978314","display_name":"Dirk Janasek","orcid":"https://orcid.org/0000-0002-4231-1224","observed_orcids":["https://orcid.org/0000-0002-4231-1224"]},"institutions":[{"id":"https://openalex.org/I4210121365","display_name":"Leibniz Institute for Analytical Sciences - ISAS","ror":"https://ror.org/02jhqqg57","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210121365"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Dirk Janasek","raw_affiliation_strings":["ISAS-Institute for Analytical Sciences, Bunsen-Kirchhoff-Str. 11, D-44139 Dortmund, Germany. d.janasek@ansci.de","ISAS \u2014 Institute for Analytical Sciences, Dortmund, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ISAS-Institute for Analytical Sciences, Bunsen-Kirchhoff-Str. 11, D-44139 Dortmund, Germany. d.janasek@ansci.de","institution_ids":["https://openalex.org/I4210121365"]},{"raw_affiliation_string":"ISAS \u2014 Institute for Analytical Sciences, Dortmund, Germany","institution_ids":["https://openalex.org/I4210121365"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041373903","display_name":"Joachim Franzke","orcid":"https://orcid.org/0000-0003-0419-1898","observed_orcids":["https://orcid.org/0000-0003-0419-1898"]},"institutions":[{"id":"https://openalex.org/I4210121365","display_name":"Leibniz Institute for Analytical Sciences - ISAS","ror":"https://ror.org/02jhqqg57","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210121365"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Joachim Franzke","raw_affiliation_strings":["ISAS \u2014 Institute for Analytical Sciences, Bunsen-Kirchhoff-Str. 11, Dortmund, D-44139, Germany","ISAS \u2014 Institute for Analytical Sciences, Dortmund, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ISAS \u2014 Institute for Analytical Sciences, Bunsen-Kirchhoff-Str. 11, Dortmund, D-44139, Germany","institution_ids":["https://openalex.org/I4210121365"]},{"raw_affiliation_string":"ISAS \u2014 Institute for Analytical Sciences, Dortmund, Germany","institution_ids":["https://openalex.org/I4210121365"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064359164","display_name":"A. Manz","orcid":"https://orcid.org/0000-0001-9712-711X","observed_orcids":["https://orcid.org/0000-0001-9712-711X"]},"institutions":[{"id":"https://openalex.org/I4210121365","display_name":"Leibniz Institute for Analytical Sciences - ISAS","ror":"https://ror.org/02jhqqg57","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210121365"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Manz","raw_affiliation_strings":["ISAS \u2014 Institute for Analytical Sciences, Bunsen-Kirchhoff-Str. 11, Dortmund, D-44139, Germany","ISAS \u2014 Institute for Analytical Sciences, Dortmund, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ISAS \u2014 Institute for Analytical Sciences, Bunsen-Kirchhoff-Str. 11, Dortmund, D-44139, Germany","institution_ids":["https://openalex.org/I4210121365"]},{"raw_affiliation_string":"ISAS \u2014 Institute for Analytical Sciences, Dortmund, Germany","institution_ids":["https://openalex.org/I4210121365"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5090978314"],"corresponding_institution_ids":["https://openalex.org/I4210121365"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":4.4953,"has_fulltext":false,"cited_by_count":727,"citation_normalized_percentile":{"value":0.96103896,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"442","issue":"7101","first_page":"374","last_page":"380"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.8574000000953674,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.8574000000953674,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.12080000340938568,"subfield":{"id":"https://openalex.org/subfields/1507","display_name":"Fluid Flow and Transfer Processes"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12327","display_name":"Various Chemistry Research Topics","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/3304","display_name":"Education"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/scaling-laws","display_name":"scaling laws","score":0.8799999952316284},{"id":"https://openalex.org/keywords/chemical-separation","display_name":"chemical separation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/chemical-reactions","display_name":"chemical reactions","score":0.5849999785423279},{"id":"https://openalex.org/keywords/chemical-detection","display_name":"chemical detection","score":0.8220000267028809},{"id":"https://openalex.org/keywords/microfluidics","display_name":"microfluidics","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C99844830","wikidata":"https://www.wikidata.org/wiki/Q102441924","display_name":"Scaling","level":2,"score":0.7658534049987793},{"id":"https://openalex.org/C22507642","wikidata":"https://www.wikidata.org/wiki/Q1069369","display_name":"Hazardous waste","level":2,"score":0.6036012172698975},{"id":"https://openalex.org/C2988430800","wikidata":"https://www.wikidata.org/wiki/Q428971","display_name":"Scaling law","level":3,"score":0.5791786909103394},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5656415820121765},{"id":"https://openalex.org/C21880701","wikidata":"https://www.wikidata.org/wiki/Q2144042","display_name":"Process engineering","level":1,"score":0.4816238284111023},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.48157835006713867},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.40224626660346985},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.22984740138053894},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.13849863409996033},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.08242639899253845},{"id":"https://openalex.org/C548081761","wikidata":"https://www.wikidata.org/wiki/Q180388","display_name":"Waste management","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046208","descriptor_name":"Microchip Analytical Procedures","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055095","descriptor_name":"Optics and Photonics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056656","descriptor_name":"Lab-On-A-Chip Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1038/nature05059","doi":"https://doi.org/10.1038/nature05059","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nature05059","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:16871204","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16871204","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:nat:nature:v:442:y:2006:i:7101:d:10.1038_nature05059","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/nature05059","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W164199980","https://openalex.org/W194427018","https://openalex.org/W1525071737","https://openalex.org/W1562528808","https://openalex.org/W1921785758","https://openalex.org/W1964148794","https://openalex.org/W1964961113","https://openalex.org/W1967407850","https://openalex.org/W1967853768","https://openalex.org/W1972466773","https://openalex.org/W1973376911","https://openalex.org/W1973465488","https://openalex.org/W1975687263","https://openalex.org/W1978277550","https://openalex.org/W1991313926","https://openalex.org/W1993660429","https://openalex.org/W1994789201","https://openalex.org/W1995859531","https://openalex.org/W1998216766","https://openalex.org/W2004709668","https://openalex.org/W2007328883","https://openalex.org/W2011796652","https://openalex.org/W2011988499","https://openalex.org/W2012156765","https://openalex.org/W2013625355","https://openalex.org/W2015022319","https://openalex.org/W2015708712","https://openalex.org/W2018911825","https://openalex.org/W2021515103","https://openalex.org/W2024794253","https://openalex.org/W2027252981","https://openalex.org/W2027521932","https://openalex.org/W2029441111","https://openalex.org/W2040724852","https://openalex.org/W2041888444","https://openalex.org/W2046478184","https://openalex.org/W2048197073","https://openalex.org/W2052319034","https://openalex.org/W2052359258","https://openalex.org/W2053788556","https://openalex.org/W2053801178","https://openalex.org/W2054196470","https://openalex.org/W2054913596","https://openalex.org/W2068451835","https://openalex.org/W2069151104","https://openalex.org/W2073193024","https://openalex.org/W2073793322","https://openalex.org/W2073834617","https://openalex.org/W2085912372","https://openalex.org/W2102123503","https://openalex.org/W2116027727","https://openalex.org/W2117056003","https://openalex.org/W2118067785","https://openalex.org/W2129963488","https://openalex.org/W2129995310","https://openalex.org/W2148626564","https://openalex.org/W2153178685","https://openalex.org/W2154916820","https://openalex.org/W2159025358","https://openalex.org/W2159511216","https://openalex.org/W2195736269","https://openalex.org/W2398272142","https://openalex.org/W2410374815","https://openalex.org/W2440063262","https://openalex.org/W2478333500","https://openalex.org/W3049328618","https://openalex.org/W3091895959","https://openalex.org/W4236472764","https://openalex.org/W4238580586","https://openalex.org/W4242858357","https://openalex.org/W4298444622"],"related_works":["https://openalex.org/W2068740292","https://openalex.org/W2021512133","https://openalex.org/W2050577542","https://openalex.org/W7214220706","https://openalex.org/W2014222073","https://openalex.org/W565352843","https://openalex.org/W2047286177","https://openalex.org/W1932504432","https://openalex.org/W2052179426","https://openalex.org/W2074708297"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":20},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":28},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":24},{"year":2020,"cited_by_count":29},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":40},{"year":2017,"cited_by_count":42},{"year":2016,"cited_by_count":57},{"year":2015,"cited_by_count":37},{"year":2014,"cited_by_count":43},{"year":2013,"cited_by_count":34},{"year":2012,"cited_by_count":42}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}