{"id":"https://openalex.org/W1992157809","doi":"https://doi.org/10.2307/3579950","title":"Low-Dose-Rate Radiation Attenuates the Response of the Tumor Suppressor TP53","display_name":"Low-Dose-Rate Radiation Attenuates the Response of the Tumor Suppressor TP53","publication_year":1999,"publication_date":"1999-03-01","ids":{"openalex":"https://openalex.org/W1992157809","doi":"https://doi.org/10.2307/3579950","mag":"1992157809","pmid":"https://pubmed.ncbi.nlm.nih.gov/10073676"},"language":"en","primary_location":{"id":"doi:10.2307/3579950","doi":"https://doi.org/10.2307/3579950","is_oa":false,"landing_page_url":"https://doi.org/10.2307/3579950","pdf_url":null,"source":{"id":"https://openalex.org/S152208300","display_name":"Radiation Research","issn_l":"0033-7587","issn":["0033-7587","1938-5404"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315745","host_organization_name":"Radiation Research Society","host_organization_lineage":["https://openalex.org/P4310315745"],"host_organization_lineage_names":["Radiation Research Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001587891","display_name":"Takeo Ohnishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeo Ohnishi","raw_affiliation_strings":["Dept. of Biology, Nara Medical University, Kashihara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Biology, Nara Medical University, Kashihara, Japan","institution_ids":["https://openalex.org/I64926303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059138390","display_name":"Xinjiang Wang","orcid":"https://orcid.org/0000-0002-1347-4112","observed_orcids":["https://orcid.org/0000-0002-1347-4112"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xinjiang Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037066787","display_name":"Akihisa Takahashi","orcid":"https://orcid.org/0000-0002-9960-2153","observed_orcids":["https://orcid.org/0000-0002-9960-2153"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akihisa Takahashi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109221510","display_name":"Ken Ohnishi","orcid":"https://orcid.org/0009-0008-3284-0596","observed_orcids":["https://orcid.org/0009-0008-3284-0596"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ken Ohnishi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111702543","display_name":"Yosuke Ejima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yosuke Ejima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.1576,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.93593209,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"151","issue":"3","first_page":"368","last_page":"368"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tp53","display_name":"TP53","score":0.8500000238418579},{"id":"https://openalex.org/keywords/low-dose-rate-irradiation","display_name":"low-dose-rate irradiation","score":0.7860000133514404},{"id":"https://openalex.org/keywords/chronic-gamma-irradiation","display_name":"chronic gamma irradiation","score":0.9210000038146973},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9179999828338623},{"id":"https://openalex.org/keywords/waf1","display_name":"WAF1","score":0.8330000042915344},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.8429999947547913},{"id":"https://openalex.org/keywords/a172-cells","display_name":"A172 cells","score":0.8740000128746033},{"id":"https://openalex.org/keywords/radiation-protection","display_name":"radiation protection","score":0.40799999237060547},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.6689674854278564},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.548697829246521},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4871201515197754},{"id":"https://openalex.org/C18231593","wikidata":"https://www.wikidata.org/wiki/Q186161","display_name":"Ionizing radiation","level":3,"score":0.4770994782447815},{"id":"https://openalex.org/C79410662","wikidata":"https://www.wikidata.org/wiki/Q1251001","display_name":"Dose\u2013response relationship","level":2,"score":0.4729618430137634},{"id":"https://openalex.org/C3017588741","wikidata":"https://www.wikidata.org/wiki/Q3042357","display_name":"Dose rate","level":2,"score":0.4548937678337097},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4414740800857544},{"id":"https://openalex.org/C125118446","wikidata":"https://www.wikidata.org/wiki/Q690200","display_name":"Radiobiology","level":3,"score":0.43509548902511597},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.4258647561073303},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.4143778085708618},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36970454454421997},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.36272141337394714},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2246791422367096},{"id":"https://openalex.org/C177322064","wikidata":"https://www.wikidata.org/wiki/Q750955","display_name":"Radiochemistry","level":1,"score":0.2201729118824005},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.19476893544197083},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08266285061836243},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004307","descriptor_name":"Dose-Response Relationship, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005720","descriptor_name":"Gamma Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011836","descriptor_name":"Radiation Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D016213","descriptor_name":"Cyclins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016213","descriptor_name":"Cyclins","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D050759","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p21","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2307/3579950","doi":"https://doi.org/10.2307/3579950","is_oa":false,"landing_page_url":"https://doi.org/10.2307/3579950","pdf_url":null,"source":{"id":"https://openalex.org/S152208300","display_name":"Radiation Research","issn_l":"0033-7587","issn":["0033-7587","1938-5404"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315745","host_organization_name":"Radiation Research Society","host_organization_lineage":["https://openalex.org/P4310315745"],"host_organization_lineage_names":["Radiation Research Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation Research","raw_type":"journal-article"},{"id":"pmid:10073676","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10073676","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1974640412","https://openalex.org/W1975456426","https://openalex.org/W1986179131","https://openalex.org/W2006812742","https://openalex.org/W2012053348","https://openalex.org/W2014308735","https://openalex.org/W2015519364","https://openalex.org/W2016492849","https://openalex.org/W2020814340","https://openalex.org/W2021491682","https://openalex.org/W2023424326","https://openalex.org/W2062211931","https://openalex.org/W2064155418","https://openalex.org/W2067262837","https://openalex.org/W2074451679","https://openalex.org/W2075248965","https://openalex.org/W2084843960","https://openalex.org/W2143778153","https://openalex.org/W2147242002"],"related_works":["https://openalex.org/W2139417508","https://openalex.org/W171522389","https://openalex.org/W2127299667","https://openalex.org/W2015134097","https://openalex.org/W380946410","https://openalex.org/W2049124358","https://openalex.org/W3021388899","https://openalex.org/W2194159459","https://openalex.org/W4408507282","https://openalex.org/W2083571524"],"abstract_inverted_index":{"Acute":[0],"low-dose":[1],"irradiation":[2,37,78,112],"(0.1-1":[3],"Gy,":[4],"1.33":[5],"Gy/min)":[6,39],"of":[7,9,21,45,76,103,125],"cells":[8,69],"a":[10,17,41,73,100],"human":[11],"glioblastoma":[12],"cell":[13],"line,":[14],"A-172,":[15],"induced":[16],"dose-dependent":[18,101],"monophasic":[19],"accumulation":[20,46],"TP53":[22,47,105,127],"(formerly":[23,29],"known":[24,30],"as":[25,31],"p53)":[26],"and":[27,57],"CDKN1A":[28],"WAF1).":[32],"In":[33],"contrast,":[34],"chronic":[35,74,111,130],"gamma":[36,77],"(0.001":[38],"produced":[40],"clear":[42],"biphasic":[43],"response":[44,102],"with":[48,72],"the":[49,58,68,104,118,126],"first":[50],"peak":[51,60],"at":[52,61,113],"1.5":[53],"h":[54,63,81,86],"(0.09":[55],"Gy)":[56,83],"second":[59],"10":[62],"(0.54":[64],"Gy).":[65],"Significantly,":[66],"when":[67],"were":[70],"preirradiated":[71],"dose":[75,97,115],"for":[79,138],"24":[80],"(1.44":[82],"or":[84],"50":[85],"(3":[87],"Gy),":[88],"they":[89],"no":[90],"longer":[91],"responded":[92],"to":[93,98,132],"an":[94],"acute":[95],"challenging":[96],"produce":[99],"pathway.":[106,122],"These":[107],"findings":[108],"suggest":[109],"that":[110],"low":[114],"rate":[116],"alters":[117],"TP53-dependent":[119],"signal":[120],"transduction":[121],"Wearing":[123],"away":[124],"pathway":[128],"by":[129],"exposure":[131],"radiation":[133,139],"may":[134],"have":[135],"important":[136],"implications":[137],"protection.":[140]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
