{"id":"https://openalex.org/W1992125773","doi":"https://doi.org/10.1021/jm0103662","title":"Water-Soluble, Core-Modified Porphyrins as Novel, Longer-Wavelength-Absorbing Sensitizers for Photodynamic Therapy. II. Effects of Core Heteroatoms and Meso-Substituents on Biological Activity","display_name":"Water-Soluble, Core-Modified Porphyrins as Novel, Longer-Wavelength-Absorbing Sensitizers for Photodynamic Therapy. II. Effects of Core Heteroatoms and Meso-Substituents on Biological Activity","publication_year":2001,"publication_date":"2001-12-19","ids":{"openalex":"https://openalex.org/W1992125773","doi":"https://doi.org/10.1021/jm0103662","mag":"1992125773","pmid":"https://pubmed.ncbi.nlm.nih.gov/11784149"},"language":"en","primary_location":{"id":"doi:10.1021/jm0103662","doi":"https://doi.org/10.1021/jm0103662","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm0103662","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040083981","display_name":"David G. Hilmey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David G. Hilmey","raw_affiliation_strings":["Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000, PDT Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, and Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 607, Rochester, New York 14642"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000, PDT Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, and Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 607, Rochester, New York 14642","institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I28792581","https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023498778","display_name":"Masako Abe","orcid":"https://orcid.org/0000-0002-9675-9817","observed_orcids":["https://orcid.org/0000-0002-9675-9817"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masako Abe","raw_affiliation_strings":["Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000, PDT Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, and Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 607, Rochester, New York 14642"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000, PDT Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, and Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 607, Rochester, New York 14642","institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I28792581","https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109959537","display_name":"Marina I. Nelen","orcid":"https://orcid.org/0000-0002-2456-7162","observed_orcids":["https://orcid.org/0000-0002-2456-7162"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marina I. Nelen","raw_affiliation_strings":["Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000, PDT Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, and Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 607, Rochester, New York 14642"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000, PDT Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, and Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 607, Rochester, New York 14642","institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I28792581","https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029715182","display_name":"Corey E. Stilts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Corey E. Stilts","raw_affiliation_strings":["Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000, PDT Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, and Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 607, Rochester, New York 14642"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000, PDT Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, and Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 607, Rochester, New York 14642","institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I28792581","https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040703058","display_name":"Gary A. Baker","orcid":"https://orcid.org/0000-0002-3052-7730","observed_orcids":["https://orcid.org/0000-0002-3052-7730"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary A. Baker","raw_affiliation_strings":["Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000, PDT Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, and Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 607, Rochester, New York 14642"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000, PDT Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, and Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 607, Rochester, New York 14642","institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I28792581","https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038469911","display_name":"Sheila N. Baker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheila N. Baker","raw_affiliation_strings":["Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000, PDT Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, and Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 607, Rochester, New York 14642"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000, PDT Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, and Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 607, Rochester, New York 14642","institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I28792581","https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036941968","display_name":"Frank V. Bright","orcid":"https://orcid.org/0000-0002-1500-5969","observed_orcids":["https://orcid.org/0000-0002-1500-5969"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank V. Bright","raw_affiliation_strings":["Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000, PDT Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, and Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 607, Rochester, New York 14642"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000, PDT Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, and Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 607, Rochester, New York 14642","institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I28792581","https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069918901","display_name":"Sherry R. Davies","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sherry R. Davies","raw_affiliation_strings":["Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000, PDT Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, and Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 607, Rochester, New York 14642"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000, PDT Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, and Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 607, Rochester, New York 14642","institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I28792581","https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082241355","display_name":"Sandra O. Gollnick","orcid":"https://orcid.org/0000-0001-6493-9306","observed_orcids":["https://orcid.org/0000-0001-6493-9306"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra O. Gollnick","raw_affiliation_strings":["Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000, PDT Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, and Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 607, Rochester, New York 14642"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000, PDT Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, and Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 607, Rochester, New York 14642","institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I28792581","https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069143717","display_name":"Allan Roy Oseroff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allan R. Oseroff","raw_affiliation_strings":["Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000, PDT Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, and Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 607, Rochester, New York 14642"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000, PDT Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, and Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 607, Rochester, New York 14642","institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I28792581","https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111687930","display_name":"Scott L. Gibson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott L. Gibson","raw_affiliation_strings":["Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000, PDT Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, and Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 607, Rochester, New York 14642"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000, PDT Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, and Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 607, Rochester, New York 14642","institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I28792581","https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015390672","display_name":"Russell Hilf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Russell Hilf","raw_affiliation_strings":["Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000, PDT Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, and Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 607, Rochester, New York 14642"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000, PDT Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, and Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 607, Rochester, New York 14642","institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I28792581","https://openalex.org/I63190737"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039149956","display_name":"Michael R. Detty","orcid":"https://orcid.org/0000-0002-8815-1481","observed_orcids":["https://orcid.org/0000-0002-8815-1481"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael R. Detty","raw_affiliation_strings":["Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000, PDT Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, and Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 607, Rochester, New York 14642"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000, PDT Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, and Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 607, Rochester, New York 14642","institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I28792581","https://openalex.org/I63190737"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5039149956"],"corresponding_institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I28792581","https://openalex.org/I63190737"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":4.5483,"has_fulltext":false,"cited_by_count":89,"citation_normalized_percentile":{"value":0.95322313,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"45","issue":"2","first_page":"449","last_page":"461"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10903","display_name":"Porphyrin and Phthalocyanine Chemistry","score":0.8496000170707703,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10903","display_name":"Porphyrin and Phthalocyanine Chemistry","score":0.8496000170707703,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.149399995803833,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/core-modified-porphyrins","display_name":"core-modified porphyrins","score":0.9160000085830688},{"id":"https://openalex.org/keywords/photosensitizers","display_name":"photosensitizers","score":0.8309999704360962},{"id":"https://openalex.org/keywords/water-soluble-porphyrins","display_name":"water-soluble porphyrins","score":0.8980000019073486},{"id":"https://openalex.org/keywords/chalcogenophenes","display_name":"chalcogenophenes","score":0.6859999895095825},{"id":"https://openalex.org/keywords/thiophene","display_name":"thiophene","score":0.49900001287460327},{"id":"https://openalex.org/keywords/selenophene","display_name":"selenophene","score":0.984000027179718},{"id":"https://openalex.org/keywords/sulfonated-porphyrins","display_name":"sulfonated porphyrins","score":0.8690000176429749},{"id":"https://openalex.org/keywords/meso-substituent-effects","display_name":"meso-substituent effects","score":0.7979999780654907},{"id":"https://openalex.org/keywords/singlet-oxygen-quantum-yield","display_name":"singlet oxygen quantum yield","score":0.9350000023841858},{"id":"https://openalex.org/keywords/phototoxicity","display_name":"phototoxicity","score":0.8930000066757202}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9238268136978149},{"id":"https://openalex.org/C20950531","wikidata":"https://www.wikidata.org/wiki/Q161940","display_name":"Heteroatom","level":3,"score":0.6174637675285339},{"id":"https://openalex.org/C2779400197","wikidata":"https://www.wikidata.org/wiki/Q242627","display_name":"Pyrrole","level":2,"score":0.5866594910621643},{"id":"https://openalex.org/C2777516457","wikidata":"https://www.wikidata.org/wiki/Q2413613","display_name":"Singlet oxygen","level":3,"score":0.4693285822868347},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.4475732445716858},{"id":"https://openalex.org/C138716334","wikidata":"https://www.wikidata.org/wiki/Q268477","display_name":"Diastereomer","level":2,"score":0.4445793628692627},{"id":"https://openalex.org/C15761196","wikidata":"https://www.wikidata.org/wiki/Q335024","display_name":"Saponification","level":2,"score":0.43865063786506653},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.43710535764694214},{"id":"https://openalex.org/C46051903","wikidata":"https://www.wikidata.org/wiki/Q909339","display_name":"Bathochromic shift","level":3,"score":0.4309748411178589},{"id":"https://openalex.org/C2779515768","wikidata":"https://www.wikidata.org/wiki/Q421916","display_name":"Diol","level":2,"score":0.42934712767601013},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.3675331473350525},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.3433462381362915},{"id":"https://openalex.org/C2780378348","wikidata":"https://www.wikidata.org/wiki/Q25351438","display_name":"Ring (chemistry)","level":2,"score":0.11086547374725342},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.07405644655227661},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.070423424243927},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002264","descriptor_name":"Carboxylic Acids","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D002264","descriptor_name":"Carboxylic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002264","descriptor_name":"Carboxylic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011166","descriptor_name":"Porphyrins","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D011166","descriptor_name":"Porphyrins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011166","descriptor_name":"Porphyrins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013053","descriptor_name":"Spectrophotometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013451","descriptor_name":"Sulfonic Acids","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D013451","descriptor_name":"Sulfonic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013451","descriptor_name":"Sulfonic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017319","descriptor_name":"Photosensitizing Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D017319","descriptor_name":"Photosensitizing Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017319","descriptor_name":"Photosensitizing Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jm0103662","doi":"https://doi.org/10.1021/jm0103662","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm0103662","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:11784149","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11784149","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1974410100","https://openalex.org/W1985011753","https://openalex.org/W1990897242","https://openalex.org/W2001212685","https://openalex.org/W2003853141","https://openalex.org/W2008536525","https://openalex.org/W2017116168","https://openalex.org/W2017671293","https://openalex.org/W2044533112","https://openalex.org/W2045388895","https://openalex.org/W2050865517","https://openalex.org/W2062566065","https://openalex.org/W2065120737","https://openalex.org/W2069920899","https://openalex.org/W2075031971","https://openalex.org/W2080479032","https://openalex.org/W2087404609","https://openalex.org/W2091210609","https://openalex.org/W2114918609","https://openalex.org/W2134602068","https://openalex.org/W2144160073","https://openalex.org/W2190800021","https://openalex.org/W2399532851","https://openalex.org/W2411581221","https://openalex.org/W4211024586","https://openalex.org/W4232006825"],"related_works":["https://openalex.org/W2075031971","https://openalex.org/W2056984273","https://openalex.org/W6981002583","https://openalex.org/W1553252993","https://openalex.org/W2076794611","https://openalex.org/W2010445323","https://openalex.org/W1974359941","https://openalex.org/W1971970236","https://openalex.org/W4408493987","https://openalex.org/W2068692841"],"abstract_inverted_index":{"Water-soluble,":[0],"core-modified":[1],"porphyrins":[2,139],"were":[3,74,116,124,212],"prepared":[4,75],"and":[5,33,85,92,98,114,120,135,233,255,268,275,328,347],"evaluated":[6,213],"as":[7,26],"sensitizers":[8],"for":[9,155,179,214,287],"photodynamic":[10],"therapy":[11],"(PDT).":[12],"The":[13,44,137,181,200],"addition":[14],"of":[15,31,46,59,78,90,96,146,176,194,225,266,271,295,298,310,332,351],"an":[16],"aromatic":[17],"aldehyde":[18],"to":[19,338],"2,5-dilithiothiophene":[20],"or":[21,173,191,280,321],"-selenophene":[22],"gave":[23,37,55,69,108,130,140,235,257],"diol":[24,50,61,80],"3":[25,51,62,81],"a":[27,38,49,60,79,204,236,243,258,291],"nearly":[28],"equimolar":[29],"mixture":[30],"meso":[32,201],"d,l":[34],"diastereomers,":[35],"which":[36],"single":[39,292],"diastereomer":[40],"following":[41,290],"careful":[42],"recrystallization.":[43],"condensation":[45,77],"pyrrole":[47,84],"with":[48,63,82,100,118,126,262,314,340],"using":[52,221],"catalytic":[53,93],"BF(3)-etherate":[54,68],"bispyrrolochalcogenophenes":[56],"(4).":[57],"Condensation":[58],"4":[64,222,263],"in":[65,87,198,219,240,283,307,358],"the":[66,88,121,156,308],"presence":[67,89],"21,23-dichalcogenaporphyrins":[70],"(5).":[71],"21-Thiaporphyrins":[72],"(6)":[73],"by":[76],"excess":[83],"benzaldehyde":[86],"tetrachlorobenzoquinone":[91],"BF(3)-etherate.":[94],"Sulfonation":[95],"5":[97],"6":[99],"concentrated":[101],"sulfuric":[102],"acid":[103],"at":[104,149,167,242,316,323,342],"100":[105],"degrees":[106],"C":[107],"sulfonated":[109],"derivatives":[110],"7-15.":[111],"Bis-4-methoxy-21,23-dithiaporphyrins":[112],"5h":[113],"5l":[115],"demethylated":[117],"BBr(3),":[119],"resulting":[122],"phenols":[123],"alkylated":[125],"ethyl":[127],"bromoacetate.":[128],"Saponification":[129],"21,23-dithiaporphyrin":[131],"dicarboxylate":[132],"salts":[133],"16":[134],"17.":[136],"21,23-core-modified":[138],"band":[141,153,164],"I":[142,154,165],"absorption":[143,189,208],"maxima":[144,166,190],"(lambda(max)":[145,175],"689-717":[147],"nm)":[148],"longer":[150,168],"wavelengths":[151,169],"than":[152,170,246],"corresponding":[157],"21-core-modified":[158],"porphyrins,":[159],"but":[160],"both":[161],"classes":[162],"had":[163,184,203],"either":[171,188],"TPPS(4)":[172],"Photofrin":[174,247,341],"630":[177,352],"nm":[178,227,334,353],"both).":[180],"core":[182],"heteroatoms":[183],"little":[185],"effect":[186],"on":[187,207],"quantum":[192],"yields":[193],"singlet":[195],"oxygen":[196],"generation":[197],"7-17.":[199],"substituents":[202],"greater":[205],"impact":[206],"maxima.":[209],"Compounds":[210,229,252],"7-17":[211],"phototoxicity":[215],"against":[216,355],"Colo-26":[217,356],"cells":[218],"culture":[220],"J":[223,264,330,349],"cm(-2)":[224,265,331,350],"570-800":[226],"light.":[228],"8-12,":[230],"14,":[231,253],"16,":[232,254],"17":[234,256],"50%":[237,259],"cell":[238,260],"kill":[239,261],"vitro":[241],"lower":[244],"concentration":[245],"[5.7":[248],"mg":[249,318,325,344],"(9":[250],"micromol)/kg].":[251],"light":[267,335,354],"submicromolar":[269],"concentrations":[270],"sensitizer.":[272,299],"Sensitizers":[273],"8":[274,305,315],"11":[276,322],"showed":[277],"no":[278],"toxicity":[279],"side":[281],"effects":[282],"BALB/c":[284,311,359],"mice":[285],"observed":[286],"90":[288],"days":[289],"intravenous":[293],"injection":[294],"10":[296],"mg/kg":[297],"Distribution":[300],"studies":[301],"show":[302],"that":[303],"sensitizer":[304],"accumulates":[306],"tumors":[309,357],"mice.":[312,360],"PDT":[313,339],"0.125":[317],"(0.13":[319],"micromol)/kg":[320,327,346],"2.5":[324,343],"(2.5":[326],"135":[329,348],"694":[333],"was":[336],"comparable":[337],"(4":[345]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}