{"id":"https://openalex.org/W1992075564","doi":"https://doi.org/10.1006/abio.2000.4651","title":"Evaluation of the Binding between Potential Anti-HIV DNA-Based Drugs and Viral Envelope Glycoprotein gp120 by Capillary Electrophoresis with Laser-Induced Fluorescence Detection","display_name":"Evaluation of the Binding between Potential Anti-HIV DNA-Based Drugs and Viral Envelope Glycoprotein gp120 by Capillary Electrophoresis with Laser-Induced Fluorescence Detection","publication_year":2000,"publication_date":"2000-09-01","ids":{"openalex":"https://openalex.org/W1992075564","doi":"https://doi.org/10.1006/abio.2000.4651","mag":"1992075564","pmid":"https://pubmed.ncbi.nlm.nih.gov/10964417"},"language":"en","primary_location":{"id":"doi:10.1006/abio.2000.4651","doi":"https://doi.org/10.1006/abio.2000.4651","is_oa":false,"landing_page_url":"https://doi.org/10.1006/abio.2000.4651","pdf_url":null,"source":{"id":"https://openalex.org/S7858788","display_name":"Analytical Biochemistry","issn_l":"0003-2697","issn":["0003-2697","1096-0309"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108048700","display_name":"Wei Zhou","orcid":"https://orcid.org/0000-0001-7534-3065","observed_orcids":["https://orcid.org/0000-0001-7534-3065"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Zhou","raw_affiliation_strings":["Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695-8204, USA","Department of Chemistry, North Carolina State University, Raleigh, North Carolina, 27695-8204","Laboratory of Structural Biology, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, North Carolina, 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695-8204, USA","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"Department of Chemistry, North Carolina State University, Raleigh, North Carolina, 27695-8204","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"Laboratory of Structural Biology, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, North Carolina, 27709","institution_ids":["https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111523357","display_name":"Kenneth B. Tomer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth B. Tomer","raw_affiliation_strings":["Laboratory of Structural Biology, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, North Carolina, 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Structural Biology, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, North Carolina, 27709","institution_ids":["https://openalex.org/I4210095140"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045876980","display_name":"Morteza G. Khaledi","orcid":"https://orcid.org/0000-0001-9248-8178","observed_orcids":["https://orcid.org/0000-0001-9248-8178"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Morteza G. Khaledi","raw_affiliation_strings":["Department of Chemistry, North Carolina State University, Raleigh, North Carolina, 27695-8204"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, North Carolina State University, Raleigh, North Carolina, 27695-8204","institution_ids":["https://openalex.org/I137902535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5045876980"],"corresponding_institution_ids":["https://openalex.org/I137902535"],"apc_list":{"value":3540,"currency":"USD","value_usd":3540},"apc_paid":null,"fwci":2.7738,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.88667026,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"284","issue":"2","first_page":"334","last_page":"341"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.7440999746322632,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.7440999746322632,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.05350000038743019,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.04340000078082085,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-gp120","display_name":"HIV-1 gp120","score":0.9929999709129333},{"id":"https://openalex.org/keywords/phosphorothioate-oligodeoxynucleotides","display_name":"phosphorothioate oligodeoxynucleotides","score":0.9470000267028809},{"id":"https://openalex.org/keywords/anti-hiv-drugs","display_name":"anti-HIV drugs","score":0.8259999752044678},{"id":"https://openalex.org/keywords/drug-protein-binding","display_name":"drug-protein binding","score":0.9380000233650208},{"id":"https://openalex.org/keywords/v3-loop","display_name":"V3 loop","score":0.8579999804496765},{"id":"https://openalex.org/keywords/chemokine-receptor-interaction","display_name":"chemokine-receptor interaction","score":0.7549999952316284},{"id":"https://openalex.org/keywords/dissociation-constant","display_name":"dissociation constant","score":0.9269999861717224},{"id":"https://openalex.org/keywords/chain-length-effects","display_name":"chain length effects","score":0.6309999823570251},{"id":"https://openalex.org/keywords/order-effects","display_name":"order effects","score":0.625},{"id":"https://openalex.org/keywords/capillary-electrophoresis-with-laser-induced-fluorescence-detection","display_name":"capillary electrophoresis with laser-induced fluorescence detection","score":0.9229999780654907}],"concepts":[{"id":"https://openalex.org/C2900643","wikidata":"https://www.wikidata.org/wiki/Q747468","display_name":"Capillary electrophoresis","level":2,"score":0.8929966688156128},{"id":"https://openalex.org/C74998103","wikidata":"https://www.wikidata.org/wiki/Q898254","display_name":"Dissociation constant","level":3,"score":0.701957106590271},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5906756520271301},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.5872146487236023},{"id":"https://openalex.org/C97380033","wikidata":"https://www.wikidata.org/wiki/Q994215","display_name":"Viral envelope","level":3,"score":0.585979700088501},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.5681790113449097},{"id":"https://openalex.org/C32786932","wikidata":"https://www.wikidata.org/wiki/Q4914013","display_name":"Binding constant","level":3,"score":0.5469274520874023},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.45854783058166504},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4510367512702942},{"id":"https://openalex.org/C1342733","wikidata":"https://www.wikidata.org/wiki/Q452891","display_name":"Laser-induced fluorescence","level":3,"score":0.4225793480873108},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.411868155002594},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.31823620200157166},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27427467703819275},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.27097898721694946},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2504461109638214},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005069","descriptor_name":"Evaluation Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007834","descriptor_name":"Lasers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019075","descriptor_name":"Electrophoresis, Capillary","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1006/abio.2000.4651","doi":"https://doi.org/10.1006/abio.2000.4651","is_oa":false,"landing_page_url":"https://doi.org/10.1006/abio.2000.4651","pdf_url":null,"source":{"id":"https://openalex.org/S7858788","display_name":"Analytical Biochemistry","issn_l":"0003-2697","issn":["0003-2697","1096-0309"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Biochemistry","raw_type":"journal-article"},{"id":"pmid:10964417","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10964417","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W82820957","https://openalex.org/W1541821319","https://openalex.org/W1965019797","https://openalex.org/W1966468207","https://openalex.org/W1969590059","https://openalex.org/W1971777539","https://openalex.org/W1972056955","https://openalex.org/W1977314808","https://openalex.org/W1981440980","https://openalex.org/W1983454661","https://openalex.org/W1985468796","https://openalex.org/W1985711808","https://openalex.org/W1995355944","https://openalex.org/W1996024432","https://openalex.org/W1998623857","https://openalex.org/W2010521915","https://openalex.org/W2014062358","https://openalex.org/W2018887770","https://openalex.org/W2019489913","https://openalex.org/W2025737481","https://openalex.org/W2034053987","https://openalex.org/W2046422030","https://openalex.org/W2060541152","https://openalex.org/W2069407559","https://openalex.org/W2074631079","https://openalex.org/W2075400869","https://openalex.org/W2078436408","https://openalex.org/W2082378946","https://openalex.org/W2089609521","https://openalex.org/W2098781795","https://openalex.org/W2098885135","https://openalex.org/W2102394058","https://openalex.org/W2103706757","https://openalex.org/W2107634357","https://openalex.org/W2113282092","https://openalex.org/W2116279732","https://openalex.org/W2144146891","https://openalex.org/W2315523661","https://openalex.org/W2324427318","https://openalex.org/W2330544195","https://openalex.org/W4239647016"],"related_works":["https://openalex.org/W2609886002","https://openalex.org/W2019098067","https://openalex.org/W2057139467","https://openalex.org/W1541821319","https://openalex.org/W1994940043","https://openalex.org/W1986495692","https://openalex.org/W2117555836","https://openalex.org/W2151290321","https://openalex.org/W2033299942","https://openalex.org/W2402551541"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}