{"id":"https://openalex.org/W1992075201","doi":"https://doi.org/10.1074/jbc.m004079200","title":"A Single Site (Ser16) Phosphorylation in Phospholamban Is Sufficient in Mediating Its Maximal Cardiac Responses to \u03b2-Agonists","display_name":"A Single Site (Ser16) Phosphorylation in Phospholamban Is Sufficient in Mediating Its Maximal Cardiac Responses to \u03b2-Agonists","publication_year":2000,"publication_date":"2000-12-01","ids":{"openalex":"https://openalex.org/W1992075201","doi":"https://doi.org/10.1074/jbc.m004079200","mag":"1992075201","pmid":"https://pubmed.ncbi.nlm.nih.gov/10988285"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m004079200","doi":"https://doi.org/10.1074/jbc.m004079200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m004079200","pdf_url":"http://www.jbc.org/article/S0021925819560410/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925819560410/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062071729","display_name":"Guoxiang Chu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guoxiang Chu","raw_affiliation_strings":["Department of Pharmacology & Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0575, USA","Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0575, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0575, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0575, USA","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015802636","display_name":"James W. Lester","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James W. Lester","raw_affiliation_strings":["Department of Pharmacology & Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0575","From the Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0575"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0575","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"From the Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0575","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074097992","display_name":"Karen B. Young","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen B. Young","raw_affiliation_strings":["Department of Pharmacology & Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0575","From the Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0575"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0575","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"From the Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0575","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108596732","display_name":"Wusheng Luo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wusheng Luo","raw_affiliation_strings":["Department of Pharmacology & Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0575","From the Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0575"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0575","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"From the Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0575","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112825515","display_name":"Jing Zhai","orcid":"https://orcid.org/0009-0002-4679-0039","observed_orcids":["https://orcid.org/0009-0002-4679-0039"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Zhai","raw_affiliation_strings":["Department of Pharmacology & Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0575","From the Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0575"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0575","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"From the Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0575","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080329479","display_name":"Evangelia Galani Kranias","orcid":"https://orcid.org/0000-0002-4621-6179","observed_orcids":["https://orcid.org/0000-0002-4621-6179"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Evangelia G. Kranias","raw_affiliation_strings":["Department of Pharmacology & Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0575","From the Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0575"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0575","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"From the Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0575","institution_ids":["https://openalex.org/I63135867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5080329479"],"corresponding_institution_ids":["https://openalex.org/I63135867"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":6.1702,"has_fulltext":true,"cited_by_count":160,"citation_normalized_percentile":{"value":0.96516261,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"275","issue":"49","first_page":"38938","last_page":"38943"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.016599999740719795,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phospholamban","display_name":"phospholamban","score":1.0},{"id":"https://openalex.org/keywords/ser16-phosphorylation","display_name":"Ser16 phosphorylation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/beta-adrenergic-stimulation","display_name":"beta-adrenergic stimulation","score":0.9599999785423279},{"id":"https://openalex.org/keywords/isoproterenol","display_name":"isoproterenol","score":0.9860000014305115},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.8960000276565552},{"id":"https://openalex.org/keywords/calcium-calmodulin-dependent-protein-kinase","display_name":"calcium/calmodulin-dependent protein kinase","score":0.9290000200271606},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.6520000100135803},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.6589999794960022},{"id":"https://openalex.org/keywords/myocardial-contractility","display_name":"cardiac contractility","score":0.5509999990463257},{"id":"https://openalex.org/keywords/calcium-kinetics","display_name":"calcium kinetics","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C17137333","wikidata":"https://www.wikidata.org/wiki/Q410105","display_name":"Phospholamban","level":3,"score":0.9314801096916199},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.8550193309783936},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5696340799331665},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5199388265609741},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.46767720580101013},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.4590098261833191},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.44098523259162903},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4202103614807129},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.41603440046310425},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.407531201839447},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38400015234947205},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36450204253196716},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3512554466724396},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3427163362503052},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23557040095329285},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.18110248446464539},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06579464673995972},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06233528256416321}],"mesh":[{"descriptor_ui":"D000099211","descriptor_name":"Phospholamban","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000252","descriptor_name":"Calcium-Transporting ATPases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007545","descriptor_name":"Isoproterenol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011943","descriptor_name":"Receptors, Adrenergic, beta","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018995","descriptor_name":"Myosin Heavy Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053498","descriptor_name":"Sarcoplasmic Reticulum Calcium-Transporting ATPases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m004079200","doi":"https://doi.org/10.1074/jbc.m004079200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m004079200","pdf_url":"http://www.jbc.org/article/S0021925819560410/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:10988285","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10988285","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m004079200","doi":"https://doi.org/10.1074/jbc.m004079200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m004079200","pdf_url":"http://www.jbc.org/article/S0021925819560410/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1276932499","display_name":null,"funder_award_id":"HL26057","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2740653044","display_name":null,"funder_award_id":"P40-RR12358","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5230796730","display_name":"TRANSGENIC MICE WITH ALTERED CALCIUM HANDLING","funder_award_id":"5p40rr012358-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G598031191","display_name":null,"funder_award_id":"HL 52318","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6710817820","display_name":"SPECIALIZED CENTER OF RESEARCH IN HEART FAILURE","funder_award_id":"P50HL052318","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000049829","display_name":null,"funder_award_id":"HL52318","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000257155","display_name":null,"funder_award_id":"HL-26057","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1992075201.pdf","grobid_xml":"https://content.openalex.org/works/W1992075201.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W58055601","https://openalex.org/W185643122","https://openalex.org/W261751860","https://openalex.org/W1499775870","https://openalex.org/W1530579275","https://openalex.org/W1534028861","https://openalex.org/W1569195670","https://openalex.org/W1571240797","https://openalex.org/W1604665359","https://openalex.org/W1967688761","https://openalex.org/W1972134881","https://openalex.org/W1991141881","https://openalex.org/W1991924275","https://openalex.org/W1999184836","https://openalex.org/W2004587179","https://openalex.org/W2017830929","https://openalex.org/W2020424651","https://openalex.org/W2020708214","https://openalex.org/W2027986863","https://openalex.org/W2031946455","https://openalex.org/W2061245367","https://openalex.org/W2092528603","https://openalex.org/W2094074899","https://openalex.org/W2095317557","https://openalex.org/W2109123990","https://openalex.org/W2114851684","https://openalex.org/W2126942951","https://openalex.org/W2131672649","https://openalex.org/W2142754357","https://openalex.org/W2169732289","https://openalex.org/W2172519975","https://openalex.org/W2317957386","https://openalex.org/W2337493068","https://openalex.org/W2428721686"],"related_works":["https://openalex.org/W2048803288","https://openalex.org/W2109123990","https://openalex.org/W2009566289","https://openalex.org/W2131672649","https://openalex.org/W2015164655","https://openalex.org/W1534028861","https://openalex.org/W7135091295","https://openalex.org/W4244783134","https://openalex.org/W2122075276","https://openalex.org/W1952008325"],"abstract_inverted_index":{"Phospholamban":[0],"(PLB)":[1],"can":[2,186],"be":[3,187],"phosphorylated":[4,188],"at":[5,13],"Ser(16)":[6,117,124,142,183,197],"by":[7,15],"cyclic":[8],"AMP-dependent":[9],"protein":[10,17],"kinase":[11,18],"and":[12,38,100,118,123,154,194],"Thr(17)":[14,36,119,191],"Ca(2+)-calmodulin-dependent":[16],"during":[19],"beta-agonist":[20,42],"stimulation.":[21,208],"A":[22],"previous":[23],"study":[24],"indicated":[25],"that":[26],"mutation":[27],"of":[28,35,40,72,80,115,136,141,151,190,196],"S16A":[29,83,137,179],"in":[30,33,45,68,88,94,120,126,144,149,163,177,184,192],"PLB":[31,57,67,87,122,147,169,185],"resulted":[32,148],"lack":[34],"phosphorylation":[37,114,125,135,195],"attenuation":[39],"the":[41,52,64,69,73,89,106,152,178,202],"stimulatory":[43],"effects":[44],"perfused":[46],"mouse":[47],"hearts.":[48],"To":[49],"further":[50],"delineate":[51],"functional":[53],"interplay":[54],"between":[55],"dual-site":[56,168],"phosphorylation,":[58],"we":[59],"generated":[60],"transgenic":[61],"mice":[62],"expressing":[63,77],"T17A":[65,81,127,145],"mutant":[66,128,138,146,180],"cardiac":[70,204],"compartment":[71],"null":[74,90],"background.":[75],"Lines":[76],"similar":[78,104,160],"levels":[79],"mutant,":[82,84],"or":[85],"wild-type":[86,121,164],"background":[91],"were":[92,103,174],"characterized":[93],"parallel.":[95],"Cardiac":[96],"myocyte":[97],"basal":[98],"mechanics":[99],"Ca(2+)":[101,155],"kinetics":[102],"among":[105],"three":[107],"groups.":[108],"Isoproterenol":[109],"stimulation":[110],"was":[111,132],"associated":[112],"with":[113],"both":[116],"PLB,":[129],"whereas":[130],"there":[131],"no":[133],"detectable":[134],"PLB.":[139],"Phosphorylation":[140],"alone":[143],"responses":[150,205],"mechanical":[153],"kinetic":[156],"parameters":[157,173],"to":[158,161,206],"isoproterenol":[159],"those":[162,172],"myocytes,":[165],"which":[166],"exhibited":[167],"phosphorylation.":[170],"However,":[171],"significantly":[175],"attenuated":[176],"myocytes.":[181],"Thus,":[182],"independently":[189],"vivo,":[193],"is":[198],"sufficient":[199],"for":[200],"mediating":[201],"maximal":[203],"beta-adrenergic":[207]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":14}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}