{"id":"https://openalex.org/W1992052760","doi":"https://doi.org/10.1093/nar/15.3.1227","title":"Utilization of DNA photolyase, pyrimidine dimer endonucleases, and alkali hydrolysis in the analysis of aberrant ABC excinuclease incisions adjacent to UV-induced DNA photoproducts","display_name":"Utilization of DNA photolyase, pyrimidine dimer endonucleases, and alkali hydrolysis in the analysis of aberrant ABC excinuclease incisions adjacent to UV-induced DNA photoproducts","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W1992052760","doi":"https://doi.org/10.1093/nar/15.3.1227","mag":"1992052760","pmid":"https://pubmed.ncbi.nlm.nih.gov/3547334","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/340520"},"language":"en","primary_location":{"id":"doi:10.1093/nar/15.3.1227","doi":"https://doi.org/10.1093/nar/15.3.1227","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/15.3.1227","pdf_url":"https://academic.oup.com/nar/article-pdf/15/3/1227/3988216/15-3-1227.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/nar/article-pdf/15/3/1227/3988216/15-3-1227.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113548949","display_name":"Gary M. Myles","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary M. Myles","raw_affiliation_strings":["University of North Carolina, School of Medicine, Department of Biochemistry 231H Chapel Hill, NC 27514, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina, School of Medicine, Department of Biochemistry 231H Chapel Hill, NC 27514, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055919829","display_name":"Bennett Van Houten","orcid":"https://orcid.org/0000-0002-4009-2478","observed_orcids":["https://orcid.org/0000-0002-4009-2478"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bennett Van Houten","raw_affiliation_strings":["University of North Carolina, School of Medicine, Department of Biochemistry 231H Chapel Hill, NC 27514, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina, School of Medicine, Department of Biochemistry 231H Chapel Hill, NC 27514, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016678671","display_name":"Aziz Sancar","orcid":"https://orcid.org/0000-0001-6469-4900","observed_orcids":["https://orcid.org/0000-0001-6469-4900"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aziz Sancar","raw_affiliation_strings":["University of North Carolina, School of Medicine, Department of Biochemistry 231H Chapel Hill, NC 27514, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina, School of Medicine, Department of Biochemistry 231H Chapel Hill, NC 27514, USA","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":null,"fwci":3.2137,"has_fulltext":true,"cited_by_count":48,"citation_normalized_percentile":{"value":0.92893488,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"15","issue":"3","first_page":"1227","last_page":"1243"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-photolyase","display_name":"DNA photolyase","score":0.753000020980835},{"id":"https://openalex.org/keywords/6-4-photoproducts","display_name":"6-4 photoproducts","score":0.8730000257492065},{"id":"https://openalex.org/keywords/pyrimidine-dimers","display_name":"pyrimidine dimers","score":0.9169999957084656},{"id":"https://openalex.org/keywords/uv-induced-dna-damage","display_name":"UV-induced DNA damage","score":0.859000027179718},{"id":"https://openalex.org/keywords/alkaline-hydrolysis","display_name":"alkaline hydrolysis","score":0.9200000166893005},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8650000095367432},{"id":"https://openalex.org/keywords/mycobacterium-luteum","display_name":"Mycobacterium luteum","score":0.875},{"id":"https://openalex.org/keywords/bacteriophage-t4","display_name":"bacteriophage T4","score":0.9819999933242798},{"id":"https://openalex.org/keywords/photoreactivation","display_name":"photoreactivation","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C38441620","wikidata":"https://www.wikidata.org/wiki/Q863983","display_name":"Phosphodiester bond","level":4,"score":0.9843942523002625},{"id":"https://openalex.org/C167975912","wikidata":"https://www.wikidata.org/wiki/Q1018722","display_name":"Pyrimidine dimer","level":4,"score":0.9646612405776978},{"id":"https://openalex.org/C165204475","wikidata":"https://www.wikidata.org/wiki/Q424241","display_name":"Photolyase","level":4,"score":0.873705267906189},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6986947655677795},{"id":"https://openalex.org/C2779321679","wikidata":"https://www.wikidata.org/wiki/Q207722","display_name":"Pyrimidine","level":2,"score":0.5960403084754944},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5784407258033752},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.5668143630027771},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.396895170211792},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.34987497329711914},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2674615979194641},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08039835095405579},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.07201871275901794},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004255","descriptor_name":"Deoxyribodipyrimidine Photo-Lyase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004706","descriptor_name":"Endodeoxyribonucleases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008190","descriptor_name":"Lyases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D011740","descriptor_name":"Pyrimidine Dimers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D043224","descriptor_name":"Deoxyribonuclease (Pyrimidine Dimer)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/nar/15.3.1227","doi":"https://doi.org/10.1093/nar/15.3.1227","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/15.3.1227","pdf_url":"https://academic.oup.com/nar/article-pdf/15/3/1227/3988216/15-3-1227.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:340520","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/340520","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:3547334","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3547334","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"},{"id":"pmh:cdr.lib.unc.edu:fb494h45x","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/ynte-5302","pdf_url":"https://doi.org/10.17615/ynte-5302","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic Acids Research, 15(3)","raw_type":"Article"},{"id":"doi:10.17615/ynte-5302","doi":"https://doi.org/10.17615/ynte-5302","is_oa":true,"landing_page_url":"https://doi.org/10.17615/ynte-5302","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1093/nar/15.3.1227","doi":"https://doi.org/10.1093/nar/15.3.1227","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/15.3.1227","pdf_url":"https://academic.oup.com/nar/article-pdf/15/3/1227/3988216/15-3-1227.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2098815549","display_name":"DNA Excision Repair and DNA Damage Checkpoints","funder_award_id":"R01GM032833","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5529433625","display_name":null,"funder_award_id":"CA0156-11","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G694257262","display_name":null,"funder_award_id":"GM32833","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1992052760.pdf","grobid_xml":"https://content.openalex.org/works/W1992052760.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W110705983","https://openalex.org/W1499426087","https://openalex.org/W1548067503","https://openalex.org/W1549704609","https://openalex.org/W1557086543","https://openalex.org/W1558516755","https://openalex.org/W1584011323","https://openalex.org/W1965547980","https://openalex.org/W1970761658","https://openalex.org/W1972590413","https://openalex.org/W2024439819","https://openalex.org/W2033860973","https://openalex.org/W2035208098","https://openalex.org/W2075236139","https://openalex.org/W2086062199","https://openalex.org/W2090436561","https://openalex.org/W2159254728"],"related_works":["https://openalex.org/W89750526","https://openalex.org/W2086062199","https://openalex.org/W1483750611","https://openalex.org/W1970224377","https://openalex.org/W2166283735","https://openalex.org/W2035208098","https://openalex.org/W1556339856","https://openalex.org/W1584011323","https://openalex.org/W1993320052","https://openalex.org/W2033860973"],"abstract_inverted_index":{"ABC":[0,64,80,123],"excinuclease":[1,65,81],"of":[2,71,104,115,122,133],"Escherichia":[3],"coli":[4],"removes":[5],"6-4":[6,138],"photoproducts":[7,73],"and":[8,24,55,58,112],"pyrimidine":[9,49,110,134,149,159],"dimers":[10,135,150],"from":[11,46,52],"DNA":[12,44,76,85],"by":[13,140],"making":[14],"two":[15],"single":[16],"strand":[17],"incisions,":[18],"one":[19],"8":[20,87],"phosphodiester":[21,29,88,95],"bonds":[22,30,89,96],"5'":[23,90],"another":[25],"4":[26,92],"or":[27,91,93,109,157],"5":[28,94],"3'":[31,97],"to":[32,69,98],"the":[33,63,99,102,105,113,119,131,141],"lesion.":[34],"We":[35,125],"describe":[36],"in":[37,74],"this":[38],"communication":[39],"a":[40,75],"method,":[41],"which":[42],"utilizes":[43],"photolyase":[45,129,144],"E.":[47],"coli,":[48],"dimer":[50],"endonucleases":[51],"M.":[53],"luteus":[54],"bacteriophage":[56],"T4,":[57],"alkali":[59],"hydrolysis,":[60],"for":[61],"analyzing":[62],"incision":[66,120],"pattern":[67,121],"corresponding":[68],"each":[70],"these":[72],"fragment.":[77],"On":[78],"occasion,":[79],"does":[82,145,154],"not":[83,137,146],"incise":[84],"exclusively":[86],"photoproduct.":[100],"Both":[101],"nature":[103],"adduct":[106],"(6-4":[107],"photoproduct":[108],"dimer)":[111],"sequence":[114],"neighboring":[116],"nucleotides":[117],"influence":[118],"excinuclease.":[124,142],"show":[126],"directly":[127],"that":[128],"stimulates":[130],"removal":[132],"(but":[136],"photoproducts)":[139],"Also,":[143],"repair":[147,155],"CC":[148],"efficiently":[151],"while":[152],"it":[153],"TT":[156],"TC":[158],"dimers.":[160]},"counts_by_year":[{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
