{"id":"https://openalex.org/W1992035355","doi":"https://doi.org/10.3109/03009738209178428","title":"A Paracorporeal Rat Heart Model for Ischemic and Reperfusion Studies","display_name":"A Paracorporeal Rat Heart Model for Ischemic and Reperfusion Studies","publication_year":1982,"publication_date":"1982-01-01","ids":{"openalex":"https://openalex.org/W1992035355","doi":"https://doi.org/10.3109/03009738209178428","mag":"1992035355","pmid":"https://pubmed.ncbi.nlm.nih.gov/7157556"},"language":"en","primary_location":{"id":"doi:10.3109/03009738209178428","doi":"https://doi.org/10.3109/03009738209178428","is_oa":true,"landing_page_url":"https://doi.org/10.3109/03009738209178428","pdf_url":"https://ujms.net/index.php/ujms/article/download/7070/12858","source":{"id":"https://openalex.org/S118285737","display_name":"Upsala Journal of Medical Sciences","issn_l":"0300-9734","issn":["0300-9734","2000-1967"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Upsala Journal of Medical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://ujms.net/index.php/ujms/article/download/7070/12858","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040456126","display_name":"Jan Hultman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1342360035","display_name":"Uppsala University Hospital","ror":"https://ror.org/01apvbh93","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1342360035"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jan Hultman","raw_affiliation_strings":["Department of Anaesthesiology, Department of General Surgery, Department of Thoracic and Cardiovascular Surgery and Department of Clinical Chemistry, University Hospital, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesiology, Department of General Surgery, Department of Thoracic and Cardiovascular Surgery and Department of Clinical Chemistry, University Hospital, Uppsala, Sweden","institution_ids":["https://openalex.org/I1342360035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031476604","display_name":"Jan Ola Forsberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1342360035","display_name":"Uppsala University Hospital","ror":"https://ror.org/01apvbh93","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1342360035"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jan Ola Forsberg","raw_affiliation_strings":["Department of Anaesthesiology , Department of General Surgery , Department of Thoracic and Cardiovascular Surgery and","Department of Cfinical Chemistry , University Hospital , Uppsala , Sweden","Department of Anaesthesiology, Department of General Surgery, Department of Thoracic and Cardiovascular Surgery and Department of Clinical Chemistry, University Hospital, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesiology , Department of General Surgery , Department of Thoracic and Cardiovascular Surgery and","institution_ids":[]},{"raw_affiliation_string":"Department of Cfinical Chemistry , University Hospital , Uppsala , Sweden","institution_ids":["https://openalex.org/I1342360035"]},{"raw_affiliation_string":"Department of Anaesthesiology, Department of General Surgery, Department of Thoracic and Cardiovascular Surgery and Department of Clinical Chemistry, University Hospital, Uppsala, Sweden","institution_ids":["https://openalex.org/I1342360035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111643989","display_name":"Hans Erik Hansson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1342360035","display_name":"Uppsala University Hospital","ror":"https://ror.org/01apvbh93","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1342360035"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Hans Erik Hansson","raw_affiliation_strings":["Department of Anaesthesiology , Department of General Surgery , Department of Thoracic and Cardiovascular Surgery and","Department of Cfinical Chemistry , University Hospital , Uppsala , Sweden","Department of Anaesthesiology, Department of General Surgery, Department of Thoracic and Cardiovascular Surgery and Department of Clinical Chemistry, University Hospital, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesiology , Department of General Surgery , Department of Thoracic and Cardiovascular Surgery and","institution_ids":[]},{"raw_affiliation_string":"Department of Cfinical Chemistry , University Hospital , Uppsala , Sweden","institution_ids":["https://openalex.org/I1342360035"]},{"raw_affiliation_string":"Department of Anaesthesiology, Department of General Surgery, Department of Thoracic and Cardiovascular Surgery and Department of Clinical Chemistry, University Hospital, Uppsala, Sweden","institution_ids":["https://openalex.org/I1342360035"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103412943","display_name":"Gunnar Ronquist","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1342360035","display_name":"Uppsala University Hospital","ror":"https://ror.org/01apvbh93","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1342360035"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Gunnar Ronquist","raw_affiliation_strings":["Department of Anaesthesiology , Department of General Surgery , Department of Thoracic and Cardiovascular Surgery and","Department of Cfinical Chemistry , University Hospital , Uppsala , Sweden","Department of Anaesthesiology, Department of General Surgery, Department of Thoracic and Cardiovascular Surgery and Department of Clinical Chemistry, University Hospital, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesiology , Department of General Surgery , Department of Thoracic and Cardiovascular Surgery and","institution_ids":[]},{"raw_affiliation_string":"Department of Cfinical Chemistry , University Hospital , Uppsala , Sweden","institution_ids":["https://openalex.org/I1342360035"]},{"raw_affiliation_string":"Department of Anaesthesiology, Department of General Surgery, Department of Thoracic and Cardiovascular Surgery and Department of Clinical Chemistry, University Hospital, Uppsala, Sweden","institution_ids":["https://openalex.org/I1342360035"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1342360035"],"apc_list":null,"apc_paid":null,"fwci":0.8053,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.73216246,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"87","issue":"3","first_page":"235","last_page":"242"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rat-heart","display_name":"rat heart","score":0.4970000088214874},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.8840000033378601},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.9440000057220459},{"id":"https://openalex.org/keywords/global-cerebral-ischemia","display_name":"global cerebral ischemia","score":0.8050000071525574},{"id":"https://openalex.org/keywords/langendorff-preparation","display_name":"isolated perfused heart","score":0.7900000214576721},{"id":"https://openalex.org/keywords/creatine-kinase-release","display_name":"creatine kinase release","score":0.7829999923706055},{"id":"https://openalex.org/keywords/myocardial-contractility","display_name":"cardiac contractility","score":0.8159999847412109},{"id":"https://openalex.org/keywords/circulatory-stability","display_name":"circulatory stability","score":0.46299999952316284},{"id":"https://openalex.org/keywords/coronary-effluent","display_name":"coronary effluent","score":0.4390000104904175}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8994917869567871},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.6570722460746765},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6304123401641846},{"id":"https://openalex.org/C36880943","wikidata":"https://www.wikidata.org/wiki/Q409458","display_name":"Creatine kinase","level":2,"score":0.5998665690422058},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5875262022018433},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.555200457572937},{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.5333744287490845},{"id":"https://openalex.org/C72859922","wikidata":"https://www.wikidata.org/wiki/Q11068","display_name":"Circulatory system","level":2,"score":0.41191366314888}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003326","descriptor_name":"Coronary Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003402","descriptor_name":"Creatine Kinase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/03009738209178428","doi":"https://doi.org/10.3109/03009738209178428","is_oa":true,"landing_page_url":"https://doi.org/10.3109/03009738209178428","pdf_url":"https://ujms.net/index.php/ujms/article/download/7070/12858","source":{"id":"https://openalex.org/S118285737","display_name":"Upsala Journal of Medical Sciences","issn_l":"0300-9734","issn":["0300-9734","2000-1967"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Upsala Journal of Medical Sciences","raw_type":"journal-article"},{"id":"pmid:7157556","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7157556","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Upsala journal of medical sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3109/03009738209178428","doi":"https://doi.org/10.3109/03009738209178428","is_oa":true,"landing_page_url":"https://doi.org/10.3109/03009738209178428","pdf_url":"https://ujms.net/index.php/ujms/article/download/7070/12858","source":{"id":"https://openalex.org/S118285737","display_name":"Upsala Journal of Medical Sciences","issn_l":"0300-9734","issn":["0300-9734","2000-1967"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Upsala Journal of Medical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1992035355.pdf","grobid_xml":"https://content.openalex.org/works/W1992035355.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W48588267","https://openalex.org/W85304853","https://openalex.org/W650982789","https://openalex.org/W1497671643","https://openalex.org/W1553328291","https://openalex.org/W1984658117","https://openalex.org/W2022434793","https://openalex.org/W2023637753","https://openalex.org/W2033705590","https://openalex.org/W2051909997","https://openalex.org/W2078757558","https://openalex.org/W2263313606","https://openalex.org/W2277283504","https://openalex.org/W2281886792","https://openalex.org/W2335088247","https://openalex.org/W2398211025","https://openalex.org/W2401774374","https://openalex.org/W2401978223","https://openalex.org/W2410892011","https://openalex.org/W2413512522","https://openalex.org/W2433475437","https://openalex.org/W4323237822"],"related_works":["https://openalex.org/W2384168141","https://openalex.org/W2358399778","https://openalex.org/W2085238682","https://openalex.org/W3194905260","https://openalex.org/W2393899884","https://openalex.org/W2030073861","https://openalex.org/W2868995954","https://openalex.org/W2851997747","https://openalex.org/W2262015707","https://openalex.org/W2014654521"],"abstract_inverted_index":{"Paracorporeal":[0],"rat":[1],"hearts":[2],"were":[3,45,69,78,125],"supplied":[4],"with":[5,128],"blood":[6,148],"derived":[7],"from":[8,130],"the":[9,23,29,47,114,123,155],"abdominal":[10],"aorta":[11],"of":[12,22,34,43,57,62,74,86,104,109],"a":[13,53],"supporting":[14,24],"rat.":[15],"The":[16,117,136],"circulatory":[17],"stability":[18],"and":[19,40,51,96,106,122,144],"working":[20],"capacity":[21],"animal":[25],"was":[26],"analyzed":[27],"in":[28,32,65,113,126],"experimental":[30],"situation":[31],"terms":[33],"PO2,":[35],"SO2,":[36],"PCO2,":[37],"HCO3,":[38],"pH":[39],"electrolytes,":[41],"all":[42],"which":[44,138],"within":[46],"normal":[48],"range":[49],"before":[50],"during":[52],"60":[54],"min":[55,85],"period":[56],"paracorporeal":[58],"perfusion.":[59],"For":[60],"evaluation":[61],"ischemic":[63],"damage":[64],"this":[66],"model":[67],"studies":[68,132],"made":[70],"on":[71,133],"three":[72],"groups":[73],"excised":[75],"hearts.":[76],"They":[77],"subjected":[79],"to":[80],"10,":[81],"15":[82],"or":[83],"20":[84],"complete":[87],"global":[88],"ischemia":[89],"at":[90],"37":[91],"degrees":[92],"C":[93],"(ambient":[94],"temperature)":[95],"reperfused":[97],"for":[98],"30":[99],"min,":[100],"including":[101],"ECG,":[102],"observations":[103],"contractility":[105],"an":[107],"analysis":[108],"creatine":[110],"kinase":[111],"efflux":[112],"coronary":[115],"effluent.":[116],"results":[118],"showed":[119],"good":[120],"reproducibility":[121],"data":[124],"accordance":[127],"reports":[129],"similar":[131],"Langendorff":[134,157],"preparations.":[135],"model,":[137],"is":[139],"easily":[140],"set":[141],"up,":[142],"inexpensive":[143],"based":[145],"upon":[146],"pulsatile":[147],"perfusion,":[149],"should":[150],"be":[151],"more":[152],"physiologic":[153],"than":[154],"conventional":[156],"preparation.":[158]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}