{"id":"https://openalex.org/W1992010473","doi":"https://doi.org/10.4161/cbt.4.9.1911","title":"Signal therapy of breast cancers by the HDAC inhibitor FK228 that blocks the activation of PAK1 and abrogates the tamoxifen-resistance","display_name":"Signal therapy of breast cancers by the HDAC inhibitor FK228 that blocks the activation of PAK1 and abrogates the tamoxifen-resistance","publication_year":2005,"publication_date":"2005-09-01","ids":{"openalex":"https://openalex.org/W1992010473","doi":"https://doi.org/10.4161/cbt.4.9.1911","mag":"1992010473","pmid":"https://pubmed.ncbi.nlm.nih.gov/16082189"},"language":"en","primary_location":{"id":"doi:10.4161/cbt.4.9.1911","doi":"https://doi.org/10.4161/cbt.4.9.1911","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cbt.4.9.1911","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cbt.4.9.1911?needAccess=true&role=button","source":{"id":"https://openalex.org/S169029442","display_name":"Cancer Biology & Therapy","issn_l":"1538-4047","issn":["1538-4047","1555-8576"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biology &amp; Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/cbt.4.9.1911?needAccess=true&role=button","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035437527","display_name":"Yumiko Hirokawa","orcid":"https://orcid.org/0000-0003-2173-6634","observed_orcids":["https://orcid.org/0000-0003-2173-6634"]},"institutions":[{"id":"https://openalex.org/I4210123010","display_name":"Ludwig Cancer Research","ror":"https://ror.org/02vh2pt65","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210123010","https://openalex.org/I4210150094"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Yumiko Hirokawa","raw_affiliation_strings":["Ludwig Institute for Cancer Research, Parkville/Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig Institute for Cancer Research, Parkville/Melbourne, Australia","institution_ids":["https://openalex.org/I4210123010"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Melissa Arnold","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123010","display_name":"Ludwig Cancer Research","ror":"https://ror.org/02vh2pt65","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210123010","https://openalex.org/I4210150094"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Melissa Arnold","raw_affiliation_strings":["Ludwig Institute for Cancer Research ; Parkville / Melbourne , Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig Institute for Cancer Research ; Parkville / Melbourne , Australia","institution_ids":["https://openalex.org/I4210123010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042615062","display_name":"Hidenori Nakajima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142395110","display_name":"Astellas Pharma (Japan)","ror":"https://ror.org/01cjash87","country_code":"JP","type":"company","lineage":["https://openalex.org/I142395110"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidenori Nakajima","raw_affiliation_strings":["Astellas Pharma Inc ; 5-2-3 Tokodai ; Tsukuba ; Ibaraki , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Astellas Pharma Inc ; 5-2-3 Tokodai ; Tsukuba ; Ibaraki , Japan","institution_ids":["https://openalex.org/I142395110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008173055","display_name":"John Raymond Zalcberg","orcid":"https://orcid.org/0000-0002-6624-0782","observed_orcids":["https://orcid.org/0000-0002-6624-0782"]},"institutions":[{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"John Zalcberg","raw_affiliation_strings":["Peter MacCallum Cancer Institute ; Melbourne , Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peter MacCallum Cancer Institute ; Melbourne , Australia","institution_ids":["https://openalex.org/I2800555584"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101548568","display_name":"Hiroshi Maruta","orcid":"https://orcid.org/0000-0002-9087-3387","observed_orcids":["https://orcid.org/0000-0002-9087-3387"]},"institutions":[{"id":"https://openalex.org/I4210123010","display_name":"Ludwig Cancer Research","ror":"https://ror.org/02vh2pt65","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210123010","https://openalex.org/I4210150094"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Hiroshi Maruta","raw_affiliation_strings":["Ludwig Institute for Cancer Research ; Parkville / Melbourne , Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig Institute for Cancer Research ; Parkville / Melbourne , Australia","institution_ids":["https://openalex.org/I4210123010"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101548568"],"corresponding_institution_ids":["https://openalex.org/I4210123010"],"apc_list":{"value":2710,"currency":"EUR","value_usd":2970},"apc_paid":null,"fwci":1.7551,"has_fulltext":true,"cited_by_count":81,"citation_normalized_percentile":{"value":0.82720971,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"4","issue":"9","first_page":"956","last_page":"960"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.8666999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.8666999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.11050000041723251,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/romidepsin","display_name":"romidepsin","score":0.859000027179718},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.8610000014305115},{"id":"https://openalex.org/keywords/pak1","display_name":"PAK1","score":0.9589999914169312},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9549999833106995},{"id":"https://openalex.org/keywords/tamoxifen-resistance","display_name":"tamoxifen resistance","score":0.9980000257492065},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.9269999861717224},{"id":"https://openalex.org/keywords/kinase-inhibition","display_name":"kinase inhibition","score":0.5630000233650208},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.8569999933242798},{"id":"https://openalex.org/keywords/ras-signaling","display_name":"Ras signaling","score":0.7519999742507935},{"id":"https://openalex.org/keywords/waf1","display_name":"WAF1","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C24901178","wikidata":"https://www.wikidata.org/wiki/Q7118116","display_name":"PAK1","level":3,"score":0.6241933107376099},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.5923250913619995},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5839002728462219},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5500400066375732},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5380048751831055},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3928985595703125},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38958168029785156},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.36250537633895874},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2748287618160248},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2692197859287262},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.26680779457092285},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.08310168981552124}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D018931","descriptor_name":"Antineoplastic Agents, Hormonal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047630","descriptor_name":"Depsipeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D047630","descriptor_name":"Depsipeptides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D054462","descriptor_name":"p21-Activated Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.4161/cbt.4.9.1911","doi":"https://doi.org/10.4161/cbt.4.9.1911","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cbt.4.9.1911","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cbt.4.9.1911?needAccess=true&role=button","source":{"id":"https://openalex.org/S169029442","display_name":"Cancer Biology & Therapy","issn_l":"1538-4047","issn":["1538-4047","1555-8576"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biology &amp; Therapy","raw_type":"journal-article"},{"id":"pmid:16082189","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16082189","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer biology & therapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4161/cbt.4.9.1911","doi":"https://doi.org/10.4161/cbt.4.9.1911","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cbt.4.9.1911","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cbt.4.9.1911?needAccess=true&role=button","source":{"id":"https://openalex.org/S169029442","display_name":"Cancer Biology & Therapy","issn_l":"1538-4047","issn":["1538-4047","1555-8576"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biology &amp; Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1992010473.pdf","grobid_xml":"https://content.openalex.org/works/W1992010473.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1971405069","https://openalex.org/W2041480649","https://openalex.org/W2793765341","https://openalex.org/W7163751685","https://openalex.org/W2608761526","https://openalex.org/W2109309944","https://openalex.org/W4255578834","https://openalex.org/W2120673604","https://openalex.org/W2154516139","https://openalex.org/W4378903041"],"abstract_inverted_index":{"PAK1,":[0,61],"a":[1,17,23],"Rac/CDC42-dependent":[2],"Ser/Thr":[3],"kinase,":[4],"is":[5,56],"required":[6],"for":[7,116,152],"both":[8],"neurofibromatosis":[9],"(NF)":[10],"and":[11,41,96,136,145],"RAS":[12,59],"transformation":[13],"in":[14,62,82,102,140],"vivo.":[15],"FK228,":[16],"histone":[18],"deacetylase":[19],"(HDAC)":[20],"inhibitor,":[21],"activates":[22],"very":[24],"specific":[25],"set":[26],"of":[27,37,45,80,90,130,155],"genes":[28],"such":[29,166],"as":[30,167],"the":[31,43,77,87,121,127,153],"tumor":[32],"suppressor":[33],"WAF1,":[34],"an":[35,108],"inhibitor":[36],"cyclin-dependent":[38],"kinases":[39],"(CDKs),":[40],"suppresses":[42],"growth":[44,129],"these":[46,83],"tumors.":[47],"In":[48,65],"addition,":[49],"this":[50,66],"drug":[51],"downregulates":[52],"cyclin":[53],"D1,":[54],"which":[55,158],"upregulated":[57],"by":[58],"through":[60],"breast":[63,103,112,132,156],"cancers.":[64,104],"study,":[67],"we":[68,106],"demonstrate":[69],"that":[70,111,143],"FK228":[71,124,144],"at":[72],"0.1-1":[73],"nM":[74],"significantly":[75],"reduces":[76],"kinase":[78],"activity":[79],"PAK1":[81,97,115],"cells,":[84],"without":[85],"affecting":[86],"protein":[88],"level":[89],"PAK1.":[91],"Interestingly,":[92],"estrogen":[93,164],"receptor":[94],"(ER)":[95],"mutually":[98],"activate":[99],"each":[100],"other":[101,146],"Here":[105],"provide":[107],"evidence":[109],"suggesting":[110,142],"cancers":[113,133,157],"require":[114],"their":[117],"estrogen-dependent":[118,128],"growth.":[119],"Moreover,":[120],"treatment":[122,154],"with":[123],"strongly":[125],"inhibits":[126],"human":[131],"(both":[134],"tamoxifen-sensitive":[135],"resistant":[137,160],"cell":[138],"lines)":[139],"vivo,":[141],"anti-PAK1":[147],"drugs":[148],"would":[149],"be":[150],"useful":[151],"become":[159],"to":[161],"currently":[162],"used":[163],"antagonists":[165],"tamoxifen.":[168]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
