{"id":"https://openalex.org/W1991979573","doi":"https://doi.org/10.1002/jps.10095","title":"Exploitation of Intracellular pH Gradients in the Cellular Delivery of Macromolecules","display_name":"Exploitation of Intracellular pH Gradients in the Cellular Delivery of Macromolecules","publication_year":2002,"publication_date":"2002-04-01","ids":{"openalex":"https://openalex.org/W1991979573","doi":"https://doi.org/10.1002/jps.10095","mag":"1991979573","pmid":"https://pubmed.ncbi.nlm.nih.gov/11948528"},"language":"en","primary_location":{"id":"doi:10.1002/jps.10095","doi":"https://doi.org/10.1002/jps.10095","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jps.10095","pdf_url":null,"source":{"id":"https://openalex.org/S130661733","display_name":"Journal of Pharmaceutical Sciences","issn_l":"0022-3549","issn":["0022-3549","1520-6017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019219512","display_name":"Aravind Asokan","orcid":"https://orcid.org/0000-0001-5563-4877","observed_orcids":["https://orcid.org/0000-0001-5563-4877"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aravind Asokan","raw_affiliation_strings":["Division of Drug Delivery & Disposition, CB # 7360, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA","Division of Drug Delivery & Disposition, CB # 7360, School of Pharmacy, Room 303\u2010C, Beard Hall, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Drug Delivery & Disposition, CB # 7360, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Division of Drug Delivery & Disposition, CB # 7360, School of Pharmacy, Room 303\u2010C, Beard Hall, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060704313","display_name":"Moo J. Cho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Moo J. Cho","raw_affiliation_strings":["Division of Drug Delivery & Disposition, CB # 7360, School of Pharmacy, Room 303-C, Beard Hall, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Drug Delivery & Disposition, CB # 7360, School of Pharmacy, Room 303-C, Beard Hall, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5060704313"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":{"value":3620,"currency":"USD","value_usd":3620},"apc_paid":null,"fwci":0.5626,"has_fulltext":false,"cited_by_count":152,"citation_normalized_percentile":{"value":0.32758621,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"91","issue":"4","first_page":"903","last_page":"913"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.5673999786376953,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.5673999786376953,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.4196999967098236,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intracellular-ph-gradient","display_name":"intracellular pH gradient","score":0.9769999980926514},{"id":"https://openalex.org/keywords/weak-acids-and-bases","display_name":"weak acids and bases","score":0.7450000047683716},{"id":"https://openalex.org/keywords/pka","display_name":"pKa","score":0.656000018119812},{"id":"https://openalex.org/keywords/lysosomes","display_name":"lysosomes","score":0.6480000019073486},{"id":"https://openalex.org/keywords/endosomes","display_name":"endosomes","score":0.7580000162124634},{"id":"https://openalex.org/keywords/membrane-partitioning","display_name":"membrane partitioning","score":0.6169999837875366},{"id":"https://openalex.org/keywords/membrane-fusion","display_name":"membrane fusion","score":0.9319999814033508},{"id":"https://openalex.org/keywords/membrane-damage","display_name":"membrane damage","score":0.8270000219345093},{"id":"https://openalex.org/keywords/liposomes","display_name":"liposomes","score":0.7049999833106995},{"id":"https://openalex.org/keywords/polymeric-carriers","display_name":"polymeric carriers","score":0.8899999856948853}],"concepts":[{"id":"https://openalex.org/C204389451","wikidata":"https://www.wikidata.org/wiki/Q178593","display_name":"Macromolecule","level":2,"score":0.7707842588424683},{"id":"https://openalex.org/C2780216420","wikidata":"https://www.wikidata.org/wiki/Q83330","display_name":"Lysosome","level":3,"score":0.6434520483016968},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.6390541791915894},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.6235159039497375},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5990625619888306},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5834708213806152},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.5509188175201416},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5321725010871887},{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.5243561267852783},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.5066867470741272},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.49757149815559387},{"id":"https://openalex.org/C78885561","wikidata":"https://www.wikidata.org/wiki/Q189055","display_name":"Cellular compartment","level":3,"score":0.45859044790267944},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4392612874507904},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.43791741132736206},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.42980819940567017},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3661929965019226},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.1968713104724884},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15954166650772095},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08631527423858643},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07765427231788635}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007424","descriptor_name":"Intracellular Fluid","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007424","descriptor_name":"Intracellular Fluid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015388","descriptor_name":"Organelles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015388","descriptor_name":"Organelles","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jps.10095","doi":"https://doi.org/10.1002/jps.10095","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jps.10095","pdf_url":null,"source":{"id":"https://openalex.org/S130661733","display_name":"Journal of Pharmaceutical Sciences","issn_l":"0022-3549","issn":["0022-3549","1520-6017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical Sciences","raw_type":"journal-article"},{"id":"pmid:11948528","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11948528","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pharmaceutical sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1692159743","display_name":null,"funder_award_id":"GM50768","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3711687936","display_name":null,"funder_award_id":"GM57557","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8654979699","display_name":"ASSAY SYSTEM FOR EVALUATING CELLULAR ANTISENSE DELIVERY","funder_award_id":"R21GM057557","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W12748762","https://openalex.org/W14021231","https://openalex.org/W41971026","https://openalex.org/W108016466","https://openalex.org/W134346215","https://openalex.org/W422406868","https://openalex.org/W1488083143","https://openalex.org/W1785209062","https://openalex.org/W1974830274","https://openalex.org/W1977502221","https://openalex.org/W1985232912","https://openalex.org/W1987586794","https://openalex.org/W1989124419","https://openalex.org/W1990623781","https://openalex.org/W1991728780","https://openalex.org/W1992593287","https://openalex.org/W1993381661","https://openalex.org/W2000121492","https://openalex.org/W2002122821","https://openalex.org/W2003021187","https://openalex.org/W2006754548","https://openalex.org/W2009447610","https://openalex.org/W2010003825","https://openalex.org/W2010655741","https://openalex.org/W2011495830","https://openalex.org/W2014259987","https://openalex.org/W2014490182","https://openalex.org/W2018116983","https://openalex.org/W2023104469","https://openalex.org/W2025636757","https://openalex.org/W2025897383","https://openalex.org/W2029349973","https://openalex.org/W2034662161","https://openalex.org/W2036167122","https://openalex.org/W2037559791","https://openalex.org/W2039381391","https://openalex.org/W2039722728","https://openalex.org/W2040655728","https://openalex.org/W2048975657","https://openalex.org/W2050657910","https://openalex.org/W2051242890","https://openalex.org/W2054192565","https://openalex.org/W2055296721","https://openalex.org/W2055332480","https://openalex.org/W2057315336","https://openalex.org/W2058417598","https://openalex.org/W2061263372","https://openalex.org/W2070280888","https://openalex.org/W2072952339","https://openalex.org/W2077783386","https://openalex.org/W2077913486","https://openalex.org/W2077934019","https://openalex.org/W2081754155","https://openalex.org/W2082253189","https://openalex.org/W2085145451","https://openalex.org/W2085285008","https://openalex.org/W2087403976","https://openalex.org/W2090211284","https://openalex.org/W2090571818","https://openalex.org/W2090588541","https://openalex.org/W2099717623","https://openalex.org/W2102535130","https://openalex.org/W2125233904","https://openalex.org/W2125380292","https://openalex.org/W2130872480","https://openalex.org/W2147680256","https://openalex.org/W2164147916","https://openalex.org/W2165451824","https://openalex.org/W2167949866","https://openalex.org/W2174160083","https://openalex.org/W2464754689","https://openalex.org/W4239750817"],"related_works":["https://openalex.org/W2037222263","https://openalex.org/W4407641986","https://openalex.org/W49991483","https://openalex.org/W2086555311","https://openalex.org/W2322316180","https://openalex.org/W2099623245","https://openalex.org/W2161976254","https://openalex.org/W2066416491","https://openalex.org/W2150332790","https://openalex.org/W2521523123"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
