{"id":"https://openalex.org/W1991968477","doi":"https://doi.org/10.1097/00002826-200211000-00005","title":"Sequential Changes in the Plasma Concentration of Risperidone Following Intentional Overdose","display_name":"Sequential Changes in the Plasma Concentration of Risperidone Following Intentional Overdose","publication_year":2002,"publication_date":"2002-11-01","ids":{"openalex":"https://openalex.org/W1991968477","doi":"https://doi.org/10.1097/00002826-200211000-00005","mag":"1991968477","pmid":"https://pubmed.ncbi.nlm.nih.gov/12469003"},"language":"en","primary_location":{"id":"doi:10.1097/00002826-200211000-00005","doi":"https://doi.org/10.1097/00002826-200211000-00005","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00002826-200211000-00005","pdf_url":null,"source":{"id":"https://openalex.org/S3349026","display_name":"Clinical Neuropharmacology","issn_l":"0362-5664","issn":["0362-5664","1537-162X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Neuropharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074796824","display_name":"Hirofumi Nishikage","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hirofumi Nishikage","raw_affiliation_strings":["Department of Kidney and Dialysis, Hyogo College of Medicine, Nishinomiya, Japan. h-nskg@hyo-med.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Kidney and Dialysis, Hyogo College of Medicine, Nishinomiya, Japan. h-nskg@hyo-med.ac.jp","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Takeshi Nakanishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Nakanishi","raw_affiliation_strings":["Department of Kidney and Dialysis, Hyogo College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Kidney and Dialysis, Hyogo College of Medicine","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001403591","display_name":"Yoshihiro Takamitsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiro Takamitsu","raw_affiliation_strings":["Department of Kidney and Dialysis, Hyogo College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Kidney and Dialysis, Hyogo College of Medicine","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039548472","display_name":"Junnosuke Yamamoto","orcid":"https://orcid.org/0009-0009-1125-7016","observed_orcids":["https://orcid.org/0009-0009-1125-7016"]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Junnosuke Yamamoto","raw_affiliation_strings":["Department of Kidney and Dialysis, Hyogo College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Kidney and Dialysis, Hyogo College of Medicine","institution_ids":["https://openalex.org/I137459256"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5074796824"],"corresponding_institution_ids":["https://openalex.org/I137459256"],"apc_list":null,"apc_paid":null,"fwci":0.8945,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.77701863,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"25","issue":"6","first_page":"307","last_page":"309"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.0551999993622303,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/risperidone","display_name":"risperidone","score":0.9980000257492065},{"id":"https://openalex.org/keywords/intentional-overdose","display_name":"intentional overdose","score":0.8859999775886536},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9359999895095825},{"id":"https://openalex.org/keywords/plasma-concentration","display_name":"plasma concentration","score":0.875},{"id":"https://openalex.org/keywords/drug-metabolites","display_name":"drug metabolites","score":0.7680000066757202},{"id":"https://openalex.org/keywords/half-life","display_name":"half-life","score":0.8190000057220459},{"id":"https://openalex.org/keywords/antipsychotic-poisoning","display_name":"antipsychotic poisoning","score":0.7710000276565552},{"id":"https://openalex.org/keywords/coma","display_name":"coma","score":0.6430000066757202},{"id":"https://openalex.org/keywords/parkinsonism","display_name":"parkinsonism","score":0.7480000257492065},{"id":"https://openalex.org/keywords/dystonia","display_name":"dystonia","score":0.9589999914169312}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8068451881408691},{"id":"https://openalex.org/C2780057945","wikidata":"https://www.wikidata.org/wiki/Q412443","display_name":"Risperidone","level":3,"score":0.733849287033081},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6529557704925537},{"id":"https://openalex.org/C193230392","wikidata":"https://www.wikidata.org/wiki/Q1663054","display_name":"Ingestion","level":2,"score":0.6030404567718506},{"id":"https://openalex.org/C3020079912","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Plasma concentration","level":2,"score":0.5996991991996765},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.49226537346839905},{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.4459284245967865},{"id":"https://openalex.org/C3941253","wikidata":"https://www.wikidata.org/wiki/Q47270","display_name":"Half-life","level":3,"score":0.4458308815956116},{"id":"https://openalex.org/C3018403923","wikidata":"https://www.wikidata.org/wiki/Q1163287","display_name":"Plasma clearance","level":3,"score":0.43399858474731445},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3091447055339813},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2605469226837158},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.16396233439445496},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068882","descriptor_name":"Paliperidone Palmitate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003128","descriptor_name":"Coma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003128","descriptor_name":"Coma","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003128","descriptor_name":"Coma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007555","descriptor_name":"Isoxazoles","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018967","descriptor_name":"Risperidone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018967","descriptor_name":"Risperidone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018967","descriptor_name":"Risperidone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D062787","descriptor_name":"Drug Overdose","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/00002826-200211000-00005","doi":"https://doi.org/10.1097/00002826-200211000-00005","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00002826-200211000-00005","pdf_url":null,"source":{"id":"https://openalex.org/S3349026","display_name":"Clinical Neuropharmacology","issn_l":"0362-5664","issn":["0362-5664","1537-162X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Neuropharmacology","raw_type":"journal-article"},{"id":"pmid:12469003","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12469003","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical neuropharmacology","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1493489845","https://openalex.org/W1986898204","https://openalex.org/W1987441780","https://openalex.org/W2105316067","https://openalex.org/W2118348785","https://openalex.org/W2142999820","https://openalex.org/W2267542151","https://openalex.org/W2321860078","https://openalex.org/W2410652401","https://openalex.org/W4246083729"],"related_works":["https://openalex.org/W2321860078","https://openalex.org/W1545676883","https://openalex.org/W2109335087","https://openalex.org/W2048223255","https://openalex.org/W1987441780","https://openalex.org/W2071388132","https://openalex.org/W1999073238","https://openalex.org/W2358066795","https://openalex.org/W1986898204","https://openalex.org/W4408465365"],"abstract_inverted_index":{"Risperidone":[0],"(RIS)":[1],"is":[2,18],"a":[3,32,51,166],"novel":[4],"antipsychotic":[5],"agent":[6],"whose":[7],"pharmacokinetics":[8,28],"have":[9],"yet":[10],"to":[11,157],"be":[12],"fully":[13],"determined.":[14,96],"In":[15,63],"particular,":[16],"little":[17],"known":[19],"about":[20],"RIS":[21,36,70,102,139,161],"following":[22,29,54,140],"an":[23,55,87],"overdose.":[24],"We":[25],"report":[26],"the":[27,40,64,77,109,120,124,131,136,158],"ingestion":[30],"of":[31,35,58,69,91,100,108,138,160],"high":[33],"dose":[34],"by":[37],"serially":[38],"measuring":[39],"plasma":[41],"concentration":[42,99],"in":[43,50,130,162],"two":[44],"patients.":[45],"These":[46,153],"patients":[47,61,170],"were":[48,95,178],"admitted":[49],"comatose":[52],"state":[53],"intentional":[56],"overdose":[57,141],"RIS;":[59],"all":[60],"survived.":[62],"first":[65,78,132],"patient,":[66],"14":[67],"mg":[68,90],"had":[71],"been":[72],"ingested":[73,86],"2":[74],"hr":[75,148],"before":[76],"blood":[79],"sample":[80],"was":[81,103,115,142,145],"obtained.":[82],"The":[83,97],"second":[84,134],"patient":[85],"estimated":[88],"90":[89],"RIS.":[92],"Seven":[93],"time-points":[94],"maximum":[98],"unaltered":[101],"325":[104],"ng/mL":[105],"and":[106,133,144,149,177],"that":[107],"principal":[110],"metabolite":[111],"(9-hydroxy-risperidone:":[112],"9-OH":[113],"RIS)":[114],"139":[116],"ng/mL.":[117],"By":[118],"plotting":[119],"time-concentration":[121],"curve":[122],"for":[123],"active":[125],"fraction":[126],"(RIS":[127],"plus":[128],"9-OH-RIS)":[129],"patients,":[135],"half-life":[137,159],"determined":[143],"approximately":[146],"12.7":[147],"17.8":[150],"hr,":[151],"respectively.":[152],"values":[154],"are":[155],"similar":[156],"healthy":[163],"individuals":[164],"ingesting":[165],"therapeutic":[167],"dose.":[168],"Two":[169],"did":[171],"not":[172],"developed":[173],"parkinsonism":[174],"nor":[175],"dystonia,":[176],"discharged":[179],"without":[180],"sequelae.":[181]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
