{"id":"https://openalex.org/W1991964131","doi":"https://doi.org/10.1002/syn.20404","title":"Time\u2010course of change in [11C]carfentanil and [11C]raclopride binding potential after a nonpharmacological challenge","display_name":"Time\u2010course of change in [11C]carfentanil and [11C]raclopride binding potential after a nonpharmacological challenge","publication_year":2007,"publication_date":"2007-06-08","ids":{"openalex":"https://openalex.org/W1991964131","doi":"https://doi.org/10.1002/syn.20404","mag":"1991964131","pmid":"https://pubmed.ncbi.nlm.nih.gov/17559096"},"language":"en","primary_location":{"id":"doi:10.1002/syn.20404","doi":"https://doi.org/10.1002/syn.20404","is_oa":false,"landing_page_url":"https://doi.org/10.1002/syn.20404","pdf_url":null,"source":{"id":"https://openalex.org/S158211696","display_name":"Synapse","issn_l":"0887-4476","issn":["0887-4476","1098-2396"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synapse","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/2027.42/56076","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102771600","display_name":"David Scott","orcid":"https://orcid.org/0000-0002-8054-7502","observed_orcids":["https://orcid.org/0000-0002-8054-7502"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David J. Scott","raw_affiliation_strings":["Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109-0720, USA","Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109-0720"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109-0720, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109-0720","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058347270","display_name":"Christian S. Stohler","orcid":"https://orcid.org/0000-0003-0443-6146","observed_orcids":["https://orcid.org/0000-0003-0443-6146"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian S. Stohler","raw_affiliation_strings":["School of Dentistry, University of Maryland, Baltimore, MD 21201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Dentistry, University of Maryland, Baltimore, MD 21201","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083886913","display_name":"Robert A. Koeppe","orcid":"https://orcid.org/0000-0002-9514-5311","observed_orcids":["https://orcid.org/0000-0002-9514-5311"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A. Koeppe","raw_affiliation_strings":["Department of Radiology, Division of Nuclear Medicine, University of Michigan, Ann Arbor, MI 48109-0720"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Division of Nuclear Medicine, University of Michigan, Ann Arbor, MI 48109-0720","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108202327","display_name":"Jon\u2010Kar Zubieta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jon\u2010Kar Zubieta","raw_affiliation_strings":["Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109-0720","Department of Radiology, Division of Nuclear Medicine, University of Michigan, Ann Arbor, MI 48109-0720"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109-0720","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Radiology, Division of Nuclear Medicine, University of Michigan, Ann Arbor, MI 48109-0720","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5108202327"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"],"apc_list":{"value":3570,"currency":"USD","value_usd":3570},"apc_paid":null,"fwci":1.322,"has_fulltext":true,"cited_by_count":57,"citation_normalized_percentile":{"value":0.74964286,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"61","issue":"9","first_page":"707","last_page":"714"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.8618000149726868,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.8618000149726868,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.051100000739097595,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.021199999377131462,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/11c-carfentanil","display_name":"[11C]carfentanil","score":0.9279999732971191},{"id":"https://openalex.org/keywords/11c-raclopride","display_name":"[11C]raclopride","score":1.0},{"id":"https://openalex.org/keywords/binding-potential","display_name":"binding potential","score":0.9570000171661377},{"id":"https://openalex.org/keywords/mu-opioid-receptor","display_name":"mu-opioid receptor","score":0.8790000081062317},{"id":"https://openalex.org/keywords/dopamine-d2-receptor","display_name":"dopamine D2 receptor","score":0.972000002861023},{"id":"https://openalex.org/keywords/sustained-pain","display_name":"sustained pain","score":0.7200000286102295},{"id":"https://openalex.org/keywords/receptor-internalization","display_name":"receptor internalization","score":0.9020000100135803},{"id":"https://openalex.org/keywords/receptor-recycling","display_name":"receptor recycling","score":0.9769999980926514},{"id":"https://openalex.org/keywords/caudate-nucleus","display_name":"caudate nucleus","score":0.9350000023841858}],"concepts":[{"id":"https://openalex.org/C2781069445","wikidata":"https://www.wikidata.org/wiki/Q7279814","display_name":"Raclopride","level":4,"score":0.9446210265159607},{"id":"https://openalex.org/C60592354","wikidata":"https://www.wikidata.org/wiki/Q4914018","display_name":"Binding potential","level":3,"score":0.6719130277633667},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5751744508743286},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5286959409713745},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5001256465911865},{"id":"https://openalex.org/C3017995582","wikidata":"https://www.wikidata.org/wiki/Q417189","display_name":"Endogenous opioid","level":4,"score":0.48981258273124695},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.46796637773513794},{"id":"https://openalex.org/C2779886867","wikidata":"https://www.wikidata.org/wiki/Q421797","display_name":"Opioid receptor","level":4,"score":0.4667418599128723},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.45761245489120483},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.4471316337585449},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.42940717935562134},{"id":"https://openalex.org/C44208683","wikidata":"https://www.wikidata.org/wiki/Q15335165","display_name":"Dopamine receptor D2","level":3,"score":0.4195074439048767},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39820829033851624},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3621561527252197},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.33019569516181946},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2996092736721039}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002250","descriptor_name":"Carbon Radioisotopes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D005283","descriptor_name":"Fentanyl","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D005283","descriptor_name":"Fentanyl","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018492","descriptor_name":"Dopamine Antagonists","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D020891","descriptor_name":"Raclopride","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/syn.20404","doi":"https://doi.org/10.1002/syn.20404","is_oa":false,"landing_page_url":"https://doi.org/10.1002/syn.20404","pdf_url":null,"source":{"id":"https://openalex.org/S158211696","display_name":"Synapse","issn_l":"0887-4476","issn":["0887-4476","1098-2396"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synapse","raw_type":"journal-article"},{"id":"pmid:17559096","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17559096","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synapse (New York, N.Y.)","raw_type":"Clinical Trial"},{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/56076","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/56076","pdf_url":"https://hdl.handle.net/2027.42/56076","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/56076","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/56076","pdf_url":"https://hdl.handle.net/2027.42/56076","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6899999976158142,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G446138349","display_name":"Neurochemical Endophenotype Responses to Pain-Stress","funder_award_id":"R01DA016423","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1991964131.pdf","grobid_xml":"https://content.openalex.org/works/W1991964131.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1630671347","https://openalex.org/W1800579485","https://openalex.org/W1821065636","https://openalex.org/W1856679114","https://openalex.org/W1934272990","https://openalex.org/W1988922574","https://openalex.org/W1990582505","https://openalex.org/W1992381398","https://openalex.org/W1996327177","https://openalex.org/W2002335692","https://openalex.org/W2006715508","https://openalex.org/W2011100195","https://openalex.org/W2011653800","https://openalex.org/W2016678309","https://openalex.org/W2022071529","https://openalex.org/W2025782867","https://openalex.org/W2031507203","https://openalex.org/W2041733000","https://openalex.org/W2049489255","https://openalex.org/W2051691068","https://openalex.org/W2054230322","https://openalex.org/W2054929374","https://openalex.org/W2055307939","https://openalex.org/W2057897067","https://openalex.org/W2065359811","https://openalex.org/W2074009301","https://openalex.org/W2079477007","https://openalex.org/W2085285717","https://openalex.org/W2093185137","https://openalex.org/W2095225735","https://openalex.org/W2099678317","https://openalex.org/W2103073562","https://openalex.org/W2104505172","https://openalex.org/W2106676291","https://openalex.org/W2116649573","https://openalex.org/W2121887890","https://openalex.org/W2125295858","https://openalex.org/W2136619214","https://openalex.org/W2140517675","https://openalex.org/W2150760506","https://openalex.org/W2157737392","https://openalex.org/W2162421322","https://openalex.org/W2309929517","https://openalex.org/W2411550141","https://openalex.org/W2443163703"],"related_works":["https://openalex.org/W2740529391","https://openalex.org/W2088247827","https://openalex.org/W2220022751","https://openalex.org/W2315579820","https://openalex.org/W2016678309","https://openalex.org/W1976780807","https://openalex.org/W4387827408","https://openalex.org/W2049491530","https://openalex.org/W2089223079","https://openalex.org/W2061976085"],"abstract_inverted_index":{"Positron":[0],"Emission":[1],"Tomography":[2],"(PET)":[3],"with":[4,41,107,130,142],"appropriate":[5],"radiotracers":[6],"and":[7,30,39,68,101,109,151,210,229],"quantification":[8],"methods":[9],"allows":[10],"the":[11,20,23,53,56,59,79,119,134,172,179,206,233],"detection":[12],"of":[13,27,58,81,91,121,208,222,235],"changes":[14,82,132,186],"in":[15,22,48,55,73,83,99,133,144,148,158,178,187,205,224],"endogenous":[16,60],"neurotransmission":[17],"by":[18,191],"determine":[19],"reduction":[21],"binding":[24],"potential":[25],"(BP)":[26],"receptors":[28],"before":[29],"after":[31],"experimental":[32],"challenges.":[33],"These":[34,154,182,217],"have":[35],"typically":[36],"employed":[37],"psychostimulants":[38],"PET":[40,214],"dopamine":[42],"(DA)":[43],"receptor":[44,66,146,169,188,225,227],"radiotracers.":[45],"However,":[46],"reductions":[47,98,143,177],"BP":[49,84,135,147,189,215],"persist":[50,157,197],"far":[51],"beyond":[52],"increases":[54],"release":[57],"neurotransmitter,":[61],"an":[62],"effect":[63,207],"ascribed":[64],"to":[65,95,116],"internalization":[67],"recycling,":[69],"a":[70,86,122,159,192],"possible":[71],"confound":[72],"repeated":[74],"studies.":[75],"Here":[76],"we":[77],"examined":[78],"time-course":[80],"during":[85],"nonpharmacological":[87,193,211],"challenge,":[88],"moderate":[89],"levels":[90,221],"sustained":[92],"pain,":[93],"shown":[94],"induce":[96],"robust":[97],"micro-opioid":[100,145],"DA":[102,167],"D2":[103,168],"BP,":[104,170],"as":[105],"measured":[106],"[(11)C]carfentanil":[108],"[(11)C]raclopride.":[110],"It":[111],"was":[112,140],"hypothesized":[113],"that,":[114],"contrary":[115],"pharmacological":[117,209],"probes,":[118],"use":[120],"more":[123],"\"physiological\"":[124],"stimulus":[125],"would":[126],"not":[127,156,196],"be":[128],"associated":[129,141],"persistent":[131],"measures.":[136,216],"The":[137],"pain":[138,173],"challenge":[139,174,194,236],"several":[149],"cortical":[150],"subcortical":[152],"regions.":[153],"did":[155,195],"subsequent":[160,199],"scan.":[161],"Similar":[162],"results":[163],"were":[164],"obtained":[165],"for":[166],"where":[171],"induced":[175,190],"significant":[176],"caudate":[180],"nucleus.":[181],"data":[183],"demonstrate":[184],"that":[185],"into":[198],"scans.":[200],"They":[201],"further":[202],"suggest":[203],"differences":[204],"probes":[212],"on":[213,232],"may":[218],"reflect":[219],"varying":[220],"change":[223],"affinity,":[226],"internalization,":[228],"recycling":[230],"depending":[231],"type":[234],"employed.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}