{"id":"https://openalex.org/W1991958201","doi":"https://doi.org/10.1159/000183058","title":"Lack of Evidence for a Role for Prostaglandins in the Mediation of Impaired Urinary Concentrating Ability in Bartter\u2019s Syndrome","display_name":"Lack of Evidence for a Role for Prostaglandins in the Mediation of Impaired Urinary Concentrating Ability in Bartter\u2019s Syndrome","publication_year":2008,"publication_date":"2008-12-03","ids":{"openalex":"https://openalex.org/W1991958201","doi":"https://doi.org/10.1159/000183058","mag":"1991958201","pmid":"https://pubmed.ncbi.nlm.nih.gov/6621756"},"language":"en","primary_location":{"id":"doi:10.1159/000183058","doi":"https://doi.org/10.1159/000183058","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000183058","pdf_url":null,"source":{"id":"https://openalex.org/S4393917655","display_name":"The Nephron journals/Nephron journals","issn_l":"1660-8151","issn":["1660-8151","2235-3186"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephron","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105529280","display_name":"James C.M. Chan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James C.M. Chan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111780024","display_name":"John R. Gill","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John R. Gill, Jr.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5028639967","display_name":"Frederic C. Bartter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frederic C. Bartter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.09521377,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"35","issue":"2","first_page":"116","last_page":"119"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11967","display_name":"Electrolyte and hormonal disorders","score":0.033900000154972076,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bartter-syndrome","display_name":"Bartter syndrome","score":0.925000011920929},{"id":"https://openalex.org/keywords/prostaglandins","display_name":"prostaglandins","score":0.902999997138977},{"id":"https://openalex.org/keywords/urinary-concentrating-ability","display_name":"urine concentrating ability","score":0.9279999732971191},{"id":"https://openalex.org/keywords/solute-clearance","display_name":"solute clearance","score":0.781000018119812},{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":0.8500000238418579},{"id":"https://openalex.org/keywords/ibuprofen","display_name":"ibuprofen","score":1.0},{"id":"https://openalex.org/keywords/prostaglandin-inhibitors","display_name":"prostaglandin inhibitors","score":0.9819999933242798},{"id":"https://openalex.org/keywords/loop-of-henle","display_name":"loop of Henle","score":0.8669999837875366},{"id":"https://openalex.org/keywords/chloride-reabsorption","display_name":"chloride reabsorption","score":0.8949999809265137},{"id":"https://openalex.org/keywords/fluid-deprivation","display_name":"fluid deprivation","score":0.5709999799728394},{"id":"https://openalex.org/keywords/pitressin","display_name":"pitressin","score":0.8840000033378601}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8116937875747681},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7897880673408508},{"id":"https://openalex.org/C56906281","wikidata":"https://www.wikidata.org/wiki/Q4391435","display_name":"Reabsorption","level":3,"score":0.7310900688171387},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.728557288646698},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.6672812700271606},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.5828956961631775},{"id":"https://openalex.org/C2778534349","wikidata":"https://www.wikidata.org/wiki/Q7900633","display_name":"Urine osmolality","level":3,"score":0.5011060237884521},{"id":"https://openalex.org/C2778437025","wikidata":"https://www.wikidata.org/wiki/Q7850936","display_name":"Tubular fluid","level":4,"score":0.44151097536087036},{"id":"https://openalex.org/C14705128","wikidata":"https://www.wikidata.org/wiki/Q643555","display_name":"Osmole","level":2,"score":0.44086557626724243},{"id":"https://openalex.org/C2910219414","wikidata":"https://www.wikidata.org/wiki/Q790971","display_name":"Bartter's syndrome","level":3,"score":0.4261522889137268},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.42143556475639343},{"id":"https://openalex.org/C33893070","wikidata":"https://www.wikidata.org/wiki/Q5500348","display_name":"Free water clearance","level":3,"score":0.41167157888412476},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.2757444679737091},{"id":"https://openalex.org/C2778242168","wikidata":"https://www.wikidata.org/wiki/Q794086","display_name":"Hypokalemia","level":2,"score":0.07473477721214294}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001477","descriptor_name":"Bartter Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006929","descriptor_name":"Hyperaldosteronism","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007052","descriptor_name":"Ibuprofen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007213","descriptor_name":"Indomethacin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007671","descriptor_name":"Kidney Concentrating Ability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011453","descriptor_name":"Prostaglandins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014556","descriptor_name":"Urine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000183058","doi":"https://doi.org/10.1159/000183058","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000183058","pdf_url":null,"source":{"id":"https://openalex.org/S4393917655","display_name":"The Nephron journals/Nephron journals","issn_l":"1660-8151","issn":["1660-8151","2235-3186"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephron","raw_type":"journal-article"},{"id":"pmid:6621756","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6621756","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephron","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337376","display_name":"NIH Clinical Center","ror":"https://ror.org/04vfsmv21"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4300482662","https://openalex.org/W2088510248","https://openalex.org/W2034948813","https://openalex.org/W2160485517","https://openalex.org/W4233394399","https://openalex.org/W2013993451","https://openalex.org/W2023079411","https://openalex.org/W2066958530","https://openalex.org/W399142955","https://openalex.org/W1980481671"],"abstract_inverted_index":{"Imparied":[0],"urinary":[1,60,91,128,147],"concentrating":[2],"ability":[3],"in":[4,9,19,48,146,149],"Bartter's":[5,150],"syndrome":[6],"may":[7,162],"result":[8],"part":[10],"from":[11,16],"overproduction":[12,142],"of":[13,25,33,36,71,80,159],"prostaglandins":[14],"and":[15,40,68,87,97,102,109,117],"the":[17,23,31,37,83,115,126,144],"defect":[18],"chloride":[20,154],"reabsorption":[21],"by":[22],"loop":[24],"Henle,":[26],"or":[27,130],"both.":[28],"To":[29],"assess":[30],"role":[32],"prostaglandins,":[34],"concentration":[35,148],"urine":[38],"before":[39],"after":[41,64,77],"treatment":[42,81,118],"with":[43,51,82,156],"prostaglandin":[44,84,141],"inhibitors":[45,122],"was":[46,62,93,105],"studied":[47],"3":[49],"patients":[50],"this":[52],"syndrome,":[53],"taking":[54],"a":[55,157],"constant":[56],"metabolic":[57],"diet.":[58],"Maximal":[59],"osmolality":[61,92,129],"determined":[63],"overnight":[65],"fluid":[66],"deprivation":[67],"during":[69],"infusion":[70],"Pitressin.":[72],"The":[73,89,133,152],"studies":[74],"were":[75],"repeated":[76],"4":[78],"days":[79],"inhibitors,":[85],"indomethacin":[86],"ibuprofen.":[88],"maximal":[90,127],"694":[94],"+/-":[95,99,107,111],"39":[96],"717":[98],"78":[100],"mosm/kg,":[101],"solute":[103,131],"clearance":[104],"1.3":[106],"0.3":[108],"1.2":[110],"0.5":[112],"ml/min":[113],"for":[114],"control":[116],"periods,":[119],"respectively.":[120],"Prostaglandin":[121],"failed":[123],"to":[124],"increase":[125],"clearance.":[132],"data":[134],"thus":[135],"suggest":[136],"that":[137],"factors":[138],"other":[139],"than":[140],"cause":[143],"impairment":[145],"syndrome.":[151],"defective":[153],"transport":[155],"loss":[158],"interstitial":[160],"hyperosmolality":[161],"be":[163],"one":[164],"such":[165],"factor.":[166]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
