{"id":"https://openalex.org/W1991925880","doi":"https://doi.org/10.1093/molbev/mss192","title":"Very Low Rate of Gene Conversion in the Yeast Genome","display_name":"Very Low Rate of Gene Conversion in the Yeast Genome","publication_year":2012,"publication_date":"2012-07-27","ids":{"openalex":"https://openalex.org/W1991925880","doi":"https://doi.org/10.1093/molbev/mss192","mag":"1991925880","pmid":"https://pubmed.ncbi.nlm.nih.gov/22844073"},"language":"en","primary_location":{"id":"doi:10.1093/molbev/mss192","doi":"https://doi.org/10.1093/molbev/mss192","is_oa":false,"landing_page_url":"https://doi.org/10.1093/molbev/mss192","pdf_url":null,"source":{"id":"https://openalex.org/S57552105","display_name":"Molecular Biology and Evolution","issn_l":"0737-4038","issn":["0737-4038","1537-1719"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology and Evolution","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058977512","display_name":"Claudio Casola","orcid":"https://orcid.org/0000-0003-4853-1866","observed_orcids":["https://orcid.org/0000-0003-4853-1866"]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claudio Casola","raw_affiliation_strings":["Department of Biology, Indiana University, USA","Department of Biology, Indiana University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Indiana University, USA","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"raw_affiliation_string":"Department of Biology, Indiana University","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041114077","display_name":"Gavin C. Conant","orcid":"https://orcid.org/0000-0002-8677-4933","observed_orcids":["https://orcid.org/0000-0002-8677-4933"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gavin C. Conant","raw_affiliation_strings":["Division of Animal Sciences, University of Missouri","Informatics Institute, University of Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Animal Sciences, University of Missouri","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Informatics Institute, University of Missouri","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038671526","display_name":"Matthew W. Hahn","orcid":"https://orcid.org/0000-0002-5731-8808","observed_orcids":["https://orcid.org/0000-0002-5731-8808"]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Matthew W. Hahn","raw_affiliation_strings":["Department of Biology, Indiana University","School of Informatics and Computing, Indiana University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Indiana University","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"raw_affiliation_string":"School of Informatics and Computing, Indiana University","institution_ids":["https://openalex.org/I592451"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5038671526"],"corresponding_institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"],"apc_list":{"value":3418,"currency":"USD","value_usd":3418},"apc_paid":null,"fwci":0.8804,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.71322399,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"29","issue":"12","first_page":"3817","last_page":"3826"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.8310999870300293,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.8310999870300293,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13664","display_name":"Genome Rearrangement Algorithms","score":0.08479999750852585,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.025699999183416367,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-duplication","display_name":"gene duplication","score":0.6399999856948853},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9179999828338623},{"id":"https://openalex.org/keywords/paralogs","display_name":"paralogs","score":0.8460000157356262},{"id":"https://openalex.org/keywords/genome-wide-analysis","display_name":"genome-wide analysis","score":0.41499999165534973}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9623669385910034},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.6683014631271362},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6517991423606873},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6103684306144714},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5772156715393066},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.4406081736087799},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3648487329483032}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005785","descriptor_name":"Gene Conversion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016013","descriptor_name":"Likelihood Functions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016681","descriptor_name":"Genome, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020440","descriptor_name":"Gene Duplication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/molbev/mss192","doi":"https://doi.org/10.1093/molbev/mss192","is_oa":false,"landing_page_url":"https://doi.org/10.1093/molbev/mss192","pdf_url":null,"source":{"id":"https://openalex.org/S57552105","display_name":"Molecular Biology and Evolution","issn_l":"0737-4038","issn":["0737-4038","1537-1719"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology and Evolution","raw_type":"journal-article"},{"id":"pmid:22844073","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22844073","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular biology and evolution","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.648.3240","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.648.3240","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://sites.bio.indiana.edu/~hahnlab/Publications/Casola_etal2012b.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W1486713639","https://openalex.org/W1641544182","https://openalex.org/W1836271588","https://openalex.org/W1881907338","https://openalex.org/W1964612763","https://openalex.org/W1964683842","https://openalex.org/W1965007570","https://openalex.org/W1969271586","https://openalex.org/W1970732273","https://openalex.org/W1972969894","https://openalex.org/W1988484106","https://openalex.org/W1996865001","https://openalex.org/W2000054946","https://openalex.org/W2018208018","https://openalex.org/W2019591778","https://openalex.org/W2020013199","https://openalex.org/W2020253171","https://openalex.org/W2024172842","https://openalex.org/W2024675966","https://openalex.org/W2028576642","https://openalex.org/W2030086669","https://openalex.org/W2030616232","https://openalex.org/W2038464976","https://openalex.org/W2040892797","https://openalex.org/W2041581620","https://openalex.org/W2041624900","https://openalex.org/W2041854849","https://openalex.org/W2044720815","https://openalex.org/W2057685263","https://openalex.org/W2061646232","https://openalex.org/W2064322162","https://openalex.org/W2067097322","https://openalex.org/W2073778187","https://openalex.org/W2076658876","https://openalex.org/W2077345500","https://openalex.org/W2077724722","https://openalex.org/W2079197003","https://openalex.org/W2081933515","https://openalex.org/W2087601715","https://openalex.org/W2087658947","https://openalex.org/W2091181646","https://openalex.org/W2091507729","https://openalex.org/W2095829109","https://openalex.org/W2097805330","https://openalex.org/W2100185570","https://openalex.org/W2102963915","https://openalex.org/W2103581172","https://openalex.org/W2104308520","https://openalex.org/W2105771473","https://openalex.org/W2110466118","https://openalex.org/W2116905253","https://openalex.org/W2116925118","https://openalex.org/W2122821321","https://openalex.org/W2123013304","https://openalex.org/W2123431154","https://openalex.org/W2124166542","https://openalex.org/W2124397449","https://openalex.org/W2127468263","https://openalex.org/W2128296317","https://openalex.org/W2131014583","https://openalex.org/W2131152571","https://openalex.org/W2132926880","https://openalex.org/W2137441463","https://openalex.org/W2144362290","https://openalex.org/W2148105436","https://openalex.org/W2149886005","https://openalex.org/W2150377670","https://openalex.org/W2161348707","https://openalex.org/W2162891889","https://openalex.org/W2163938340","https://openalex.org/W2169540909","https://openalex.org/W2171022989","https://openalex.org/W2263005842","https://openalex.org/W4213319185","https://openalex.org/W4297845870","https://openalex.org/W6629097426"],"related_works":["https://openalex.org/W2181533873","https://openalex.org/W7025504433","https://openalex.org/W2440346163","https://openalex.org/W2028576642","https://openalex.org/W7098411969","https://openalex.org/W2103273771","https://openalex.org/W2067097322","https://openalex.org/W4386504347","https://openalex.org/W2041581620","https://openalex.org/W2275478399"],"abstract_inverted_index":{"Gene":[0],"duplication":[1,30,70,86,125,159],"is":[2,162],"a":[3,32,196,264],"major":[4],"driver":[5],"of":[6,28,34,38,48,56,63,85,91,105,141,157,188,200,213,225,232,256],"organismal":[7],"adaptation":[8],"and":[9,11,25,115,182,261],"evolution":[10,55],"plays":[12],"an":[13,233,237],"important":[14],"role":[15],"in":[16,81,95,127,137,160,190,204,207,215,269],"multiple":[17],"human":[18],"diseases.":[19],"Whole-genome":[20],"analyses":[21,193,268],"have":[22],"shown":[23],"similar":[24],"high":[26,83,223],"rates":[27,146],"gene":[29,50,57,69,124,135,158],"across":[31],"variety":[33],"eukaryotic":[35],"species.":[36],"Most":[37],"these":[39],"studies,":[40],"however,":[41],"did":[42],"not":[43],"address":[44],"the":[45,54,89,96,128,155,186,221,246,253],"possible":[46],"impact":[47],"interlocus":[49],"conversion":[51,66,136,145,198,226],"(IGC)":[52],"on":[53],"duplicates.":[58],"Because":[59],"IGC":[60,106,189,214,257],"homogenizes":[61],"pairs":[62],"duplicates,":[64],"widespread":[65],"would":[67,152],"cause":[68],"events":[71],"that":[72,134,154,178,220],"happened":[73],"long":[74],"ago":[75],"to":[76,103,112,195,236,250],"appear":[77],"more":[78],"recent,":[79],"resulting":[80],"artificially":[82],"estimates":[84,212],"rates.":[87],"Although":[88],"majority":[90],"genome-wide":[92],"studies":[93],"(including":[94],"budding":[97],"yeast":[98,129,138],"Saccharomyces":[99],"cerevisiae":[100],"[Scer])":[101],"point":[102,194],"levels":[104,224],"between":[107,202],"paralogs":[108,203,260],"ranging":[109],"from":[110,230],"2%":[111],"18%,":[113],"Gao":[114,181],"Innan":[116,119],"(Gao":[117],"LZ,":[118],"H.":[120],"2004.":[121],"Very":[122],"low":[123],"rate":[126,156],"genome.":[130],"Science":[131],"306:1367-1370.)":[132],"found":[133,227],"affected":[139],">80%":[140],"paralog":[142],"pairs.":[143],"If":[144],"really":[147],"are":[148],"this":[149,169,205],"high,":[150],"it":[151],"imply":[153],"eukaryotes":[161],"much":[163],"lower":[164],"than":[165],"previously":[166,228],"reported.":[167],"In":[168,241],"work,":[170],"we":[171],"apply":[172],"four":[173],"different":[174],"methodologies-including":[175],"one":[176],"approach":[177],"closely":[179],"mirrors":[180],"Innan's":[183],"method-to":[184],"estimate":[185],"level":[187,199],"Scer.":[191],"Our":[192],"maximum":[197],"13%":[201],"species,":[206],"close":[208],"agreement":[209],"with":[210],"most":[211,247],"eukaryotes.":[216,271],"We":[217],"also":[218],"show":[219],"exceedingly":[222],"derive":[229],"application":[231],"accurate":[234],"method":[235],"inappropriate":[238],"data":[239],"set.":[240],"conclusion,":[242],"our":[243],"work":[244],"provides":[245],"striking":[248],"evidence":[249],"date":[251],"supporting":[252],"reduced":[254],"incidence":[255],"among":[258],"Scer":[259],"sets":[262],"up":[263],"framework":[265],"for":[266],"future":[267],"other":[270]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}