{"id":"https://openalex.org/W1991908401","doi":"https://doi.org/10.1081/hem-120016372","title":"MOLECULAR SPECTRUM OF\u03b1-THALASSEMIA IN TUNISIA: EPIDEMIOLOGY AND DETECTION AT BIRTH","display_name":"MOLECULAR SPECTRUM OF\u03b1-THALASSEMIA IN TUNISIA: EPIDEMIOLOGY AND DETECTION AT BIRTH","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W1991908401","doi":"https://doi.org/10.1081/hem-120016372","mag":"1991908401","pmid":"https://pubmed.ncbi.nlm.nih.gov/12484630"},"language":"en","primary_location":{"id":"doi:10.1081/hem-120016372","doi":"https://doi.org/10.1081/hem-120016372","is_oa":false,"landing_page_url":"https://doi.org/10.1081/hem-120016372","pdf_url":null,"source":{"id":"https://openalex.org/S81929299","display_name":"Hemoglobin","issn_l":"0363-0269","issn":["0363-0269","1532-432X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hemoglobin","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090325360","display_name":"Amine Zora\u00ef","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142087","display_name":"Institut Pasteur de Tunis","ror":"https://ror.org/04pwyer06","country_code":"TN","type":"facility","lineage":["https://openalex.org/I4210142087"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Amine Zorai","raw_affiliation_strings":["Hemoglobinopathies Group, Laboratory of Hematology, Pasteur Institute of Tunis, 1002 Tunis le Belvedere, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hemoglobinopathies Group, Laboratory of Hematology, Pasteur Institute of Tunis, 1002 Tunis le Belvedere, Tunisia","institution_ids":["https://openalex.org/I4210142087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018066889","display_name":"Cornelis L. Harteveld","orcid":"https://orcid.org/0000-0002-5135-6491","observed_orcids":["https://orcid.org/0000-0002-5135-6491"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Cornelis L. Harteveld","raw_affiliation_strings":["Hemoglobinopathies Laboratory, Department of Human and Clinical Genetics, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL LeidenThe Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hemoglobinopathies Laboratory, Department of Human and Clinical Genetics, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL LeidenThe Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033461536","display_name":"Achech Bakir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142087","display_name":"Institut Pasteur de Tunis","ror":"https://ror.org/04pwyer06","country_code":"TN","type":"facility","lineage":["https://openalex.org/I4210142087"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Achech Bakir","raw_affiliation_strings":["Hemoglobinopathies Group, Laboratory of Hematology, Pasteur Institute of Tunis, 1002 Tunis le BelvedereTunisia; Obstetrical Gynecology Service, H\u00f4pital de Tunis, 1002 TunisTunisia","Hemoglobinopathies Group, Laboratory of Hematology, Pasteur Institute of Tunis, 1002 Tunis le BelvedereTunisia","Obstetrical Gynecology Service, H\u00f4pital de Tunis, 1002 TunisTunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hemoglobinopathies Group, Laboratory of Hematology, Pasteur Institute of Tunis, 1002 Tunis le BelvedereTunisia; Obstetrical Gynecology Service, H\u00f4pital de Tunis, 1002 TunisTunisia","institution_ids":["https://openalex.org/I4210142087"]},{"raw_affiliation_string":"Hemoglobinopathies Group, Laboratory of Hematology, Pasteur Institute of Tunis, 1002 Tunis le BelvedereTunisia","institution_ids":["https://openalex.org/I4210142087"]},{"raw_affiliation_string":"Obstetrical Gynecology Service, H\u00f4pital de Tunis, 1002 TunisTunisia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049455365","display_name":"Peter van Delft","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Peter Van Delft","raw_affiliation_strings":["Hemoglobinopathies Laboratory, Department of Human and Clinical Genetics, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL LeidenThe Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hemoglobinopathies Laboratory, Department of Human and Clinical Genetics, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL LeidenThe Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049184963","display_name":"Abdelaziz Falfoul","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abdelaziz Falfoul","raw_affiliation_strings":["Obstetrical Gynecology Service, CHU Maamouri, 8000 NabeulTunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Obstetrical Gynecology Service, CHU Maamouri, 8000 NabeulTunisia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035971626","display_name":"Koussay Dellagi","orcid":"https://orcid.org/0000-0001-7920-7490","observed_orcids":["https://orcid.org/0000-0001-7920-7490"]},"institutions":[{"id":"https://openalex.org/I4210142087","display_name":"Institut Pasteur de Tunis","ror":"https://ror.org/04pwyer06","country_code":"TN","type":"facility","lineage":["https://openalex.org/I4210142087"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Koussay Dellagi","raw_affiliation_strings":["Hemoglobinopathies Group, Laboratory of Hematology, Pasteur Institute of Tunis, 1002 Tunis le BelvedereTunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hemoglobinopathies Group, Laboratory of Hematology, Pasteur Institute of Tunis, 1002 Tunis le BelvedereTunisia","institution_ids":["https://openalex.org/I4210142087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088368718","display_name":"Salem Abb\u00e8s","orcid":"https://orcid.org/0000-0002-0863-0491","observed_orcids":["https://orcid.org/0000-0002-0863-0491"]},"institutions":[{"id":"https://openalex.org/I4210142087","display_name":"Institut Pasteur de Tunis","ror":"https://ror.org/04pwyer06","country_code":"TN","type":"facility","lineage":["https://openalex.org/I4210142087"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Salem Abbes","raw_affiliation_strings":["Hemoglobinopathies Group, Laboratory of Hematology, Pasteur Institute of Tunis, 1002 Tunis le BelvedereTunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hemoglobinopathies Group, Laboratory of Hematology, Pasteur Institute of Tunis, 1002 Tunis le BelvedereTunisia","institution_ids":["https://openalex.org/I4210142087"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103565140","display_name":"Piero C. Giordano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Piero C. Giordano","raw_affiliation_strings":["Hemoglobinopathies Laboratory, Department of Human and Clinical Genetics, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL LeidenThe Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hemoglobinopathies Laboratory, Department of Human and Clinical Genetics, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL LeidenThe Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8455,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.70018709,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"26","issue":"4","first_page":"353","last_page":"362"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-thalassemia","display_name":"alpha-thalassemia","score":0.9890000224113464},{"id":"https://openalex.org/keywords/molecular-spectra","display_name":"molecular spectra","score":0.906000018119812},{"id":"https://openalex.org/keywords/tunisia","display_name":"Tunisia","score":0.43799999356269836},{"id":"https://openalex.org/keywords/hb-bart-s","display_name":"Hb Bart's","score":0.6869999766349792},{"id":"https://openalex.org/keywords/hb-h-disease","display_name":"Hb H disease","score":0.8379999995231628},{"id":"https://openalex.org/keywords/newborn-screening","display_name":"newborn screening","score":0.6899999976158142},{"id":"https://openalex.org/keywords/umbilical-cord-blood","display_name":"umbilical cord blood","score":0.9340000152587891},{"id":"https://openalex.org/keywords/5-utr-polymorphism","display_name":"5'UTR polymorphism","score":0.6990000009536743},{"id":"https://openalex.org/keywords/tunisian-population","display_name":"Tunisian population","score":0.4620000123977661}],"concepts":[{"id":"https://openalex.org/C2781400336","wikidata":"https://www.wikidata.org/wiki/Q1091552","display_name":"Microcytosis","level":4,"score":0.8722864389419556},{"id":"https://openalex.org/C37463918","wikidata":"https://www.wikidata.org/wiki/Q387981","display_name":"Allele frequency","level":4,"score":0.5980368852615356},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.565079391002655},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5617696642875671},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46538084745407104},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.44393375515937805},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32795095443725586},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23852577805519104},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23225760459899902},{"id":"https://openalex.org/C2777417653","wikidata":"https://www.wikidata.org/wiki/Q1313081","display_name":"Iron deficiency","level":3,"score":0.1096925139427185},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10057669878005981},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.07627519965171814},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004909","descriptor_name":"Erythrocyte Indices","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004913","descriptor_name":"Erythrocytes, Abnormal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004913","descriptor_name":"Erythrocytes, Abnormal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005312","descriptor_name":"Fetal Blood","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006455","descriptor_name":"Hemoglobins, Abnormal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006580","descriptor_name":"Genetic Carrier Screening","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014416","descriptor_name":"Tunisia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015997","descriptor_name":"Neonatal Screening","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017085","descriptor_name":"alpha-Thalassemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017085","descriptor_name":"alpha-Thalassemia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D017085","descriptor_name":"alpha-Thalassemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017085","descriptor_name":"alpha-Thalassemia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1081/hem-120016372","doi":"https://doi.org/10.1081/hem-120016372","is_oa":false,"landing_page_url":"https://doi.org/10.1081/hem-120016372","pdf_url":null,"source":{"id":"https://openalex.org/S81929299","display_name":"Hemoglobin","issn_l":"0363-0269","issn":["0363-0269","1532-432X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hemoglobin","raw_type":"journal-article"},{"id":"pmid:12484630","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12484630","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hemoglobin","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:pasteur-02037773v1","doi":null,"is_oa":false,"landing_page_url":"https://riip.hal.science/pasteur-02037773","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hemoglobin, 2009, 26 (4), pp.353-362. ⟨10.1081/HEM-120016372⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W59262730","https://openalex.org/W147021489","https://openalex.org/W201598703","https://openalex.org/W1585156201","https://openalex.org/W1963642464","https://openalex.org/W1976927195","https://openalex.org/W1984774134","https://openalex.org/W1985193818","https://openalex.org/W2006986726","https://openalex.org/W2011943774","https://openalex.org/W2018205338","https://openalex.org/W2018825702","https://openalex.org/W2019158560","https://openalex.org/W2040307394","https://openalex.org/W2041591811","https://openalex.org/W2054595120","https://openalex.org/W2068094532","https://openalex.org/W2072272460","https://openalex.org/W2072740900","https://openalex.org/W2075054758","https://openalex.org/W2083048402","https://openalex.org/W2087542095","https://openalex.org/W2140556388","https://openalex.org/W2158619082","https://openalex.org/W2266088244","https://openalex.org/W2413692181","https://openalex.org/W2954076048"],"related_works":["https://openalex.org/W2117132508","https://openalex.org/W1965780912","https://openalex.org/W2101116005","https://openalex.org/W3201470423","https://openalex.org/W1998155263","https://openalex.org/W2094527610","https://openalex.org/W2165455875","https://openalex.org/W2031106110","https://openalex.org/W2367895092","https://openalex.org/W2921025132"],"abstract_inverted_index":{"We":[0],"present":[1],"the":[2,5,21,31,46,49,62,67,72,97,104,125,130,137,141,157,163,188,193,197,205,211,220,225,229,233,237,245,253,259],"characterization":[3],"of":[4,11,20,25,33,48,66,132,185,224,236,244],"molecular":[6],"spectrum":[7],"and":[8,17,23,60,119,135,162,175,228],"frequency":[9,184,201],"data":[10],"alpha-thal":[12,34,117,199],"(thal)":[13],"defects":[14,118],"in":[15,187,204,210,219,232,242],"Tunisia,":[16],"an":[18,51,182],"evaluation":[19],"efficacy":[22],"limitations":[24],"Hb":[26,54,78,133],"Bart's":[27,79,134],"(gamma4)":[28],"measurement":[29],"for":[30,129],"screening":[32],"at":[35,82,172,177,258],"birth.":[36],"Cord":[37],"blood":[38,255],"samples":[39,76,256],"were":[40,84,111,122,240,250],"collected":[41,89,112],"from":[42,86,96,106],"two":[43],"different":[44],"areas:":[45],"northeast":[47,206],"country,":[50],"area":[52],"where":[53],"H":[55],"(beta4)":[56],"disease":[57],"frequently":[58],"occurs,":[59],"Tunis,":[61],"capital":[63],"city,":[64],"representative":[65],"average":[68,212],"Tunisian":[69,213],"population.":[70,214],"From":[71],"first":[73],"group,":[74],"110":[75],"with":[77,181],"and/or":[80],"microcytosis":[81],"birth":[83],"selected":[85,128,189],"1270":[87],"randomly":[88],"samples.":[90,191],"Two":[91],"additional":[92],"population":[93,195],"samples,":[94,127,196],"one":[95],"same":[98,238],"northeastern":[99,126,190],"region":[100],"(n":[101,108],"=":[102,109],"90),":[103],"other":[105],"Tunis":[107],"104)":[110],"randomly.":[113],"Nine":[114],"common":[115,143],"deletional":[116],"nondeletional":[120],"mutations":[121],"screened.":[123],"In":[124,192],"presence":[131],"microcytosis,":[136],"-alpha3.7":[138],"deletion":[139,161,165],"was":[140,179,202],"most":[142],"defect":[144],"(4.5%":[145],"allele":[146,183,200],"frequency)":[147],"followed":[148],"by":[149],"a":[150],"polyadenylation":[151],"(poly":[152],"A)":[153],"signal":[154],"mutation":[155],"(1.8%),":[156],"five":[158],"nucleotide":[159],"(nt)":[160],"-alpha4.2":[164],"(both":[166],"0.9%).":[167],"The":[168,215],"African":[169,230],"polymorphism":[170,218,231],"(G-->TCGGCCC":[171],"position":[173],"7238":[174],"T-->G":[176],"7174)":[178],"found":[180,241,251],"11%":[186],"random":[194],"overall":[198],"4%":[203],"region,":[207],"against":[208],"2%":[209],"+14":[216],"(G-->C)":[217],"5'UTR":[221],"(untranslated":[222],"region)":[223],"alpha2":[226],"gene":[227],"second":[234],"intron":[235],"gene,":[239],"3.5%":[243],"alleles.":[246],"No":[247],"alpha0-thal":[248],"alleles":[249],"among":[252],"304":[254],"studied":[257],"DNA":[260],"level":[261],"during":[262],"this":[263],"survey.":[264]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}