{"id":"https://openalex.org/W1991908200","doi":"https://doi.org/10.1158/0008-5472.can-08-0232","title":"A Novel Bispecific, Trivalent Antibody Construct for Targeting Pancreatic Carcinoma","display_name":"A Novel Bispecific, Trivalent Antibody Construct for Targeting Pancreatic Carcinoma","publication_year":2008,"publication_date":"2008-06-15","ids":{"openalex":"https://openalex.org/W1991908200","doi":"https://doi.org/10.1158/0008-5472.can-08-0232","mag":"1991908200","pmid":"https://pubmed.ncbi.nlm.nih.gov/18559529"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-08-0232","doi":"https://doi.org/10.1158/0008-5472.can-08-0232","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-08-0232","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108410851","display_name":"David V. Gold","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131484","display_name":"Center for Molecular Medicine and Immunology","ror":"https://ror.org/03fhjvs31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210131484"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David V. Gold","raw_affiliation_strings":["1Garden State Cancer Center, Center for Molecular Medicine and Immunology, Belleville, New Jersey;","Garden State Cancer Center, Center for Molecular Medicine and Immunology, Belleville, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Garden State Cancer Center, Center for Molecular Medicine and Immunology, Belleville, New Jersey;","institution_ids":["https://openalex.org/I4210131484"]},{"raw_affiliation_string":"Garden State Cancer Center, Center for Molecular Medicine and Immunology, Belleville, New Jersey, USA","institution_ids":["https://openalex.org/I4210131484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003890903","display_name":"David M. Goldenberg","orcid":"https://orcid.org/0000-0001-5539-421X","observed_orcids":["https://orcid.org/0000-0001-5539-421X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I4210131484","display_name":"Center for Molecular Medicine and Immunology","ror":"https://ror.org/03fhjvs31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210131484"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Goldenberg","raw_affiliation_strings":["1Garden State Cancer Center, Center for Molecular Medicine and Immunology, Belleville, New Jersey;","University of Rochester Medical Center, Rochester, NY, University of Texas M. D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Garden State Cancer Center, Center for Molecular Medicine and Immunology, Belleville, New Jersey;","institution_ids":["https://openalex.org/I4210131484"]},{"raw_affiliation_string":"University of Rochester Medical Center, Rochester, NY, University of Texas M. D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I28792581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045775470","display_name":"Habibe Karacay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I4210131484","display_name":"Center for Molecular Medicine and Immunology","ror":"https://ror.org/03fhjvs31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210131484"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Habibe Karacay","raw_affiliation_strings":["1Garden State Cancer Center, Center for Molecular Medicine and Immunology, Belleville, New Jersey;","University of Rochester Medical Center, Rochester, NY, University of Texas M. D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Garden State Cancer Center, Center for Molecular Medicine and Immunology, Belleville, New Jersey;","institution_ids":["https://openalex.org/I4210131484"]},{"raw_affiliation_string":"University of Rochester Medical Center, Rochester, NY, University of Texas M. D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I28792581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110966471","display_name":"Edmund A. Rossi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I4210156640","display_name":"IBC Pharmaceuticals (India)","ror":"https://ror.org/0558bev76","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210156640"]}],"countries":["IN","US"],"is_corresponding":false,"raw_author_name":"Edmund A. Rossi","raw_affiliation_strings":["2IBC Pharmaceuticals, Inc.; and","University of Rochester Medical Center, Rochester, NY, University of Texas M. D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2IBC Pharmaceuticals, Inc.; and","institution_ids":["https://openalex.org/I4210156640"]},{"raw_affiliation_string":"University of Rochester Medical Center, Rochester, NY, University of Texas M. D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I28792581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109346302","display_name":"Chien\u2010Hsing Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I4210126919","display_name":"Immunomedics (United States)","ror":"https://ror.org/02pf50490","country_code":"US","type":"company","lineage":["https://openalex.org/I4210126919"]},{"id":"https://openalex.org/I4210156640","display_name":"IBC Pharmaceuticals (India)","ror":"https://ror.org/0558bev76","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210156640"]}],"countries":["IN","US"],"is_corresponding":false,"raw_author_name":"Chien-Hsing Chang","raw_affiliation_strings":["2IBC Pharmaceuticals, Inc.; and","3Immunomedics, Inc., Morris Plains, New Jersey","University of Rochester Medical Center, Rochester, NY, University of Texas M. D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2IBC Pharmaceuticals, Inc.; and","institution_ids":["https://openalex.org/I4210156640"]},{"raw_affiliation_string":"3Immunomedics, Inc., Morris Plains, New Jersey","institution_ids":["https://openalex.org/I4210126919"]},{"raw_affiliation_string":"University of Rochester Medical Center, Rochester, NY, University of Texas M. D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I28792581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018738015","display_name":"Thomas M. Cardillo","orcid":"https://orcid.org/0000-0002-9427-8358","observed_orcids":["https://orcid.org/0000-0002-9427-8358"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I4210126919","display_name":"Immunomedics (United States)","ror":"https://ror.org/02pf50490","country_code":"US","type":"company","lineage":["https://openalex.org/I4210126919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas M. Cardillo","raw_affiliation_strings":["3Immunomedics, Inc., Morris Plains, New Jersey","University of Rochester Medical Center, Rochester, NY, University of Texas M. D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Immunomedics, Inc., Morris Plains, New Jersey","institution_ids":["https://openalex.org/I4210126919"]},{"raw_affiliation_string":"University of Rochester Medical Center, Rochester, NY, University of Texas M. D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I28792581"]}]},{"author_position":"middle","author":{"id":null,"display_name":"William J. McBride","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I4210126919","display_name":"Immunomedics (United States)","ror":"https://ror.org/02pf50490","country_code":"US","type":"company","lineage":["https://openalex.org/I4210126919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William J. McBride","raw_affiliation_strings":["3Immunomedics, Inc., Morris Plains, New Jersey","University of Rochester Medical Center, Rochester, NY, University of Texas M. D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Immunomedics, Inc., Morris Plains, New Jersey","institution_ids":["https://openalex.org/I4210126919"]},{"raw_affiliation_string":"University of Rochester Medical Center, Rochester, NY, University of Texas M. D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I28792581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043569662","display_name":"Robert M. Sharkey","orcid":"https://orcid.org/0000-0003-1408-0905","observed_orcids":["https://orcid.org/0000-0003-1408-0905"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I4210131484","display_name":"Center for Molecular Medicine and Immunology","ror":"https://ror.org/03fhjvs31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210131484"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M. Sharkey","raw_affiliation_strings":["1Garden State Cancer Center, Center for Molecular Medicine and Immunology, Belleville, New Jersey;","University of Rochester Medical Center, Rochester, NY, University of Texas M. D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Garden State Cancer Center, Center for Molecular Medicine and Immunology, Belleville, New Jersey;","institution_ids":["https://openalex.org/I4210131484"]},{"raw_affiliation_string":"University of Rochester Medical Center, Rochester, NY, University of Texas M. D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I28792581"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.167,"has_fulltext":false,"cited_by_count":72,"citation_normalized_percentile":{"value":0.97128272,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"68","issue":"12","first_page":"4819","last_page":"4826"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bispecific-antibodies","display_name":"bispecific antibodies","score":0.8370000123977661},{"id":"https://openalex.org/keywords/pam-4","display_name":"PAM-4","score":0.8259999752044678},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.8069999814033508},{"id":"https://openalex.org/keywords/pretargeting","display_name":"pretargeting","score":0.906000018119812},{"id":"https://openalex.org/keywords/radiolabeled-peptides","display_name":"radiolabeled peptides","score":0.5960000157356262},{"id":"https://openalex.org/keywords/111in","display_name":"indium-111","score":0.8100000023841858},{"id":"https://openalex.org/keywords/yttrium-90","display_name":"yttrium-90","score":0.9570000171661377},{"id":"https://openalex.org/keywords/radioimmunotherapy","display_name":"radioimmunotherapy","score":0.7820000052452087},{"id":"https://openalex.org/keywords/radionuclide-imaging","display_name":"scintigraphy","score":0.7590000033378601},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.9110000133514404},{"id":"https://openalex.org/keywords/tumor-uptake","display_name":"tumor uptake","score":0.5870000123977661},{"id":"https://openalex.org/keywords/humanized-antibody","display_name":"humanized monoclonal antibody","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C2777836882","wikidata":"https://www.wikidata.org/wiki/Q22907915","display_name":"Pretargeting","level":5,"score":0.962307333946228},{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.7351201772689819},{"id":"https://openalex.org/C2776146153","wikidata":"https://www.wikidata.org/wiki/Q7281276","display_name":"Radioimmunotherapy","level":4,"score":0.6905595064163208},{"id":"https://openalex.org/C3020495827","wikidata":"https://www.wikidata.org/wiki/Q426141","display_name":"Bispecific antibody","level":4,"score":0.5341431498527527},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5269445180892944},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5265398621559143},{"id":"https://openalex.org/C2779931791","wikidata":"https://www.wikidata.org/wiki/Q161515","display_name":"DOTA","level":3,"score":0.48704054951667786},{"id":"https://openalex.org/C29144244","wikidata":"https://www.wikidata.org/wiki/Q506441","display_name":"Hapten","level":3,"score":0.4661750793457031},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44863361120224},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.44118648767471313},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4308408498764038},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.41475623846054077},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38834184408187866},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2816675901412964},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24010860919952393},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2358485460281372},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11623865365982056},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07708072662353516},{"id":"https://openalex.org/C197404232","wikidata":"https://www.wikidata.org/wiki/Q319827","display_name":"Chelation","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002272","descriptor_name":"Carcinoembryonic Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006241","descriptor_name":"Haptens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007205","descriptor_name":"Indium Radioisotopes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016499","descriptor_name":"Radioimmunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018033","descriptor_name":"Antibodies, Bispecific","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D018033","descriptor_name":"Antibodies, Bispecific","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.can-08-0232","doi":"https://doi.org/10.1158/0008-5472.can-08-0232","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-08-0232","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:18559529","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18559529","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1831473154","display_name":"Bispecific Antibody Pretargeted Therapy of Pancreatic Cancer","funder_award_id":"R01CA115755","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1987875679","display_name":null,"funder_award_id":"CA096924","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4773058374","display_name":null,"funder_award_id":"CA115755","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1543479634","https://openalex.org/W1657493296","https://openalex.org/W1975433606","https://openalex.org/W1982492189","https://openalex.org/W1986652053","https://openalex.org/W1987890709","https://openalex.org/W2002815766","https://openalex.org/W2003393676","https://openalex.org/W2003919433","https://openalex.org/W2014767306","https://openalex.org/W2016750769","https://openalex.org/W2021396643","https://openalex.org/W2023408096","https://openalex.org/W2032076922","https://openalex.org/W2037803066","https://openalex.org/W2041046058","https://openalex.org/W2044958968","https://openalex.org/W2051057004","https://openalex.org/W2054081701","https://openalex.org/W2056322315","https://openalex.org/W2098070203","https://openalex.org/W2112893695","https://openalex.org/W2115073791","https://openalex.org/W2115762559","https://openalex.org/W2128110805","https://openalex.org/W2128882353","https://openalex.org/W2130725852","https://openalex.org/W2133255804","https://openalex.org/W2148341111","https://openalex.org/W2151119213","https://openalex.org/W2153706622","https://openalex.org/W2159435688","https://openalex.org/W2165418706","https://openalex.org/W2171652281","https://openalex.org/W2185524839","https://openalex.org/W2293039128","https://openalex.org/W3010583873","https://openalex.org/W3188866652"],"related_works":["https://openalex.org/W2241006746","https://openalex.org/W2133255804","https://openalex.org/W2268900098","https://openalex.org/W2134736445","https://openalex.org/W1543566929","https://openalex.org/W2401018260","https://openalex.org/W34397475","https://openalex.org/W2135136599","https://openalex.org/W50488002","https://openalex.org/W1988890935"],"abstract_inverted_index":{"Preclinical":[0],"and":[1,14,43,54,65,153,254],"clinical":[2],"studies":[3,64],"have":[4,20],"demonstrated":[5],"the":[6,23,60,69,91,126,129,151,170,175,203,240],"application":[7],"of":[8,16,25,68,128,143,156,174,256],"radiolabeled":[9,38,70,144,263],"mAb-PAM4":[10,53],"for":[11,40,52,56,184,202,250],"nuclear":[12,66],"imaging":[13,42,67,146,249],"radioimmunotherapy":[15],"pancreatic":[17,84,257],"carcinoma.":[18],"We":[19],"now":[21],"examined":[22],"ability":[24],"a":[26,37,47,233],"novel":[27],"PAM4-based,":[28],"bispecific":[29,49],"monoclonal":[30],"antibody":[31],"(mAb)":[32],"construct,":[33],"TF10,":[34],"to":[35,96],"pretarget":[36],"peptide":[39],"improved":[41,248],"therapy.":[44],"TF10":[45,71,244],"is":[46],"humanized,":[48],"mAb,":[50],"divalent":[51],"monovalent":[55],"mAb-679,":[57],"reactive":[58],"against":[59],"histamine-succinyl-glycine":[61],"hapten.":[62],"Biodistribution":[63],"and/or":[72],"TF10-pretargeted":[73,176],"hapten-peptide":[74],"(IMP-288)":[75],"were":[76,199],"conducted":[77],"in":[78,120,158,166],"nude":[79],"mice":[80],"bearing":[81],"CaPan1":[82],"human":[83],"cancer":[85,258],"xenografts.":[86],"(125)I-TF10":[87],"cleared":[88],"rapidly":[89],"from":[90],"blood,":[92],"with":[93,117,213,261],"levels":[94],"decreasing":[95],"<1%":[97],"injected":[98],"dose":[99,225],"per":[100],"gram":[101],"(ID/g)":[102],"by":[103],"16":[104,135,195],"hours.":[105,196],"Tumor":[106,172],"uptake":[107,149,173],"was":[108,133,164,178,188],"3.47":[109],"+/-":[110,180,191],"0.66%":[111],"ID/g":[112,193],"at":[113,194,209,218],"this":[114],"time":[115],"point":[116],"no":[118,154],"accumulation":[119],"any":[121,159],"normal":[122,160],"tissue.":[123,161],"To":[124],"show":[125],"utility":[127],"pretargeting":[130,204,230,245],"approach,":[131],"(111)In-IMP-288":[132,177,185],"administered":[134],"hours":[136,141],"after":[137],"TF10.":[138],"At":[139],"3":[140,210],"postadministration":[142],"peptide,":[145],"showed":[147],"intense":[148],"within":[150],"tumors":[152],"evidence":[155],"accretion":[157],"No":[162],"targeting":[163],"observed":[165],"animals":[167],"given":[168],"only":[169,189],"(111)In-peptide.":[171],"24.3":[179],"1.7%":[181],"ID/g,":[182],"whereas":[183],"alone":[186],"it":[187],"0.12":[190],"0.002%":[192],"Tumor/blood":[197],"ratios":[198],"significantly":[200],"greater":[201,234],"group":[205],"(":[206,215],"approximately":[207,216],"1,000:1":[208],"hours)":[211],"compared":[212,260],"(111)In-PAM4-IgG":[214],"5:1":[217],"24":[219],"hours;":[220],"P":[221],"<":[222],"0.0003).":[223],"Radiation":[224],"estimates":[226],"suggested":[227],"that":[228,243],"TF10/(90)Y-peptide":[229],"would":[231],"provide":[232,247],"antitumor":[235],"effect":[236],"than":[237],"(90)Y-PAM4-IgG.":[238],"Thus,":[239],"results":[241],"suggest":[242],"may":[246],"early":[251],"detection,":[252],"diagnosis,":[253],"treatment":[255],"as":[259],"directly":[262],"PAM4-IgG.":[264]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":11}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}