{"id":"https://openalex.org/W1991893802","doi":"https://doi.org/10.1016/j.bbrc.2010.01.026","title":"Suppression of thioredoxin-1 induces premature senescence in normal human fibroblasts","display_name":"Suppression of thioredoxin-1 induces premature senescence in normal human fibroblasts","publication_year":2010,"publication_date":"2010-01-15","ids":{"openalex":"https://openalex.org/W1991893802","doi":"https://doi.org/10.1016/j.bbrc.2010.01.026","mag":"1991893802","pmid":"https://pubmed.ncbi.nlm.nih.gov/20074557"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbrc.2010.01.026","doi":"https://doi.org/10.1016/j.bbrc.2010.01.026","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2010.01.026","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101491506","display_name":"Jennifer J. Young","orcid":"https://orcid.org/0000-0002-3265-9112","observed_orcids":["https://orcid.org/0000-0002-3265-9112"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer J. Young","raw_affiliation_strings":["Biology Department, Massachusetts Institute of Technology, Cambridge, MA 02139, USA","Biology Department, Massachusetts Institute of Technology, Cambridge, MA 02139, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department, Massachusetts Institute of Technology, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Biology Department, Massachusetts Institute of Technology, Cambridge, MA 02139, United States","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082364020","display_name":"Asmita Patel","orcid":"https://orcid.org/0000-0002-4255-711X","observed_orcids":["https://orcid.org/0000-0002-4255-711X"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Asmita Patel","raw_affiliation_strings":["Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Miami, Miami, FL 33136, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Miami, Miami, FL 33136, United States","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030836964","display_name":"Priyamvada Rai","orcid":"https://orcid.org/0000-0001-7822-7553","observed_orcids":["https://orcid.org/0000-0001-7822-7553"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Priyamvada Rai","raw_affiliation_strings":["Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Miami, Miami, FL 33136, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Miami, Miami, FL 33136, United States","institution_ids":["https://openalex.org/I145608581"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5030836964"],"corresponding_institution_ids":["https://openalex.org/I145608581"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":1.9474,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.84257941,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"392","issue":"3","first_page":"363","last_page":"368"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.6474999785423279,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.6474999785423279,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.2953999936580658,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.04639999940991402,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thioredoxin-1","display_name":"thioredoxin-1","score":1.0},{"id":"https://openalex.org/keywords/premature-senescence","display_name":"premature senescence","score":0.9179999828338623},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9829999804496765},{"id":"https://openalex.org/keywords/dermal-fibroblasts","display_name":"dermal fibroblasts","score":0.8709999918937683},{"id":"https://openalex.org/keywords/p53-p21-pathway","display_name":"p53/p21 pathway","score":0.9039999842643738},{"id":"https://openalex.org/keywords/p16ink4a","display_name":"p16INK4a","score":0.9539999961853027},{"id":"https://openalex.org/keywords/sv40-large-t-antigen","display_name":"SV40 large T antigen","score":0.9409999847412109},{"id":"https://openalex.org/keywords/redox-homeostasis","display_name":"redox homeostasis","score":0.9399999976158142},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.625},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.765999972820282},{"id":"https://openalex.org/keywords/shrna-knockdown","display_name":"shRNA knockdown","score":0.7990000247955322}],"concepts":[{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.6386946439743042},{"id":"https://openalex.org/C3623737","wikidata":"https://www.wikidata.org/wiki/Q421219","display_name":"Thioredoxin","level":3,"score":0.5664495229721069},{"id":"https://openalex.org/C2909947164","wikidata":"https://www.wikidata.org/wiki/Q6139748","display_name":"Premature aging","level":2,"score":0.5076621770858765},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47161322832107544},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45036929845809937},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.337868869304657},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3179302513599396},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.302461713552475},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2385881543159485},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.19086110591888428}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013879","descriptor_name":"Thioredoxins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013879","descriptor_name":"Thioredoxins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015595","descriptor_name":"Skin Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbrc.2010.01.026","doi":"https://doi.org/10.1016/j.bbrc.2010.01.026","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2010.01.026","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:20074557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20074557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320318541","display_name":"Sylvester Comprehensive Cancer Center, University of Miami Health Systems","ror":"https://ror.org/0552r4b12"},{"id":"https://openalex.org/F4320334047","display_name":"Geriatric Research Education and Clinical Center","ror":"https://ror.org/01nh3sx96"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1545398558","https://openalex.org/W1809723326","https://openalex.org/W1951314249","https://openalex.org/W1965048434","https://openalex.org/W1970438992","https://openalex.org/W1971076522","https://openalex.org/W1977046275","https://openalex.org/W1977706961","https://openalex.org/W1978775178","https://openalex.org/W1980911765","https://openalex.org/W1990801507","https://openalex.org/W1992049458","https://openalex.org/W1998104906","https://openalex.org/W1998356787","https://openalex.org/W2002022907","https://openalex.org/W2027345413","https://openalex.org/W2027443731","https://openalex.org/W2028802443","https://openalex.org/W2032297850","https://openalex.org/W2034269086","https://openalex.org/W2036676765","https://openalex.org/W2036756042","https://openalex.org/W2037915406","https://openalex.org/W2041866985","https://openalex.org/W2042000503","https://openalex.org/W2045409933","https://openalex.org/W2047446944","https://openalex.org/W2051146905","https://openalex.org/W2059775504","https://openalex.org/W2059974240","https://openalex.org/W2075808770","https://openalex.org/W2083326631","https://openalex.org/W2085200149","https://openalex.org/W2085742094","https://openalex.org/W2088566849","https://openalex.org/W2091865841","https://openalex.org/W2103650142","https://openalex.org/W2104908670","https://openalex.org/W2112655328","https://openalex.org/W2115235864","https://openalex.org/W2126055383","https://openalex.org/W2130191536","https://openalex.org/W2146576618","https://openalex.org/W3025746616"],"related_works":["https://openalex.org/W2126055383","https://openalex.org/W4390988774","https://openalex.org/W2346843548","https://openalex.org/W1964351662","https://openalex.org/W2129326379","https://openalex.org/W2062595647","https://openalex.org/W2808561350","https://openalex.org/W2622643738","https://openalex.org/W2966030695","https://openalex.org/W2051158533"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}