{"id":"https://openalex.org/W1991867211","doi":"https://doi.org/10.1016/j.bone.2007.12.129","title":"Structure activity relationships of nitrogen containing bisphosphonates which induce conformational changes in farnesyl pyrophosphate synthase","display_name":"Structure activity relationships of nitrogen containing bisphosphonates which induce conformational changes in farnesyl pyrophosphate synthase","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W1991867211","doi":"https://doi.org/10.1016/j.bone.2007.12.129","mag":"1991867211"},"language":"en","primary_location":{"id":"doi:10.1016/j.bone.2007.12.129","doi":"https://doi.org/10.1016/j.bone.2007.12.129","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bone.2007.12.129","pdf_url":null,"source":{"id":"https://openalex.org/S121725775","display_name":"Bone","issn_l":"1873-2763","issn":["1873-2763","8756-3282"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012817393","display_name":"James E. Dunford","orcid":"https://orcid.org/0000-0002-9932-4042","observed_orcids":["https://orcid.org/0000-0002-9932-4042"]},"institutions":[{"id":"https://openalex.org/I2801809904","display_name":"Nuffield Orthopaedic Centre","ror":"https://ror.org/0036ate90","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801809904","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James E. Dunford","raw_affiliation_strings":["Nuffield Department of Orthopaedic Surgery, The Botnar Research Centre, Oxford University, Nuffield Orthopaedic Centre, Headington, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Orthopaedic Surgery, The Botnar Research Centre, Oxford University, Nuffield Orthopaedic Centre, Headington, Oxford, United Kingdom","institution_ids":["https://openalex.org/I2801809904","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060273712","display_name":"Aaron A. A. Kwaasi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801809904","display_name":"Nuffield Orthopaedic Centre","ror":"https://ror.org/0036ate90","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801809904","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Aaron A. Kwaasi","raw_affiliation_strings":["Nuffield Department of Orthopaedic Surgery, The Botnar Research Centre, Oxford University, Nuffield Orthopaedic Centre, Headington, Oxford, United Kingdom","Structural Genomics Consortium, The Botnar Research Centre, Oxford University, Nuffield Orthopaedic Centre, Headington, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Orthopaedic Surgery, The Botnar Research Centre, Oxford University, Nuffield Orthopaedic Centre, Headington, Oxford, United Kingdom","institution_ids":["https://openalex.org/I2801809904","https://openalex.org/I40120149"]},{"raw_affiliation_string":"Structural Genomics Consortium, The Botnar Research Centre, Oxford University, Nuffield Orthopaedic Centre, Headington, Oxford, United Kingdom","institution_ids":["https://openalex.org/I2801809904","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076200465","display_name":"K.L. Kavanagh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801809904","display_name":"Nuffield Orthopaedic Centre","ror":"https://ror.org/0036ate90","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801809904","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kathryn L. Kavanagh","raw_affiliation_strings":["Structural Genomics Consortium, The Botnar Research Centre, Oxford University, Nuffield Orthopaedic Centre, Headington, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Genomics Consortium, The Botnar Research Centre, Oxford University, Nuffield Orthopaedic Centre, Headington, Oxford, United Kingdom","institution_ids":["https://openalex.org/I2801809904","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081312172","display_name":"Michael J. Rogers","orcid":"https://orcid.org/0000-0002-1818-9249","observed_orcids":["https://orcid.org/0000-0002-1818-9249"]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael J. Rogers","raw_affiliation_strings":["Bone & Musculoskeletal Research Program, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone & Musculoskeletal Research Program, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom","institution_ids":["https://openalex.org/I195460627"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030288845","display_name":"Udo C. T. Oppermann","orcid":"https://orcid.org/0000-0001-9984-5342","observed_orcids":["https://orcid.org/0000-0001-9984-5342"]},"institutions":[{"id":"https://openalex.org/I2801809904","display_name":"Nuffield Orthopaedic Centre","ror":"https://ror.org/0036ate90","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801809904","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Udo Oppermann","raw_affiliation_strings":["Structural Genomics Consortium, The Botnar Research Centre, Oxford University, Nuffield Orthopaedic Centre, Headington, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Genomics Consortium, The Botnar Research Centre, Oxford University, Nuffield Orthopaedic Centre, Headington, Oxford, United Kingdom","institution_ids":["https://openalex.org/I2801809904","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111593743","display_name":"B Barnett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bobby B. Barnett","raw_affiliation_strings":["Department of Chemistry, University of Cincinnati, Cincinnati, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Cincinnati, Cincinnati, USA","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070859925","display_name":"Frank H. Ebetino","orcid":"https://orcid.org/0000-0002-9133-1360","observed_orcids":["https://orcid.org/0000-0002-9133-1360"]},"institutions":[{"id":"https://openalex.org/I74680897","display_name":"Procter & Gamble (United States)","ror":"https://ror.org/04dkns738","country_code":"US","type":"company","lineage":["https://openalex.org/I74680897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank H. Ebetino","raw_affiliation_strings":["Procter & Gamble Pharmaceuticals, Mason, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Procter & Gamble Pharmaceuticals, Mason, USA","institution_ids":["https://openalex.org/I74680897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113647774","display_name":"R. Graham","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Graham","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5068713744","display_name":"R.G.G. Russell","orcid":"https://orcid.org/0000-0002-4136-1828","observed_orcids":["https://orcid.org/0000-0002-4136-1828"]},"institutions":[{"id":"https://openalex.org/I2801809904","display_name":"Nuffield Orthopaedic Centre","ror":"https://ror.org/0036ate90","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801809904","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G. Russell","raw_affiliation_strings":["Nuffield Department of Orthopaedic Surgery, The Botnar Research Centre, Oxford University, Nuffield Orthopaedic Centre, Headington, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Orthopaedic Surgery, The Botnar Research Centre, Oxford University, Nuffield Orthopaedic Centre, Headington, Oxford, United Kingdom","institution_ids":["https://openalex.org/I2801809904","https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3960,"currency":"USD","value_usd":3960},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.1505544,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"42","issue":null,"first_page":"S71","last_page":"S71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.8661999702453613,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.8661999702453613,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.033799998462200165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11748","display_name":"Organophosphorus compounds synthesis","score":0.020800000056624413,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitrogen-containing-bisphosphonates","display_name":"nitrogen-containing bisphosphonates","score":0.8970000147819519},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8489999771118164},{"id":"https://openalex.org/keywords/farnesyl-pyrophosphate-synthase","display_name":"farnesyl diphosphate synthase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/conformational-change","display_name":"conformational change","score":0.7590000033378601},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8289999961853027},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/homocysteine","display_name":"homocysteine","score":0.9739999771118164},{"id":"https://openalex.org/keywords/alu-elements","display_name":"Alu elements","score":0.8690000176429749},{"id":"https://openalex.org/keywords/line-1-elements","display_name":"LINE-1 elements","score":0.7429999709129333},{"id":"https://openalex.org/keywords/repetitive-elements","display_name":"repetitive elements","score":0.7279999852180481}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.8415219187736511},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7218071222305298},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6259031295776367},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6203022599220276},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.509917140007019},{"id":"https://openalex.org/C48931128","wikidata":"https://www.wikidata.org/wiki/Q412199","display_name":"Alu element","level":5,"score":0.4778699278831482},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43542858958244324},{"id":"https://openalex.org/C189235521","wikidata":"https://www.wikidata.org/wiki/Q4087270","display_name":"Bisulfite sequencing","level":5,"score":0.4316260814666748},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33433449268341064},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3263248801231384},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.2125001847743988},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.15728634595870972},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.14987564086914062}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.bone.2007.12.129","doi":"https://doi.org/10.1016/j.bone.2007.12.129","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bone.2007.12.129","pdf_url":null,"source":{"id":"https://openalex.org/S121725775","display_name":"Bone","issn_l":"1873-2763","issn":["1873-2763","8756-3282"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.46000000834465027,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2775911402","https://openalex.org/W2114269452","https://openalex.org/W1989231052","https://openalex.org/W2971842001","https://openalex.org/W2067738146","https://openalex.org/W2051811459","https://openalex.org/W2162833751","https://openalex.org/W2222206590","https://openalex.org/W1998428550","https://openalex.org/W2921772208"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}