{"id":"https://openalex.org/W1991774530","doi":"https://doi.org/10.1016/0003-2697(78)90824-2","title":"Preparation, isolation, analysis, and characterization of 3-benzo[a]pyrenyl-\u03b2-d-glucopyranosiduronic acid: A metabolite of 3-hydroxybenzo[a]pyrene with potentially high carcinogenic activity","display_name":"Preparation, isolation, analysis, and characterization of 3-benzo[a]pyrenyl-\u03b2-d-glucopyranosiduronic acid: A metabolite of 3-hydroxybenzo[a]pyrene with potentially high carcinogenic activity","publication_year":1978,"publication_date":"1978-11-01","ids":{"openalex":"https://openalex.org/W1991774530","doi":"https://doi.org/10.1016/0003-2697(78)90824-2","mag":"1991774530","pmid":"https://pubmed.ncbi.nlm.nih.gov/9762092"},"language":"en","primary_location":{"id":"doi:10.1016/0003-2697(78)90824-2","doi":"https://doi.org/10.1016/0003-2697(78)90824-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0003-2697(78)90824-2","pdf_url":null,"source":{"id":"https://openalex.org/S7858788","display_name":"Analytical Biochemistry","issn_l":"0003-2697","issn":["0003-2697","1096-0309"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091494582","display_name":"David Barrie Johnson","orcid":"https://orcid.org/0000-0001-7348-4016","observed_orcids":["https://orcid.org/0000-0001-7348-4016"]},"institutions":[{"id":"https://openalex.org/I59386820","display_name":"MRIGlobal","ror":"https://ror.org/0320rar10","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I59386820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David B. Johnson","raw_affiliation_strings":["Midwest Research Institute, Kansas City, Missouri 64110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Midwest Research Institute, Kansas City, Missouri 64110, USA","institution_ids":["https://openalex.org/I59386820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063505159","display_name":"James F. Engel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59386820","display_name":"MRIGlobal","ror":"https://ror.org/0320rar10","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I59386820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James F. Engel","raw_affiliation_strings":["Midwest Research Institute 425 Volker Boulevard Kansas City Missouri 64110 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Midwest Research Institute 425 Volker Boulevard Kansas City Missouri 64110 USA","institution_ids":["https://openalex.org/I59386820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113544551","display_name":"Evelyn E. Murrill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59386820","display_name":"MRIGlobal","ror":"https://ror.org/0320rar10","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I59386820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evelyn E. Murrill","raw_affiliation_strings":["Midwest Research Institute 425 Volker Boulevard Kansas City Missouri 64110 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Midwest Research Institute 425 Volker Boulevard Kansas City Missouri 64110 USA","institution_ids":["https://openalex.org/I59386820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083846767","display_name":"Patrick E. Guire","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59386820","display_name":"MRIGlobal","ror":"https://ror.org/0320rar10","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I59386820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick E. Guire","raw_affiliation_strings":["Midwest Research Institute 425 Volker Boulevard Kansas City Missouri 64110 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Midwest Research Institute 425 Volker Boulevard Kansas City Missouri 64110 USA","institution_ids":["https://openalex.org/I59386820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109974660","display_name":"Charles W. Barker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59386820","display_name":"MRIGlobal","ror":"https://ror.org/0320rar10","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I59386820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles W. Barker","raw_affiliation_strings":["Midwest Research Institute 425 Volker Boulevard Kansas City Missouri 64110 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Midwest Research Institute 425 Volker Boulevard Kansas City Missouri 64110 USA","institution_ids":["https://openalex.org/I59386820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082693973","display_name":"Cindy M. Bardwell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59386820","display_name":"MRIGlobal","ror":"https://ror.org/0320rar10","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I59386820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cindy M. Bardwell","raw_affiliation_strings":["Midwest Research Institute 425 Volker Boulevard Kansas City Missouri 64110 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Midwest Research Institute 425 Volker Boulevard Kansas City Missouri 64110 USA","institution_ids":["https://openalex.org/I59386820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057044214","display_name":"Alice Shan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59386820","display_name":"MRIGlobal","ror":"https://ror.org/0320rar10","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I59386820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alice Y. Shan","raw_affiliation_strings":["Midwest Research Institute 425 Volker Boulevard Kansas City Missouri 64110 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Midwest Research Institute 425 Volker Boulevard Kansas City Missouri 64110 USA","institution_ids":["https://openalex.org/I59386820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016980081","display_name":"Melvin J. Swanson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59386820","display_name":"MRIGlobal","ror":"https://ror.org/0320rar10","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I59386820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melvin J. Swanson","raw_affiliation_strings":["Midwest Research Institute 425 Volker Boulevard Kansas City Missouri 64110 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Midwest Research Institute 425 Volker Boulevard Kansas City Missouri 64110 USA","institution_ids":["https://openalex.org/I59386820"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088841828","display_name":"Jacqueline G. Stone-Heurner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59386820","display_name":"MRIGlobal","ror":"https://ror.org/0320rar10","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I59386820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacqueline G. Stone-Heurner","raw_affiliation_strings":["Midwest Research Institute 425 Volker Boulevard Kansas City Missouri 64110 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Midwest Research Institute 425 Volker Boulevard Kansas City Missouri 64110 USA","institution_ids":["https://openalex.org/I59386820"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I59386820"],"apc_list":{"value":3540,"currency":"USD","value_usd":3540},"apc_paid":null,"fwci":0.2934,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.48719747,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"91","issue":"1","first_page":"138","last_page":"145"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.6401000022888184,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.6401000022888184,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.23559999465942383,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.038600001484155655,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/3-hydroxybenzo-a-pyrene","display_name":"3-hydroxybenzo[a]pyrene","score":0.996999979019165},{"id":"https://openalex.org/keywords/glucuronidation","display_name":"glucuronidation","score":0.7089999914169312},{"id":"https://openalex.org/keywords/rabbit-liver-microsomes","display_name":"rabbit liver microsomes","score":0.8149999976158142},{"id":"https://openalex.org/keywords/glucuronide-metabolites","display_name":"glucuronide metabolites","score":0.4860000014305115},{"id":"https://openalex.org/keywords/carcinogenicity","display_name":"carcinogenicity","score":0.6380000114440918},{"id":"https://openalex.org/keywords/polycyclic-aromatic-hydrocarbons","display_name":"polycyclic aromatic hydrocarbons","score":0.8659999966621399},{"id":"https://openalex.org/keywords/field-desorption-mass-spectrometry","display_name":"field desorption mass spectrometry","score":0.746999979019165},{"id":"https://openalex.org/keywords/radiotracer-technique","display_name":"radiotracer technique","score":0.38999998569488525}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8859487771987915},{"id":"https://openalex.org/C2778951431","wikidata":"https://www.wikidata.org/wiki/Q415723","display_name":"Pyrene","level":2,"score":0.849486768245697},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.7359621524810791},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.7238479256629944},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.6175862550735474},{"id":"https://openalex.org/C2779186261","wikidata":"https://www.wikidata.org/wiki/Q137786","display_name":"Glucuronide","level":3,"score":0.5136053562164307},{"id":"https://openalex.org/C2776648616","wikidata":"https://www.wikidata.org/wiki/Q409216","display_name":"Glucuronic acid","level":3,"score":0.46396270394325256},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.20891907811164856},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20589712262153625},{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001580","descriptor_name":"Benzopyrenes","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001580","descriptor_name":"Benzopyrenes","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D001580","descriptor_name":"Benzopyrenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0003-2697(78)90824-2","doi":"https://doi.org/10.1016/0003-2697(78)90824-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0003-2697(78)90824-2","pdf_url":null,"source":{"id":"https://openalex.org/S7858788","display_name":"Analytical Biochemistry","issn_l":"0003-2697","issn":["0003-2697","1096-0309"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Biochemistry","raw_type":"journal-article"},{"id":"pmid:9762092","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9762092","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W583281421","https://openalex.org/W1975869908","https://openalex.org/W1989659171","https://openalex.org/W2011766997","https://openalex.org/W2047080537","https://openalex.org/W2054031732","https://openalex.org/W2055044562","https://openalex.org/W2516957916"],"related_works":["https://openalex.org/W1985222127","https://openalex.org/W2039080703","https://openalex.org/W2462603834","https://openalex.org/W2170341524","https://openalex.org/W2041508687","https://openalex.org/W2055044562","https://openalex.org/W2027360130","https://openalex.org/W2028983900","https://openalex.org/W2169954195","https://openalex.org/W61629809"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}