{"id":"https://openalex.org/W1991769604","doi":"https://doi.org/10.1007/s11095-005-5884-1","title":"The Influence of Iontophoresis on Acyclovir Transport and Accumulation in Rabbit Ear Skin","display_name":"The Influence of Iontophoresis on Acyclovir Transport and Accumulation in Rabbit Ear Skin","publication_year":2005,"publication_date":"2005-08-24","ids":{"openalex":"https://openalex.org/W1991769604","doi":"https://doi.org/10.1007/s11095-005-5884-1","mag":"1991769604","pmid":"https://pubmed.ncbi.nlm.nih.gov/16132364"},"language":"en","primary_location":{"id":"doi:10.1007/s11095-005-5884-1","doi":"https://doi.org/10.1007/s11095-005-5884-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11095-005-5884-1","pdf_url":null,"source":{"id":"https://openalex.org/S103865650","display_name":"Pharmaceutical Research","issn_l":"0724-8741","issn":["0724-8741","1573-904X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033794388","display_name":"Cristina Padula","orcid":"https://orcid.org/0000-0003-1024-524X","observed_orcids":["https://orcid.org/0000-0003-1024-524X"]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cristina Padula","raw_affiliation_strings":["Dipartimento Farmaceutico, University of Parma, Parco Area delle Scienze, 43100 Parma, Italy","Dipartimento Farmaceutico, University of Parma, Parma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento Farmaceutico, University of Parma, Parco Area delle Scienze, 43100 Parma, Italy","institution_ids":["https://openalex.org/I124601658"]},{"raw_affiliation_string":"Dipartimento Farmaceutico, University of Parma, Parma, Italy","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Francesca Sartori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Sartori","raw_affiliation_strings":["Dipartimento Farmaceutico, University of Parma, Parco Area delle Scienze, 43100, Parma, Italy","Dipartimento Farmaceutico, University of Parma, Parma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento Farmaceutico, University of Parma, Parco Area delle Scienze, 43100, Parma, Italy","institution_ids":["https://openalex.org/I124601658"]},{"raw_affiliation_string":"Dipartimento Farmaceutico, University of Parma, Parma, Italy","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010635794","display_name":"Fabio Marra","orcid":"https://orcid.org/0000-0002-4194-7925","observed_orcids":["https://orcid.org/0000-0002-4194-7925"]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabio Marra","raw_affiliation_strings":["Dipartimento Farmaceutico, University of Parma, Parco Area delle Scienze, 43100, Parma, Italy","Dipartimento Farmaceutico, University of Parma, Parma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento Farmaceutico, University of Parma, Parco Area delle Scienze, 43100, Parma, Italy","institution_ids":["https://openalex.org/I124601658"]},{"raw_affiliation_string":"Dipartimento Farmaceutico, University of Parma, Parma, Italy","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076630196","display_name":"Patrizia Santi","orcid":"https://orcid.org/0000-0001-7601-7894","observed_orcids":["https://orcid.org/0000-0001-7601-7894"]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Patrizia Santi","raw_affiliation_strings":["Dipartimento Farmaceutico, University of Parma, Parco Area delle Scienze, 43100, Parma, Italy","Dipartimento Farmaceutico, University of Parma, Parma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento Farmaceutico, University of Parma, Parco Area delle Scienze, 43100, Parma, Italy","institution_ids":["https://openalex.org/I124601658"]},{"raw_affiliation_string":"Dipartimento Farmaceutico, University of Parma, Parma, Italy","institution_ids":["https://openalex.org/I124601658"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5076630196"],"corresponding_institution_ids":["https://openalex.org/I124601658"],"apc_list":{"value":4690,"currency":"USD","value_usd":4690},"apc_paid":null,"fwci":1.9437,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.80017079,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"22","issue":"9","first_page":"1519","last_page":"1524"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11455","display_name":"Microbial Inactivation Methods","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iontophoresis","display_name":"iontophoresis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/acyclovir","display_name":"acyclovir","score":1.0},{"id":"https://openalex.org/keywords/transdermal-drug-delivery","display_name":"transdermal drug delivery","score":0.7689999938011169},{"id":"https://openalex.org/keywords/skin-permeation","display_name":"skin permeation","score":0.9120000004768372},{"id":"https://openalex.org/keywords/drug-accumulation","display_name":"drug accumulation","score":0.8080000281333923},{"id":"https://openalex.org/keywords/electromigration","display_name":"electromigration","score":0.7990000247955322},{"id":"https://openalex.org/keywords/electro-osmosis","display_name":"electroosmosis","score":0.7730000019073486},{"id":"https://openalex.org/keywords/skin-ph","display_name":"skin pH","score":0.5210000276565552},{"id":"https://openalex.org/keywords/epidermis-and-dermis","display_name":"epidermis and dermis","score":0.7570000290870667}],"concepts":[{"id":"https://openalex.org/C183529106","wikidata":"https://www.wikidata.org/wiki/Q1528394","display_name":"Iontophoresis","level":2,"score":0.9954278469085693},{"id":"https://openalex.org/C50670333","wikidata":"https://www.wikidata.org/wiki/Q907651","display_name":"Permeation","level":3,"score":0.8159774541854858},{"id":"https://openalex.org/C2777624698","wikidata":"https://www.wikidata.org/wiki/Q505531","display_name":"Dermis","level":2,"score":0.6184773445129395},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5894558429718018},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4856680631637573},{"id":"https://openalex.org/C2776458125","wikidata":"https://www.wikidata.org/wiki/Q1827343","display_name":"Epidermis (zoology)","level":2,"score":0.4349213242530823},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.41787731647491455},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38729536533355713},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.355705201625824},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.2507498860359192},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.21167516708374023},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1647050678730011},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1445293128490448},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07194352149963379},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.060489267110824585},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000212","descriptor_name":"Acyclovir","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D004423","descriptor_name":"Ear","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007478","descriptor_name":"Iontophoresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s11095-005-5884-1","doi":"https://doi.org/10.1007/s11095-005-5884-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11095-005-5884-1","pdf_url":null,"source":{"id":"https://openalex.org/S103865650","display_name":"Pharmaceutical Research","issn_l":"0724-8741","issn":["0724-8741","1573-904X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical Research","raw_type":"journal-article"},{"id":"pmid:16132364","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16132364","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W39467990","https://openalex.org/W86778073","https://openalex.org/W134131940","https://openalex.org/W253728726","https://openalex.org/W262972381","https://openalex.org/W396925355","https://openalex.org/W1514293297","https://openalex.org/W1536230179","https://openalex.org/W1841321563","https://openalex.org/W1970698909","https://openalex.org/W1972799272","https://openalex.org/W1977965188","https://openalex.org/W1991602036","https://openalex.org/W1991947885","https://openalex.org/W2011246886","https://openalex.org/W2012209516","https://openalex.org/W2033135742","https://openalex.org/W2038344803","https://openalex.org/W2047592628","https://openalex.org/W2047830434","https://openalex.org/W2078219275","https://openalex.org/W2081904429","https://openalex.org/W2082314761","https://openalex.org/W2105029470","https://openalex.org/W2110653835","https://openalex.org/W3102433126","https://openalex.org/W4240820823","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W86778073","https://openalex.org/W2088577873","https://openalex.org/W1964492469","https://openalex.org/W1991947885","https://openalex.org/W2004881675","https://openalex.org/W1555895245","https://openalex.org/W2166632409","https://openalex.org/W2081904429","https://openalex.org/W1998811737","https://openalex.org/W1991602036"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}