{"id":"https://openalex.org/W1991733965","doi":"https://doi.org/10.1515/jpem.2000.13.2.149","title":"Breast Milk Leptin Concentrations in Initial and Terminal Milk Samples: Relationships to Maternal and Infant Plasma Leptin Concentrations, Adiposity, Serum Glucose, Insulin, Lipid and Lipoprotein Levels","display_name":"Breast Milk Leptin Concentrations in Initial and Terminal Milk Samples: Relationships to Maternal and Infant Plasma Leptin Concentrations, Adiposity, Serum Glucose, Insulin, Lipid and Lipoprotein Levels","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W1991733965","doi":"https://doi.org/10.1515/jpem.2000.13.2.149","mag":"1991733965","pmid":"https://pubmed.ncbi.nlm.nih.gov/10711659"},"language":"en","primary_location":{"id":"doi:10.1515/jpem.2000.13.2.149","doi":"https://doi.org/10.1515/jpem.2000.13.2.149","is_oa":false,"landing_page_url":"https://doi.org/10.1515/jpem.2000.13.2.149","pdf_url":null,"source":{"id":"https://openalex.org/S18163555","display_name":"Journal of Pediatric Endocrinology and Metabolism","issn_l":"0334-018X","issn":["0334-018X","2191-0251"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Endocrinology and Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011767149","display_name":"Birsen U\u00e7ar","orcid":"https://orcid.org/0000-0002-7746-6058","observed_orcids":["https://orcid.org/0000-0002-7746-6058"]},"institutions":[{"id":"https://openalex.org/I51209816","display_name":"Eski\u015fehir Osmangazi University","ror":"https://ror.org/01dzjez04","country_code":"TR","type":"education","lineage":["https://openalex.org/I51209816"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"B. U\u00e7ar","raw_affiliation_strings":["Department of Pediatrics, Faculty of Medicine, University of Osmangazi, Eski\u015fehir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Faculty of Medicine, University of Osmangazi, Eski\u015fehir, Turkey","institution_ids":["https://openalex.org/I51209816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086332937","display_name":"Birg\u00fcl K\u0131rel","orcid":"https://orcid.org/0000-0002-8313-5677","observed_orcids":["https://orcid.org/0000-0002-8313-5677"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. K\u0131rel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006803754","display_name":"\u00d6zcan B\u00f6r","orcid":"https://orcid.org/0000-0002-1662-3259","observed_orcids":["https://orcid.org/0000-0002-1662-3259"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u00d6. B\u00f6r,","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077795975","display_name":"Fatma Sultan K\u0131l\u0131\u00e7","orcid":"https://orcid.org/0000-0002-5356-696X","observed_orcids":["https://orcid.org/0000-0002-5356-696X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. Sultan \u039a\u0131l\u0131\u00e7","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020759073","display_name":"Nesrin Do\u011fruel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u039d. Do\u011fruel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064565873","display_name":"Sultan Durmu\u015f Aydo\u011fdu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Durmu\u015f Aydo\u011fdu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5020946585","display_name":"Neslihan Tek\u0131n","orcid":"https://orcid.org/0000-0002-2993-5737","observed_orcids":["https://orcid.org/0000-0002-2993-5737"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. Tekin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2400,"currency":"EUR","value_usd":2712},"apc_paid":null,"fwci":4.5434,"has_fulltext":false,"cited_by_count":92,"citation_normalized_percentile":{"value":0.94555242,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"13","issue":"2","first_page":"149","last_page":"56"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.9448000192642212,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.9448000192642212,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.030400000512599945,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10979","display_name":"Breastfeeding Practices and Influences","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.9229999780654907},{"id":"https://openalex.org/keywords/breast-milk","display_name":"breast milk","score":0.777999997138977},{"id":"https://openalex.org/keywords/breast-milk-composition","display_name":"breast milk composition","score":0.6420000195503235},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.6510000228881836},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.7459999918937683},{"id":"https://openalex.org/keywords/lipoproteins","display_name":"lipoproteins","score":0.7329999804496765},{"id":"https://openalex.org/keywords/adiposity","display_name":"adiposity","score":0.6809999942779541},{"id":"https://openalex.org/keywords/serum-glucose","display_name":"serum glucose","score":0.734000027179718},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/serum-triglycerides","display_name":"serum triglycerides","score":0.7960000038146973},{"id":"https://openalex.org/keywords/satiety","display_name":"satiety","score":0.7419999837875366},{"id":"https://openalex.org/keywords/lactation","display_name":"lactation","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.9263671636581421},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8126240968704224},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8052309155464172},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7003000974655151},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.6222925186157227},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6126865148544312},{"id":"https://openalex.org/C2775871700","wikidata":"https://www.wikidata.org/wiki/Q22728","display_name":"Breast milk","level":2,"score":0.6085072755813599},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.47335124015808105},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.35386574268341064},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.29309991002082825},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17354491353034973},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05685549974441528}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008895","descriptor_name":"Milk, Human","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1515/jpem.2000.13.2.149","doi":"https://doi.org/10.1515/jpem.2000.13.2.149","is_oa":false,"landing_page_url":"https://doi.org/10.1515/jpem.2000.13.2.149","pdf_url":null,"source":{"id":"https://openalex.org/S18163555","display_name":"Journal of Pediatric Endocrinology and Metabolism","issn_l":"0334-018X","issn":["0334-018X","2191-0251"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Endocrinology and Metabolism","raw_type":"journal-article"},{"id":"pmid:10711659","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10711659","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pediatric endocrinology & metabolism : JPEM","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565},{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.6735000014305115}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1989878570","https://openalex.org/W1997423410","https://openalex.org/W2004197857","https://openalex.org/W2013799006","https://openalex.org/W2014050305","https://openalex.org/W2032549686","https://openalex.org/W2060313221","https://openalex.org/W2071620017","https://openalex.org/W2124312838","https://openalex.org/W2140700470","https://openalex.org/W2142430176","https://openalex.org/W2157906165"],"related_works":["https://openalex.org/W2014869394","https://openalex.org/W2057812646","https://openalex.org/W2022707231","https://openalex.org/W2117673844","https://openalex.org/W3189344574","https://openalex.org/W2008506994","https://openalex.org/W2368684912","https://openalex.org/W2100763317","https://openalex.org/W2460268440","https://openalex.org/W2077107352"],"abstract_inverted_index":{"Leptin":[0,98],"has":[1],"recently":[2],"been":[3],"shown":[4],"to":[5,53,189,221,249],"be":[6,219,233],"present":[7],"in":[8,22,101,107],"human":[9,23],"milk":[10,24,50,82,103,112,191,209,225,240],"and":[11,25,30,40,48,76,88,121,128,131,139,145,154,159,167,170,183,197,207,226,243],"is":[12],"produced":[13],"by":[14],"mammary":[15],"epithelial":[16],"cells.":[17],"We":[18,43,213],"studied":[19],"leptin":[20,33,51,56,114,125,182,193,210,217,241,245],"concentrations":[21,52,115,126,172,186],"its":[26],"relationships":[27],"with":[28,118,134,152],"maternal":[29,108,120,135,153,162,179,216],"infant":[31,94,122,155,223],"plasma":[32,109,123,180],"concentrations,":[34],"adiposity,":[35,156],"serum":[36,136,157,163,184],"glucose,":[37],"insulin,":[38],"lipid":[39,169],"lipoprotein":[41,141,171],"levels.":[42],"also":[44],"compared":[45],"the":[46,93,222,250,255],"initial":[47,206],"terminal":[49,208],"investigate":[54],"whether":[55],"acts":[57],"as":[58],"a":[59],"satiety":[60],"factor.":[61],"Venous":[62],"blood":[63],"samples":[64,83],"were":[65,84,104,187],"obtained":[66],"from":[67,73],"18":[68],"healthy":[69],"lactating":[70],"women":[71],"aged":[72],"17-42":[74],"years":[75],"their":[77],"3-120":[78],"day-old":[79],"infants.":[80],"Breast":[81,111],"collected":[85],"just":[86],"before":[87],"immediately":[89],"after":[90],"suckling,":[91],"when":[92],"had":[95],"self-terminated":[96],"sucking.":[97],"mean":[99],"values":[100],"breast":[102,190,239],"lower":[105],"than":[106,236],"(p<0.001).":[110],"log":[113,124,181,192],"positively":[116],"correlated":[117,133],"both":[119],"(p<0.001":[127,144],"p=0.001,":[129],"respectively)":[130],"negatively":[132],"total":[137],"cholesterol":[138,142],"low-density":[140],"levels":[143,166,211],"p<0.01,":[146],"respectively),":[147],"but":[148],"did":[149],"not":[150,247],"correlate":[151],"glucose":[158],"insulin":[160],"levels,":[161,242],"HDL-C,":[164],"triglyceride":[165],"infants'":[168],"(p>0.05).":[173,212],"Using":[174],"stepwise":[175],"multiple":[176],"regression":[177],"analysis,":[178],"HDL-C":[185],"related":[188],"concentration":[194],"(R2=0.82;":[195],"p<0.0001":[196],"p<0.001,":[198],"respectively).":[199],"There":[200],"was":[201],"no":[202],"significant":[203],"difference":[204],"between":[205],"concluded":[214],"that":[215,244],"may":[218,227,232],"transferred":[220],"via":[224],"exert":[228],"biological":[229],"effects;":[230],"there":[231],"factors":[234],"other":[235],"adiposity":[237],"affecting":[238],"might":[246],"contribute":[248],"development":[251],"of":[252,257],"satiation":[253],"at":[254],"end":[256],"suckling.":[258]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}