{"id":"https://openalex.org/W1991730752","doi":"https://doi.org/10.1016/s0024-3205(98)00028-9","title":"HL-004, the ACAT inhibitor, prevents the progression of atherosclerosis in cholesterol-fed rabbits","display_name":"HL-004, the ACAT inhibitor, prevents the progression of atherosclerosis in cholesterol-fed rabbits","publication_year":1998,"publication_date":"1998-02-01","ids":{"openalex":"https://openalex.org/W1991730752","doi":"https://doi.org/10.1016/s0024-3205(98)00028-9","mag":"1991730752","pmid":"https://pubmed.ncbi.nlm.nih.gov/9519807"},"language":"en","primary_location":{"id":"doi:10.1016/s0024-3205(98)00028-9","doi":"https://doi.org/10.1016/s0024-3205(98)00028-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0024-3205(98)00028-9","pdf_url":null,"source":{"id":"https://openalex.org/S175775512","display_name":"Life Sciences","issn_l":"0024-3205","issn":["0024-3205","1879-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015060161","display_name":"Yumiko Asami","orcid":"https://orcid.org/0000-0001-7111-6201","observed_orcids":["https://orcid.org/0000-0001-7111-6201"]},"institutions":[{"id":"https://openalex.org/I144245601","display_name":"Taisho Pharmaceutical (Japan)","ror":"https://ror.org/033nw2736","country_code":"JP","type":"company","lineage":["https://openalex.org/I144245601"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yumiko Asami","raw_affiliation_strings":["Research Laboratories, Taisho Pharmaceutical Co. Ltd., Ohmiya, Saitama, Japan. S10960@ccam.taisho.co.jp","Research Laboratories, Taisho Pharmaceutical Co., Ltd., Ohmiya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories, Taisho Pharmaceutical Co. Ltd., Ohmiya, Saitama, Japan. S10960@ccam.taisho.co.jp","institution_ids":["https://openalex.org/I144245601"]},{"raw_affiliation_string":"Research Laboratories, Taisho Pharmaceutical Co., Ltd., Ohmiya, Japan","institution_ids":["https://openalex.org/I144245601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080686681","display_name":"Izumi Yamagishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I144245601","display_name":"Taisho Pharmaceutical (Japan)","ror":"https://ror.org/033nw2736","country_code":"JP","type":"company","lineage":["https://openalex.org/I144245601"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Izumi Yamagishi","raw_affiliation_strings":["Research Laboratories, Taisho Pharmaceutical Co. Ltd., Ohmiya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories, Taisho Pharmaceutical Co. Ltd., Ohmiya, Japan","institution_ids":["https://openalex.org/I144245601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035935266","display_name":"Shigeru Murakami","orcid":"https://orcid.org/0000-0001-6062-5561","observed_orcids":["https://orcid.org/0000-0001-6062-5561"]},"institutions":[{"id":"https://openalex.org/I144245601","display_name":"Taisho Pharmaceutical (Japan)","ror":"https://ror.org/033nw2736","country_code":"JP","type":"company","lineage":["https://openalex.org/I144245601"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeru Murakami","raw_affiliation_strings":["Research Laboratories, Taisho Pharmaceutical Co. Ltd., Ohmiya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories, Taisho Pharmaceutical Co. Ltd., Ohmiya, Japan","institution_ids":["https://openalex.org/I144245601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112659639","display_name":"Hiroaki Araki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I144245601","display_name":"Taisho Pharmaceutical (Japan)","ror":"https://ror.org/033nw2736","country_code":"JP","type":"company","lineage":["https://openalex.org/I144245601"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroaki Araki","raw_affiliation_strings":["Research Laboratories, Taisho Pharmaceutical Co. Ltd., Ohmiya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories, Taisho Pharmaceutical Co. Ltd., Ohmiya, Japan","institution_ids":["https://openalex.org/I144245601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073148481","display_name":"Katsuharu Tsuchida","orcid":"https://orcid.org/0000-0002-5460-5617","observed_orcids":["https://orcid.org/0000-0002-5460-5617"]},"institutions":[{"id":"https://openalex.org/I144245601","display_name":"Taisho Pharmaceutical (Japan)","ror":"https://ror.org/033nw2736","country_code":"JP","type":"company","lineage":["https://openalex.org/I144245601"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuharu Tsuchida","raw_affiliation_strings":["Research Laboratories, Taisho Pharmaceutical Co. Ltd., Ohmiya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories, Taisho Pharmaceutical Co. Ltd., Ohmiya, Japan","institution_ids":["https://openalex.org/I144245601"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055771560","display_name":"Shohei Higuchi","orcid":"https://orcid.org/0000-0002-5301-1390","observed_orcids":["https://orcid.org/0000-0002-5301-1390"]},"institutions":[{"id":"https://openalex.org/I144245601","display_name":"Taisho Pharmaceutical (Japan)","ror":"https://ror.org/033nw2736","country_code":"JP","type":"company","lineage":["https://openalex.org/I144245601"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shohei Higuchi","raw_affiliation_strings":["Research Laboratories, Taisho Pharmaceutical Co. Ltd., Ohmiya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories, Taisho Pharmaceutical Co. Ltd., Ohmiya, Japan","institution_ids":["https://openalex.org/I144245601"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5015060161"],"corresponding_institution_ids":["https://openalex.org/I144245601"],"apc_list":{"value":3810,"currency":"USD","value_usd":3810},"apc_paid":null,"fwci":1.3591,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.76961722,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"62","issue":"12","first_page":"1055","last_page":"1063"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acat-inhibitors","display_name":"ACAT inhibitors","score":0.8149999976158142},{"id":"https://openalex.org/keywords/acyl-coa-cholesterol-acyltransferase","display_name":"acyl-CoA:cholesterol acyltransferase","score":0.972000002861023},{"id":"https://openalex.org/keywords/atherosclerosis-prevention","display_name":"atherosclerosis prevention","score":0.9290000200271606},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.8700000047683716},{"id":"https://openalex.org/keywords/cholesterol-absorption-inhibition","display_name":"cholesterol absorption inhibition","score":0.6340000033378601},{"id":"https://openalex.org/keywords/cholesterol-lowering-effect","display_name":"cholesterol-lowering effect","score":0.9350000023841858},{"id":"https://openalex.org/keywords/serum-cholesterol","display_name":"serum cholesterol","score":0.7580000162124634},{"id":"https://openalex.org/keywords/aortic-atherosclerotic-lesions","display_name":"aortic atherosclerotic lesions","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cholesterol-fed-rabbits","display_name":"cholesterol-fed rabbits","score":0.9020000100135803}],"concepts":[{"id":"https://openalex.org/C37002583","wikidata":"https://www.wikidata.org/wiki/Q418755","display_name":"Sterol O-acyltransferase","level":4,"score":0.7722587585449219},{"id":"https://openalex.org/C2779091943","wikidata":"https://www.wikidata.org/wiki/Q1079120","display_name":"Hyperlipidemia","level":3,"score":0.7053229808807373},{"id":"https://openalex.org/C2779980429","wikidata":"https://www.wikidata.org/wiki/Q101004","display_name":"Aorta","level":2,"score":0.6845120191574097},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.6255951523780823},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5869603157043457},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5785921216011047},{"id":"https://openalex.org/C2776864027","wikidata":"https://www.wikidata.org/wiki/Q615993","display_name":"Thoracic aorta","level":3,"score":0.5240747332572937},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4431351125240326},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4224501848220825},{"id":"https://openalex.org/C2777882243","wikidata":"https://www.wikidata.org/wiki/Q11090","display_name":"Small intestine","level":2,"score":0.4173392057418823},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.14496737718582153},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.09817594289779663}],"mesh":[{"descriptor_ui":"D000083","descriptor_name":"Acetanilides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001013","descriptor_name":"Aorta, Thoracic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001161","descriptor_name":"Arteriosclerosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001161","descriptor_name":"Arteriosclerosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002785","descriptor_name":"Sterol O-Acyltransferase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D002785","descriptor_name":"Sterol O-Acyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002791","descriptor_name":"Cholesterol, Dietary","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0024-3205(98)00028-9","doi":"https://doi.org/10.1016/s0024-3205(98)00028-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0024-3205(98)00028-9","pdf_url":null,"source":{"id":"https://openalex.org/S175775512","display_name":"Life Sciences","issn_l":"0024-3205","issn":["0024-3205","1879-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences","raw_type":"journal-article"},{"id":"pmid:9519807","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9519807","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W53284464","https://openalex.org/W1775749144","https://openalex.org/W1821737351","https://openalex.org/W1965815352","https://openalex.org/W1975533062","https://openalex.org/W1977736083","https://openalex.org/W1987003348","https://openalex.org/W1990573487","https://openalex.org/W2007246603","https://openalex.org/W2008343996","https://openalex.org/W2058679420","https://openalex.org/W2070096118","https://openalex.org/W2116890637","https://openalex.org/W2125123943","https://openalex.org/W2171081408","https://openalex.org/W2173237738","https://openalex.org/W2186320764","https://openalex.org/W2188814922","https://openalex.org/W2189179707","https://openalex.org/W2341319159","https://openalex.org/W2342920521","https://openalex.org/W2427363579","https://openalex.org/W2468541493"],"related_works":["https://openalex.org/W2158159977","https://openalex.org/W1998380071","https://openalex.org/W2055120366","https://openalex.org/W2076781651","https://openalex.org/W1988950548","https://openalex.org/W1967388458","https://openalex.org/W2427363579","https://openalex.org/W7099154871","https://openalex.org/W3099477267","https://openalex.org/W2009194516"],"abstract_inverted_index":null,"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}