{"id":"https://openalex.org/W1991698857","doi":"https://doi.org/10.1002/stem.493","title":"Vitamin C Promotes Widespread Yet Specific DNA Demethylation of the Epigenome in Human Embryonic Stem Cells","display_name":"Vitamin C Promotes Widespread Yet Specific DNA Demethylation of the Epigenome in Human Embryonic Stem Cells","publication_year":2010,"publication_date":"2010-08-05","ids":{"openalex":"https://openalex.org/W1991698857","doi":"https://doi.org/10.1002/stem.493","mag":"1991698857","pmid":"https://pubmed.ncbi.nlm.nih.gov/20687155"},"language":"en","primary_location":{"id":"doi:10.1002/stem.493","doi":"https://doi.org/10.1002/stem.493","is_oa":false,"landing_page_url":"https://doi.org/10.1002/stem.493","pdf_url":null,"source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061486466","display_name":"Tung-Liang Chung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4210125287","display_name":"Stem Cells Australia","ror":"https://ror.org/03antpb48","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210125287"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]},{"id":"https://openalex.org/I60733029","display_name":"Monash Institute of Medical Research","ror":"https://ror.org/05p96ba03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2802600346","https://openalex.org/I60733029"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Tung-Liang Chung","raw_affiliation_strings":["Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland, Australia","Australian Stem Cell Centre, Melbourne, Victoria, Australia","Monash Institute of Medical Research, Monash University, Melbourne, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"Australian Stem Cell Centre, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I4210125287"]},{"raw_affiliation_string":"Monash Institute of Medical Research, Monash University, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I56590836","https://openalex.org/I60733029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050491672","display_name":"Romulo Martin Brena","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Romulo M. Brena","raw_affiliation_strings":["USC Epigenome Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USC Epigenome Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Gabriel Kolle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Gabriel Kolle","raw_affiliation_strings":["Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040120471","display_name":"Sean Michael Grimmond","orcid":"https://orcid.org/0000-0002-8102-7998","observed_orcids":["https://orcid.org/0000-0002-8102-7998"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Sean M. Grimmond","raw_affiliation_strings":["Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032108534","display_name":"Benjamin P. Berman","orcid":"https://orcid.org/0000-0002-2099-9005","observed_orcids":["https://orcid.org/0000-0002-2099-9005"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin P. Berman","raw_affiliation_strings":["USC Epigenome Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USC Epigenome Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025761663","display_name":"Peter W. Laird","orcid":"https://orcid.org/0000-0001-9117-3641","observed_orcids":["https://orcid.org/0000-0001-9117-3641"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter W. Laird","raw_affiliation_strings":["USC Epigenome Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USC Epigenome Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085891063","display_name":"Mart\u00edn F. Pera","orcid":"https://orcid.org/0000-0001-6239-0428","observed_orcids":["https://orcid.org/0000-0001-6239-0428"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin F. Pera","raw_affiliation_strings":["Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066605681","display_name":"Ernst Jurgen Wolvetang","orcid":"https://orcid.org/0000-0002-2146-6614","observed_orcids":["https://orcid.org/0000-0002-2146-6614"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Ernst Jurgen Wolvetang","raw_affiliation_strings":["Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I165143802"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5066605681"],"corresponding_institution_ids":["https://openalex.org/I165143802"],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":null,"fwci":3.9053,"has_fulltext":true,"cited_by_count":182,"citation_normalized_percentile":{"value":0.94567899,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"28","issue":"10","first_page":"1848","last_page":"1855"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9023000001907349,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9023000001907349,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.09529999643564224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.984000027179718},{"id":"https://openalex.org/keywords/dna-demethylation","display_name":"DNA demethylation","score":0.984000027179718},{"id":"https://openalex.org/keywords/human-embryonic-stem-cells","display_name":"human embryonic stem cells","score":0.984000027179718},{"id":"https://openalex.org/keywords/epigenome","display_name":"epigenome","score":0.8560000061988831},{"id":"https://openalex.org/keywords/cpg-islands","display_name":"CpG islands","score":0.8479999899864197},{"id":"https://openalex.org/keywords/pluripotency","display_name":"pluripotency","score":0.8140000104904175},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.8790000081062317},{"id":"https://openalex.org/keywords/fibroblast-reprogramming","display_name":"fibroblast reprogramming","score":0.9110000133514404},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6349999904632568},{"id":"https://openalex.org/keywords/transcription-start-site","display_name":"transcription start sites","score":0.7139999866485596},{"id":"https://openalex.org/keywords/stem-cell-differentiation","display_name":"stem cell differentiation","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.898642897605896},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.8247408866882324},{"id":"https://openalex.org/C16824249","wikidata":"https://www.wikidata.org/wiki/Q5205753","display_name":"DNA demethylation","level":5,"score":0.7404190897941589},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.721546471118927},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6833429336547852},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5626064538955688},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5593335032463074},{"id":"https://openalex.org/C117717151","wikidata":"https://www.wikidata.org/wiki/Q3589155","display_name":"Epigenome","level":5,"score":0.541074275970459},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.5379024744033813},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48033490777015686},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.45091870427131653},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.43150418996810913},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.41172608733177185},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3757346570491791},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35987192392349243},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2891237139701843}],"mesh":[{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056484","descriptor_name":"Jumonji Domain-Containing Histone Demethylases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/stem.493","doi":"https://doi.org/10.1002/stem.493","is_oa":false,"landing_page_url":"https://doi.org/10.1002/stem.493","pdf_url":null,"source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells","raw_type":"journal-article"},{"id":"pmid:20687155","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20687155","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cells (Dayton, Ohio)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306141","display_name":"Susan G. Komen for the Cure","ror":"https://ror.org/02nadbe75"},{"id":"https://openalex.org/F4320306171","display_name":"California Institute for Regenerative Medicine","ror":"https://ror.org/033m8b439"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1851592922","https://openalex.org/W1917376005","https://openalex.org/W1976787939","https://openalex.org/W1979686262","https://openalex.org/W2014852291","https://openalex.org/W2037850779","https://openalex.org/W2063333928","https://openalex.org/W2065751798","https://openalex.org/W2077981176","https://openalex.org/W2081098333","https://openalex.org/W2086943348","https://openalex.org/W2108664872","https://openalex.org/W2110065044","https://openalex.org/W2122683221","https://openalex.org/W2123667649","https://openalex.org/W2133148543","https://openalex.org/W2133501984","https://openalex.org/W2133938268","https://openalex.org/W2138442302","https://openalex.org/W2141856502","https://openalex.org/W2148048540","https://openalex.org/W2148521032","https://openalex.org/W2158217645","https://openalex.org/W2169494000","https://openalex.org/W2170546016"],"related_works":["https://openalex.org/W3179701492","https://openalex.org/W2034643404","https://openalex.org/W4251804510","https://openalex.org/W2735414420","https://openalex.org/W2309117218","https://openalex.org/W2141776504","https://openalex.org/W329791829","https://openalex.org/W3123015392","https://openalex.org/W7100791761","https://openalex.org/W2144587135"],"abstract_inverted_index":{"Vitamin":[0],"C":[1],"(ascorbate)":[2],"is":[3,80],"a":[4,42,54,131],"widely":[5],"used":[6],"medium":[7],"supplement":[8],"in":[9,30,141],"embryonic":[10,32],"stem":[11,33,38,124],"cell":[12,39],"culture.":[13],"Here,":[14],"we":[15],"show":[16,52,87],"that":[17,53,67,88,99,109,143],"ascorbate":[18],"causes":[19],"widespread,":[20],"consistent,":[21],"and":[22,66,116,137,148],"remarkably":[23],"specific":[24,138],"DNA":[25,58],"demethylation":[26,46],"of":[27,56,70,114,119],"1,847":[28],"genes":[29,60],"human":[31],"cells":[34,125],"(hESCs),":[35],"including":[36],"important":[37],"genes,":[40],"with":[41,96,105],"clear":[43],"bias":[44],"toward":[45],"at":[47],"CpG":[48],"island":[49],"boundaries.":[50],"We":[51,85],"subset":[55],"these":[57],"demethylated":[59,72,111],"displays":[61],"concomitant":[62],"gene":[63,91,97,107],"expression":[64],"changes":[65,140],"the":[68,71,76,89,106],"position":[69],"CpGs":[73],"relative":[74],"to":[75,82,121],"transcription":[77],"start":[78],"site":[79],"correlated":[81],"such":[83],"changes.":[84],"further":[86],"ascorbate-demethylated":[90],"set":[92],"not":[93],"only":[94],"overlaps":[95],"sets":[98,108],"have":[100],"bivalent":[101],"marks,":[102],"but":[103],"also":[104],"are":[110],"during":[112,117],"differentiation":[113],"hESCs":[115,142],"reprogramming":[118,149],"fibroblasts":[120],"induced":[122],"pluritotent":[123],"(iPSCs).":[126],"Our":[127],"data":[128],"thus":[129],"identify":[130],"novel":[132],"link":[133],"between":[134],"ascorbate-mediated":[135],"signaling":[136],"epigenetic":[139],"might":[144],"impact":[145],"on":[146],"pluripotency":[147],"pathways.":[150]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":18},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}