{"id":"https://openalex.org/W1991685111","doi":"https://doi.org/10.1046/j.1365-2249.1996.d01-779.x","title":"Dendritic cells and tolerance induction","display_name":"Dendritic cells and tolerance induction","publication_year":1996,"publication_date":"1996-09-01","ids":{"openalex":"https://openalex.org/W1991685111","doi":"https://doi.org/10.1046/j.1365-2249.1996.d01-779.x","mag":"1991685111","pmid":"https://pubmed.ncbi.nlm.nih.gov/8809125","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2200533"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-2249.1996.d01-779.x","doi":"https://doi.org/10.1046/j.1365-2249.1996.d01-779.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2249.1996.d01-779.x","pdf_url":null,"source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2200533","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063324769","display_name":"Raymond John Steptoe","orcid":"https://orcid.org/0000-0002-6513-6406","observed_orcids":["https://orcid.org/0000-0002-6513-6406"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R J Steptoe","raw_affiliation_strings":["Pittsburgh Transplantation Institute and Departments of Surgery and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pittsburgh Transplantation Institute and Departments of Surgery and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069651723","display_name":"Angus W. Thomson","orcid":"https://orcid.org/0000-0001-6731-8871","observed_orcids":["https://orcid.org/0000-0001-6731-8871"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A W Thomson","raw_affiliation_strings":["Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2894,"currency":"GBP","value_usd":3816},"apc_paid":null,"fwci":4.9337,"has_fulltext":false,"cited_by_count":121,"citation_normalized_percentile":{"value":0.95621429,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"105","issue":"3","first_page":"397","last_page":"402"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":1.0},{"id":"https://openalex.org/keywords/tolerance-induction","display_name":"tolerance induction","score":0.8640000224113464},{"id":"https://openalex.org/keywords/antigen-presenting-cells","display_name":"antigen-presenting cells","score":0.8450000286102295},{"id":"https://openalex.org/keywords/central-tolerance","display_name":"central tolerance","score":0.8169999718666077},{"id":"https://openalex.org/keywords/tolerogenic-dendritic-cells","display_name":"tolerogenic dendritic cells","score":0.847000002861023},{"id":"https://openalex.org/keywords/allograft-rejection","display_name":"allograft rejection","score":0.8650000095367432},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.9570000171661377},{"id":"https://openalex.org/keywords/immunosuppressive-therapy","display_name":"immunosuppressive therapy","score":0.8849999904632568},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.8920000195503235}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6369584798812866},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4930057227611542}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1046/j.1365-2249.1996.d01-779.x","doi":"https://doi.org/10.1046/j.1365-2249.1996.d01-779.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2249.1996.d01-779.x","pdf_url":null,"source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2200533","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2200533","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},{"id":"pmid:8809125","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8809125","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2200533","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2200533","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1886189932","display_name":"LIVER TRANSPLANTATION: THE ROLE OF DENDRITIC CELLS","funder_award_id":"R01DK049745","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5098781873","display_name":null,"funder_award_id":"R01DK49745-10A1","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":89,"referenced_works":["https://openalex.org/W102297139","https://openalex.org/W147094622","https://openalex.org/W165610152","https://openalex.org/W248089139","https://openalex.org/W340285342","https://openalex.org/W340951685","https://openalex.org/W1499886609","https://openalex.org/W1505516118","https://openalex.org/W1526039364","https://openalex.org/W1531669606","https://openalex.org/W1534619079","https://openalex.org/W1534836439","https://openalex.org/W1549471106","https://openalex.org/W1572210960","https://openalex.org/W1583694308","https://openalex.org/W1600951427","https://openalex.org/W1658116990","https://openalex.org/W1664456366","https://openalex.org/W1751022716","https://openalex.org/W1880220168","https://openalex.org/W1888921446","https://openalex.org/W1923564277","https://openalex.org/W1964931837","https://openalex.org/W1970229526","https://openalex.org/W1970570766","https://openalex.org/W1976062079","https://openalex.org/W1990931210","https://openalex.org/W1992611128","https://openalex.org/W1994194561","https://openalex.org/W1997156142","https://openalex.org/W2004275733","https://openalex.org/W2004737377","https://openalex.org/W2007265487","https://openalex.org/W2009914165","https://openalex.org/W2019522474","https://openalex.org/W2024352457","https://openalex.org/W2027238003","https://openalex.org/W2033541702","https://openalex.org/W2034104654","https://openalex.org/W2037626742","https://openalex.org/W2039964292","https://openalex.org/W2044512941","https://openalex.org/W2051503155","https://openalex.org/W2051658534","https://openalex.org/W2056318117","https://openalex.org/W2058796077","https://openalex.org/W2064020805","https://openalex.org/W2069100407","https://openalex.org/W2070720378","https://openalex.org/W2075376701","https://openalex.org/W2078169017","https://openalex.org/W2082754049","https://openalex.org/W2086585027","https://openalex.org/W2086704878","https://openalex.org/W2089325023","https://openalex.org/W2091020747","https://openalex.org/W2091420555","https://openalex.org/W2095016279","https://openalex.org/W2096152012","https://openalex.org/W2099458553","https://openalex.org/W2100034606","https://openalex.org/W2100656607","https://openalex.org/W2101186488","https://openalex.org/W2108207978","https://openalex.org/W2110340781","https://openalex.org/W2122814661","https://openalex.org/W2124376809","https://openalex.org/W2127803059","https://openalex.org/W2129361645","https://openalex.org/W2132243512","https://openalex.org/W2132552157","https://openalex.org/W2133188511","https://openalex.org/W2135277567","https://openalex.org/W2138367343","https://openalex.org/W2142356948","https://openalex.org/W2144700815","https://openalex.org/W2145049340","https://openalex.org/W2148619935","https://openalex.org/W2148647317","https://openalex.org/W2152918507","https://openalex.org/W2155345778","https://openalex.org/W2160585720","https://openalex.org/W2166676682","https://openalex.org/W2166876123","https://openalex.org/W2168577269","https://openalex.org/W2177327503","https://openalex.org/W2418549794","https://openalex.org/W2736360565","https://openalex.org/W2992947392"],"related_works":["https://openalex.org/W1975284062","https://openalex.org/W2076899204","https://openalex.org/W1988253315","https://openalex.org/W2076071350","https://openalex.org/W3157124650","https://openalex.org/W2025937462","https://openalex.org/W2770689447","https://openalex.org/W4256072793","https://openalex.org/W232162960","https://openalex.org/W195468919"],"abstract_inverted_index":{"Dendritic":[0],"cells":[1,11],"(DC)":[2],"are":[3,59],"widely":[4],"accepted":[5],"as":[6,62],"the":[7,23,37,78,87,95,103],"most":[8],"potent":[9],"antigen-presenting":[10],"(APC),":[12],"and":[13,28,40],"considerable":[14],"interest":[15],"has":[16,45],"been":[17,46],"generated":[18],"in":[19,49,55,94],"their":[20],"potential":[21,63,71],"for":[22],"immunological":[24],"therapy":[25,80],"of":[26,36,43,65,81,89,97,102,106],"cancer":[27],"infectious":[29],"disease.":[30],"Recently,":[31],"however,":[32],"a":[33,53,74],"broader":[34],"understanding":[35],"phenotypic":[38],"diversity":[39],"functional":[41],"heterogeneity":[42],"DC":[44,58,91],"acquired.":[47],"Thus,":[48],"addition":[50],"to":[51,77],"having":[52],"role":[54],"central":[56],"tolerance,":[57],"now":[60],"regarded":[61],"modulators":[64],"peripheral":[66],"immune":[67],"responses.":[68],"Harnessing":[69],"this":[70],"may":[72],"offer":[73],"new":[75,100],"approach":[76],"immunosuppressive":[79],"allograft":[82],"rejection":[83],"or":[84],"autoimmunity.":[85],"Here,":[86],"concept":[88],"\"tolerogenic\"":[90],"is":[92],"placed":[93],"context":[96],"rapidly":[98],"accumulating":[99],"evidence":[101],"diverse":[104],"properties":[105],"these":[107],"important":[108],"APC.":[109]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
