{"id":"https://openalex.org/W1991662335","doi":"https://doi.org/10.1002/art.21573","title":"Risk genotypes in folate\u2010dependent enzymes and their association with methotrexate\u2010related side effects in rheumatoid arthritis","display_name":"Risk genotypes in folate\u2010dependent enzymes and their association with methotrexate\u2010related side effects in rheumatoid arthritis","publication_year":2006,"publication_date":"2006-01-30","ids":{"openalex":"https://openalex.org/W1991662335","doi":"https://doi.org/10.1002/art.21573","mag":"1991662335","pmid":"https://pubmed.ncbi.nlm.nih.gov/16447238"},"language":"en","primary_location":{"id":"doi:10.1002/art.21573","doi":"https://doi.org/10.1002/art.21573","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.21573","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis &amp; Rheumatism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030335777","display_name":"Michael H. Weisman","orcid":"https://orcid.org/0000-0001-5568-388X","observed_orcids":["https://orcid.org/0000-0001-5568-388X"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael H. Weisman","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, California, USA","Cedars-Sinai Medical Center; Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Cedars-Sinai Medical Center; Los Angeles, California","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059206584","display_name":"Daniel E. Furst","orcid":"https://orcid.org/0000-0001-7857-2373","observed_orcids":["https://orcid.org/0000-0001-7857-2373","https://orcid.org/0000-0002-4018-7629"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel E. Furst","raw_affiliation_strings":["University of California\u2013Los Angeles Geffen School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California\u2013Los Angeles Geffen School of Medicine","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063292556","display_name":"Grace S. Park","orcid":"https://orcid.org/0000-0002-2075-5502","observed_orcids":["https://orcid.org/0000-0002-2075-5502"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grace S. Park","raw_affiliation_strings":["University of California\u2013Los Angeles Geffen School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California\u2013Los Angeles Geffen School of Medicine","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014147030","display_name":"Joel M. Kremer","orcid":"https://orcid.org/0000-0001-6674-9901","observed_orcids":["https://orcid.org/0000-0001-6674-9901"]},"institutions":[{"id":"https://openalex.org/I4210159453","display_name":"Center for Rheumatology","ror":"https://ror.org/04rtaxr13","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210159453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel M. Kremer","raw_affiliation_strings":["The Center for Rheumatology, Albany, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Center for Rheumatology, Albany, New York","institution_ids":["https://openalex.org/I4210159453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113676309","display_name":"Katie Smith","orcid":"https://orcid.org/0009-0008-7799-3676","observed_orcids":["https://orcid.org/0009-0008-7799-3676"]},"institutions":[{"id":"https://openalex.org/I4210094228","display_name":"Prometheus Biosciences (United States)","ror":"https://ror.org/00jkh1375","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katie M. Smith","raw_affiliation_strings":["Prometheus Laboratories, San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prometheus Laboratories, San Diego, California","institution_ids":["https://openalex.org/I4210094228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071430304","display_name":"Daniel J. Wallace","orcid":"https://orcid.org/0000-0002-2502-1372","observed_orcids":["https://orcid.org/0000-0002-2502-1372"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J. Wallace","raw_affiliation_strings":["Cedars-Sinai Medical Center; Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center; Los Angeles, California","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110203793","display_name":"Jacques R. Caldwell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124370","display_name":"Radiant Research (United States)","ror":"https://ror.org/03fz1e596","country_code":"US","type":"company","lineage":["https://openalex.org/I4210124370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacques R. Caldwell","raw_affiliation_strings":["Radiant Research, Daytona Beach, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiant Research, Daytona Beach, Florida","institution_ids":["https://openalex.org/I4210124370"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073369495","display_name":"Thierry Dervieux","orcid":"https://orcid.org/0000-0002-3799-4438","observed_orcids":["https://orcid.org/0000-0002-3799-4438"]},"institutions":[{"id":"https://openalex.org/I4210094228","display_name":"Prometheus Biosciences (United States)","ror":"https://ror.org/00jkh1375","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thierry Dervieux","raw_affiliation_strings":["Prometheus Laboratories, San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prometheus Laboratories, San Diego, California","institution_ids":["https://openalex.org/I4210094228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.969,"has_fulltext":false,"cited_by_count":145,"citation_normalized_percentile":{"value":0.98630929,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"54","issue":"2","first_page":"607","last_page":"612"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.3910999894142151,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.3910999894142151,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.3345000147819519,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.2264000028371811,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methotrexate-toxicity","display_name":"methotrexate toxicity","score":0.8960000276565552},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/folate-dependent-enzymes","display_name":"folate-dependent enzymes","score":0.9480000138282776},{"id":"https://openalex.org/keywords/thymidylate-synthase","display_name":"thymidylate synthase","score":0.828000009059906},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.718999981880188},{"id":"https://openalex.org/keywords/alopecia","display_name":"hair loss","score":0.8109999895095825},{"id":"https://openalex.org/keywords/gastrointestinal-toxicity","display_name":"gastrointestinal toxicity","score":0.75},{"id":"https://openalex.org/keywords/central-nervous-system-toxicity","display_name":"central nervous system toxicity","score":0.7730000019073486}],"concepts":[{"id":"https://openalex.org/C43563269","wikidata":"https://www.wikidata.org/wiki/Q424709","display_name":"Methylenetetrahydrofolate reductase","level":4,"score":0.7313640713691711},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7281126976013184},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7131312489509583},{"id":"https://openalex.org/C123321153","wikidata":"https://www.wikidata.org/wiki/Q22676802","display_name":"Thymidylate synthase","level":4,"score":0.7027920484542847},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.6151987314224243},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.5907847285270691},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.58455491065979},{"id":"https://openalex.org/C2779932687","wikidata":"https://www.wikidata.org/wiki/Q24770006","display_name":"Serine hydroxymethyltransferase","level":4,"score":0.47948703169822693},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4654781222343445},{"id":"https://openalex.org/C80315684","wikidata":"https://www.wikidata.org/wiki/Q2737583","display_name":"Methionine synthase","level":4,"score":0.4365392327308655},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.4229128360748291},{"id":"https://openalex.org/C2781382166","wikidata":"https://www.wikidata.org/wiki/Q50573407","display_name":"Antifolate","level":4,"score":0.42255839705467224},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4077501893043518},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24217218160629272},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.23800599575042725},{"id":"https://openalex.org/C2778397455","wikidata":"https://www.wikidata.org/wiki/Q50429865","display_name":"Antimetabolite","level":3,"score":0.21682792901992798},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.13142254948616028},{"id":"https://openalex.org/C2780912031","wikidata":"https://www.wikidata.org/wiki/Q180341","display_name":"Methionine","level":3,"score":0.11793917417526245},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11066487431526184},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.0},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.0},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009709","descriptor_name":"Nucleotide Deaminases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009709","descriptor_name":"Nucleotide Deaminases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012696","descriptor_name":"Glycine Hydroxymethyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012696","descriptor_name":"Glycine Hydroxymethyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013940","descriptor_name":"Thymidylate Synthase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013940","descriptor_name":"Thymidylate Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D019877","descriptor_name":"Hydroxymethyl and Formyl Transferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019877","descriptor_name":"Hydroxymethyl and Formyl Transferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042965","descriptor_name":"Methylenetetrahydrofolate Reductase (NADPH2)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D042965","descriptor_name":"Methylenetetrahydrofolate Reductase (NADPH2)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/art.21573","doi":"https://doi.org/10.1002/art.21573","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.21573","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis &amp; Rheumatism","raw_type":"journal-article"},{"id":"pmid:16447238","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16447238","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis and rheumatism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1508817529","https://openalex.org/W1965116295","https://openalex.org/W1983377872","https://openalex.org/W1983779362","https://openalex.org/W2013864512","https://openalex.org/W2027069016","https://openalex.org/W2043415837","https://openalex.org/W2055280685","https://openalex.org/W2056019134","https://openalex.org/W2065419533","https://openalex.org/W2078993588","https://openalex.org/W2106208000","https://openalex.org/W2110177517","https://openalex.org/W2115030795","https://openalex.org/W2118172857","https://openalex.org/W2121261755","https://openalex.org/W2131658103","https://openalex.org/W2152348310","https://openalex.org/W2328999771","https://openalex.org/W4294350064"],"related_works":["https://openalex.org/W2351211109","https://openalex.org/W2269523990","https://openalex.org/W2051893175","https://openalex.org/W2043415837","https://openalex.org/W7099657610","https://openalex.org/W1977466305","https://openalex.org/W2081407149","https://openalex.org/W650641267","https://openalex.org/W2406346260","https://openalex.org/W1984273588"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Methotrexate":[1],"(MTX)":[2],"is":[3,8],"an":[4,243,255,280],"antifolate":[5],"agent":[6],"that":[7,266],"often":[9],"associated":[10,23,169,197,223,241],"with":[11,24,31,124,129,155,170,198,224,242,254],"toxicity.":[12],"This":[13],"study":[14,45,72,146],"investigated":[15],"whether":[16],"risk":[17,77,130,273],"genotypes":[18,78,131,168,274],"for":[19,39,54],"folate-dependent":[20,276],"enzymes":[21,277],"are":[22],"the":[25,67,110,174,271],"toxicity":[26],"of":[27,46,69,90,120,150,238,248,257,270,283],"MTX":[28,53],"in":[29,41,79,173,275],"patients":[30,48,142,152,286],"rheumatoid":[32],"arthritis":[33],"(RA).":[34],"METHODS:":[35],"Blood":[36],"was":[37,196,240],"collected":[38],"analysis":[40],"a":[42,70,148,156,250,267],"muticenter,":[43],"cross-sectional":[44],"RA":[47,285],"who":[49,287],"had":[50],"been":[51],"receiving":[52],"at":[55,66,144],"least":[56],"1":[57],"month":[58],"prior":[59],"to":[60,108,114,232,291],"enrollment,":[61],"and":[62,99,106,127,186,214],"side":[63,157,171,200,251,289],"effects":[64,172,201,290],"occurring":[65],"time":[68],"single":[71],"visit":[73],"were":[74,104,132,178,222],"recorded.":[75],"Low-penetrance":[76],"methylenetetrahydrofolate":[80],"reductase":[81],"(MTHFR)":[82],"677TT,":[83],"thymidylate":[84],"synthase":[85],"(TSER)":[86],"*2/*2":[87],"(variable":[88],"number":[89],"tandem":[91],"repeats),":[92],"amino":[93],"imidazole":[94],"ribonucleotide":[95],"transformylase":[96],"(ATIC)":[97],"347GG,":[98],"serine":[100],"hydroxymethyltransferase":[101],"(SHMT1)":[102],"1420CC":[103,188,216],"measured":[105],"summed":[107],"constitute":[109],"toxicogenetic":[111,227],"index":[112,228,237,256,269],"specific":[113],"each":[115],"patient.":[116],"Statistical":[117],"analyses":[118],"consisted":[119],"logistic":[121],"regression":[122],"models":[123],"clustered-center":[125],"effects,":[126],"associations":[128],"expressed":[133],"as":[134],"adjusted":[135],"odds":[136],"ratios":[137],"(ORs).":[138],"RESULTS:":[139],"Among":[140],"214":[141],"enrolled":[143],"4":[145],"sites,":[147],"total":[149],"67":[151],"(31%)":[153],"presented":[154],"effect":[158,252],"(gastrointestinal":[159],"event,":[160],"headache,":[161],"lethargy,":[162],"alopecia,":[163],"cough,":[164],"or":[165],"dyspnea).":[166],"Risk":[167],"central":[175],"nervous":[176],"system":[177],"MTHFR":[179],"677TT":[180],"(OR":[181,189,202,209,217],"3.3,":[182],"P":[183,191,204,211,219],"<":[184,192,205,212,220,260],"0.01)":[185,213,221],"SHMT1":[187,215],"2.4,":[190],"0.05).":[193],"ATIC":[194],"347GG":[195],"gastrointestinal":[199],"3.0,":[203],"0.01),":[206],"while":[207],"TSER*2/*2":[208],"5.4,":[210],"3.2,":[218],"alopecia.":[225],"The":[226],"ranged":[229],"from":[230],"0":[231,258],"3":[233,239],"(median":[234],"1).":[235],"An":[236],"approximately":[244],"7-fold":[245],"higher":[246],"likelihood":[247],"having":[249],"compared":[253],"(P":[259],"0.01).":[261],"CONCLUSION:":[262],"These":[263],"data":[264],"suggest":[265],"composite":[268],"cumulative":[272],"may":[278],"be":[279],"effective":[281],"means":[282],"profiling":[284],"develop":[288],"MTX.":[292]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
