{"id":"https://openalex.org/W1991636099","doi":"https://doi.org/10.1038/sj.bjc.6605794","title":"Quercetin induced apoptosis in association with death receptors and fludarabine in cells isolated from chronic lymphocytic leukaemia patients","display_name":"Quercetin induced apoptosis in association with death receptors and fludarabine in cells isolated from chronic lymphocytic leukaemia patients","publication_year":2010,"publication_date":"2010-07-20","ids":{"openalex":"https://openalex.org/W1991636099","doi":"https://doi.org/10.1038/sj.bjc.6605794","mag":"1991636099","pmid":"https://pubmed.ncbi.nlm.nih.gov/20648016","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2938248"},"language":"en","primary_location":{"id":"doi:10.1038/sj.bjc.6605794","doi":"https://doi.org/10.1038/sj.bjc.6605794","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6605794","pdf_url":"https://www.nature.com/articles/6605794.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/6605794.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069067418","display_name":"Maria Russo","orcid":"https://orcid.org/0000-0001-8385-9184","observed_orcids":["https://orcid.org/0000-0001-8385-9184"]},"institutions":[{"id":"https://openalex.org/I4210087001","display_name":"Institute of Food Science","ror":"https://ror.org/0013zhk30","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210087001","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Russo","raw_affiliation_strings":["Institute of Food Sciences, National Research Council, Avellino 83100, Italy","Institute of Food Sciences-National Research Council, Avellino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Food Sciences, National Research Council, Avellino 83100, Italy","institution_ids":["https://openalex.org/I4210087001","https://openalex.org/I4210155236"]},{"raw_affiliation_string":"Institute of Food Sciences-National Research Council, Avellino, Italy","institution_ids":["https://openalex.org/I4210087001","https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042308831","display_name":"Carmela Spagnuolo","orcid":"https://orcid.org/0000-0001-7877-9382","observed_orcids":["https://orcid.org/0000-0001-7877-9382"]},"institutions":[{"id":"https://openalex.org/I4210087001","display_name":"Institute of Food Science","ror":"https://ror.org/0013zhk30","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210087001","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C Spagnuolo","raw_affiliation_strings":["Institute of Food Sciences, National Research Council, Avellino, 83100, Italy","Institute of Food Sciences-National Research Council, Avellino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Food Sciences, National Research Council, Avellino, 83100, Italy","institution_ids":["https://openalex.org/I4210087001","https://openalex.org/I4210155236"]},{"raw_affiliation_string":"Institute of Food Sciences-National Research Council, Avellino, Italy","institution_ids":["https://openalex.org/I4210087001","https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S Volpe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111929","display_name":"Azienda Ospedaliera S.Giuseppe Moscati","ror":"https://ror.org/021jxzw96","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210111929"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S Volpe","raw_affiliation_strings":["Onco-Haematology Division, SG Moscati Hospital, Avellino, 83100, Italy","Onco-Haematology Division, SG Moscati Hospital, Avellino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Onco-Haematology Division, SG Moscati Hospital, Avellino, 83100, Italy","institution_ids":["https://openalex.org/I4210111929"]},{"raw_affiliation_string":"Onco-Haematology Division, SG Moscati Hospital, Avellino, Italy","institution_ids":["https://openalex.org/I4210111929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071157009","display_name":"Annalisa Mupo","orcid":"https://orcid.org/0000-0002-2771-0462","observed_orcids":["https://orcid.org/0000-0002-2771-0462"]},"institutions":[{"id":"https://openalex.org/I4210087001","display_name":"Institute of Food Science","ror":"https://ror.org/0013zhk30","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210087001","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A Mupo","raw_affiliation_strings":["Institute of Food Sciences, National Research Council, Avellino, 83100, Italy","Institute of Food Sciences-National Research Council, Avellino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Food Sciences, National Research Council, Avellino, 83100, Italy","institution_ids":["https://openalex.org/I4210087001","https://openalex.org/I4210155236"]},{"raw_affiliation_string":"Institute of Food Sciences-National Research Council, Avellino, Italy","institution_ids":["https://openalex.org/I4210087001","https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082136018","display_name":"Idolo Tedesco","orcid":"https://orcid.org/0000-0002-0574-1380","observed_orcids":["https://orcid.org/0000-0002-0574-1380"]},"institutions":[{"id":"https://openalex.org/I4210087001","display_name":"Institute of Food Science","ror":"https://ror.org/0013zhk30","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210087001","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"I Tedesco","raw_affiliation_strings":["Institute of Food Sciences, National Research Council, Avellino, 83100, Italy","Institute of Food Sciences-National Research Council, Avellino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Food Sciences, National Research Council, Avellino, 83100, Italy","institution_ids":["https://openalex.org/I4210087001","https://openalex.org/I4210155236"]},{"raw_affiliation_string":"Institute of Food Sciences-National Research Council, Avellino, Italy","institution_ids":["https://openalex.org/I4210087001","https://openalex.org/I4210155236"]}]},{"author_position":"last","author":{"id":null,"display_name":"G-L Russo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087001","display_name":"Institute of Food Science","ror":"https://ror.org/0013zhk30","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210087001","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"G-L Russo","raw_affiliation_strings":["Institute of Food Sciences, National Research Council, Avellino, 83100, Italy","Institute of Food Sciences-National Research Council, Avellino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Food Sciences, National Research Council, Avellino, 83100, Italy","institution_ids":["https://openalex.org/I4210087001","https://openalex.org/I4210155236"]},{"raw_affiliation_string":"Institute of Food Sciences-National Research Council, Avellino, Italy","institution_ids":["https://openalex.org/I4210087001","https://openalex.org/I4210155236"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210087001","https://openalex.org/I4210155236"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":4.8133,"has_fulltext":true,"cited_by_count":54,"citation_normalized_percentile":{"value":0.94936912,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"103","issue":"5","first_page":"642","last_page":"648"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.6195999979972839,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.6195999979972839,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.3393999934196472,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.03229999914765358,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":1.0},{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.9520000219345093},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8849999904632568},{"id":"https://openalex.org/keywords/death-receptors","display_name":"death receptors","score":0.8769999742507935},{"id":"https://openalex.org/keywords/trail","display_name":"TRAIL","score":0.9290000200271606},{"id":"https://openalex.org/keywords/fludarabine","display_name":"fludarabine","score":0.9570000171661377},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9010000228881836},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.8510000109672546},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":0.9589999914169312},{"id":"https://openalex.org/keywords/drug-sensitisation","display_name":"drug sensitisation","score":0.5699999928474426},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.75}],"concepts":[{"id":"https://openalex.org/C2779263901","wikidata":"https://www.wikidata.org/wiki/Q185916","display_name":"Fludarabine","level":4,"score":0.7808480858802795},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6879889369010925},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5728223919868469},{"id":"https://openalex.org/C88634738","wikidata":"https://www.wikidata.org/wiki/Q24769543","display_name":"Annexin","level":3,"score":0.5510236024856567},{"id":"https://openalex.org/C2781263971","wikidata":"https://www.wikidata.org/wiki/Q409478","display_name":"Quercetin","level":3,"score":0.521342396736145},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.4984917640686035},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.44965505599975586},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4247146546840668},{"id":"https://openalex.org/C66008609","wikidata":"https://www.wikidata.org/wiki/Q14866113","display_name":"Fas ligand","level":4,"score":0.4206653833389282},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39434993267059326},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37148815393447876},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3233354389667511},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2099837064743042},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1806372106075287},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.12055656313896179},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10958811640739441},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.05585962533950806},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011794","descriptor_name":"Quercetin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014740","descriptor_name":"Vidarabine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019014","descriptor_name":"fas Receptor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D053218","descriptor_name":"Receptors, Death Domain","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D053221","descriptor_name":"TNF-Related Apoptosis-Inducing Ligand","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1038/sj.bjc.6605794","doi":"https://doi.org/10.1038/sj.bjc.6605794","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6605794","pdf_url":"https://www.nature.com/articles/6605794.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:20648016","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20648016","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2938248","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2938248/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Cancer","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/sj.bjc.6605794","doi":"https://doi.org/10.1038/sj.bjc.6605794","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6605794","pdf_url":"https://www.nature.com/articles/6605794.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1991636099.pdf","grobid_xml":"https://content.openalex.org/works/W1991636099.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W183694329","https://openalex.org/W1243376384","https://openalex.org/W1976754594","https://openalex.org/W1976916701","https://openalex.org/W1977791393","https://openalex.org/W2002112016","https://openalex.org/W2003892126","https://openalex.org/W2023958883","https://openalex.org/W2026046537","https://openalex.org/W2030631359","https://openalex.org/W2031034039","https://openalex.org/W2037951556","https://openalex.org/W2038761970","https://openalex.org/W2041421828","https://openalex.org/W2041520207","https://openalex.org/W2055593155","https://openalex.org/W2058837319","https://openalex.org/W2059381010","https://openalex.org/W2070193300","https://openalex.org/W2072551769","https://openalex.org/W2074152898","https://openalex.org/W2076564689","https://openalex.org/W2077703166","https://openalex.org/W2087843541","https://openalex.org/W2094242997","https://openalex.org/W2094992173","https://openalex.org/W2109375301","https://openalex.org/W2125988618","https://openalex.org/W2128635872","https://openalex.org/W2135270635","https://openalex.org/W2141534282","https://openalex.org/W2142099365","https://openalex.org/W2144312770","https://openalex.org/W2150416060","https://openalex.org/W2154849537","https://openalex.org/W2159364831","https://openalex.org/W2169238639","https://openalex.org/W2328332463","https://openalex.org/W2522162609","https://openalex.org/W4211009566","https://openalex.org/W4236487956"],"related_works":["https://openalex.org/W1965992243","https://openalex.org/W1871409931","https://openalex.org/W2072551769","https://openalex.org/W2044956722","https://openalex.org/W2093149339","https://openalex.org/W1989738561","https://openalex.org/W2770942148","https://openalex.org/W2119576166","https://openalex.org/W1985518658","https://openalex.org/W4225415038"],"abstract_inverted_index":{"BACKGROUND:":[0],"Quercetin":[1,117],"is":[2],"a":[3,52,206],"flavonoid":[4],"naturally":[5],"present":[6],"in":[7,152,174,203,211,214],"food":[8],"and":[9,47,49,68,87,113,121,133,136,170],"beverages":[10],"belonging":[11],"to":[12,29,38,50,96,110,138,168],"the":[13,25,149,187,193,197],"large":[14],"class":[15],"of":[16,27,144,155,196,205,209],"phytochemicals":[17],"with":[18,70,146,159,190,216],"potential":[19,207],"anti-cancer":[20],"properties.":[21],"Here,":[22],"we":[23],"investigated":[24],"ability":[26],"quercetin":[28,86,145,160,210],"sensitise":[30],"primary":[31],"cells":[32,63,154,176],"from":[33,66,178],"chronic":[34],"lymphocytic":[35],"leukaemia":[36],"(CLL)":[37],"death":[39,124,173],"receptor":[40],"(DR)":[41],"agonists,":[42],"recombinant":[43,82],"TNF-related-apoptosis-inducing":[44],"ligand":[45],"(rTRAIL)":[46],"anti-CD95,":[48],"fludarabine,":[51],"widely":[53],"used":[54,95],"chemotherapeutic":[55],"drug":[56],"against":[57],"CLL.":[58],"METHODS:":[59],"Peripheral":[60],"white":[61],"blood":[62],"were":[64],"isolated":[65,177],"patients":[67,180],"incubated":[69],"medium":[71],"containing":[72],"50":[73],"ng":[74,80],"ml":[75,81],"anti-CD95":[76],"agonist":[77],"antibody;":[78],"10":[79],"TRAIL;":[83],"10-25":[84],"microM":[85,89],"3.5-14":[88],"fludarabine.":[90],"Neutral":[91],"Red":[92],"assay":[93],"was":[94,103],"measure":[97],"cell":[98,123,129,172],"viability,":[99,130],"where":[100],"as":[101,125],"apoptosis":[102],"assessed":[104],"by":[105,127,186],"determining":[106],"caspase-3":[107,132],"activity,":[108],"exposure":[109],"Annexin":[111,139],"V":[112],"PARP":[114],"fragmentation.":[115],"RESULTS:":[116],"significantly":[118],"enhanced":[119],"anti-CD95-":[120],"rTRAIL-induced":[122],"shown":[126],"decreased":[128],"increased":[131],"-9":[134],"activities,":[135],"positivity":[137],"V.":[140],"In":[141],"addition,":[142],"association":[143],"fludarabine":[147],"increases":[148],"apoptotic":[150],"response":[151],"CLL":[153,179],"about":[156],"two-fold":[157],"compared":[158],"monotreatment.":[161],"CONCLUSION:":[162],"This":[163],"work":[164],"shows":[165],"that":[166],"resistance":[167],"DR-":[169],"fludarabine-induced":[171],"leukaemic":[175],"can":[181],"be":[182],"ameliorated":[183],"or":[184],"bypassed":[185],"combined":[188],"treatment":[189],"quercetin.":[191],"Considering":[192],"low":[194],"toxicity":[195],"molecule,":[198],"our":[199],"study":[200],"results":[201],"are":[202],"favour":[204],"use":[208],"adjuvant":[212],"chemotherapy":[213],"combination":[215],"other":[217],"drugs.":[218]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
