{"id":"https://openalex.org/W1991625655","doi":"https://doi.org/10.1161/01.atv.0000193627.12516.1d","title":"Distinct Cellular Loci for the ABCA1-Dependent and ABCA1-Independent Lipid Efflux Mediated by Endogenous Apolipoprotein E Expression","display_name":"Distinct Cellular Loci for the ABCA1-Dependent and ABCA1-Independent Lipid Efflux Mediated by Endogenous Apolipoprotein E Expression","publication_year":2005,"publication_date":"2005-10-28","ids":{"openalex":"https://openalex.org/W1991625655","doi":"https://doi.org/10.1161/01.atv.0000193627.12516.1d","mag":"1991625655","pmid":"https://pubmed.ncbi.nlm.nih.gov/16254198"},"language":"en","primary_location":{"id":"doi:10.1161/01.atv.0000193627.12516.1d","doi":"https://doi.org/10.1161/01.atv.0000193627.12516.1d","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.atv.0000193627.12516.1d","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056424666","display_name":"Zhihua Huang","orcid":"https://orcid.org/0000-0001-5710-5231","observed_orcids":["https://orcid.org/0000-0001-5710-5231"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhi H. Huang","raw_affiliation_strings":["From the Departments of Medicine (Z.H.H., T.M.) and Pharmacology (T.M.), University of Illinois at Chicago; and the Department of Medicine (M.L.F.), Massachusetts General Hospital, Harvard Medical School, Boston, Mass","Zhi H. Huang From the Departments of Medicine (Z.H.H., T.M.) and Pharmacology (T.M.), University of Illinois at Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine (Z.H.H., T.M.) and Pharmacology (T.M.), University of Illinois at Chicago; and the Department of Medicine (M.L.F.), Massachusetts General Hospital, Harvard Medical School, Boston, Mass","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I39422238","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Zhi H. Huang From the Departments of Medicine (Z.H.H., T.M.) and Pharmacology (T.M.), University of Illinois at Chicago","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102852421","display_name":"Michael L. Fitzgerald","orcid":"https://orcid.org/0000-0003-2346-9250","observed_orcids":["https://orcid.org/0000-0003-2346-9250"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael L. Fitzgerald","raw_affiliation_strings":["From the Departments of Medicine (Z.H.H., T.M.) and Pharmacology (T.M.), University of Illinois at Chicago; and the Department of Medicine (M.L.F.), Massachusetts General Hospital, Harvard Medical School, Boston, Mass","Michael L. Fitzgerald From the Departments of Medicine (Z.H.H., T.M.) and Pharmacology (T.M.), University of Illinois at Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine (Z.H.H., T.M.) and Pharmacology (T.M.), University of Illinois at Chicago; and the Department of Medicine (M.L.F.), Massachusetts General Hospital, Harvard Medical School, Boston, Mass","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I39422238","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Michael L. Fitzgerald From the Departments of Medicine (Z.H.H., T.M.) and Pharmacology (T.M.), University of Illinois at Chicago","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110088558","display_name":"Theodore Mazzone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theodore Mazzone","raw_affiliation_strings":["From the Departments of Medicine (Z.H.H., T.M.) and Pharmacology (T.M.), University of Illinois at Chicago; and the Department of Medicine (M.L.F.), Massachusetts General Hospital, Harvard Medical School, Boston, Mass","Theodore Mazzone From the Departments of Medicine (Z.H.H., T.M.) and Pharmacology (T.M.), University of Illinois at Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine (Z.H.H., T.M.) and Pharmacology (T.M.), University of Illinois at Chicago; and the Department of Medicine (M.L.F.), Massachusetts General Hospital, Harvard Medical School, Boston, Mass","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I39422238","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Theodore Mazzone From the Departments of Medicine (Z.H.H., T.M.) and Pharmacology (T.M.), University of Illinois at Chicago","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2368,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.7238732,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"26","issue":"1","first_page":"157","last_page":"162"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.9559999704360962},{"id":"https://openalex.org/keywords/abca1","display_name":"ABCA1","score":1.0},{"id":"https://openalex.org/keywords/lipid-efflux","display_name":"lipid efflux","score":0.8410000205039978},{"id":"https://openalex.org/keywords/sterol-efflux","display_name":"sterol efflux","score":0.9670000076293945},{"id":"https://openalex.org/keywords/phospholipid-efflux","display_name":"phospholipid efflux","score":0.9169999957084656},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9350000023841858},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.5989999771118164},{"id":"https://openalex.org/keywords/dermal-fibroblasts","display_name":"dermal fibroblasts","score":0.7630000114440918}],"concepts":[{"id":"https://openalex.org/C2777704780","wikidata":"https://www.wikidata.org/wiki/Q21115210","display_name":"ABCA1","level":4,"score":0.9249705076217651},{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.7439753413200378},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.7144711017608643},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.4868759214878082},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4690811038017273},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39221906661987305},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.379564106464386},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.36184781789779663},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20467859506607056},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19760242104530334},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.048078835010528564}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013261","descriptor_name":"Sterols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016632","descriptor_name":"Apolipoprotein A-I","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017737","descriptor_name":"Macrophages, Peritoneal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020405","descriptor_name":"Dermis","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064286","descriptor_name":"ATP Binding Cassette Transporter 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1161/01.atv.0000193627.12516.1d","doi":"https://doi.org/10.1161/01.atv.0000193627.12516.1d","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.atv.0000193627.12516.1d","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},{"id":"pmid:16254198","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16254198","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, thrombosis, and vascular biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.520.7780","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.520.7780","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://atvb.ahajournals.org/content/26/1/157.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.982.301","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.982.301","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://atvb.ahajournals.org/content/atvbaha/26/1/157.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8202950719","display_name":"Macrophage Cholesterol Metabolism and ApoE Synthesis","funder_award_id":"R01HL039653","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W274686055","https://openalex.org/W1490060007","https://openalex.org/W1854805603","https://openalex.org/W1908587496","https://openalex.org/W1912307511","https://openalex.org/W1970259339","https://openalex.org/W1970261570","https://openalex.org/W1986755882","https://openalex.org/W1987436224","https://openalex.org/W1991376375","https://openalex.org/W1992980650","https://openalex.org/W1995873562","https://openalex.org/W2007548915","https://openalex.org/W2017670475","https://openalex.org/W2019796869","https://openalex.org/W2047330360","https://openalex.org/W2049660003","https://openalex.org/W2053674077","https://openalex.org/W2055382682","https://openalex.org/W2059059166","https://openalex.org/W2066557706","https://openalex.org/W2067541521","https://openalex.org/W2068646590","https://openalex.org/W2072433515","https://openalex.org/W2103714932","https://openalex.org/W2114199907","https://openalex.org/W2122062568","https://openalex.org/W2124913210","https://openalex.org/W2128738849","https://openalex.org/W2129096786","https://openalex.org/W2130388575","https://openalex.org/W2133238095","https://openalex.org/W2140793104","https://openalex.org/W2155839544","https://openalex.org/W2168763691","https://openalex.org/W2185058201","https://openalex.org/W2276906655","https://openalex.org/W2319467927","https://openalex.org/W2324147954"],"related_works":["https://openalex.org/W7100161311","https://openalex.org/W2140793104","https://openalex.org/W1976551565","https://openalex.org/W2156476693","https://openalex.org/W2036699721","https://openalex.org/W2151211162","https://openalex.org/W2114199907","https://openalex.org/W1013739981","https://openalex.org/W2089579052","https://openalex.org/W1912307511"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Macrophage":[1],"expression":[2,58,76,104,180],"of":[3,59,77,102,138,168,198,212],"both":[4,70,160],"apolipoprotein":[5],"E":[6],"(apoE)":[7],"and":[8,20,35,72,88,162,171],"ABCA1":[9,36,98,161,179],"have":[10],"been":[11],"shown":[12],"to":[13,21],"modulate":[14],"lipid":[15,48,123,129,203],"efflux":[16,49,92,114,124,130,146,153,185,204],"from":[17,65,115,128,148],"these":[18],"cells":[19,149,158],"play":[22],"an":[23,106,199],"important":[24],"atheroprotective":[25],"role":[26],"in":[27,52,61,80,91,157],"vivo.":[28],"We":[29],"evaluated":[30],"the":[31,135,169,196,207],"relationship":[32],"between":[33],"apoE":[34,60,79,103,107,144,189],"for":[37,174,183,202],"regulating":[38],"cellular":[39],"sterol":[40,71,86,113,176],"efflux.":[41,74,177],"METHODS":[42],"AND":[43],"RESULTS:":[44],"ApoE-mediated,":[45,120],"but":[46,121],"ABCA1-independent,":[47,122],"was":[50,93,132,154],"demonstrated":[51],"3":[53],"model":[54],"systems.":[55],"First,":[56],"adenoviral-mediated":[57],"dermal":[62],"fibroblasts":[63],"isolated":[64],"ABCA1(-/-)":[66,116],"mice":[67],"significantly":[68,111],"increased":[69,85],"phospholipid":[73],"Second,":[75],"human":[78],"a":[81,166],"macrophage":[82],"cell":[83],"line":[84],"efflux,":[87],"this":[89],"increment":[90],"not":[94],"reduced":[95,112],"by":[96],"suppressing":[97],"expression.":[99],"Third,":[100],"reduction":[101],"using":[105],"small":[108],"interfering":[109],"RNA":[110],"mouse":[117],"peritoneal":[118],"macrophages.":[119],"could":[125],"be":[126],"differentiated":[127],"that":[131,205],"dependent":[133],"on":[134],"extracellular":[136],"accumulation":[137],"secreted":[139],"apoE,":[140,163],"because":[141],"exogenous":[142],"cell-derived":[143],"stimulated":[145],"only":[147],"expressing":[150,159],"ABCA1.":[151],"Sterol":[152],"usually":[155],"highest":[156],"likely":[164],"representing":[165],"summation":[167],"ABCA1-dependent":[170],"-independent":[172],"pathways":[173],"apoE-mediated":[175,184],"CONCLUSIONS:":[178],"is":[181],"required":[182],"when":[186],"endogenously":[187],"synthesized":[188],"accumulates":[190],"extracellularly.":[191],"Our":[192],"results,":[193],"however,":[194],"establish":[195],"existence":[197],"ABCA1-independent":[200],"pathway":[201],"requires":[206],"intracellular":[208],"synthesis":[209],"and/or":[210],"transport":[211],"apoE.":[213]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}