{"id":"https://openalex.org/W1991597342","doi":"https://doi.org/10.1371/journal.pone.0066334","title":"Resistance to Streptozotocin-Induced Autoimmune Diabetes in Absence of Complement C3: Myeloid-Derived Suppressor Cells Play a Role","display_name":"Resistance to Streptozotocin-Induced Autoimmune Diabetes in Absence of Complement C3: Myeloid-Derived Suppressor Cells Play a Role","publication_year":2013,"publication_date":"2013-06-18","ids":{"openalex":"https://openalex.org/W1991597342","doi":"https://doi.org/10.1371/journal.pone.0066334","mag":"1991597342","pmid":"https://pubmed.ncbi.nlm.nih.gov/23824734","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3688892"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0066334","doi":"https://doi.org/10.1371/journal.pone.0066334","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0066334","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0066334&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0066334&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111592979","display_name":"Xiaogang Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaogang Gao","raw_affiliation_strings":["Department of Organ Transplantation, Shanghai ChangZheng Hospital, Second Military Medical University, Shanghai, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organ Transplantation, Shanghai ChangZheng Hospital, Second Military Medical University, Shanghai, P. R. China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210099558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045744782","display_name":"Huanhai Liu","orcid":"https://orcid.org/0000-0001-9756-7588","observed_orcids":["https://orcid.org/0000-0001-9756-7588","https://orcid.org/0009-0000-2432-7241"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huanhai Liu","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, Shanghai ChangZheng Hospital, Second Military Medical University, Shanghai, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, Shanghai ChangZheng Hospital, Second Military Medical University, Shanghai, P. R. China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210099558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112844549","display_name":"Bin He","orcid":"https://orcid.org/0000-0001-8468-7492","observed_orcids":["https://orcid.org/0000-0001-8468-7492"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801518579","display_name":"XinHua Hospital","ror":"https://ror.org/04dzvks42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801518579"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin He","raw_affiliation_strings":["Department of Anesthesiology and Critical Care Medicine, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Critical Care Medicine, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, P. R. China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801518579"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002798633","display_name":"Zhiren Fu","orcid":"https://orcid.org/0000-0001-7288-6769","observed_orcids":["https://orcid.org/0000-0001-7288-6769"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhiren Fu","raw_affiliation_strings":["Department of Organ Transplantation, Shanghai ChangZheng Hospital, Second Military Medical University, Shanghai, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organ Transplantation, Shanghai ChangZheng Hospital, Second Military Medical University, Shanghai, P. R. China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210099558"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5002798633"],"corresponding_institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210099558"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.3159,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.79013476,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"8","issue":"6","first_page":"e66334","last_page":"e66334"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.8759999871253967,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.8759999871253967,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.05719999969005585,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.013299999758601189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":0.9409999847412109},{"id":"https://openalex.org/keywords/complement-c3","display_name":"complement C3","score":0.8299999833106995},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9739999771118164},{"id":"https://openalex.org/keywords/autoimmune-diabetes","display_name":"autoimmune diabetes","score":0.925000011920929},{"id":"https://openalex.org/keywords/arginase-1","display_name":"arginase-1","score":0.7979999780654907},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":1.0},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9599999785423279},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9089999794960022},{"id":"https://openalex.org/keywords/t-cell-proliferation-inhibition","display_name":"T cell proliferation inhibition","score":0.6930000185966492},{"id":"https://openalex.org/keywords/complement-deficiency","display_name":"complement deficiency","score":0.824999988079071},{"id":"https://openalex.org/keywords/diabetes-resistance","display_name":"diabetes resistance","score":0.39800000190734863}],"concepts":[{"id":"https://openalex.org/C164007495","wikidata":"https://www.wikidata.org/wiki/Q24721374","display_name":"Arginase","level":4,"score":0.781684160232544},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.6366602182388306},{"id":"https://openalex.org/C2908810637","wikidata":"https://www.wikidata.org/wiki/Q1797833","display_name":"Autoimmune diabetes","level":4,"score":0.5916006565093994},{"id":"https://openalex.org/C55721878","wikidata":"https://www.wikidata.org/wiki/Q15220362","display_name":"Myeloid-derived Suppressor Cell","level":4,"score":0.5734313726425171},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5722818374633789},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5409752726554871},{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.5071961879730225},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.41692090034484863},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4071248471736908},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.31064027547836304},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28470730781555176},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2775072157382965},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.26224491000175476},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.2142018973827362},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.11046597361564636},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07247161865234375},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.05163988471031189},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000072737","descriptor_name":"Myeloid-Derived Suppressor Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003176","descriptor_name":"Complement C3","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013311","descriptor_name":"Streptozocin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0066334","doi":"https://doi.org/10.1371/journal.pone.0066334","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0066334","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0066334&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2695353","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3688892","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:23824734","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23824734","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3688892","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3688892/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.784.9914","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.784.9914","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/8e/e1/pone.0066334.PMC3688892.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:220767d9733e48a3a101bcb11a4d7b69","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/220767d9733e48a3a101bcb11a4d7b69","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 6, p e66334 (2013)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/724836","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/_Resistance_to_Streptozotocin_Induced_Autoimmune_Diabetes_in_Absence_of_Complement_C3_Myeloid_Derived_Suppressor_Cells_Play_a_Role_/724836","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0066334","doi":"https://doi.org/10.1371/journal.pone.0066334","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0066334","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0066334&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G229446640","display_name":"miRNA-1\u548cmiRNA-133\u5728\u7f3a\u8840\u540e\u5904\u7406\u7684\u5fc3\u808c\u4fdd\u62a4\u673a\u5236\u4e2d\u7684\u8c03\u63a7\u4f5c\u7528\u7814\u7a76","funder_award_id":"30901470","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7342182068","display_name":"AGEs\u5bf9\u7cd6\u5c3f\u75c5\u65e9\u671f\u76ae\u80a4\u7684\u635f\u5bb3\u4f5c\u7528\u53ca\u673a\u5236\u7814\u7a76","funder_award_id":"81100585","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8545736611","display_name":"Beclin 1\u4ecb\u5bfc\u7684\u7ec6\u80de\u81ea\u566c\u5728\u809d\u810f\u514d\u75ab\u8010\u53d7\u4e2d\u7684\u4f5c\u7528\u673a\u5236\u7814\u7a76","funder_award_id":"31100639","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320309612","display_name":"Natural Science Foundation of Shanghai","ror":null},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1991597342.pdf","grobid_xml":"https://content.openalex.org/works/W1991597342.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W39406438","https://openalex.org/W315197452","https://openalex.org/W1581761477","https://openalex.org/W1989862144","https://openalex.org/W1990061395","https://openalex.org/W2015133779","https://openalex.org/W2017344189","https://openalex.org/W2048554655","https://openalex.org/W2050291713","https://openalex.org/W2052502118","https://openalex.org/W2059688175","https://openalex.org/W2067465778","https://openalex.org/W2079957089","https://openalex.org/W2082137006","https://openalex.org/W2085937163","https://openalex.org/W2086841832","https://openalex.org/W2095455162","https://openalex.org/W2110271242","https://openalex.org/W2117576368","https://openalex.org/W2120407692","https://openalex.org/W2125066479","https://openalex.org/W2126747080","https://openalex.org/W2130870648","https://openalex.org/W2131058743","https://openalex.org/W2138281334","https://openalex.org/W2144156694","https://openalex.org/W2149437353","https://openalex.org/W2160390319","https://openalex.org/W2170123390","https://openalex.org/W2209228374"],"related_works":["https://openalex.org/W2048554655","https://openalex.org/W2052502118","https://openalex.org/W2188357609","https://openalex.org/W7100429449","https://openalex.org/W2126747080","https://openalex.org/W2552752030","https://openalex.org/W2141194243","https://openalex.org/W2034837120","https://openalex.org/W1282632","https://openalex.org/W2001712566"],"abstract_inverted_index":{"The":[0,14],"contribution":[1],"of":[2,7,43,70,76,97,122,147,156,161],"complement":[3,44,148,162],"to":[4,39,73,141],"the":[5,74,95,145],"development":[6,96],"autoimmune":[8,165],"diabetes":[9,40,78,98,143],"has":[10],"been":[11],"proposed":[12],"recently.":[13],"underlying":[15,158],"mechanisms,":[16],"however,":[17],"remain":[18],"poorly":[19],"understood.":[20],"We":[21],"hypothesize":[22],"that":[23,135],"myeloid-derived":[24],"suppressor":[25],"cells":[26,57],"(MDSC),":[27],"which":[28,150],"act":[29],"as":[30,120],"regulators":[31],"in":[32,37,41,52,79,99,116,139,144],"autoimmunity,":[33],"play":[34],"a":[35],"role":[36],"resistance":[38,140],"absence":[42,146],"C3.":[45],"Indeed,":[46],"MDSC":[47,71,86,114,130,136],"number":[48],"was":[49],"increased":[50],"significantly":[51],"STZ-treated":[53,117],"C3-/-":[54,80,85,118],"mice.":[55],"These":[56,132],"highly":[58],"expressed":[59],"arginase":[60,100],"I":[61],"and":[62,93,106],"inducible":[63],"nitric":[64],"oxide":[65],"synthase":[66],"(iNOS).":[67],"Importantly,":[68],"depletion":[69,121],"led":[72],"occurrence":[75],"overt":[77],"mice":[81,119],"after":[82],"STZ.":[83],"Furthermore,":[84],"actively":[87],"suppressed":[88],"diabetogenic":[89],"T":[90],"cell":[91],"proliferation":[92],"prevented/delayed":[94],"and/or":[101],"iNOS-dependent":[102],"manner.":[103],"Both":[104],"Tregs":[105,123],"transforming":[107],"growth":[108],"factor-\u03b2":[109],"(TGF-\u03b2)":[110],"are":[111,137],"crucial":[112],"for":[113,154],"induction":[115],"or":[124],"blocking":[125],"TGF-\u03b2":[126],"bioactivity":[127],"dramatically":[128],"decreased":[129],"number.":[131],"findings":[133],"indicate":[134],"implicated":[138],"STZ-induced":[142],"C3,":[149],"may":[151],"be":[152],"helpful":[153],"understanding":[155],"mechanisms":[157],"preventive":[159],"effects":[160],"deficiency":[163],"on":[164],"diseases.":[166]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
