{"id":"https://openalex.org/W1991580166","doi":"https://doi.org/10.1016/j.hrthm.2009.09.058","title":"NOS1AP Is a Genetic Modifier of Congenital Long-QT Syndrome","display_name":"NOS1AP Is a Genetic Modifier of Congenital Long-QT Syndrome","publication_year":2009,"publication_date":"2009-10-30","ids":{"openalex":"https://openalex.org/W1991580166","doi":"https://doi.org/10.1016/j.hrthm.2009.09.058","mag":"1991580166"},"language":"en","primary_location":{"id":"doi:10.1016/j.hrthm.2009.09.058","doi":"https://doi.org/10.1016/j.hrthm.2009.09.058","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.hrthm.2009.09.058","pdf_url":null,"source":{"id":"https://openalex.org/S163651451","display_name":"Heart Rhythm","issn_l":"1547-5271","issn":["1547-5271","1556-3871"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart Rhythm","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021994330","display_name":"Lia Crotti","orcid":"https://orcid.org/0000-0001-8739-6527","observed_orcids":["https://orcid.org/0000-0001-8739-6527","https://orcid.org/0000-0002-5728-3158"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]},{"id":"https://openalex.org/I4210151645","display_name":"Policlinico San Matteo Fondazione","ror":"https://ror.org/05w1q1c88","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210151645","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lia Crotti","raw_affiliation_strings":["Univ of Pavia and Fondazione IRCCS Policlinico S Matteo, Pavia, Italy","University of Pavia and Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Pavia and Fondazione IRCCS Policlinico S Matteo, Pavia, Italy","institution_ids":["https://openalex.org/I25217355","https://openalex.org/I4210151645"]},{"raw_affiliation_string":"University of Pavia and Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy","institution_ids":["https://openalex.org/I25217355","https://openalex.org/I4210151645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111499694","display_name":"Roberto Insolia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]},{"id":"https://openalex.org/I4210151645","display_name":"Policlinico San Matteo Fondazione","ror":"https://ror.org/05w1q1c88","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210151645","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberto Insolia","raw_affiliation_strings":["Univ of Pavia and Fondazione IRCCS Policlinico S Matteo, Pavia, Italy","University of Pavia and Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Pavia and Fondazione IRCCS Policlinico S Matteo, Pavia, Italy","institution_ids":["https://openalex.org/I25217355","https://openalex.org/I4210151645"]},{"raw_affiliation_string":"University of Pavia and Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy","institution_ids":["https://openalex.org/I25217355","https://openalex.org/I4210151645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037755930","display_name":"Maria Cristina Monti","orcid":"https://orcid.org/0000-0003-1586-527X","observed_orcids":["https://orcid.org/0000-0003-1586-527X"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Cristina Monti","raw_affiliation_strings":["Univ of Pavia, Pavia, Italy","University of Pavia, Pavia / Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Pavia, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]},{"raw_affiliation_string":"University of Pavia, Pavia / Italy","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074266882","display_name":"Matteo Pedrazzini","orcid":"https://orcid.org/0000-0002-0675-4845","observed_orcids":["https://orcid.org/0000-0002-0675-4845"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]},{"id":"https://openalex.org/I4210151645","display_name":"Policlinico San Matteo Fondazione","ror":"https://ror.org/05w1q1c88","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210151645","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Matteo Pedrazzini","raw_affiliation_strings":["Univ of Pavia and Fondazione IRCCS Policlinico S Matteo, Pavia, Italy","University of Pavia and Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Pavia and Fondazione IRCCS Policlinico S Matteo, Pavia, Italy","institution_ids":["https://openalex.org/I25217355","https://openalex.org/I4210151645"]},{"raw_affiliation_string":"University of Pavia and Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy","institution_ids":["https://openalex.org/I25217355","https://openalex.org/I4210151645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026068834","display_name":"Erika Taravelli","orcid":"https://orcid.org/0000-0002-6777-3185","observed_orcids":["https://orcid.org/0000-0002-6777-3185"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]},{"id":"https://openalex.org/I4210151645","display_name":"Policlinico San Matteo Fondazione","ror":"https://ror.org/05w1q1c88","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210151645","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Erika Taravelli","raw_affiliation_strings":["Univ of Pavia and Fondazione IRCCS Policlinico S Matteo, Pavia, Italy","University of Pavia and Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Pavia and Fondazione IRCCS Policlinico S Matteo, Pavia, Italy","institution_ids":["https://openalex.org/I25217355","https://openalex.org/I4210151645"]},{"raw_affiliation_string":"University of Pavia and Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy","institution_ids":["https://openalex.org/I25217355","https://openalex.org/I4210151645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011959091","display_name":"Anna L. Peljto","orcid":"https://orcid.org/0000-0002-8389-0736","observed_orcids":["https://orcid.org/0000-0002-8389-0736"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Peljto","raw_affiliation_strings":["Columbia Univ. Medical Ctr, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia Univ. Medical Ctr, New York, NY","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114255540","display_name":"Althea Goosen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Althea Goosen","raw_affiliation_strings":["Univ of Stellenbosch, Tygerberg, South Africa","University of Stellenbosch; Tygerberg, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Stellenbosch, Tygerberg, South Africa","institution_ids":["https://openalex.org/I26092322"]},{"raw_affiliation_string":"University of Stellenbosch; Tygerberg, South Africa","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005320768","display_name":"Paul A. Brink","orcid":"https://orcid.org/0000-0001-8538-5824","observed_orcids":["https://orcid.org/0000-0001-8538-5824"]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Paul A. Brink","raw_affiliation_strings":["Univ of Stellenbosch, Tygerberg, South Africa","University of Stellenbosch; Tygerberg, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Stellenbosch, Tygerberg, South Africa","institution_ids":["https://openalex.org/I26092322"]},{"raw_affiliation_string":"University of Stellenbosch; Tygerberg, South Africa","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110590031","display_name":"David A. Greenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Greenberg","raw_affiliation_strings":["Columbia-Presbyterian Medical Ctr, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia-Presbyterian Medical Ctr, New York, NY","institution_ids":["https://openalex.org/I1340179700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013224321","display_name":"Peter J. Schwartz","orcid":"https://orcid.org/0000-0003-0367-1048","observed_orcids":["https://orcid.org/0000-0003-0367-1048"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]},{"id":"https://openalex.org/I4210151645","display_name":"Policlinico San Matteo Fondazione","ror":"https://ror.org/05w1q1c88","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210151645","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Peter J. Schwartz","raw_affiliation_strings":["Univ of Pavia and Fondazione IRCCS Policlinico S Matteo, Pavia, Italy","University of Pavia and Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Pavia and Fondazione IRCCS Policlinico S Matteo, Pavia, Italy","institution_ids":["https://openalex.org/I25217355","https://openalex.org/I4210151645"]},{"raw_affiliation_string":"University of Pavia and Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy","institution_ids":["https://openalex.org/I25217355","https://openalex.org/I4210151645"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013560175","display_name":"Alfred L. George","orcid":"https://orcid.org/0000-0002-3993-966X","observed_orcids":["https://orcid.org/0000-0002-3993-966X"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alfred L. George","raw_affiliation_strings":["Vanderbilt Univ, Nashville, TN","Vanderbilt University,Nashville,TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ, Nashville, TN","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt University,Nashville,TN","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.12490971,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"6","issue":"11","first_page":"1695","last_page":"1695"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nos1ap","display_name":"NOS1AP","score":0.9869999885559082},{"id":"https://openalex.org/keywords/congenital-long-qt-syndrome","display_name":"congenital long QT syndrome","score":0.8379999995231628},{"id":"https://openalex.org/keywords/modifier-genes","display_name":"genetic modifiers","score":0.9279999732971191},{"id":"https://openalex.org/keywords/qt-interval-prolongation","display_name":"QT prolongation","score":0.9319999814033508},{"id":"https://openalex.org/keywords/sudden-cardiac-death","display_name":"sudden cardiac death","score":0.871999979019165},{"id":"https://openalex.org/keywords/neuronal-nitric-oxide-synthase","display_name":"neuronal nitric oxide synthase","score":0.9179999828338623},{"id":"https://openalex.org/keywords/arrhythmogenic-substrate","display_name":"arrhythmogenic substrate","score":0.7200000286102295},{"id":"https://openalex.org/keywords/south-african-population","display_name":"South African population","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.873275101184845},{"id":"https://openalex.org/C2779703243","wikidata":"https://www.wikidata.org/wiki/Q653924","display_name":"Long QT syndrome","level":3,"score":0.8104324340820312},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7759655714035034},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4702562093734741},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4625190496444702},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4565753936767578},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.43910717964172363},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3414405584335327},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11995944380760193},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11726102232933044},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.hrthm.2009.09.058","doi":"https://doi.org/10.1016/j.hrthm.2009.09.058","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.hrthm.2009.09.058","pdf_url":null,"source":{"id":"https://openalex.org/S163651451","display_name":"Heart Rhythm","issn_l":"1547-5271","issn":["1547-5271","1556-3871"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart Rhythm","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4245932990","https://openalex.org/W2116008876","https://openalex.org/W2132199634","https://openalex.org/W2157436620","https://openalex.org/W2736779891","https://openalex.org/W3037939857","https://openalex.org/W2034273091","https://openalex.org/W4210347672","https://openalex.org/W3005544936","https://openalex.org/W2123928498"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}