{"id":"https://openalex.org/W1991567031","doi":"https://doi.org/10.1021/bi701987n","title":"Different Conformational Switches Underlie the Calmodulin-Dependent Modulation of Calcium Pumps and Channels","display_name":"Different Conformational Switches Underlie the Calmodulin-Dependent Modulation of Calcium Pumps and Channels","publication_year":2008,"publication_date":"2008-01-18","ids":{"openalex":"https://openalex.org/W1991567031","doi":"https://doi.org/10.1021/bi701987n","mag":"1991567031","pmid":"https://pubmed.ncbi.nlm.nih.gov/18201104"},"language":"en","primary_location":{"id":"doi:10.1021/bi701987n","doi":"https://doi.org/10.1021/bi701987n","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi701987n","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031799214","display_name":"Curt B. Boschek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Curt B. Boschek","raw_affiliation_strings":["Cell Biology and Biochemistry Group, Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352","Cell Biology and Biochemistry Group, Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology and Biochemistry Group, Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352","institution_ids":["https://openalex.org/I142606810"]},{"raw_affiliation_string":"Cell Biology and Biochemistry Group, Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, USA","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102248681","display_name":"Hongye Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongye Sun","raw_affiliation_strings":["Cell Biology and Biochemistry Group, Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology and Biochemistry Group, Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018562881","display_name":"Diana J. Bigelow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diana J. Bigelow","raw_affiliation_strings":["Cell Biology and Biochemistry Group, Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology and Biochemistry Group, Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034507169","display_name":"Thomas C. Squier","orcid":"https://orcid.org/0000-0003-0735-3194","observed_orcids":["https://orcid.org/0000-0003-0735-3194"]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas C. Squier","raw_affiliation_strings":["Cell Biology and Biochemistry Group, Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology and Biochemistry Group, Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352","institution_ids":["https://openalex.org/I142606810"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5034507169"],"corresponding_institution_ids":["https://openalex.org/I142606810"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.5633,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.60125003,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"47","issue":"6","first_page":"1640","last_page":"1651"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.7383000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.7383000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.13439999520778656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.03269999846816063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calmodulin","display_name":"calmodulin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/plasma-membrane-ca2-atpase","display_name":"plasma membrane Ca2+-ATPase","score":0.9670000076293945},{"id":"https://openalex.org/keywords/ryanodine-receptor-ryr1","display_name":"ryanodine receptor RyR1","score":0.8579999804496765},{"id":"https://openalex.org/keywords/calcium-release-channel","display_name":"calcium release channel","score":0.6800000071525574},{"id":"https://openalex.org/keywords/conformational-switch","display_name":"conformational switching","score":0.6809999942779541},{"id":"https://openalex.org/keywords/excimer-fluorescence","display_name":"excimer fluorescence","score":0.8939999938011169},{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"allosteric regulation","score":0.7990000247955322},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C29688787","wikidata":"https://www.wikidata.org/wiki/Q409145","display_name":"Calmodulin","level":3,"score":0.8545706272125244},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7084351778030396},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.5923789739608765},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5796476602554321},{"id":"https://openalex.org/C113217602","wikidata":"https://www.wikidata.org/wiki/Q416781","display_name":"Ryanodine receptor","level":3,"score":0.48242315649986267},{"id":"https://openalex.org/C2776333580","wikidata":"https://www.wikidata.org/wiki/Q18031340","display_name":"RYR1","level":4,"score":0.4737818241119385},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.45229944586753845},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.37158215045928955},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3375470042228699},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31527814269065857},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15027779340744019},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13689151406288147},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07440945506095886}],"mesh":[{"descriptor_ui":"D000252","descriptor_name":"Calcium-Transporting ATPases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002147","descriptor_name":"Calmodulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi701987n","doi":"https://doi.org/10.1021/bi701987n","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi701987n","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:18201104","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18201104","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G8066983602","display_name":"Reactive Oxygen Species and Aging","funder_award_id":"P01AG012993","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W4300177093"],"related_works":["https://openalex.org/W2732992555","https://openalex.org/W1989847738","https://openalex.org/W1997520683","https://openalex.org/W2031011317","https://openalex.org/W2912015248","https://openalex.org/W2999832671","https://openalex.org/W4319917298","https://openalex.org/W1993320492","https://openalex.org/W2081888177","https://openalex.org/W3004921933"],"abstract_inverted_index":{"We":[0,103],"have":[1],"used":[2],"fluorescence":[3,60],"spectroscopy":[4],"to":[5,64,115,161,170,184,259,298],"investigate":[6],"the":[7,18,23,43,76,116,121,136,139,162,166,187,191,201,205,214,237,244,247,281,293],"structure":[8,114,245],"of":[9,16,47,55,68,75,95,119,132,141,155,165,190,204,217,223,240,246,276,283,295],"calmodulin":[10],"(CaM)":[11],"bound":[12,69,160],"with":[13,34,108,145,256],"CaM-binding":[14,81,117,147,163,188,202,215],"sequences":[15,82,118,189],"either":[17,280],"plasma":[19],"membrane":[20],"Ca-ATPase":[21,122,167,192,206,260],"or":[22,292],"skeletal":[24],"muscle":[25],"ryanodine":[26],"receptor":[27],"(RyR1)":[28],"calcium":[29],"release":[30],"channel.":[31],"Following":[32],"derivatization":[33],"N-(1-pyrene)maleimide":[35],"at":[36],"engineered":[37],"sites":[38],"(T34C":[39],"and":[40,45,92,99,123,138,193,261],"T110C)":[41],"within":[42,80],"N-":[44,137],"C-domains":[46,140],"CaM,":[48],"contact":[49,133,234],"interactions":[50,134,235,297],"between":[51,135,177,236],"these":[52,146],"opposing":[53,238],"domains":[54,179,239],"CaM":[56,90,106,142,159,178,185,199,224,241,257],"resulted":[57],"in":[58,89,111,126,143,168,180,242,266],"excimer":[59,127,156],"that":[61,83,105,129,271],"permits":[62,93],"us":[63],"monitor":[65],"conformational":[66],"states":[67],"CaM.":[70],"Complementary":[71],"measurements":[72,94],"take":[73],"advantage":[74],"unique":[77],"conserved":[78],"Trp":[79],"functions":[84],"as":[85],"a":[86,97,112,151,173,208,264,284],"hydrophobic":[87],"anchor":[88],"binding":[91,258,269],"both":[96,120],"local":[98],"global":[100],"peptide":[101,248],"structure.":[102,211],"find":[104],"binds":[107],"high":[109],"affinity":[110],"collapsed":[113],"RyR1,":[124,171],"resulting":[125],"formation":[128,157],"is":[130,150],"indicative":[131],"complex":[144],"peptides.":[148],"There":[149],"4-fold":[152],"larger":[153],"amount":[154],"for":[158,232,289],"sequence":[164,203,216],"comparison":[169],"indicating":[172],"closer":[174],"structural":[175,253],"coupling":[176],"this":[181],"complex.":[182,249],"Prior":[183],"association,":[186,200],"RyR1":[194,218,262,300],"are":[195],"conformationally":[196,220],"disordered.":[197],"Upon":[198],"assumes":[207],"highly":[209],"ordered":[210],"In":[212],"comparison,":[213],"remains":[219],"disordered":[221],"irrespective":[222],"binding.":[225],"These":[226],"results":[227],"suggest":[228],"an":[229],"important":[230],"role":[231],"interdomain":[233],"stabilizing":[243],"The":[250],"substantially":[251],"different":[252,273],"responses":[254],"associated":[255],"indicates":[263],"plasticity":[265],"their":[267],"respective":[268],"mechanisms":[270,275],"accomplishes":[272],"physical":[274],"allosteric":[277],"regulation,":[278],"involving":[279],"dissociation":[282],"C-terminal":[285],"regulatory":[286],"domain":[287],"necessary":[288],"pump":[290],"activation":[291],"modulation":[294],"intersubunit":[296],"diminish":[299],"channel":[301],"activity.":[302]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
