{"id":"https://openalex.org/W1991483230","doi":"https://doi.org/10.1016/s1529-1049(02)00155-1","title":"Novel ribozyme, RNA decoy, and siRNA approaches to inhibition of HIV in a gene therapy setting","display_name":"Novel ribozyme, RNA decoy, and siRNA approaches to inhibition of HIV in a gene therapy setting","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W1991483230","doi":"https://doi.org/10.1016/s1529-1049(02)00155-1","mag":"1991483230"},"language":"en","primary_location":{"id":"doi:10.1016/s1529-1049(02)00155-1","doi":"https://doi.org/10.1016/s1529-1049(02)00155-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1529-1049(02)00155-1","pdf_url":null,"source":{"id":"https://openalex.org/S43553728","display_name":"Clinical and Applied Immunology Reviews","issn_l":"1529-1049","issn":["1529-1049","1878-5441"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Applied Immunology Reviews","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088904031","display_name":"Alessandro Michienzi","orcid":"https://orcid.org/0000-0002-9133-8482","observed_orcids":["https://orcid.org/0000-0002-9133-8482"]},"institutions":[{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alessandro Michienzi","raw_affiliation_strings":["Division of Molecular Biology, Beckman Research Institute of the City of Hope, 450 E. Duarte Road, Duarte, CA 91010 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Biology, Beckman Research Institute of the City of Hope, 450 E. Duarte Road, Duarte, CA 91010 USA","institution_ids":["https://openalex.org/I4387156432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001187257","display_name":"Daniela Castanotto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniela Castanotto","raw_affiliation_strings":["Division of Molecular Biology, Beckman Research Institute of the City of Hope, 450 E. Duarte Road, Duarte, CA 91010 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Biology, Beckman Research Institute of the City of Hope, 450 E. Duarte Road, Duarte, CA 91010 USA","institution_ids":["https://openalex.org/I4387156432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024216842","display_name":"Nancy Lee","orcid":"https://orcid.org/0000-0002-6663-0713","observed_orcids":["https://orcid.org/0000-0002-6663-0713"]},"institutions":[{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy Lee","raw_affiliation_strings":["Division of Molecular Biology, Beckman Research Institute of the City of Hope, 450 E. Duarte Road, Duarte, CA 91010 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Biology, Beckman Research Institute of the City of Hope, 450 E. Duarte Road, Duarte, CA 91010 USA","institution_ids":["https://openalex.org/I4387156432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028028396","display_name":"Shirley Xin Li","orcid":"https://orcid.org/0000-0002-7085-1850","observed_orcids":["https://orcid.org/0000-0002-7085-1850"]},"institutions":[{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shirley Li","raw_affiliation_strings":["Division of Virology, Beckman Research Institute of the City of Hope, 450 E. Duarte Road, Duarte, CA 91010 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Virology, Beckman Research Institute of the City of Hope, 450 E. Duarte Road, Duarte, CA 91010 USA","institution_ids":["https://openalex.org/I4387156432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105465338","display_name":"JOHN A. ZAIA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John A. Zaia","raw_affiliation_strings":["Division of Virology, Beckman Research Institute of the City of Hope, 450 E. Duarte Road, Duarte, CA 91010 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Virology, Beckman Research Institute of the City of Hope, 450 E. Duarte Road, Duarte, CA 91010 USA","institution_ids":["https://openalex.org/I4387156432"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046038634","display_name":"John J. Rossi","orcid":"https://orcid.org/0000-0003-1238-9335","observed_orcids":["https://orcid.org/0000-0003-1238-9335"]},"institutions":[{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John J. Rossi","raw_affiliation_strings":["Division of Molecular Biology, Beckman Research Institute of the City of Hope, 450 E. Duarte Road, Duarte, CA 91010 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Biology, Beckman Research Institute of the City of Hope, 450 E. Duarte Road, Duarte, CA 91010 USA","institution_ids":["https://openalex.org/I4387156432"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5046038634"],"corresponding_institution_ids":["https://openalex.org/I4387156432"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07373272,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"4-5","first_page":"223","last_page":"233"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.5062999725341797,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.5062999725341797,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.30959999561309814,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.12540000677108765,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.9290000200271606},{"id":"https://openalex.org/keywords/rna-decoys","display_name":"RNA decoys","score":0.9589999914169312},{"id":"https://openalex.org/keywords/sirna","display_name":"siRNA","score":0.9340000152587891},{"id":"https://openalex.org/keywords/hiv-1-integration","display_name":"HIV-1 integration","score":0.6499999761581421},{"id":"https://openalex.org/keywords/viral-reservoir","display_name":"viral reservoir","score":0.703000009059906},{"id":"https://openalex.org/keywords/aids","display_name":"AIDS","score":0.4620000123977661},{"id":"https://openalex.org/keywords/hiv-replication-inhibition","display_name":"HIV replication inhibition","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C76346623","wikidata":"https://www.wikidata.org/wiki/Q205858","display_name":"Ribozyme","level":4,"score":0.8893719911575317},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.7506223917007446},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5105522871017456},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4827544093132019},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4730769097805023},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4532628059387207},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.4236186742782593},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3373175859451294},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.314005970954895},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19444730877876282}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s1529-1049(02)00155-1","doi":"https://doi.org/10.1016/s1529-1049(02)00155-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1529-1049(02)00155-1","pdf_url":null,"source":{"id":"https://openalex.org/S43553728","display_name":"Clinical and Applied Immunology Reviews","issn_l":"1529-1049","issn":["1529-1049","1878-5441"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Applied Immunology Reviews","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1482247814","https://openalex.org/W1488192195","https://openalex.org/W1611419331","https://openalex.org/W1842382339","https://openalex.org/W1896714280","https://openalex.org/W1987483457","https://openalex.org/W1988967884","https://openalex.org/W2002615250","https://openalex.org/W2006416369","https://openalex.org/W2013179689","https://openalex.org/W2020422048","https://openalex.org/W2030406803","https://openalex.org/W2032812303","https://openalex.org/W2038783205","https://openalex.org/W2051585221","https://openalex.org/W2060270384","https://openalex.org/W2072466707","https://openalex.org/W2072849848","https://openalex.org/W2075182023","https://openalex.org/W2083787054","https://openalex.org/W2084851425","https://openalex.org/W2085985329","https://openalex.org/W2105086165","https://openalex.org/W2117991391","https://openalex.org/W2120280335","https://openalex.org/W2128882718","https://openalex.org/W2129121113","https://openalex.org/W2140618402","https://openalex.org/W2140817134","https://openalex.org/W2147896158","https://openalex.org/W2174261124","https://openalex.org/W2306779823","https://openalex.org/W2462110782","https://openalex.org/W3021552163","https://openalex.org/W7033783247"],"related_works":["https://openalex.org/W2026018374","https://openalex.org/W2382505613","https://openalex.org/W2021985794","https://openalex.org/W2161076191","https://openalex.org/W2026595768","https://openalex.org/W2042040228","https://openalex.org/W2188358604","https://openalex.org/W2026102468","https://openalex.org/W2057041879","https://openalex.org/W2399881892"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
