{"id":"https://openalex.org/W1991473086","doi":"https://doi.org/10.1172/jci105094","title":"Action of Complement in Hereditary Angioneurotic Edema: The Role of C\u20321-Esterase *","display_name":"Action of Complement in Hereditary Angioneurotic Edema: The Role of C\u20321-Esterase *","publication_year":1964,"publication_date":"1964-11-01","ids":{"openalex":"https://openalex.org/W1991473086","doi":"https://doi.org/10.1172/jci105094","mag":"1991473086","pmid":"https://pubmed.ncbi.nlm.nih.gov/14223932","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/442008"},"language":"en","primary_location":{"id":"doi:10.1172/jci105094","doi":"https://doi.org/10.1172/jci105094","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci105094","pdf_url":"http://www.jci.org/articles/view/105094/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/105094/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111696189","display_name":"Virginia H. Donaldson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2799501412","display_name":"St. Vincent Charity Hospital","ror":"https://ror.org/00dbcz291","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799501412"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Virginia H. Donaldson","raw_affiliation_strings":["(From the Research Division, St. Vincent Charity Hospital, the Department of Medicine,","Department of Pediatrics, Harvard Medical School, and the Children's Hospital Medical Center, Boston, Mass","Western Reserve University School of Medicine, Cleveland, Ohio;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(From the Research Division, St. Vincent Charity Hospital, the Department of Medicine,","institution_ids":["https://openalex.org/I2799501412"]},{"raw_affiliation_string":"Department of Pediatrics, Harvard Medical School, and the Children's Hospital Medical Center, Boston, Mass","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Western Reserve University School of Medicine, Cleveland, Ohio;","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111433586","display_name":"Fred S. Rosen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2799501412","display_name":"St. Vincent Charity Hospital","ror":"https://ror.org/00dbcz291","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799501412"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fred S. Rosen","raw_affiliation_strings":["Harvard Medical School , and the Children's Hospital Medical Center , Boston , Mass","(From the Research Division, St. Vincent Charity Hospital, the Department of Medicine,","Department of Pediatrics, Harvard Medical School, and the Children's Hospital Medical Center, Boston, Mass","Western Reserve University School of Medicine, Cleveland, Ohio;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School , and the Children's Hospital Medical Center , Boston , Mass","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"(From the Research Division, St. Vincent Charity Hospital, the Department of Medicine,","institution_ids":["https://openalex.org/I2799501412"]},{"raw_affiliation_string":"Department of Pediatrics, Harvard Medical School, and the Children's Hospital Medical Center, Boston, Mass","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Western Reserve University School of Medicine, Cleveland, Ohio;","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":11.0776,"has_fulltext":true,"cited_by_count":193,"citation_normalized_percentile":{"value":0.98659517,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"43","issue":"11","first_page":"2204","last_page":"2213"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hereditary-angioedema","display_name":"hereditary angioedema","score":0.9919999837875366},{"id":"https://openalex.org/keywords/c1-esterase","display_name":"C1 esterase","score":0.9160000085830688},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.6579999923706055},{"id":"https://openalex.org/keywords/c1q","display_name":"C1q","score":0.6740000247955322},{"id":"https://openalex.org/keywords/c1r","display_name":"C1r","score":0.8519999980926514},{"id":"https://openalex.org/keywords/c1s","display_name":"C1s","score":0.9909999966621399},{"id":"https://openalex.org/keywords/c1-inhibitor","display_name":"C1 inhibitor","score":0.7730000019073486},{"id":"https://openalex.org/keywords/complement-c3","display_name":"complement C3","score":0.3179999887943268},{"id":"https://openalex.org/keywords/c5","display_name":"C5","score":0.5239999890327454},{"id":"https://openalex.org/keywords/c5a","display_name":"C5a","score":0.5759999752044678},{"id":"https://openalex.org/keywords/c5b","display_name":"C5b","score":0.5669999718666077},{"id":"https://openalex.org/keywords/membrane-attack-complex","display_name":"membrane attack complex","score":0.4620000123977661},{"id":"https://openalex.org/keywords/c3b","display_name":"C3b","score":0.33799999952316284},{"id":"https://openalex.org/keywords/c3bbb","display_name":"C3bBb","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C2777788586","wikidata":"https://www.wikidata.org/wiki/Q2096745","display_name":"Hereditary angioedema","level":2,"score":0.6968594193458557},{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.6332572102546692},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.552168071269989},{"id":"https://openalex.org/C2780791683","wikidata":"https://www.wikidata.org/wiki/Q846785","display_name":"Action (physics)","level":2,"score":0.519059956073761},{"id":"https://openalex.org/C2777261171","wikidata":"https://www.wikidata.org/wiki/Q418750","display_name":"Esterase","level":3,"score":0.4680931866168976},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4544506371021271},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3462560772895813},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.30189159512519836},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2541014850139618},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21444839239120483},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13960883021354675},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.08671069145202637},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.059179455041885376},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000799","descriptor_name":"Angioedema","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001796","descriptor_name":"Blood Protein Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002199","descriptor_name":"Capillary Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003168","descriptor_name":"Complement Fixation Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003173","descriptor_name":"Complement C1s","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004796","descriptor_name":"Clinical Enzyme Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004950","descriptor_name":"Esterases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007122","descriptor_name":"Immunoelectrophoresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008661","descriptor_name":"Metabolism, Inborn Errors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054179","descriptor_name":"Angioedemas, Hereditary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci105094","doi":"https://doi.org/10.1172/jci105094","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci105094","pdf_url":"http://www.jci.org/articles/view/105094/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:442008","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/442008","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:14223932","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14223932","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci105094","doi":"https://doi.org/10.1172/jci105094","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci105094","pdf_url":"http://www.jci.org/articles/view/105094/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306086","display_name":"National Hemophilia Foundation","ror":"https://ror.org/01fz8x241"},{"id":"https://openalex.org/F4320306179","display_name":"John A. Hartford Foundation","ror":"https://ror.org/03ktbzq37"},{"id":"https://openalex.org/F4320306368","display_name":"Hartford Foundation for Public Giving","ror":"https://ror.org/020fy4d02"},{"id":"https://openalex.org/F4320309374","display_name":"Ohio State University","ror":"https://ror.org/00rs6vg23"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1991473086.pdf","grobid_xml":"https://content.openalex.org/works/W1991473086.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W178665079","https://openalex.org/W222515578","https://openalex.org/W232788984","https://openalex.org/W292882338","https://openalex.org/W656212184","https://openalex.org/W1487874169","https://openalex.org/W1488206449","https://openalex.org/W1497280552","https://openalex.org/W1522956225","https://openalex.org/W1527088163","https://openalex.org/W1553308770","https://openalex.org/W1569993633","https://openalex.org/W1596323429","https://openalex.org/W1608351824","https://openalex.org/W1611482599","https://openalex.org/W1915715190","https://openalex.org/W1919811399","https://openalex.org/W1969598319","https://openalex.org/W1973892030","https://openalex.org/W1981018725","https://openalex.org/W1986048266","https://openalex.org/W1986978262","https://openalex.org/W2004357920","https://openalex.org/W2006564813","https://openalex.org/W2034304959","https://openalex.org/W2040523375","https://openalex.org/W2051931035","https://openalex.org/W2053297958","https://openalex.org/W2053339912","https://openalex.org/W2062378363","https://openalex.org/W2067508980","https://openalex.org/W2078264642","https://openalex.org/W2078962683","https://openalex.org/W2079313403","https://openalex.org/W2087926948","https://openalex.org/W2094702217","https://openalex.org/W2137103323","https://openalex.org/W2159142992","https://openalex.org/W2166452726","https://openalex.org/W2167347428","https://openalex.org/W2254141096","https://openalex.org/W2314231620","https://openalex.org/W2315351478","https://openalex.org/W2321234878","https://openalex.org/W2330051243","https://openalex.org/W2331506478","https://openalex.org/W2334727921","https://openalex.org/W4235998792","https://openalex.org/W4298068647","https://openalex.org/W4313375524","https://openalex.org/W6630363279","https://openalex.org/W6991056862"],"related_works":["https://openalex.org/W2068579363","https://openalex.org/W7099297604","https://openalex.org/W2152920771","https://openalex.org/W2032954616","https://openalex.org/W1985590078","https://openalex.org/W2081660344","https://openalex.org/W2424219873","https://openalex.org/W2439506926","https://openalex.org/W1981626645","https://openalex.org/W62525439"],"abstract_inverted_index":{"Thus,":[0],"symptoms":[1],"of":[2,11,27,36,61,87,97,107,127,188,220,247,254,277,302],"hereditary":[3,260],"angioneurotic":[4,53,261],"edema":[5,262],"were":[6],"associated":[7],"with":[8,184],"enhanced":[9],"generation":[10],"C'1-esterase.Ratnoff":[12],"and":[13,31,71,103,129,147,163,168,171,191,201,216,223,279],"Lepow":[14,128],"have":[15,131],"dem-":[16],"onstrated":[17],"that":[18,32,133,161,243],"C'1-esterase":[19,37,124,205,209,248],"can":[20,38,210],"increase":[21,47],"vascular":[22,48],"permeability":[23,49],"in":[24,50,58,63,75,79,177,259],"the":[25,28,158,213],"skin":[26],"guinea":[29],"pig":[30],"purified":[33],"serum":[34,237],"inhibitor":[35,256],"impair":[39],"this":[40,255],"response":[41],"(10).C'1-esterase":[42],"may":[43,135],"also":[44],"serve":[45],"to":[46,119,143,157,204,296],"heredi-":[51],"tary":[52],"edema.Methods":[54],"Nomenclature.Complement":[55],"activity":[56],"resides":[57],"a":[59,111,195,298],"group":[60],"proteins":[62],"fresh":[64],"serum.Although":[65],"required":[66],"for":[67],"im-":[68],"mune":[69],"hemolysis":[70],"immune":[72,178],"cellular":[73],"injury":[74],"vitro,":[76],"its":[77],"role":[78],"human":[80,236],"physiology":[81],"is":[82,117,150],"unclear.Four":[83],"major":[84],"com-":[85,221],"ponents":[86],"complement":[88],"are":[89],"designated":[90],"by":[91,269,287],"number,":[92],"indi-":[93],"cating":[94],"chronological":[95],"order":[96],"their":[98],"discovery:":[99],"C'1,":[100],"C'2,":[101],"C'3,":[102],"C'4":[104],"(11).A":[105],"part":[106],"C'1":[108,134],"exists":[109],"as":[110,144,175,194,293],"proenzyme":[112],"which,":[113],"under":[114],"appropriate":[115],"conditions,":[116],"converted":[118],"an":[120,151,239,275,294],"active":[121],"enzyme":[122],"called":[123,165],"(12-18).Recent":[125],"studies":[126],"associates":[130],"shown":[132],"be":[136],"chromatographically":[137,200],"resolved":[138],"into":[139],"three":[140],"subcomponents,":[141],"referred":[142],"C'lq,":[145],"C'lr,":[146],"C'ls":[148],"(19).C'lq":[149],"11":[152],"S":[153],"globulin,":[154],"probably":[155],"identical":[156],"pro-":[159],"tein":[160],"Mfiller-Eberhard":[162],"Kunkel":[164],"C'O":[166],"(20)":[167],"Taranta,":[169],"Weiss,":[170],"Franklin":[172],"(21)":[173],"described":[174,186],"participating":[176],"hemolysis.C'1r":[179],"was":[180,192,199,257,264,285],"not":[181],"identi-":[182],"fiable":[183],"previously":[185],"components":[187,219],"comple-":[189],"ment":[190],"proposed":[193],"new":[196],"component":[197],"(19).C'1s":[198],"antigenically":[202],"related":[203],"(17-19,":[206],"22).Once":[207],"activated,":[208],"readily":[211],"inactivate":[212],"fourth":[214],"(C'4)":[215],"second":[217],"(C'2)":[218],"plement":[222],"hydrolyze":[224],"several":[225],"synthetic":[226],"amino":[227],"acid":[228],"esters,":[229],"most":[230],"notably":[231],"N-acetyl-L-tyrosine":[232],"ethyl":[233],"ester":[234],"(12-15).Normal":[235],"contains":[238],"a2":[240],"globu-":[241],"lin":[242],"inhibits":[244],"these":[245],"actions":[246],"stoichio-":[249],"metrically":[250],"(15,":[251],"23-25).The":[252],"action":[253],"absent":[258],"(8).Procedure.Serum":[263],"separated":[265],"from":[266],"clotted":[267],"blood":[268],"centrifugation":[270],"at":[271,281],"0\u00b0":[272],"C":[273],"within":[274],"hour":[276],"venipuncture":[278],"stored":[280],"-600":[282],"C.":[283],"Plasma":[284],"obtained":[286],"using":[288],"disodium":[289],"ethylenediamine":[290],"tetraacetate":[291],"(EDTA)":[292],"anticoagulant":[295],"provide":[297],"final":[299],"plasma":[300],"concentration":[301],"2204":[303]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
