{"id":"https://openalex.org/W1991472877","doi":"https://doi.org/10.1111/j.1365-2249.2006.03161.x","title":"Mannan-binding lectin plasma levels in leprosy: deficiency confers protection against the lepromatous but not the tuberculoid forms","display_name":"Mannan-binding lectin plasma levels in leprosy: deficiency confers protection against the lepromatous but not the tuberculoid forms","publication_year":2006,"publication_date":"2006-07-12","ids":{"openalex":"https://openalex.org/W1991472877","doi":"https://doi.org/10.1111/j.1365-2249.2006.03161.x","mag":"1991472877","pmid":"https://pubmed.ncbi.nlm.nih.gov/16907914","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1809702"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2249.2006.03161.x","doi":"https://doi.org/10.1111/j.1365-2249.2006.03161.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2249.2006.03161.x","pdf_url":null,"source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1809702","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050852577","display_name":"Luciana Nasser Dornelles","orcid":"https://orcid.org/0009-0008-3553-3495","observed_orcids":["https://orcid.org/0009-0008-3553-3495"]},"institutions":[{"id":"https://openalex.org/I52418104","display_name":"Universidade Federal do Paran\u00e1","ror":"https://ror.org/05syd6y78","country_code":"BR","type":"education","lineage":["https://openalex.org/I52418104"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"L N Dornelles","raw_affiliation_strings":["Immunopathology Laboratory and Department of Medical Pathology, Federal University of Paran\u00e1, Curitiba, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunopathology Laboratory and Department of Medical Pathology, Federal University of Paran\u00e1, Curitiba, Brazil","institution_ids":["https://openalex.org/I52418104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021026604","display_name":"Lilian Pereira\u2010Ferrari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52418104","display_name":"Universidade Federal do Paran\u00e1","ror":"https://ror.org/05syd6y78","country_code":"BR","type":"education","lineage":["https://openalex.org/I52418104"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"L Pereira-Ferrari","raw_affiliation_strings":["Immunopathology Laboratory and Department of Medical Pathology, Federal University of Paran\u00e1, Curitiba, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunopathology Laboratory and Department of Medical Pathology, Federal University of Paran\u00e1, Curitiba, Brazil","institution_ids":["https://openalex.org/I52418104"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028857982","display_name":"Iara Messias-Reason","orcid":"https://orcid.org/0000-0002-5573-260X","observed_orcids":["https://orcid.org/0000-0002-5573-260X"]},"institutions":[{"id":"https://openalex.org/I52418104","display_name":"Universidade Federal do Paran\u00e1","ror":"https://ror.org/05syd6y78","country_code":"BR","type":"education","lineage":["https://openalex.org/I52418104"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["BR","DE"],"is_corresponding":true,"raw_author_name":"I Messias-Reason","raw_affiliation_strings":["Immunopathology Laboratory and Department of Medical Pathology, Federal University of Paran\u00e1, Curitiba, Brazil","Institute for Tropical Medicine, University of T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunopathology Laboratory and Department of Medical Pathology, Federal University of Paran\u00e1, Curitiba, Brazil","institution_ids":["https://openalex.org/I52418104"]},{"raw_affiliation_string":"Institute for Tropical Medicine, University of T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5028857982"],"corresponding_institution_ids":["https://openalex.org/I52418104","https://openalex.org/I8087733"],"apc_list":{"value":2894,"currency":"GBP","value_usd":3816},"apc_paid":null,"fwci":5.7265,"has_fulltext":false,"cited_by_count":79,"citation_normalized_percentile":{"value":0.9629076,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"145","issue":"3","first_page":"463","last_page":"468"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12107","display_name":"Leprosy Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12107","display_name":"Leprosy Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mannose-binding-lectin","display_name":"mannose-binding lectin","score":0.9210000038146973},{"id":"https://openalex.org/keywords/mbl-deficiency","display_name":"MBL deficiency","score":0.9729999899864197},{"id":"https://openalex.org/keywords/leprosy","display_name":"leprosy","score":0.9929999709129333},{"id":"https://openalex.org/keywords/lepromatous-leprosy","display_name":"lepromatous leprosy","score":0.9639999866485596},{"id":"https://openalex.org/keywords/tuberculoid-leprosy","display_name":"tuberculoid leprosy","score":0.996999979019165},{"id":"https://openalex.org/keywords/mycobacterium-leprae","display_name":"Mycobacterium leprae","score":0.9779999852180481},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9210000038146973},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.8180000185966492},{"id":"https://openalex.org/keywords/host-defense","display_name":"host defense","score":0.47600001096725464},{"id":"https://openalex.org/keywords/serum-mbl-levels","display_name":"serum MBL levels","score":0.6340000033378601},{"id":"https://openalex.org/keywords/dimorphic-leprosy","display_name":"dimorphic leprosy","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7101157903671265},{"id":"https://openalex.org/C2779846462","wikidata":"https://www.wikidata.org/wiki/Q6527832","display_name":"Lepromatous leprosy","level":3,"score":0.6012526750564575},{"id":"https://openalex.org/C2776457596","wikidata":"https://www.wikidata.org/wiki/Q7850839","display_name":"Tuberculoid leprosy","level":4,"score":0.5855268239974976},{"id":"https://openalex.org/C189413060","wikidata":"https://www.wikidata.org/wiki/Q415443","display_name":"Mannan-binding lectin","level":3,"score":0.5808213949203491},{"id":"https://openalex.org/C2779719659","wikidata":"https://www.wikidata.org/wiki/Q24577942","display_name":"Mannan","level":3,"score":0.5564586520195007},{"id":"https://openalex.org/C2780695269","wikidata":"https://www.wikidata.org/wiki/Q36956","display_name":"Leprosy","level":2,"score":0.5342311859130859},{"id":"https://openalex.org/C2780758401","wikidata":"https://www.wikidata.org/wiki/Q408693","display_name":"Lectin","level":2,"score":0.5134833455085754},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4369509816169739},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42872196435928345},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32651573419570923},{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.0664815902709961},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007918","descriptor_name":"Leprosy","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007918","descriptor_name":"Leprosy","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009166","descriptor_name":"Mycobacterium leprae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015440","descriptor_name":"Leprosy, Lepromatous","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015440","descriptor_name":"Leprosy, Lepromatous","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015441","descriptor_name":"Leprosy, Tuberculoid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015441","descriptor_name":"Leprosy, Tuberculoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016009","descriptor_name":"Chi-Square Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037601","descriptor_name":"Mannose-Binding Lectin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D037601","descriptor_name":"Mannose-Binding Lectin","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-2249.2006.03161.x","doi":"https://doi.org/10.1111/j.1365-2249.2006.03161.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2249.2006.03161.x","pdf_url":null,"source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1809702","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1809702","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},{"id":"pmid:16907914","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16907914","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Comparative Study"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1809702","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1809702","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1678073641","https://openalex.org/W1911746360","https://openalex.org/W1976148865","https://openalex.org/W1979930475","https://openalex.org/W1981256115","https://openalex.org/W1986699467","https://openalex.org/W1992925322","https://openalex.org/W1998005981","https://openalex.org/W2013436094","https://openalex.org/W2028064878","https://openalex.org/W2036755053","https://openalex.org/W2039657286","https://openalex.org/W2047233465","https://openalex.org/W2056715659","https://openalex.org/W2061999695","https://openalex.org/W2064001879","https://openalex.org/W2070618971","https://openalex.org/W2079932819","https://openalex.org/W2084129860","https://openalex.org/W2086643790","https://openalex.org/W2100967062","https://openalex.org/W2111672348","https://openalex.org/W2111806738","https://openalex.org/W2131085727","https://openalex.org/W2138386305","https://openalex.org/W2140506074","https://openalex.org/W2151797745","https://openalex.org/W2152799956","https://openalex.org/W2158620829","https://openalex.org/W2169875026","https://openalex.org/W4211207211","https://openalex.org/W4292000778","https://openalex.org/W4296464062"],"related_works":["https://openalex.org/W3165459558","https://openalex.org/W2142099771","https://openalex.org/W2108424597","https://openalex.org/W1998005981","https://openalex.org/W4293248646","https://openalex.org/W4296464062","https://openalex.org/W2049425159","https://openalex.org/W3083182020","https://openalex.org/W4221111502","https://openalex.org/W2954767996"],"abstract_inverted_index":{"Mannan-binding":[0],"lectin":[1],"(MBL)":[2],"is":[3],"an":[4],"important":[5],"component":[6],"of":[7,23,120,176,190,245,252],"the":[8,28,87,174,185,196,203,225,243,246],"first-line":[9],"defence":[10],"against":[11,30,50,242],"infections.":[12],"Evidence":[13],"has":[14],"shown":[15],"that":[16],"MBL":[17,45,98,121,177,218,240],"deficiency,":[18],"reducing":[19],"phagocytosis":[20],"and":[21,56,74,81,93,108,136,157,181,201,219,249],"internalization":[22],"intracellular":[24,31],"pathogens":[25],"may":[26],"protect":[27],"host":[29],"infections":[32],"such":[33],"as":[34],"leprosy.":[35,253],"In":[36],"this":[37],"study,":[38],"we":[39],"speculated":[40],"whether":[41],"genetically":[42],"determined":[43],"low":[44,122],"serum":[46,112],"levels":[47,113,178,221],"confer":[48],"protection":[49],"Mycobacterium":[51],"leprae":[52],"infection.":[53],"One":[54],"hundred":[55],"ninety-one":[57],"patients":[58,88,131,138,180,197,226],"with":[59,86,129,134,146],"leprosy,":[60],"presenting":[61],"lepromatous":[62,130,204],"(n":[63,67,71,76],"=":[64,68,72,77,143,161,199,207,228,231],"118),":[65],"tuberculoid":[66,137],"31),":[69],"dimorph":[70],"30)":[73],"indeterminate":[75],"12)":[78],"clinical":[79,186],"forms":[80],"110":[82],"healthy":[83],"controls":[84,135,182],"matched":[85],"according":[89],"to":[90,211],"sex,":[91],"age":[92],"ethnic":[94],"background":[95],"were":[96,100],"investigated.":[97],"concentrations":[99],"measured":[101],"in":[102,173,195,202,224],"a":[103,236],"double-antibody":[104],"enzyme":[105],"immune":[106],"assay":[107],"C-reactive":[109],"protein":[110],"(CRP)":[111],"by":[114],"nephelometry.":[115],"A":[116,213],"significant":[117,171],"negative":[118],"association":[119],"values":[123],"(<":[124],"100":[125],"ng/ml)":[126],"was":[127,169,192,222],"observed":[128,223],"when":[132,209],"comparing":[133],"[10/118,":[139],"8.47%versus":[140],"21/110,":[141],"19.09%P":[142],"0.03":[144],"chi(2)":[145],"Yates'":[147],"correction,":[148],"odds":[149],"ratio":[150],"(OR)":[151],"0.39,":[152],"confidence":[153],"interval":[154],"(CI)":[155],"0.18-0.88":[156],"8/31,":[158],"25.81%,":[159],"P":[160],"0.02,":[162],"OR":[163],"0.27,":[164],"CI":[165],"0.09-0.75,":[166],"respectively].":[167],"There":[168],"no":[170],"difference":[172],"distribution":[175],"between":[179,217],"or":[183],"among":[184],"forms.":[187],"The":[188],"concentration":[189],"CRP":[191,220],"significantly":[193],"increased":[194],"(P":[198,206,227],"0.0002)":[200],"form":[205,251],"0.0001)":[208],"compared":[210],"controls.":[212],"weak":[214],"positive":[215],"correlation":[216],"0.010,":[229],"R":[230],"0.255).":[232],"These":[233],"data":[234],"suggest":[235],"protective":[237],"role":[238],"for":[239],"deficiency":[241],"development":[244],"most":[247],"severe":[248],"multi-bacillary":[250]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
