{"id":"https://openalex.org/W1991470105","doi":"https://doi.org/10.1111/j.1572-0241.1999.01012.x","title":"Increased Risk of Cancer in Ulcerative Colitis: A Population-Based Cohort Study","display_name":"Increased Risk of Cancer in Ulcerative Colitis: A Population-Based Cohort Study","publication_year":1999,"publication_date":"1999-04-01","ids":{"openalex":"https://openalex.org/W1991470105","doi":"https://doi.org/10.1111/j.1572-0241.1999.01012.x","mag":"1991470105","pmid":"https://pubmed.ncbi.nlm.nih.gov/10201481"},"language":"en","primary_location":{"id":"doi:10.1111/j.1572-0241.1999.01012.x","doi":"https://doi.org/10.1111/j.1572-0241.1999.01012.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1572-0241.1999.01012.x","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108351840","display_name":"Per Karl\u00e9n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Per Karl\u00e9n","raw_affiliation_strings":["Department of Medicine, S\u00f6der Hospital, Karolinska Institute, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, S\u00f6der Hospital, Karolinska Institute, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114259980","display_name":"Robert L\u00f6fberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Robert L\u00f6fberg","raw_affiliation_strings":["Department of Gastroenterology, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017627555","display_name":"Olle Brostr\u00f6m","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Olle Brostr\u00f6m","raw_affiliation_strings":["Department of Medicine, S\u00f6der Hospital, Karolinska Institute, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, S\u00f6der Hospital, Karolinska Institute, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109290138","display_name":"Carl-Eric Leijonmarck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099778","display_name":"Saint G\u00f6ran Hospital","ror":"https://ror.org/00x6s3a91","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210099778"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Carl-Eric Leijonmarck","raw_affiliation_strings":["Department of Surgery, St. G\u00f6rans Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, St. G\u00f6rans Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I4210099778"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079506211","display_name":"Goran Hellers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"G\u00f6ran Hellers","raw_affiliation_strings":["Department of Surgery, Karolinska Institute, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Karolinska Institute, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109101679","display_name":"P.-G. Persson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801939835","display_name":"Region Stockholm","ror":"https://ror.org/02zrae794","country_code":"SE","type":"government","lineage":["https://openalex.org/I2801939835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Per-Gunnar Persson","raw_affiliation_strings":["Division of Epidemiology, Institute of Environmental Medicine, Karolinska Institute and Epidemiological Unit, Stockholm County Council, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Epidemiology, Institute of Environmental Medicine, Karolinska Institute and Epidemiological Unit, Stockholm County Council, Stockholm, Sweden","institution_ids":["https://openalex.org/I2801939835","https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5108351840"],"corresponding_institution_ids":["https://openalex.org/I28166907"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":6.0796,"has_fulltext":false,"cited_by_count":223,"citation_normalized_percentile":{"value":0.96521825,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"94","issue":"4","first_page":"1047","last_page":"1052"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13569","display_name":"Microscopic Colitis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":1.0},{"id":"https://openalex.org/keywords/cancer-risk","display_name":"cancer risk","score":0.7649999856948853},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hepatobiliary-cancer","display_name":"hepatobiliary cancer","score":0.9800000190734863},{"id":"https://openalex.org/keywords/primary-sclerosing-cholangitis","display_name":"primary sclerosing cholangitis","score":0.984000027179718},{"id":"https://openalex.org/keywords/pulmonary-cancer","display_name":"pulmonary cancer","score":0.7919999957084656},{"id":"https://openalex.org/keywords/extracolonic-malignancies","display_name":"extracolonic malignancies","score":0.9890000224113464},{"id":"https://openalex.org/keywords/standardized-morbidity-ratio","display_name":"standardized morbidity ratio","score":0.8429999947547913},{"id":"https://openalex.org/keywords/cancer-incidence","display_name":"cancer incidence","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9717142581939697},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.8918968439102173},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5683947801589966},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5088696479797363},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.49030259251594543},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4834093153476715},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.44952574372291565},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.3766968250274658},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33070188760757446},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.32477349042892456},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.12143927812576294}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001661","descriptor_name":"Biliary Tract Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D012042","descriptor_name":"Registries","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013548","descriptor_name":"Sweden","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1572-0241.1999.01012.x","doi":"https://doi.org/10.1111/j.1572-0241.1999.01012.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1572-0241.1999.01012.x","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},{"id":"doi:10.1016/s0002-9270(99)00067-2","doi":"https://doi.org/10.1016/s0002-9270(99)00067-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0002-9270(99)00067-2","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Gastroenterology","raw_type":"journal-article"},{"id":"pmid:10201481","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10201481","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of gastroenterology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W311702697","https://openalex.org/W1675012494","https://openalex.org/W1850437525","https://openalex.org/W1965872791","https://openalex.org/W1969867334","https://openalex.org/W1976435960","https://openalex.org/W1981716296","https://openalex.org/W1983292376","https://openalex.org/W1988768977","https://openalex.org/W2019185937","https://openalex.org/W2026700811","https://openalex.org/W2026992407","https://openalex.org/W2027491899","https://openalex.org/W2033354101","https://openalex.org/W2048204343","https://openalex.org/W2055638945","https://openalex.org/W2056075928","https://openalex.org/W2077839744","https://openalex.org/W2081857152","https://openalex.org/W2102400835","https://openalex.org/W2115205193","https://openalex.org/W2157503717","https://openalex.org/W2291394920","https://openalex.org/W2324962687","https://openalex.org/W2412795291","https://openalex.org/W2614197161"],"related_works":["https://openalex.org/W1969867334","https://openalex.org/W2075563968","https://openalex.org/W4381309426","https://openalex.org/W2070299891","https://openalex.org/W2056075928","https://openalex.org/W2157503717","https://openalex.org/W2391585258","https://openalex.org/W4310500097","https://openalex.org/W1901681710","https://openalex.org/W2999636890"],"abstract_inverted_index":{"OBJECTIVE:":[0],"There":[1],"is":[2,197,212],"an":[3,129,202],"increased":[4,198,203],"risk":[5,96,159,218],"of":[6,44,74,105,132,160,201,205,219],"colorectal":[7,133,206],"cancer":[8,21,82,162,195,221],"among":[9,109],"patients":[10,25,46,61],"with":[11,47,91,114,152,179,223],"ulcerative":[12],"colitis":[13],"(UC).":[14],"However,":[15],"the":[16,35,66,71,98,180,193,226],"overall":[17,194],"and":[18,39,54,70,140,207],"site":[19],"specific":[20],"risks":[22],"in":[23,49,64,85,97,143,225],"these":[24],"have":[26],"been":[27],"investigated":[28],"to":[29],"a":[30,41,216],"limited":[31],"extent.":[32],"To":[33],"study":[34,43],"association":[36],"between":[37,52],"UC":[38,48,99,191],"cancer,":[40],"population-based":[42],"1547":[45],"Stockholm":[50,86],"diagnosed":[51],"1955":[53],"1984":[55],"was":[56,156,163],"carried":[57],"out.":[58],"METHODS:":[59],"The":[60,158],"were":[62,88,176],"followed":[63],"both":[65],"National":[67,72],"Cancer":[68],"Register":[69,76],"Cause":[73],"Death":[75],"until":[77],"1989.":[78],"For":[79],"comparisons,":[80],"regional":[81],"incidence":[83,196,204],"rates":[84],"County":[87],"used":[89],"together":[90],"individually":[92],"computed":[93],"person-years":[94],"at":[95],"disease":[100],"cohort.":[101],"RESULTS:":[102],"A":[103],"total":[104],"121":[106],"malignancies":[107,175],"occurred":[108],"97":[110],"individuals":[111],"as":[112],"compared":[113,178,222],"89.8":[115],"expected":[116,182],"(standardized":[117],"morbidity":[118],"ratio":[119],"[SMR]":[120],"=":[121,146,166,184],"1.4;":[122],"95%":[123,137,148,168,186],"confidence":[124],"interval":[125],"(CI),":[126],"1.1-1.6).":[127],"Overall,":[128],"excess":[130],"number":[131],"cancers":[134,142],"(SMR,":[135],"4.1;":[136],"CI,":[138,149,169,187],"2.7-5.8),":[139],"hepatobiliary":[141,208],"men":[144],"(SMR":[145,165,183],"6.0;":[147],"2.8-11.1)":[150],"associated":[151],"primary":[153],"sclerosing":[154],"cholangitis,":[155],"observed.":[157],"pulmonary":[161,220],"decreased":[164,217],"0.3;":[167],"0.1-0.9).":[170],"In":[171,190],"all,":[172],"91":[173],"extracolonic":[174],"observed,":[177],"82.3":[181],"1.11;":[185],"0.9-1.3).":[188],"CONCLUSIONS:":[189],"patients,":[192],"mainly":[199],"because":[200],"cancer.":[209],"This":[210],"increase":[211],"partly":[213],"counterbalanced":[214],"by":[215],"that":[224],"general":[227],"population.":[228]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
