{"id":"https://openalex.org/W1991397384","doi":"https://doi.org/10.6116/kjh.2012.27.2.61","title":"Neuroprotective effect of the water extract of Angelicae Gigantis Radix Palva in ischemic stroke rats","display_name":"Neuroprotective effect of the water extract of Angelicae Gigantis Radix Palva in ischemic stroke rats","publication_year":2012,"publication_date":"2012-03-30","ids":{"openalex":"https://openalex.org/W1991397384","doi":"https://doi.org/10.6116/kjh.2012.27.2.61","mag":"1991397384"},"language":"en","primary_location":{"id":"doi:10.6116/kjh.2012.27.2.61","doi":"https://doi.org/10.6116/kjh.2012.27.2.61","is_oa":true,"landing_page_url":"https://doi.org/10.6116/kjh.2012.27.2.61","pdf_url":"http://koreascience.or.kr:80/article/JAKO201211666469285.pdf","source":{"id":"https://openalex.org/S2913471374","display_name":"The Korea Journal of Herbology","issn_l":"1229-1765","issn":["1229-1765","2288-7199"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":"https://openalex.org/P4362724898","host_organization_name":"Korea Association of Herbology","host_organization_lineage":["https://openalex.org/P4362724898"],"host_organization_lineage_names":["Korea Association of Herbology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Korea Journal of Herbology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://koreascience.or.kr:80/article/JAKO201211666469285.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ki-Ho Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205490536","display_name":"Dongguk University","ror":"https://ror.org/057q6n778","country_code":"KR","type":"education","lineage":["https://openalex.org/I205490536"]},{"id":"https://openalex.org/I4387154421","display_name":"Dongguk University WISE","ror":"https://ror.org/01dsa5866","country_code":"KR","type":"education","lineage":["https://openalex.org/I205490536","https://openalex.org/I4387154421"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ki-Ho Park","raw_affiliation_strings":["Department of Herbology , College of Oriental Medicine , Dongguk University , Gyeongju 780-714 , Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Herbology , College of Oriental Medicine , Dongguk University , Gyeongju 780-714 , Republic of Korea","institution_ids":["https://openalex.org/I205490536","https://openalex.org/I4387154421"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002342747","display_name":"Tae Woo Oh","orcid":"https://orcid.org/0000-0001-7184-6503","observed_orcids":["https://orcid.org/0000-0001-7184-6503"]},"institutions":[{"id":"https://openalex.org/I205490536","display_name":"Dongguk University","ror":"https://ror.org/057q6n778","country_code":"KR","type":"education","lineage":["https://openalex.org/I205490536"]},{"id":"https://openalex.org/I4387154421","display_name":"Dongguk University WISE","ror":"https://ror.org/01dsa5866","country_code":"KR","type":"education","lineage":["https://openalex.org/I205490536","https://openalex.org/I4387154421"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Tae-Woo Oh","raw_affiliation_strings":["Department of Herbology , College of Oriental Medicine , Dongguk University , Gyeongju 780-714 , Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Herbology , College of Oriental Medicine , Dongguk University , Gyeongju 780-714 , Republic of Korea","institution_ids":["https://openalex.org/I205490536","https://openalex.org/I4387154421"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018228594","display_name":"Yong\u2010Ki Park","orcid":"https://orcid.org/0000-0002-1148-662X","observed_orcids":["https://orcid.org/0000-0002-1148-662X"]},"institutions":[{"id":"https://openalex.org/I205490536","display_name":"Dongguk University","ror":"https://ror.org/057q6n778","country_code":"KR","type":"education","lineage":["https://openalex.org/I205490536"]},{"id":"https://openalex.org/I4387154421","display_name":"Dongguk University WISE","ror":"https://ror.org/01dsa5866","country_code":"KR","type":"education","lineage":["https://openalex.org/I205490536","https://openalex.org/I4387154421"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yong-Ki Park","raw_affiliation_strings":["Department of Herbology , College of Oriental Medicine , Dongguk University , Gyeongju 780-714 , Republic of Korea","Dongguk University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Herbology , College of Oriental Medicine , Dongguk University , Gyeongju 780-714 , Republic of Korea","institution_ids":["https://openalex.org/I205490536","https://openalex.org/I4387154421"]},{"raw_affiliation_string":"Dongguk University","institution_ids":["https://openalex.org/I205490536"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.08875997,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"27","issue":"2","first_page":"61","last_page":"67"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.5396000146865845,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.5396000146865845,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.1348000019788742,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.07259999960660934,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angelica-gigas","display_name":"Angelica gigas","score":0.8550000190734863},{"id":"https://openalex.org/keywords/aqueous-extract","display_name":"aqueous extract","score":0.7860000133514404},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9200000166893005},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.9890000224113464},{"id":"https://openalex.org/keywords/transient-middle-cerebral-artery-occlusion","display_name":"transient middle cerebral artery occlusion","score":0.9869999885559082},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9089999794960022},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9089999794960022},{"id":"https://openalex.org/keywords/angiopoietin-1","display_name":"angiopoietin-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tie2-receptor","display_name":"Tie2 receptor","score":0.9879999756813049},{"id":"https://openalex.org/keywords/blood-brain-barrier-permeability","display_name":"blood-brain barrier permeability","score":0.9660000205039978},{"id":"https://openalex.org/keywords/infarct-size","display_name":"infarct size","score":0.847000002861023},{"id":"https://openalex.org/keywords/neuronal-damage","display_name":"neuronal injury","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.8425807952880859},{"id":"https://openalex.org/C2777649898","wikidata":"https://www.wikidata.org/wiki/Q5415983","display_name":"Evans Blue","level":2,"score":0.6951777935028076},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6650363206863403},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6392101049423218},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.6281260848045349},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.6105042695999146},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.501009464263916},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.4901934266090393},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.4425967335700989},{"id":"https://openalex.org/C2779091547","wikidata":"https://www.wikidata.org/wiki/Q287565","display_name":"Radix (gastropod)","level":2,"score":0.4397071897983551},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4242438077926636},{"id":"https://openalex.org/C113045295","wikidata":"https://www.wikidata.org/wiki/Q7916465","display_name":"Vascular permeability","level":2,"score":0.41775110363960266},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3367748260498047},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2576136589050293},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24953171610832214},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.23321875929832458},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18336689472198486},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14080628752708435},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.1360914409160614},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.6116/kjh.2012.27.2.61","doi":"https://doi.org/10.6116/kjh.2012.27.2.61","is_oa":true,"landing_page_url":"https://doi.org/10.6116/kjh.2012.27.2.61","pdf_url":"http://koreascience.or.kr:80/article/JAKO201211666469285.pdf","source":{"id":"https://openalex.org/S2913471374","display_name":"The Korea Journal of Herbology","issn_l":"1229-1765","issn":["1229-1765","2288-7199"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":"https://openalex.org/P4362724898","host_organization_name":"Korea Association of Herbology","host_organization_lineage":["https://openalex.org/P4362724898"],"host_organization_lineage_names":["Korea Association of Herbology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Korea Journal of Herbology","raw_type":"journal-article"},{"id":"mag:3176839547","doi":null,"is_oa":false,"landing_page_url":"http://dspace.kci.go.kr/handle/kci/1357416","pdf_url":null,"source":{"id":"https://openalex.org/S2913471374","display_name":"The Korea Journal of Herbology","issn_l":"1229-1765","issn":["1229-1765","2288-7199"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":"https://openalex.org/P4362724898","host_organization_name":"Korea Association of Herbology","host_organization_lineage":["https://openalex.org/P4362724898"],"host_organization_lineage_names":["Korea Association of Herbology"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\ub300\ud55c\ubcf8\ucd08\ud559\ud68c\uc9c0(\ubcf8\ucd08\ubd84\uacfc\ud559\ud68c\uc9c0)","raw_type":null}],"best_oa_location":{"id":"doi:10.6116/kjh.2012.27.2.61","doi":"https://doi.org/10.6116/kjh.2012.27.2.61","is_oa":true,"landing_page_url":"https://doi.org/10.6116/kjh.2012.27.2.61","pdf_url":"http://koreascience.or.kr:80/article/JAKO201211666469285.pdf","source":{"id":"https://openalex.org/S2913471374","display_name":"The Korea Journal of Herbology","issn_l":"1229-1765","issn":["1229-1765","2288-7199"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":"https://openalex.org/P4362724898","host_organization_name":"Korea Association of Herbology","host_organization_lineage":["https://openalex.org/P4362724898"],"host_organization_lineage_names":["Korea Association of Herbology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Korea Journal of Herbology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1991397384.pdf","grobid_xml":"https://content.openalex.org/works/W1991397384.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W615717189","https://openalex.org/W752015848","https://openalex.org/W833888068","https://openalex.org/W1243676497","https://openalex.org/W1536285992","https://openalex.org/W1584623699","https://openalex.org/W1783580437","https://openalex.org/W1966067258","https://openalex.org/W1974962627","https://openalex.org/W1978200757","https://openalex.org/W2013661589","https://openalex.org/W2015615473","https://openalex.org/W2016685143","https://openalex.org/W2018895167","https://openalex.org/W2046953754","https://openalex.org/W2054353907","https://openalex.org/W2066908346","https://openalex.org/W2104239928","https://openalex.org/W2112505121","https://openalex.org/W2404921381"],"related_works":["https://openalex.org/W3176839547","https://openalex.org/W2090032537","https://openalex.org/W833888068","https://openalex.org/W2946914851","https://openalex.org/W615717189","https://openalex.org/W2051226942","https://openalex.org/W3088387783","https://openalex.org/W2256746640","https://openalex.org/W1584623699","https://openalex.org/W167828696"],"abstract_inverted_index":{"Objective":[0],":":[1,53,132,165],"Angelica":[2],"Gigas":[3],"Nakai":[4],"is":[5,22],"a":[6],"popular":[7],"oriental":[8],"medicine":[9],"used":[10],"for":[11,78],"the":[12,28,47],"treatment":[13],"of":[14,19,27,31,49,65,111,143,146,153],"vascular":[15,112],"diseases.":[16],"The":[17],"aim":[18],"this":[20],"study":[21,167],"to":[23],"investigate":[24],"neuroprotective":[25,174],"effect":[26,175],"water":[29,61,134,171],"extract":[30,62,135,172],"Anelicae":[32],"Gigantis":[33],"Radix":[34],"Palva":[35],"(AG)":[36],"in":[37,123,140],"transient":[38],"middle":[39],"cerebral":[40],"artery":[41],"occlusion":[42],"(tMCAO)-induced":[43],"ischemic":[44,141],"rats":[45,55],"via":[46],"regulation":[48],"angiogenesis-related":[50],"molecules.":[51],"Methods":[52],"Sprague-Dawley":[54],"were":[56,83,92],"intraperitoneally":[57],"administrated":[58],"with":[59,180],"AG":[60,133,170],"at":[63],"doses":[64],"10,":[66],"25,":[67],"50":[68],"mg/kg":[69],"body":[70],"weight":[71],"after":[72],"tMCAO":[73],"(90":[74],"min":[75],"occlusion).":[76],"reperfusion":[77],"24":[79],"hr":[80],"infarction":[81,138],"volumes":[82],"measured":[84],"by":[85,97,107,128,176],"2,3,5-tetrazolium":[86],"chloride":[87],"(TTC)":[88],"staining.":[89],"Brain":[90],"tissues":[91,125],"observed":[93],"neuronal":[94,147],"cell":[95],"injuries":[96],"nissl":[98],"staining,":[99],"and":[100,119,151,185],"also":[101],"brain-blood":[102],"barrier":[103],"(BBB)":[104],"permeability":[105,150],"change":[106],"evans":[108],"blue.":[109],"Expression":[110],"endothelial":[113],"growth":[114],"factor":[115,183],"(VEGF),":[116],"angiopoietin-1":[117],"(Ang-1)":[118],"Tie-2":[120],"receptor":[121],"protein":[122,155,158],"brain":[124],"was":[126,159],"determined":[127],"western":[129],"blot.":[130],"Results":[131],"significantly":[136],"reduced":[137],"volume":[139],"brains":[142],"rats,":[144],"degradation":[145],"cell,":[148],"BBB":[149,178],"expression":[152],"VEGF":[154,184],"dose-dependently.":[156],"Ang-1":[157],"increased":[160],"dose-dependantly,":[161],"not":[162],"significantly.":[163],"Conclusion":[164],"This":[166],"suggests":[168],"that":[169],"shows":[173],"preventing":[177],"breakdown,":[179],"regulating":[181],"angiogenesis":[182],"Ang-1.":[186]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}